• Smart Structures and Systems
• /
• 제8권1호
• /
• pp.17-37
• /
• 2011

The microcantilever (MCL) sensor is one of the most promising platforms for next-generation label-free biosensing applications. It outperforms conventional label-free detection methods in terms of portability and parallelization. In this paper, an overview of recent advances in our understanding of the coupling between biomolecular interactions and MCL responses is given. A dual compact optical MCL sensing platform was built to enable biosensing experiments both in gas-phase environments and in solutions. The thermal bimorph effect was found to be an effective nanomanipulator for the MCL platform calibration. The study of the alkanethiol self-assembly monolayer (SAM) chain length effect revealed that 1-octanethiol ($C_8H_{17}SH$) induced a larger deflection than that from 1-dodecanethiol ($C_{12}H_{25}SH$) in solutions. Using the clinically relevant biomarker C-reactive protein (CRP), we revealed that the analytical sensitivity of the MCL reached a diagnostic level of $1{\sim}500{\mu}g/ml$ within a 7% coefficient of variation. Using grazing incident x-ray diffractometer (GIXRD) analysis, we found that the gold surface was dominated by the (111) crystalline plane. Moreover, using X-ray photoelectron spectroscopy (XPS) analysis, we confirmed that the Au-S covalent bonds occurred in SAM adsorption whereas CRP molecular bindings occurred in protein analysis. First principles density functional theory (DFT) simulations were also used to examine biomolecular adsorption mechanisms. Multiscale modeling was then developed to connect the interactions at the molecular level with the MCL mechanical response. The alkanethiol SAM chain length effect in air was successfully predicted using the multiscale scheme.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권2호
• /
• pp.753-756
• /
• 2015

Background: Red cell distribution width (RDW) is one of the standard parameters with blood cell counts. Much previous research has indicated that it increases in cases of systemic inflammation or cardiametabolic incident. However, information on the relation of RDW with solid tumors causing systemic inflammation is limited. In the present research, we examined the relation of RDW with malignant and benign lesions of the colon. Materials and Methods: 115 patients with colon polyps (group 1), and 30 with colon cancer (group 2) who were diagnosed histopathologically in our clinic between January 2010-January 2013 were scanned retrospectively. Patients with anemia, hematologic diseases and active inflammation were excluded. RDW, mean corpuscular volume (MCV), hemoglobin (Hgb) and platelet (Plt) measurements were recorded and their relations with the malignant and benign lesions of the colon were examined. Results: Both groups were similar in age and gender distribution. RDW values of patients with colon cancer were significantly higher than the patients with colon polyp (p=0,01). No significant differences were detected between the two groups in terms of MCV and Plt values (p>0,05). Conclusions: RDW can be used as an early warning biomarker for solid colon tumors. Further prospective research is required on the relations of cheap and easily measured RDW parameters with colon malignancies.

• 한국ITS학회 논문지
• /
• 제10권2호
• /
• pp.1-8
• /
• 2011

교통체증은 도시지역에서 심각한 경제적, 사회적 비용을 초래하는 원인으로 간주되고 있다. ITS기법은 첨단 센싱, 컴퓨팅, 그리고 통신기술을 이용해 교통체증을 경감시킬 수 있는 훌륭한 수단이다. 본 연구는 차량과 주변 인프라 그리고 차량 간의 무선통신을 통한 중앙제어식 그리고 분산식 첨단통행자정보시스템의 프레임워크를 제안하고 전형적인 $6{\times}6$ 도시형 도로망에서 그 효과를 시뮬레이션 기법을 이용하여 분석하고자 한다. 본 논문의 연구결과로서는 교통류, 무선통신 라디오 레인지 그리고 통신차량의 보급률 등에 따라 제안된 첨단통행자정보시스템은 교통사고로 야기된 정체지역을 우회할 수 있는 최적의 노선을 제공함으로써 운전자의 통행시간을 줄여주는 효과를 보였다. 다양한 연구 환경에서도 중앙제어식 그리고 분산식 첨단통행자정보시스템은 거의 동일한 효과를 보였는바, 분산식 첨단통행자정보시스템은 고가의 건설비와 설치 운영비를 요구하는 중앙제어식 첨단통행자정보시스템을 대신할 수 있는 시스템으로 기대된다.

