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Effects of 3,5,3'-triiodo-L-thyronine ($T^3$) on Growth of GR-transgenic Coho Salmon, Oncorhynchus Kitsutch

  • Kang, Duk-Young;Robert H. Devlin
    • Proceedings of the Korean Society of Embryo Transfer Conference
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    • 2002.11a
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    • pp.101-101
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    • 2002
  • GH-transgenic coho salmon (Oncorhynchus kitsutch) juveniles in tGH*T$_3$and tGH*PTU were fed with the diets containing 1 ug/g fish of 3,5,3'-triiodo-L-thyronine (T$_3$) and 30 ug/g fish of 6-n-propyl-2- thiouracil (PTU), respectively, to assess the effect of these drugs on the change of physiological activity, growth and survival rate in comparison with normal transgenic (tGH*C) and nontransgenic coho salmon (Wild) for 90 days. Although the daily food intakes of all transgenic (tGH)-groups were higher than Wild, the amount was reduced by exogenous PTU supply. The fred efficiencies of tGH-groups were lower than Wild, but the efficiency was reduced both by T$_3$and PTU. The survival rate of tGH-group was significantly higher than that of Wild, but there was no significant difference among tGH-groups. Although the growth of tGH-coho salmon was faster than Wild. the growth rate of transgenic salmon was increased by exogenous T$_3$, but was reduced by PTU Plasma TT$_4$levels of tGH-groups was approximately 2-fold higher relative to Wild, but there were no difference of plasma TT$_4$levels among tGH-groups. plasma TT$_3$level or tGH-coho salmon was increased by exogenous T$_3$administration, but was reduced by exogenous PTU. In addition, although plasma GH levels of all tGH-groups were higher than that of Wild, the GH level in plasma of transgenic coho salmon was increased by exogenous T$_3$and reduced by exogenous PTU. In the meantime, the transgenic fishes also displayed head, jaw and opercular abnormalities typical of the offsets of this gene construct in coho salmon, indicating that some imbalance in growth processes has been induced. However, the abnormalities of transgenic coho salmon was reduced following exogenous PTU administration.

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Effects of Sa-Mul-Tang on Immunocytes of L1210 Cells-transplanted or Antitumor Drugs-administered Mice (사물탕이 L1210 세포 이식 및 항암제를 투여한 마우스의 면역세포에 미치는 영향)

  • Yu, Dong-Hwa;Kwon, Jin;Oh, Chan-Ho;Eun, Jae-Soon
    • Korean Journal of Pharmacognosy
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    • v.29 no.2
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    • pp.110-119
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    • 1998
  • Sa-Mul-Tang(SMT) consist of Rehmanniae Radix Preparata, Paeoniae Radix Alba, Cnidii Rhizoma and Angelicae Gigantis Radix. In L1210 cells-transplanted BALB/c mice, T-lymphocyte apoptosis, $CD8^+T_C$ cells population in thymocyte and nitric oxide production in macrophage were enhanced, but phagocytic activity was decreased. SMT suppressed T-lymphocyte apoptosis and enhanced CD^4+T_H$ cells population, but did not affect nitric oxide production and phagocytic activity in L1210 cells-transplanted mice. In antitumor drugs-injected mice, T-lymphocyte apoptosis was enhanced, but $CD4^+T_H/CD8^+T_C$, cells population and T-lymphocyte proliferation were decreased. SMT suppressed T-lymphocyte apoptosis, and enhanced $CD8^+T_C$ cells population, T-lymphocyte proliferation and phagocytic activity in vincristine-injected mice. These results suggest that SMT enhances T cell-mediated immunity in L1210 cell-transplanted mice, and enhances T cell-mediated immunity and phagocytic activity in vincristine-injected mice.

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EXISTENCE OF POSITIVE SOLUTIONS FOR SINGULAR IMPULSIVE DIFFERENTIAL EQUATIONS WITH INTEGRAL BOUNDARY CONDITIONS

  • Miao, Chunmei;Ge, Weigao;Zhang, Zhaojun
    • The Pure and Applied Mathematics
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    • v.21 no.3
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    • pp.147-163
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    • 2014
  • In this paper, we study the existence of positive solutions for singular impulsive differential equations with integral boundary conditions $$\{u^{{\prime}{\prime}}(t)+q(t)f(t,u(t),u^{\prime}(t))=0,\;t{\in}\mathbb{J}^{\prime},\\{\Delta}u(t_k)=I_k(u(t_k),u^{\prime}(t_k)),\;k=1,2,{\cdots},p,\\{\Delta}u^{\prime}(t_k)=-L_k(u(t_k),u^{\prime}(t_k)),\;k=1,2,{\cdots},p,\\u=(0)={\int}_{0}^{1}g(t)u(t)dt,\;u^{\prime}=0,$$) where the nonlinearity f(t, u, v) may be singular at v = 0. The proof is based on the theory of Leray-Schauder degree, together with a truncation technique. Some recent results in the literature are generalized and improved.

