• Journal of Korean Neurosurgical Society
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• v.64 no.2
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• pp.271-281
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• 2021

Objective : Immune checkpoint inhibitors (ICIs) are approved for treating non-small-cell lung cancer (NSCLC); however, the safety and efficacy of combined ICI and Gamma Knife radiosurgery (GKS) treatment remain undefined. In this study, we retrospectively analyzed patients treated with ICIs with or without GKS at our institute to manage patients with brain metastases from NSCLC. Methods : We retrospectively reviewed medical records of patients with brain metastases from NSCLC treated with ICIs between January 2015 and December 2017. Of 134 patients, 77 were assessable for brain responses and categorized into three groups as follows : group A, ICI alone (n=26); group B, ICI with concurrent GKS within 14 days (n=24); and group C, ICI with non-concurrent GKS (n=27). Results : The median follow-up duration after brain metastasis diagnosis was 19.1 months (range, 1-77). At the last follow-up, 53 patients (68.8%) died, 20 were alive, and four were lost to follow-up. The estimated median overall survival (OS) of all patients from the date of brain metastasis diagnosis was 20.0 months (95% confidence interval, 12.5-27.7) (10.0, 22.5, and 42.1 months in groups A, B, and C, respectively). The OS was shorter in group A than in group C (p=0.001). The intracranial disease progression-free survival (p=0.569), local progression-free survival (p=0.457), and complication rates did not significantly differ among the groups. Twelve patients showed leptomeningeal seeding (LMS) during follow-up. The 1-year LMS-free rate in treated with ICI alone group (69.1%) was significantly lower than that in treated with GKS before ICI treatment or within 14 days group (93.2%) (p=0.004). Conclusion : GKS with ICI showed no favorable OS outcome in treating brain metastasis from NSCLC. However, GKS with ICI did not increase the risk of complications. Furthermore, compared with ICI alone, GKS with ICI may be associated with a reduced incidence of LMS. Further understanding of the mechanism, which remains unknown, may help improve the quality of life of patients with brain metastasis.

• Journal of the Korean association of regional geographers
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• v.17 no.4
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• pp.395-415
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• 2011

The aging of population stems from the decline of birth and death rates. A sudden aging society results in a variety of social issues like the poverty, role loss, alienation, health problems, etc. of the elderly. What counts in solving these issue is to make good use of the leisure time of the elderly. Leisure activities in the elderly help maintain and improve their mental and physical health, and have a great influence on improving the quality of life in the elderly. In addition, they contribute to building up a healthy social structure by forming a social intimacy. Despite these positive aspects of leisure activities, however, multiple factors prevent the leisure activities of the elderly from being actively pursued. In this respect, since there is a need to take a look at how the varied leisure activities of the elderly expose themselves in different regions, this study made an investigation so as to see what characteristics and differences each region has in the leisure activities of the elderly 65 or above. As a result, the following facts were found out: the elderly in Seoul enjoy a relatively wide range of leisure activities compared with other regions; the elderly in Gwangju spend their time mainly at home: and the elderly in the Goheung region take part in leisure activities aimed at promoting friendship. It was also revealed that there are differences among different regions in the areas of leisure activities, including the types of participation in leisure activities, the types of leisure activities at and out of home, the purpose and satisfaction of leisure activities and the frequency of domestic trips.

• Journal of Korean Academy of Nursing
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• v.23 no.2
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• pp.255-268
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• 1993

