• Proceedings of the Korean Vacuum Society Conference
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• 2010.02a
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• pp.14-15
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• 2010

Recently there has been growing interest in topological insulators or the quantum spin Hall (QSH) phase, which are insulating materials with bulk band gaps but have metallic edge states that are formed topologically and robust against any non-magnetic impurity [1]. In a three-dimensional material, the two-dimensional surface states correspond to the edge states (topological metal) and their intriguing nature in terms of electronic and spin structures have been experimentally observed in bulk Bi1-xSbx single crystals [2,3,4]. However, if we want to know the transport properties of these topological metals, high purity samples as well as very low temperature will be needed because of the contribution from bulk states or impurity effects. In a recent report, it was also shown that an intriguing coupling between the surface and bulk states will occur [5]. A simple solution to this bothersome problem is to prepare a topological metal on an ultrathin film, in which the surface-to-bulk ratio is drastically increased. Therefore in the present study, we have investigated if there is a method to make an ultrathin Bi1-xSbx film on a semiconductor substrate. From reflection high-energy electron diffraction observation, it was found that single crystal Bi1-xSbx films (0${\sim}30\;{\AA}A$ can be prepared on Si(111)-$7{\times}7$. The transport properties of such films were characterized by in situ monolithic micro four-point probes [6]. The temperature dependence of the resistivity for the x=0.1 samples was insulating when the film thickness was $240\;{\AA}A$. However, it became metallic as the thickness was reduced down to $30\;{\AA}A$, indicating surface-state dominant electrical conduction. Figure 1 shows the Fermi surface of $40\;{\AA}A$ thick Bi0.92Sb0.08 (a) and Bi0.84Sb0.16 (b) films mapped by angle-resolved photoemission spectroscopy. The basic features of the electronic structure of these surface states were shown to be the same as those found on bulk surfaces, meaning that topological metals can be prepared at the surface of an ultrathin film. The details will be given in the presentation.

• Tuberculosis and Respiratory Diseases
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• v.57 no.4
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• pp.358-363
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• 2004

Background : Photodynamic therapy (PDT) involves the use of photosensitizing agents for treatment of malignant disease. PDT is approved by the U.S. Food and Drug Administration for the endobronchial microinvasive nonsmall cell lung cancer and for palliation in patients with obstructing tumors. We report our experience and results of PDT in lung cancer. Method : Ten patients with lung cancer who were diagnosed in Chosun university hospital by histologic confirm through bronchoscopy were included between August 2002 and May 2003. The photosensitizer (Photogem$^{(R)}$, Lomonosov institute of Fine Chemical, Russia/dose 2.0 mg/kg body weight) was injected 48 hours prior to the PDT session. For PDT with the photosensitizer (Photogem$^{(R)}$), Diode LASER system (Biolitec Inc., Germany, wavelength; 633nm) were used. PDTs were done at 48-72 hours after photogem injection. Follow up bronchoscopy and chest X-ray or thorax computerized tomography were done for evaluate PDT response. Results : 9 of 10 patients with endobronchial obstruction showed partial remission with bronchus opening after PDT. Direct reaction of the tumor to PDT was similar in despite of its localization. It was as follows; edema, hyperemia, in-situ bleeding, fibrin film occurrence. Any other complications such as sunburns of skin, inflammation within the PDT zone were not occurred by the end of the fourth week. Conclusion : In the advanced endobronchial disease, PDT has been shown to be useful in treating endobronchial tumors that are causing clinically significant dyspnea or are likely to progress and lead to further clinical complications, such as postobstructive pneumonia.

• Journal of Pharmaceutical Investigation
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• v.26 no.2
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• pp.71-82
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• 1996