An Evaluation of Thyroid Hormones$(T_4,\;T_3\;&\;Free\;T_4)$ Concentrations During Pregnancy (임신중(姙娠中) 유리(遊離)Thyroxine $(T_4)$의 동태(動態))

  • Lee, Kyu-Bo;Kim, Ji-Yeul
    • The Korean Journal of Nuclear Medicine
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    • v.15 no.1
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    • pp.21-25
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    • 1981
  • Serum concentrations of $T_4,\;T_3$, and free $T_4$ were measured by radioimmunoassay in normal pregnant women at each trimesters, in postpartum women, and cord blood of neonates. Total $T_4$ were increased during pregnancy, remarkably high in the first trimester, and also somewhat increased in postpartum, and normal in neonate. Total $T_3$ were in normal range during pregnancy, but increased in postpartum, whereas decreased in neonate. Free $T_4$ were decreased in 2nd and 3rd trimesters of pregnancy, however normal in post partum and neonate.

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Study on Eating Behavior of Holstein Steers by Growth Stages (Bos taurus) (Holstein 거세 비육우 성장단계별 채식 행동에 관한 연구)

  • Hea, Byeong-Joon;Kim, Eun Joong;Lee, Sang Moo
    • Journal of The Korean Society of Grassland and Forage Science
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    • v.41 no.4
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    • pp.234-241
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    • 2021
  • This study was carried out to investigate the effects of a different growing stage on the eating and ruminating behavior of Holstein steer (Bos taurus). A total of nine Holstein steers were divided into three growing stage groups (T1: growth stage, 8 months old, T2: Early fattening stage, 15 months old, T3: late fattening stage, 24 months old) with 3 replicates. In the feeding method, concentrate was offered at 1.62% of the body weight per treatment, respectively. And the forage was fed ad libitum for all treatment. The results of behaviors are summarized as follows: The rate of dry matter intake compared to body weight (DMI/BW, %) was high in the order of T1(2.21%) > T2(2.09%) > T3(1.39%). Eating time, ruminating time and resting time were significantly higher in T1, T2 and T3, respectively(p<0.05, 0.01). Chewing time was significantly lower in T3 than in T1 and T2(p<0.01). The number of bolus and the number of total chews were significantly higher in T2 than those of the other treatments(p<0.01). However ruminating time per bolus and the number of bolus per minute were not significantly different among the treatments. The numbers of drinking and defecating were not significantly different among the treatments. The number of urinating was significantly higher T1 than those of the other treatments(p<0.01). Time of drinking, defecating and urinating was not significantly difference among the treatments.

A Method for Dynamic Clustering-based Efficient Management in Large-Scale IoT Environment (대규모 IoT 컴퓨팅 환경에서 동적 클러스터링 기반 효율적 관리 기법)

  • Kim, Dae Young;La, Hyun Jung
    • Journal of Internet Computing and Services
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    • v.15 no.6
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    • pp.85-97
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    • 2014
  • IoT devices that collect information for end users and provide various services like giving traffic or weather information to them that are located everywhere aim to raise quality of life. Currently, the number of devices has dramatically increased so that there are many companies and laboratories for developing various IoT devices in the world. However, research about IoT computing such as connecting IoT devices or management is at an early stage. A server node that manages lots of IoT device in IoT computing environment is certainly needed. But, it is difficult to manage lots of devices efficiently. However, anyone cannot surly know about how many servers are needed or where they are located in the environment. In this paper, we suggest a method that is a way to dynamic clustering IoT computing environment by logical distance among devices. With our proposed method, we can ensure to manage the quality in large-scale IoT environment efficiently.

Effects of feeding different proportions of silver leaf desmodium (Desmodium uncinatum) with banana (Musa paradisiaca) leaf on nutrient utilization in Horro sheep fed a basal diet of natural grass hay

  • Chali, Diriba;Nurfeta, Ajebu;Banerjee, Sandip;Eik, Lars Olav
    • Asian-Australasian Journal of Animal Sciences
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    • v.31 no.9
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    • pp.1449-1457
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    • 2018
  • Objective: The objective was to evaluate feed intake, digestibility, body weight change and carcass characteristics of sheep fed a basal diet of hay supplemented with banana leaves and silver leaf desmodium. Methods: Thirty yearling lambs with an average initial body weight of $15.85{\pm}1.6kg$ were grouped into six blocks of five rams in each block. The treatments were: hay alone (T1), hay+100% banana leaf (T2), hay+67% banana leaf+33% desmodium leaf (T3), hay+33% banana leaf+67% desmodium leaf (T4), andhay+100% desmodium leaf (T5). Three hundred grams of treatment diets were offered daily on as fed basis. The feeding and digestibility trials lasted for 84 and 7 days, respectively, followed by carcass evaluation. Results: The total dry matter (DM) intake for T3, T4, and T5 were greater (p<0.05) than those fed T1 and T2 diets. The lowest (p<0.05) organic matter (OM) intake was recorded in rams reared on T1 diet. The total crude protein (CP) intake was in the following order: T5>T4>T3>T2>T1. Ram lambs receiving supplementary diets had higher (p<0.05) DM, OM, CP, neutral detergent fiber and acid detergent fiber digestibility compared with the control diet. The empty body weight and slaughter weight was highest (p<0.05) in rams receiving T3, T4, and T5 diets. The average daily gain and feed conversion efficiency was highest (p<0.05) in rams receiving the supplementary diets. The dressing percentage on the basis of hot carcass weight linearly increased with increasing levels of desmodium. Rams reared on supplementary diet had higher (p<0.05) rib eye area compared with the control diet. Conclusion: In conclusion, when banana leaf is used as a supplement to poor quality grass, better body weight gain was obtained when fed in combination with desmodium.