This descriptive correlational research was conducted to compare the relationship between self-esteem performance of antenatal care and health pro-motion lifestyles for unmarried and married pregnant women. The sample consisted of 94 married women attending one general hospital and residing in Seoul and 82 unmarried women from two social institutes for unmarried women. The tool used for this study was a structured questionnaire which was developed and revised by the researcher. The tool consisted of 12 items related to demographic characteristics, 10 items on self-esteem measurement, 20 items on performance of antenatal care and 37 items on health promotion lifestyle profile. The data collected from the interviews were analyzing using the SPSS, yielding frequencies, percentiles, means, standard deviations, t-test, ANOVA, Pearson’s Product Moment Correlation. The results of this study are as follows : 1) The demographic variables for the two groups were heterogenous except for religion. 2) The results of the comparison between the two groups were significantly different for self-esteem, married women(mean 20.41, standard deviation 3. 94) had higher scores on self-esteem than unmarried women(mean 24.02, standard deviation 4.11), (t=-5.91, p .001) 3) There was a stastically significant difference between the two groups on the health promotion lifestyle profile. The married women had higher scores on the health promotion lifestyle profile (t=7.22, p〈.001) 4) The score for married women on performance of antenatal care has higher than the score for unmarried women(t=8.83, p〈.001) 5) With regard to the relationship between health promotion lifestyle and performance of antenatal care and self-esteem, the correlation coefficient between self-esteem and health Promotion lifestyle for married women was .45, between per formance of antenatal care and health promotion lifestyle, .54, between self-esteem and performance of antenatal care, .32. For the unmarried women, between self-esteem and health promotion lifestyle, .39, between performance of antenatal care and health promotion lifestyle, .67, between self-esteem and performance of antenatal care, .30. 6) There was a statistically significant different between the two groups on all subconcepts of the health promotion lifestyle profile (p〈.001). 7) Comparison of the order of the scores between the two groups for the married women showed that the highest score was for nutrition, then self-actualization, interpersonal support, health responsibility, stress management and exercise in that order. For the unmarried women the highest score was for self-actualization followed by nutrition, interpersonal support, stress management, health responsibility, and exercise in that order. The score in the exercise domain was lowest in both groups. In conclusion, on the basis of the results of this study, resources and protection facilities for unmarried pregnant women could be improved through government policies and health care policies that would allow unmarried women to utilize significant social support resources and actualize health pro-motion lifestyles. Nursing should offer interventions to increase psychosocial adjustment and support tp improve the quality of life for unmarried pregnant women and further to promote improved growth and development of the infants.

• Journal of agriculture & life science
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• v.45 no.2
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• pp.93-101
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• 2011

This study was conducted to investigate the effect of probiotic from pine needle microbes on growth performance, blood characteristics, carcass traits and economy of pigs. One hundred eighty pigs (L${\times}$Y${\times}$D, average body weight=75 kg) were grouped and housed with 15 animals per pen for 3 replications per each treatment. The ingredients and pine needle microbes mixed and fermented on anaerobic condition for 10 days to make the fermented diet. The basal diet was substituted with 0 (CON), 3 (T1), 5 (T2) and 10% (T3) of fermented diet, the pigs were fed for 42 days and slaughtered at the end of the trial to measure the carcass traits. Crude protein concentration of fermented diet on 10 day was higher (p<0.05) than that of on 0 day, while crude fiber concentration and pH were lower (p<0.05). The supplementation of fermented diet did not affect on growth performance and feed intake. Hemoglobin concentration of whole blood in T3 was higher (p<0.05) than that of CON, and hematocrit concentrations in CON and T1 were higher (p<0.05) than that of T2 and T3. The concentration of platelet was higher (p<0.05) in T1 than in T2 and T3. The CON had higher (p<0.05) total cholesterol, LDL-cholesterol and triglycerides concentrations than the treatments, whereas lower (p<0.05) HDL-cholesterol concentration. Carcass weight and dressing in T1 and T3 were higher (p<0.05) than those of CON and T2. The backfat thickness was higher (p<0.05) in CON and T2 than in T3. The carcass grade and economy improved by supplementation of fermented diet compare to CON. In conclusion, the supplementation of fermented diet using probiotics from pine needle microbes could improve health and meat quality and reduce the feed cost of pigs.

• Journal of the Korean Association of Geographic Information Studies
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• v.15 no.2
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• pp.23-34
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• 2012

As the quality of life grows, the role of cultural facilities in urban areas is becoming more important. However, due to various reasons, the location of these facilities shows the geographical imbalance between urban regions. Even though provision of road network can improve this kind of urban problem, in many countries, the provision of urban infrastructure plays a role which is magnifies the cultural gap between regions and socio-economic classes. The findings of this study are as follows. First of all, the inequality of accessibility to cultural facilities is shown over the period. Cross-sectional data shows that the higher the income of a region, the higher the accessibility index(AI) of the zone to cultural facilities at any time. Next, the provision of road network contributes the improvement of AI of high income region. Finally the provision of new facilities has a tendency that these kind of facilities are located to make AI of high income zone better. It means that the decision making by city government intensifies the geographical inequality. This result would be very useful in the decision making process for determining the number and the location of cultural facilities and other similar urban infrastructure as well. Also it will be helpful for the selection of optimal location which considered not only physical distances but also social equalities.