This study has been undertaken to evaluate hydrophobic cyclodextrin(CD) derivatives as a sustained release carrier of azidothymidine(AZT), AZT, which has potent activity against AIDS and AIDS-related complex as thymidine analogue, has been reported that it has significant toxicity and short half life. Therefore, it is necessary to design sustained release oral dosage form to avoid undesirable side effects attributable to an excessive plasma concentration and to reduce the frequency of administration of AZT. Inclusion complexes of AZT with $acetyl-{\beta}-cyclodextrin\;(AC{\beta}CD)$ and $triacetyl-{\beta}-cyclodextrin(TA{\beta}CD)$ were prepared by solvent evaporation method. Interactions of AZT with CD were investigated by Differential Scanning Calorimetry(DSC) and Infrared Spectrophotometry(IR). The decreasing order of water solubilities of AZT and AZT-CD inclusion complexes were as follows; $AZT\;(27.873{\pm}0.015,mg/ml)\;>\;AZT-AC{\beta}CD\;(3.377{\pm}0.003)\;>\;AZT-TA{\beta}CD\;(2.528{\pm}0.001)$. Partition coefficients of $AZT-AC{\beta}CD\;and;\AZT-TA{\beta}CD$ inclusion complexes were increased by 1.27-fold, 1.54-fold in pH 1.2 and 1.32-fold, 1.47-fold in pH 6.8 in comparison with that of AZT. The mean dissolution time (MDT, min) which represents the rapidity of dissolution rate of AZT, $AZT-AC{\beta}CD,\;AZT-TA{\beta}CD$ were 5.12, 14.02 and 19.38 min in pH 1.2 and 2.52, 15.19 and 18.19 min in pH 6.8. AZT was very rapidly and completely dissolved in pH 1.2 and pH 6.8 within 5 minutes. But AZT-CD inclusion complexes showed the sustained release pattern in comparison with AZT alone. The simultaneous in situ nasal and jejunal recirculation study to compare the intrinsic absorptivity and the property of absorption sites revealed that the absorption of $AZT-TA{\beta}CD\;(N:35.35{\pm}1.08%,\;J:27.47{\pm}1.18%)$ was more than that of $AZT\;(N:16.89{\pm}2.25%,\;J:15.86{\pm}2.33%)$. The above results suggest that $TA{\beta}CD$ which is a hydrophobic cyclodextrin may serve as sustained release carrier with absorption enhancing effect.

• Explosives and Blasting
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• v.18 no.2
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• pp.7-13
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• 2000

Abstract The characteristics of bed rock in the study area was classified by means of the crack coefficient estimated from the seismic velocities of in-situ and intact rocks. Various statistical methods were investigated in order to minimize the possible errors in estimating the predictive equation of blasting vibration and to enhance the determination coefficient $R^2$, for more reliable estimation. The determination coefficient showed the highest in the analysis for those groups using weighting function with the number of samples. The analysis for the weighting function employed with standard coefficient and variance also enhanced the determination coefficients significantly compared to the others, but the reliability was slightly lower than results obtained former method. Therefore the most reliable predictive equation of blasting vibration was found to be obtained from a regression analysis of the mean vibration level using the weighting of same distance groups within 15m with the same explosive charge weight per delay. The coefficients, K and n 317.4 and -1.66, respectively, when using the square root scaling, and 209.9 and -1.66, respectively, when using the cube root scaling. The analysis also showed that the square root scaling may be used in the distance less than 31m form the blast source, and the cube root scaling in the distance more than 31m for safe design.

• Korean Journal of Soil Science and Fertilizer
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• v.35 no.4
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• pp.207-215
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• 2002

Changes in salinity, hydraulic conductivity and penetration resistance in a reclaimed tidal land reclaimed in 1986 were studied. The salinity monitoring based on electrical conductivity of saturated extract, ECe, was conducted from 1994, when the land use for experimental crop production started after tile drainage. The site was abandoned since 1999. The hydraulic conductivity was measured by a sand fill auger hole method, and the resistance was measured with a dynamic penetrometer in situ. The averaged ECe in 1994 was $33.7dS\;m^{-1}$ ranging from 25.5 to $44.8dS\;m^{-1}$, and was decreased to $25.7dS\;m^{-1}$ with large range from 0.8 to $70.3dS\;m^{-1}$ before experiment was $1.89{\times}10^{-7}m\;s^{-1}$. It increased to $1.32{\times}10^6m\;s^{-1}$ in the top 20-cm soil with large variability, while it showed $3.44{\times}10^7m\;s^{-1}$ beneath the 20-cm soil depth with less variability. The penetration resistance of the soil ranged from 0.05 to 9.99MPa. The vertical distribution of penetration resistance indicated the hardened layer was developed at the depth of 20~40 cm where the hydraulic conductivity was sharply decreased.

• Tunnel and Underground Space
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• v.28 no.6
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• pp.635-650
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• 2018

Many people have been recognized that the Korean Peninsula is no longer safe area from the earthquake by the recent earthquakes occurred in the country. The earthquakes that occurred at Pohang and Gyeongju appeared differently from them considered in the seismic design and researches on the seismic design method have been also conducted by many researchers. Studies on seismic loads are mainly focused on existing superstructures, and research involving them has been actively carried out in reality. However, paper regarding structural stability of reinforcement from seismic load such as soil-nails, rock-bolts, ground anchors which were constructed to ensure stability of serviced structure have been published rarely. In this study, ground anchor been effected by static load and seismic load which is settled in the weathered rock is analyzed. Results for static load are obtained from field test and seismic load is from numerical analysis. In this study, the behavioral characteristics of the ground anchor were analyzed by numerical analysis in case of seismic loading based on the result of the in-situ tensile test of the ground anchor settled weathered rock. As a result, settlement of concrete block due to application of tension force for ground anchor occurred as well as following loss of axial force for ground anchor. Also, as bond length and period of seismic load are longer, increasement of displacement is greater.

