• Title/Summary/Keyword: Inclusion

Search Result 4,273, Processing Time 0.03 seconds

Free Vibration Analysis of Al Cantilever Square Plates with a Brass Inclusion (황동 개재물이 있는 Al 외팔형 정사각판의 자유진동해석)

  • Lee, Youn-bok;Lee, Young-shin;Lee, Se-hoon
    • Transactions of the Korean Society for Noise and Vibration Engineering
    • /
    • v.15 no.12 s.105
    • /
    • pp.1347-1354
    • /
    • 2005
  • The free vibration characteristics of Al cantilever square plates with a brass inclusion were analyzed experimentally and numerically The experimentally obtained natural frequencies and mode shapes were compared with the FEM analysis results. The impulse exciting method was used for experiment and ANSYS software package was used for FEM analysis. The natural frequencies obtained iron experiment and numerical analysis matched within $0\%$. It was found that the natural frequencies of the Al cantilever square plates with a brass inclusion decrease as the size of inclusion increases. For the third mode shape, comparing the nodal line of the Al plate and the Al plate with a inclusion, the mode shape showed the reversed quadratic curve. The natural frequencies of inclusion plate were decreased as the location of inclusion moves from the clamped edge to the tree edge.

Dissolution Rate and Bioavailability of Acyclovir, Antiviral Agent, by Cyclodextrin Inclusion Complexation (시클로텍스트린 포접복합체 형성에 의한 항바이러스제 아시클로버의 용출속도 및 생체이용률)

  • Park, Seung-Hyun;Kim, Ha-Hyung;Lee, Kwang-Pyo
    • Journal of Pharmaceutical Investigation
    • /
    • v.28 no.4
    • /
    • pp.257-266
    • /
    • 1998
  • To improve the solubility and dissolution rate of acyclovir (ACV), which is low oral bioavailability due to its properties of slight solubility in water and incomplete gastrointestinal absorption, the solid inclusion complexes of ACV with ${\alpha}CD$, ${\beta}CD$, $DM{\beta}CD$ in molar ratio of 1:1 were prepared by the freeze-drying method. The inclusion complexes were investigated by solubility study, UV, IR and DSC. The dissolution rate of ACV was significantly increased by ACV-CDs inclusion complex formation in artificial intestinal fluid at pH 6.8. The enhanced dissolution rate of ACV could be due to an increase of solubility and the formation of an amorphous structures through inclusion complexation with CDs. Especially, $ACV-DM{\beta}CD$ inclusion complex enhanced the maximum plasma concentration levels and AUC following oral administration compared to those of ACV alone. The present results suggest that $ACV-DM{\beta}CD$ inclusion complex serves as a potential carrier for improving the solubility, the dissolution rate and the bioavailability of ACV.

  • PDF

Enhancement of Solubility and Disolution Rate of Poorly Water-soluble Naproxen by Coplexation with $2-Hyldroxypropylo-{\beta}-cyclodextrin$

  • Lee, Beom-Jin;Lee, Jeong-Ran
    • Archives of Pharmacal Research
    • /
    • v.18 no.1
    • /
    • pp.22-26
    • /
    • 1995
  • The solubility and dissolution rate of naproxen (NPX) complexed with 2-hydroxypropyl-.betha.-cyc-lodextrin (2-HP.betha.CD) using coprecipitation, evaporation, freeze-drying and kneading method were investigated. Solubility of NPX linearly increased (correlation cefficient, 0.995) as $2-HP\betaCD$ concentraction increased, resutling in $A_l$ type phase solubility curve. Inclusion complexes prepared by four different methods were compared by different methods were compared by dfferential scanning calorimetry(DSC). The NPX showed sharp endothemic peak around $156^{\circ}C$ but inclusion complexes by evaporation, freeze-drying and kneading method showed very broad peak without distinct phase transtion temperature. In contrast, inclusion complex prepared by coprecipitation method resulted in detectable peak around $156^{\circ}C$ which is similar to NPX, suggesting incoplete formation of indusion co plex. Dissolution rate of inclusion complexes prepared by evaporation, frezz-drying and kneding except coprecipitation method was largely enhanced in the simultaed gastric and intestinal fluid when compared to NPX powder and commercial $NA-XEN^\registered$tablet. However, about 65% of NPX in gstric fluid. in case of inclusion complex prepared by coprecipitation method, formation of inclusion complex appeared to be incoplete, resulting in no marked enhancement of dissolution rate. From these findings, inclusion complexes of poorly water-soluble NPX with $2-HP\betaCD$ were useful to increase soubility and dissolution rate, resting in enhancement of bioavailability and minimization of gastrointestinal toxicity of drug upon oral administration of inclusion complex.

