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http://dx.doi.org/10.5536/KJPS.2009.36.4.293

Effect of Maternal Age on Chromosome Aberrations and Telomere Quantity in Chick Embryos  

Lee, Soo-Hee (Department of Animal Science and Biotechnology, Jinju National University)
Subramani, Vinod K. (Department of Animal Science and Biotechnology, Jinju National University)
Sohn, Sea-Hwan (Department of Animal Science and Biotechnology, Jinju National University)
Publication Information
Korean Journal of Poultry Science / v.36, no.4, 2009 , pp. 293-300 More about this Journal
Abstract
The rate of fetus with abnormal chromosomes increase with maternal age. Nondisjunction of aging oocyte chromosome is a major reason for the increased rate of abnormalities. Telomeres are the ends of eukaryotic chromosome, which are essential for chromosome stability and are related in cell senescence. This study was carried out to analyze the chromosome aberration rate and amount of telomeric DNA in chick embryo along with maternal age. Fertilized eggs and blood were sampled from White Leghorn layers starting at 20 weeks through to 70 weeks age at 10 weeks interval. Chromosome aberration rate was analyzed by karyotyping. The amounts of telomeric DNA in embryonic cells and lymphocytes were quantified by Quantitative Fluorescence in situ Hybridization method. The chromosome aberration rate in chick embryos significantly differed with maternal age. The chromosome aberration rate increased at early laying period and beyond 70 weeks of maternal age. Therefore, chromosome aberration rate was affected by maternal age due to ovulated oocytes state. However, the amount of telomeric DNA on embryonic cells did not differ significantly with maternal age. Thus, maternal age does not affects telomere quantity in their embryos due to cellular reprograming at early embryonic stage after fertilization.
Keywords
oocyte; aging; chromosome aberration; telomere; Q-FISH;
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Times Cited By KSCI : 5  (Citation Analysis)
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