• 한국광학회지
• /
• 제5권1호
• /
• pp.138-143
• /
• 1994

거친 표면을 가진 물체의 미소변위를 1차원 CCD소자와 레이저 스펙클(laser speckle) 방법을 이용하여 측정하였다. 거친 표면에서 산란된 레이저 광이 이루는 스펙클 무늬를 물체의 이동 전후에 얻고, 그것의 상호상관함수(cross-correlation)를 계산하여 스펙클 변위를 계산한다. 1차원 CCD소자를 이용하여 물체이동 전후의 스펙클 무늬를 측정하고, 레이저 스펙클 변위값을 386 PC로 인터페이스하여 PC에서 계산한다. 사용한 CCD 소자의 화소 간격은 $15\mu\textrm{m}$이고, 화소의 개수는 1728개이다. 스펙클 변위와 물체의 이동거리와는 비는 레이저 빔의 파면의 곡률에따라 1.03으로부터 5.20까지 변화한다. CCD 픽셀의 간격이 $15\mu\textrm{m}$이므로 물체의 $3\mu\textrm{m}$ 이동을 감지해 낼 수 있다.

• 한국광학회지
• /
• 제14권1호
• /
• pp.97-102
• /
• 2003

이차원 표면 플라즈몬의 공명 흡수와 포토 마스크를 이용하여 11-MUA(11-Mercaptoundecanoic acid)와 11-MUOH(11-Mercaptoundecanol) 둥으로 이루어진 자기조립 단분자막(Self-Assembled Monolayer; SAM)의 다채널 영상을 얻었다. 통상의 Photoresist를 이용한 리토그래피 대신에 Thiol bonding의 광산화를 이용하여 패터닝 과정을 줄이고, 백색광 및 대역통과 필터(λ$_{0}$=633nm)를 이용하여 입사광으로써 레이저를 사용할 때 나타나는 간섭무늬를 줄였다. 이로부터 나타나는 이차원 영상의 명암을 정량적으로 보정하면 수 나노미터(nm) 두께의 변화를 측정할 수 있다. 또한 표면 플라즈몬 공명법은 국소화된 근접장 (소산장)을 이용하는 방법으로서, 통상 많이 이용되는 형광법 등에서 나타나는 광탈색(Photobleaching)이나 소광(Quenching) 현상이 없이 시료의 처리가 간단하고, 영상 신호의 시간에 따른 변화가 극히 적으며, 실시간으로 신호의 변화를 측정할 수 있다는 장점이 있다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제17권sup3호
• /
• pp.197-200
• /
• 2016

On an international scale, the burden of cancer in absolute numbers continues to increase, mainly due to aging of population in many countries, the overall growth of the world population, changing lifestyle with increasing cancer-causing behavior, like cigarette smoking, changing dietary habits and sedentary life. Cancer is the second-leading cause of death and disability in the world, after only heart disease. Recently, increasing incidence and mortality of cancer have also become evident in the developing world. In Iraq and particularly in Basrah in the southern part of the country, the burden has definitely increased and deserves extensive research. The present paper is part of an extensive household survey carried out in Basrah in 2013. Among the objectives was to validate official cancer registration in the governorate. The cross-sectional survey had a retrospective component to inquire about the incidence of cancer and cancer-related deaths during the three years preceding the date of inquiry (2010-2012). A convenient sample of 6,999 households with 40,688 inhabitants using multistage cluster sampling was surveyed involving all urban and rural areas of Basrah. The official cancer registration activities in Basrah seemed to have attained a high level of registration coverage (70-80%) but the gap, represented by missed cases, is still high enough to criticize the system. Most of the missing cases were either not notified by treating facilities or they were diagnosed and treated outside Basrah. Using a set of parameters, the pattern of cancer was consistent based on data of the household survey and data of the cancer registry but a gap still existed in the coverage of incident cancer and mortality by cancer registration. Integrated serious steps are required to contain the risk of cancer and its burden on the patient through improving the registration process, improving early detection, diagnostic and management capabilities and encouraging scientific research to explore the hidden risk factors and possible causes of low registration coverage. Periodic household surveys seemed feasible and essential to support routine registration.

• 한국재료학회지
• /
• 제11권4호
• /
• pp.247-250
• /
• 2001

광이 입사되는 수광면에 그물망(web)모양의 얕은 $P^{+}$ -diffusion 영역을 갖는 새로운 구조의 적색광 검출 Si pin photodiode를 제작하고 그 특성을 분석하였다. 제작된 소자의 전기.광학적 특성을 -5V의 동작전압에서 측정한 결과, 접합 커패시턴스와 암전류는 각각 4pF와 235pA로 나타났으며 670nm의 중심파장을 갖는 1.6㎼의 입사광 전력 아래에서 광신호 전류와 감도특성은 각각 0.48$\mu\textrm{A}$와 0.30A/W로 나타났다. 제작된 소자는 종래의 circular type photodiode에 비해 개선된 감도 특성을 나타내었으며 670~700nm의 파장영역에서 최대 spectral response를 보였다. 본 연구에서의 web-patterned Si photodiode는 red light optics 응용에서 디지털 신호처리시 우수한 신호분리 능력을 나타낼 것으로 기대된다.