  • PDF

An Empirical Study of Financial Inclusion and Financial System Stability in ASEAN-4

  • NA'IM, Hadi;SUBAGIARTA, I Wayan;WIBOWO, Rudy;WARDHONO, Adhitya
    • The Journal of Asian Finance, Economics and Business
    • /
    • v.8 no.7
    • /
    • pp.139-150
    • /
    • 2021
  • The financial system is a relatively important sector in the economy of a country. Its role in providing access to financial services to people is able to support a better economy. The main problem in this financial system is caused by the barriers that prevent individuals or companies from accessing these financial services. This study aims to empirically analyze the relationship financial inclusion and financial system stability in ASEAN 4 (Indonesia, Malaysia, Thailand, and The Philippines). Financial inclusion proxied by the financial inclusion through credit variable and other banking variables such as the number of financial services access, banking asset, and financial system stabilization is seen from banking performance through non-performing loan and Z score instruments. Empirically, the study uses panel data in the form of annual data for 2005-2016. The method used Panel VAR. The result shows that financial inclusion affects the stability of the financial system in ASEAN 4. This indicates that financial development through financial inclusion can encourage stability of the financial system in ASEAN 4. In this globalization era, the integrated financial system is increasing, this research shows the importance of developing financial inclusion by eliminating barriers to financial exclusion.

A Theoretical Research for the Conceptualization of Social Inclusion about the Disabled -From Social Exclusion to Inclusion- (장애인의 사회적 포함(Social Inclusion)의 개념화에 대한 이론적 고찰 -사회적 배제에서 포함으로-)

  • Shin, Yuri;Kim, Kyungmee;Yoo, Dongchul;Kim, Dongki
    • Korean Journal of Social Welfare
    • /
    • v.65 no.3
    • /
    • pp.5-28
    • /
    • 2013
  • As the interests in social inclusion is increasing, researches on social inclusion in the welfare of the disability positively are being implemented lately. It is required to be the reconsideration on previous perspectives and suggestion of the necessity of a new concept for acquiring equal accessibility on rights and resources, etc as a citizenship. It is evaluated to be useful as the perspective or approach of social inclusion in suggestion of policies and practices tasks for enhancing quality of life of the disadvantaged including the disabled and for their participating fully in overall social scopes. Therefore, firstly on tried to make understanding in each concept, constituents, characteristic, usefulness and restriction, etc about both of social exclusion and inclusion fundamentally. On discusses how to conceptualize social inclusion of the disabled, and meanings in applying the concept or approach of social inclusion to welfare of the disability through the based mentioned results.

  • PDF

Public Kindergarten Teachers' Concept Knowledge on Inclusion Education (장애유아통합교육에 대한 공립유치원 유아교사의 개념지식)

  • Kim, Jeong Mi;Kim, Sang Lim
    • Korean Journal of Child Education & Care
    • /
    • v.18 no.4
    • /
    • pp.267-277
    • /
    • 2018
  • Objective: The purpose of the study was to examine public kindergarten teachers' concept knowledge on inclusion education and to compare concept knowledge by teacher types (general teachers with experience of inclusion, general teachers without experience of inclusion, and special teachers). Methods: The subjects, sixty early childhood teachers in public kindergarten, were asked to draw concept maps illustrating their understanding of inclusion education for young children. The collected concept maps were analyzed using the methods utilized by Novak and Gowin (1984) as well as You and Kim (2018). Results: The results were as follows. First, 209 superordinate concepts were shown, and they were categorized into 13 representative superordinate concepts. Second, 1,585 subordinate concepts were shown. Among them, partial inclusion, complete inclusion, and teacher cooperation were frequently used. Third, contents of concept knowledge on inclusion education varied by teacher types. Conclusion/Implications: Discussions were included to support and enhance early childhood teachers' content knowledge on inclusion education for young children with special needs.