Functional Analysis of Fibroblastic Reticular Cells Derived from Mouse Lymph Node via Bidirectional Crosstalk with T Cells (T세포와 양방향 작용을 통한 마우스 림프절로부터 분리된 fibroblastic reticular cell의 기능적 분석)

  • Park, Sung Hee;Lee, Jong-Hwan
    • Journal of Life Science
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    • v.23 no.10
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    • pp.1199-1208
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    • 2013
  • Fibroblastic reticular cells (FRCs) form the structural backbone of the T zone provide a guidance path for immigrating T cells in the lymph node (LN). FRCs may contribute directly to developing T-cell biology in the LN and allow analyses of fundamental aspects of FRC biology related to T cells. FRCs inhibited T-cell apoptosis, and FRC culture supernatants strongly induced the expression of Bcl-xL in T cells against doxorubicin. Coculture of FRC and T cells resulted in rearrangements of the actin cytoskeleton, as well as global changes in the morphology of the FRCs. In addition, when cocultured, the T cells adhered to the FRC monolayer, and the membrane intercellular adhesion molecule (ICAM)-1 was slightly increased by day-dependent manner. In contrast, the expression of soluble ICAM-1 was dramatically increased in a day-dependent manner. Several chemokines, such as CCL5, CXCL1, CXCL5, CXCL16, CCL8, CXCL13, and ICAM-1, and MMPs were expressed in FRCs sensed by tumor necrosis factor (TNF) families. Nuclear factor kappa B ($NF{\kappa}B$)-RelA of the $NF{\kappa}B$ canonical pathway was translocated into FRC nuclear by $TNF{\alpha}$. In contrast, p52 proteolyzed from p100, a counterpart of RelB of the noncanonical $NF{\kappa}B$ pathway, accumulated in the peripheral FRC nucleus by agonistic anti-$LT{\beta}R$ antibody. In summary, we propose a model in which FRCs engage in bidirectional crosstalk to increase the efficiency of T-cell biology. This cooperative feedback loop may help to maintain tissue integrity and function during immune responses.

STRONG CONVERGENCE THEOREMS FOR LOCALLY PSEUDO-CONTRACTIVE MAPPINGS IN BANACH SPACES

  • Jung, Jong-Soo
    • Communications of the Korean Mathematical Society
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    • v.17 no.1
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    • pp.37-51
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    • 2002
  • Let X be a reflexive Banach space with a uniformly Gateaux differentiable norm, C a nonempty bounded open subset of X, and T a continuous mapping from the closure of C into X which is locally pseudo-contractive mapping on C. We show that if the closed unit ball of X has the fixed point property for nonexpansive self-mappings and T satisfies the following condition: there exists z $\in$ C such that ∥z-T(z)∥<∥x-T(x)∥ for all x on the boundary of C, then the trajectory tlongrightarrowz$_{t}$$\in$C, t$\in$[0, 1) defined by the equation z$_{t}$ = tT(z$_{t}$)+(1-t)z is continuous and strongly converges to a fixed point of T as t longrightarrow 1 ̄.ow 1 ̄.

How to Improve the Welfare of Science & Technology Personnel : Based on the Comprehensive Welfare Town for S&T Personnel (과학기술인의 종합복지 향상방안 : 과학기술인 종합복지타운 건립을 중심으로)

  • 이종민;임상현;정선양
    • Proceedings of the Technology Innovation Conference
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    • 2006.02a
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    • pp.150-169
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    • 2006
  • Science & Technology (S&T) personnel have played a major role to develop our country since S&T is the most important factor to increase national competitiveness in the 21st century. Therefore, it is very essential to increase the welfare of S&T personnel in order to increase national S&T and economic competitiveness. However, the welfare of S&T personnel has not been discussed sufficiently not only in academic research, but also in actual S&T policies. It has caused many. social problems (for example, avoiding fields of S&T of young generation, low social recognition of S&T community and so on). Under this background, this paper aims at investigating how to effectively improve S&T personnel's welfare. For this purpose, we deal with a theoretical review on the welfare of S&T personnel. After that, we will suggest 'Comprehensive Welfare Town for S&T Personnel' as a method of improving the welfare of S&T personnel.

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