• 제어로봇시스템학회:학술대회논문집
• /
• 제어로봇시스템학회 2000년도 제15차 학술회의논문집
• /
• pp.50-50
• /
• 2000

In this paper, a new measuring system is :proposed which can measure the fine 6-DOF displacement of rigid bodies. Its measurement principle is based on detection of laser beam reflected from a specially fabricated mirror that looks like a triangular pyramid having an equilateral cross-sectional shape. The mirror has three lateral reflective surfaces inclined 45$^{\circ}$ to its bottom surface. We call this mirror 3-facet mirror. The 3-facet mirror is mounted on the object whose 6-DOF displacement is to be measured. The measurement is operated by a laser-based optical system composed of a 3-facet mirror, a laser source, three position-sensitive detectors(PSD). In the sensor system, three PSDs are located at three corner points of a triangular formation, which is an equilateral triangular formation tying parallel to the reference plane. The sensitive areas of three PSDs are oriented toward the center point of the triangular formation. The object whose 6-DOF displacement is to be measured is situated at the center with the 3-facet mirror on its top surface. A laser beam is emitted from the laser source located at the upright position and vertically incident on the top of the 3-fatcet mirror. Since each reflective facet faces toward each PSD, the laser beam is reflected at the 3-facet mirror and splits into three sub-beams, each of which is reflected from the three facets and finally arrives at three PSDs, respectively. Since each PSD is a 2-dimensional sensor, we can acquire the information on the 6-DOF displacement of the 3-facet mirror. From this principle, we can get 6-DOF displacement of any object simply by mounting the 3-facet mirror on the object. In this paper, we model the relationship between the 6-DOF displacement of the object and the outputs of three PSDs. And, a series of simulations are performed to demonstrate the effectiveness of the proposed method. The simulation results show that the proposed sensing system can be an effective means of obtaining 3-dimensional position and orientation of arbitrary objects.

• 품질경영학회지
• /
• 제48권2호
• /
• pp.241-256
• /
• 2020

Purpose: Certain places in Seoul such as Shinchon, Hongdae, and Gangnam, often suffer from sudden overflow of mobile population which can cause serious safety problems. This study suggests the application of spatial CUSUM control chart in monitoring areal population mobility data which is recently provided by Seoul metropolitan government. Methods: Monitoring series of standardized local Moran's I enables one to detect spatio-temporal out-of-control status based on the accumulation of past patterns. Moreover, we visualize such pattern map for more intuitive comprehension of the phenomenon. As a case study, we have analyzed the female mobility population aged 25 to 29 appeared in 51 Jipgyegu near Hongik university on fridays from January, 2017 to June, 2018. They are validated by exploring related articles and through local due diligence. Results: The results of the analysis provide insights in figuring out if the change of the mobility population is short-term by particular incident or long-term by spatial alteration, which allows strategic approach in constructing response system. Specific case near popular downtown near Hongik University has shown that newly opened hotels, shops of global sports brand and franchise bookstores have attracted young female population. Conclusion: We expect that the results of our study contribute to planning effective distribution of administrative resources to prepare against drastic increase in floating population. Furthermore, it can be useful in commercial area analysis and age/gender specific marketing strategy for companies.

• 대한교통학회지
• /
• 제32권5호
• /
• pp.522-530
• /
• 2014

교통관리센터에 축적되어 있는 속도 이력데이터에는 반복 비반복 정체 시공간 전개에 대한 상세한 정보가 모두 들어있으나, 도해법에 의해 다루어져 왔기 때문에 많은 양의 이력데이터를 처리하여 교통상황예측이나 정보제공에 활용할 수 없는 한계가 존재하였다. 본 논문에서는, 기존의 Classification과 Density-Based Clustering 알고리즘을 속도 시공간 데이터 특성에 맞게 조합하고 변형하여 정체 시공간 영역을 자동 인식하는 알고리즘과, 정체파급길이, 파급속도, 해소속도 등 정체 시공간 전개 패턴의 특성치를 산정하는 알고리즘을 개발하였다, 본 알고리즘은, 교통관리센터에 축적되어 있는 방대한 양의 이력데이터를 자동으로 분석하여 자세한 정체 관련 정보를 추출할 수 있고, 산정된 특성치를 가지고 각 센터의 필요에 따라 다양한 정보를 2차 생성하고 활용할 수 있는 장점이 있다. 본 연구결과는 향후 반복 비반복 정체에 대한 예측과 대응이 획기적으로 개선되는데 초석이 될 것으로 기대된다.