• Health Policy and Management
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• v.32 no.2
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• pp.190-204
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• 2022

Background: In Korea, the population is rapidly aging, and the types of households for the elderly are also diversifying. The self-rated health of the elderly is a valuable health indicator that can comprehensively represent the overall quality of life along with physical, mental, and functional health. On the other hand, studies on the association between household type and self-rated health of the elderly are still insufficient. Thus, this study analyzed the association between household type and self-rated health by gender in Korean older adults. Methods: Using data from the analysis of the National Survey of Older Koreans 2017, 10,299 elderly people aged 65 and over were targeted. For the accuracy of the analysis data, 9,910 people were selected as the study sample by excluding proxy responses, those diagnosed with dementia, and non-response. And technical analysis, univariate analysis using the Rao-Scott chi-square test, and logical regression analysis involving survey characteristics were conducted by gender. Results: According to the adjusted model with all variables, in both men and women, the odds ratio of self-rated health 'bad' in 'couple (with ill spouse)' was significantly higher than 'couple (with spouse)'. It was 2.54 (95% confidence interval [CI], 2.05-3.15) for men and 2.11 (95% CI, 1.70-2.62) for women. In addition, the odds ratio of self-rated health 'bad' in 'living with adult children' was 1.43 (95% CI, 1.09-1.87) for men and 1.42 (95% CI, 1.15-1.75) for women, which was more significant in women than men. Conclusion: This study states that there is an association between gender, household type, and self-rated health of the elderly, and the health of a spouse and cohabitation with children have a significant effect on self-rated health. As a result, in order to improve the health status of the elderly, health promotion and health care policies involving the characteristics of the elderly's gender and household type are needed.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2013.05a
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• pp.209-212
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• 2013

The Nuri process of emphasis by the Ministry of Education to promote is standardized curriculum at the national level for the education and care. It is to improve the quality of pre-school education and Ensure a fair starting line early in life and It emphasizes character education in all areas of the window. Nuri the process of development of a the insect robot for the Creativity education Increased the interesting and educational effects. Assembly and the effect on learning of educational content using a VR educational robot using the existing floor assembly using the online website to help assemble and learning raised. Order to take advantage of information technology in the information-based society requires the active interest and motivation in learning, creative learning toddlers learning robot are also needed. A three-dimensional model of the robot, and augmented by linking through the marker, the target marker and the camera relative to the coordinate system of augmented reality, seeking to convert the marker to be used in augmented reality marker patterns within a pre-defined patternto be able to make a decision on what of. The fusion of a smart education through training and reinforcement the educational assembly of the robot in the real world window that is represented by a virtual environment in this paper to present a new form of state-of-the-art smart training, you will want to lay the foundation of the nation through the early national talent nurturing talent.

• The Journal of the Korea Contents Association
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• v.12 no.10
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• pp.195-204
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• 2012

The purpose of this study is to suggest the improvement plan for the welfare in the park through the empirical test on the park facilities, which are the hardware, and the service contents, which are the software, in the urban parks of Busan. Therefore, to identify the welfare of the parks in Busan, this study took 7 urban parks as samples according to the plate method of experts, and conducted the questionnaire survey from 1,500 persons using these parks. The IPA analysis results on the importance and the satisfaction of the users on the form of use, facilities and the contents of the park are as follows. First, the convenient facilities, which are the hardware of the park, are represented as a intensive management item. Second, the importance and the satisfaction for all the facilities and the contents of each park are significant differences. according to the location of each park and the characteristics of each principal park users. Such results mean that the Busan urban park operation does not satisfy the expectation of the park users for the welfare facilities in the parks. Therefore, it implies that to activate the urban parks and to improve the quality of life than the present, the aceessibility of the local residents to the information should be reinforced through the development of contents to reflect the region and the desires of the users and through building and managing the homepage of the urban parks.