A study on the Mechanical Characteristics by the Internal Quality of Connecting Rod Materials for Trucks (트럭용 커넥팅 로드 소재의 내부 품질에 따른 기계적 특성 연구)

  • 김동현
    • Journal of the Korean Society of Manufacturing Technology Engineers
    • /
    • v.7 no.1
    • /
    • pp.75-81
    • /
    • 1998
  • We have studied internal quality including chemical compositions, microscopic structure and nonmetallic inclusion of test materials. We have analyzed tensile strength value, hardness value, impact value etc. In analyzing internal quality, all of the test materials showed typical ferrite+pearlite structure. But nonmetallic inclusion showed oxide and sulfide inclusions in medium carbon steels, and sulfide inclusion is S-free cutting steels. In ca+ S-free cutting steels, the calcium aluminate and sulfide complex inclusion had low-melting points as deformation of sulfide and oxide inclusion is existed. It was found that tensile strength and hardness give maximum value in medium carbon steels, where as minimum in Ca + -free cutting steels. But values of elongation, reduction of area impact are reverse. Fracture surface of impact specimen is ductile in free cutting steels but brittle in medium cabon steels.

  • PDF

INFLUENCE OF INCLUSION ON INTERNAL DEFECT IN MULTI-STAGE EXTRUSION

  • Yoshida Y.;Fukaya Y.;Yukawa N.;Ishikawa T.;Ito K.
    • Proceedings of the Korean Society for Technology of Plasticity Conference
    • /
    • 2003.10b
    • /
    • pp.51-54
    • /
    • 2003
  • Internal defects such as chevron crack occasionally occur in the process of cold extrusion or cold drawing. It is known that the existence and property of inclusion greatly influences the generation of the internal crack. However, in the plastic working field, research about the effect of the inclusion on the fracture is not theoretically analyzed. This paper describes effects of the physical property of inclusion on the internal fracture generation in the process. Prediction of fracture was evaluated by critical damage value calculated by the equation of Cockcroft & Latham and its change by the inclusion physical property such as size and stiffness was investigated.

  • PDF

Traumatic Epidermal Inclusion Cyst under Anterolateral Thigh Free Flap on Great Toe

  • Lee, Jun Ho;Choi, Hwan Jun
    • Archives of Reconstructive Microsurgery
    • /
    • v.24 no.1
    • /
    • pp.37-39
    • /
    • 2015
  • Epidermal inclusion cyst is a common mass in life. It is covered with a stratified squamous epithelium, thus, there is a granular cell layer adjacent to the keratin-containing cyst lumen. It can be caused by mechanical force, trauma, or a spontaneous event. It can rupture spontaneously or be ruptured by external mechanical forces. Epidermal inclusion cysts that exhibit inflammation or recur should be removed by simple excision. In this case, the patient showed an epidermal inclusion cyst under an anterolateral thigh free flap, which can cause the palpable mass to go unnoticed. First we thought he had neuroma formation after a surgical procedure on his foot. However it was an epidermal inclusion cyst, which was diagnosed by a special pathologist. It is a curious and rare case.

Inclusion Complexation of Chlorpropamide with Cyclodextrins (클로로프로파미드와 싸이클로덱스트린과의 포접 화합물에 관한 연구)

  • 정경혜;김길수;구영순
    • YAKHAK HOEJI
    • /
    • v.30 no.2
    • /
    • pp.87-95
    • /
    • 1986
  • Inclusion complexation of $\alpha$-cyclodextrin($\alpha$-CD), $\beta$-cyclodextrin($\beta$-CD) and tri-O-methyl-$\beta$-cyclodextrin(tri-O-methyl-$\beta$-CD) with chlorpamide(CPA) in aqueous solution and in the solid state were studied by the solubility method, spectroscopy (UV, IR), differential scanning calorimetry (DSC) and powder X-ray diffractometry, and all their molar ratios were found to be 1:1. The solid complexes of CPA with three kinds of cyclodextrins were prepared by a freezedrying method, and their dissolution behaviors were examined. As a result, the release of CPA from the inclusion complexes was significantly improved. The intrinsic dissolution rate of CPA in cyclodextrin inclusion complexes was about 51 times ($\alpha$-CD inclusion complex) and 12 tmies ($\beta$-CD inclusion complex) larger than that of intact CPA.

  • PDF