• Journal of Korea Water Resources Association
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• v.54 no.3
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• pp.167-179
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• 2021

In order to characterize the mixing process of confluence for understanding the impacts of a river on the other river, it has been crucial to analyze the spatial mixing patterns for main streams depending on various inflow conditions of tributaries. However, most conventional studies have mostly relied upon hydraulic or water quality numerical models for understanding mixing pattern analysis of confluences, due to the difficulties to acquire a wide spatial range of in-situ data for characterizing mixing process. In this study, backscatters (or SNR) measured from ADCPs were particularly used to track sediment mixing assuming that it could be a surrogate to estimate the suspended sediment concentration. Raw backscatter data were corrected by considering the beam spreading and absorption by water. Also, an optical Laser diffraction instrument (LISST) was used to verify the method of acoustic backscatter and to collect the particle size distribution of main stream and tributary. In addition, image-based spatial distributions of sediment mixture in the confluence were monitored in various flow conditions by using an unmanned aerial vehicle (UAV), which were compared with the spatial distribution of acoustic backscatter. As results, we found that when acoustic backscatter by ADCPs were well processed, they could be proper indicators to identify the spatial patterns of the three-dimensional mixing process between two rivers. For this study, flow and sediment mixing characteristics were investigated in the confluence between Nakdong and Nam river.

• Journal of the Korean Geotechnical Society
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• v.25 no.9
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• pp.29-43
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• 2009

As computational technologies have been developed, the load transfer analysis method using load transfer curves is widely performed. Now the load transfer analysis methods are widely used in our country. But most of the curves using in the analysis have been developed in foreign countries. In this study we gathered the data of in situ pile load tests on domestic nine sites in order to derive load transfer curves of driven steel pipe piles. Then we derived average lines of $f/f_{max}$-w/D curves for sandy and clayey soils respectively, which are expressed by hyperbolic function. And the results using these curves and the results using TZPile 2.0 (Analysis program of pile) were compared and analyzed with the results of pile load tests on domestic 3 sites in order to ascertain the applicability of the curves. The results show that the load-settlement relations using the curves in this study are more similar to the measured data and more conservative than those using TZPile 2.0.

• Korean Journal of Plant Resources
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• v.30 no.2
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• pp.176-190
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• 2017

South Korea is the northernmost distributional territory on the Camellietea japonicae (evergreen broad-leaved forests of the warm-temperate zone) in East Asia. A total of 40 stands were collected in terms of an ecologically-naturalized wild tea population (WTP), and their species composition was analyzed by $Z{\ddot{u}}rich$-Montpellier School's method with preliminary regard to forest canopy idendtification. Stand types were characterized by ecological flora's criteria such as Raunkiaer's life-form, neophyte, zonal distribution, and nativeness of species. Expansion of WTP distribution into the interior of the peninsula was recognized, than expected. The highest and northernmost WTPs have been recorded at Mt. Palgong, Daegu (390 m a.s.l.) and Iksan Jeonbuk (latitude $36^{\circ}$ 03' 33''), respectively. Altitudinal and latitudinal WTP distribution of Korea under continental climate shows lower than Japanese situation under oceanic climate. Community structure generally involved a few human interferences. Syngeographically WTP distribution was limited on the warm-temperate zone and the southernmost cool-temperate southern submontane zone. First driving force on distributional expansion of the WTP was anthropogenic, particularly in the northernmost distribution area. We finally confirmed an actual existence of the WTP in South Korea and suggested a long-term monitoring on the WTPs in national view of in-situ genetic resources with higher frost-resistance.

• Korean Journal of Poultry Science
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• v.36 no.4
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• pp.293-300
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• 2009

The rate of fetus with abnormal chromosomes increase with maternal age. Nondisjunction of aging oocyte chromosome is a major reason for the increased rate of abnormalities. Telomeres are the ends of eukaryotic chromosome, which are essential for chromosome stability and are related in cell senescence. This study was carried out to analyze the chromosome aberration rate and amount of telomeric DNA in chick embryo along with maternal age. Fertilized eggs and blood were sampled from White Leghorn layers starting at 20 weeks through to 70 weeks age at 10 weeks interval. Chromosome aberration rate was analyzed by karyotyping. The amounts of telomeric DNA in embryonic cells and lymphocytes were quantified by Quantitative Fluorescence in situ Hybridization method. The chromosome aberration rate in chick embryos significantly differed with maternal age. The chromosome aberration rate increased at early laying period and beyond 70 weeks of maternal age. Therefore, chromosome aberration rate was affected by maternal age due to ovulated oocytes state. However, the amount of telomeric DNA on embryonic cells did not differ significantly with maternal age. Thus, maternal age does not affects telomere quantity in their embryos due to cellular reprograming at early embryonic stage after fertilization.