• The Journal of Korean Obstetrics and Gynecology
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• v.19 no.2
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• pp.240-260
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• 2006

Purpose : The objective of this study is to serve guidelines for the investigation and management of uterine myomas with KM therapies. Methods : English-language articles from PubMed and Korean-language articles from the database of the journal of oriental gynecology were reviewed from 2000 to 2005, using the key words 'uterine myoma', 'uterine leiomyoma', 'fibroid', 'uterine artery embolization', 'endometrial ablation', 'myomectomy', and jagungguenjong(子宮筋腫)'. Results and Limits : The areas of clinical practices considered in formulating this guideline are assessment, KM therapies, medical treatments, myolysis, selective artery occlusion, endometrial ablation and surgical therapies including myomectomy and hysterectomy. Implementation of this guideline would optimize the decision-making process of women with uterine myomas and further investigation or therapy of their KM doctors. But we don't have abundant evidences of clinical trials of uterine myoma treated with KM therapy, though we treat or manage that with every-day clinical practices. Moreover cultural gaps between Korea and other western countries make many differences in the attitude to surgical therapies, especially hysterectomy. So it is very difficult to compare W therapies with other therapies. Moreover it is much difficult to estimate cost-effectiveness and benefit of those therapies in QOL. Conclusions : The majority of uterine myoma is asymptomatic and will not require any intervention or further investigation. But unmarried women who wish to marry and get pregnant want to find safe therapy for their asymptomatic uterine myomas. In that case, most of the patients prefer non-surgical therapy to surgical therapy. So KM herbal medicinal therapy is a good alternative method for those patients. For the symptomatic myomas, hysterectomy offers a definitive solution. However, it is not the best solution for women who wish to preserve their uterus. So KM therapy is a good alternative for them. But the predicted benefits of alternative therapies including KM therapy must be carefully weighed against the Possible risks of these therapies. To improve the quality of life of both women with asymptomatic and symptomatic myomas, selecting and treating patients should be done carefully. Moreover, the effect of KM therapy has to evaluated, comparing the possible situation without treatment and the benefit of constant treatment as a health-care system.

• Journal of Nutrition and Health
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• v.45 no.6
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• pp.577-587
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• 2012

This study was conducted to investigate the consumption pattern and perception of traditional soy sauce and soybean paste products in male and female adults aged 19 and over in Seoul and Gyeonggi-do areas in order to promote the development of the products' industry. The survey was conducted between October 1 to October 15, 2011 among 294 male and female adults aged 19 years and over in Seoul and Gyeonggi-do areas. The gender distribution of the subjects was 33.3% males and 66.7% females. For a perception on traditional dietary life, the degree for enjoying meals with cooked rice as the staple food revealed that 32.3% of the subjects responded 'strongly agree'. The intake frequency of traditional soy sauce and soybean paste products in the subjects of the study showed that in the case of doenjang, 49.7% of the participants consumed it twice a week and 21.4% consumed it once a week. For gochujang, 59.9% consumed it twice a week and 19.0% consumed it once a week. The perception on the preparation method for traditional soy sauce and soybean paste products showed a low level for traditional soy sauce and soybean paste products. The reason for purchasing traditional foods showed that 77.6% of the subjects made purchases for convenience and 8.2% purchased it for its small package. For the subjects, the priority for purchasing traditional soy sauce and soybean paste products was as follows: in the first rank, ingredients & origin made up 33.7% and price comprised of 26.2% of the priority. Regarding satisfaction for soy sauce and soybean paste products in the market, the degree of satisfaction was high for gochujang. With regard to gender difference, female subjects showed a significantly lower satisfaction for cheonggukjang and kuk-ganjang, and a significantly higher satisfaction for chin-ganjang, compared to the male subjects. The results of the study depicted that consumer's requirement was high for traditional soy sauce and soybean paste products in the market, particularly for the safety of the products in the market. Consumer satisfaction was relatively positive yet, some efforts are needed in order to improve the quality of cheonggukjang and kuk-ganjang.