• Journal of Embryo Transfer
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• v.29 no.2
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• pp.101-109
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• 2014

Matrix Metalloproteinases (MMP)-2 and -9 are participated in embryo development, implantation, remodeling of epithelial cell and ovulation. The objective of this study is to evaluate an impact of MMP2 and MMP9 on embryonic developmental competence as well as gene expression profiles of in vitro-produced bovine embryos. After in vitro fertilization, embryos of all groups were transferred into IVC-2 medium treated with MMP2 and MMP9 to check the optimum concentration on the basis of embryo development competence and cell numbers. The optimum concentrations for MMP2 and 9 were 1,200 ng/ml and 300 ng/ml. The blastocyst development competence was not different among 1,200 ng/ml of MMP2 vs. 300 ng/ml of MMP9 vs. combined MMP2 + 9 vs. control groups ($41.46{\pm}10.66$ vs. $37.73{\pm}8.92$ vs. $45.11{\pm}11.41%$ vs. $41.59{\pm}11.88$, respectively). Furthermore, the developmental competences to hatching and hatched blastocysts were not also different among the same groups ($79.84{\pm}12.63$ vs. $83.3{\pm}17.46$ vs. $78.55{\pm}14.48%$ vs. $72.02{\pm}14.09$). In addition, total cell number was significantly (p<0.05) greater in blastocyst treated with MMP9 300 ng/ml among all treatment groups. On the other hand, there was no significant difference of ICM vs. TE ratio in all groups. The expression of five out of six genes (i.e., MMP2, MMP9, IFNt, SSLP1 and HNRNPA2B1) was different among the groups. The expression of IFNt and HNRNPA2B1 genes was significantly greater in MMP9 (p<0.05), but there was no difference of MMP9 expression between MMP2 and MMP9 group (p>0.05). The normalized expression of MMP2 and SSLP1 was greater in MMP2 than other groups (p<0.05). In conclusion, MMPs treatment during IVC-2 medium was remarkably effected on blastocyst developmental competence and gene expression profiles that are related to embryo quality and implantation.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.6
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• pp.524-537
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• 2017

This study examined the relationship between the sociodemographic characteristics, health related factors, physical functions (ADL, IADL), mental functions (CES-D, MMSE-K), oral health impact profile (OHIP-14), and the quality of life (WHOQOL-BREF) for the elderly in long-term care facilities. The research was conducted in 602 facility allowance beneficiaries authorized to be eligible for long-term care in long-term care facilities through personal interviews using a structured questionnaire from May 1 to June 30, 2016. As a result, the quality of life was lower among females than males in the group receiving government subsidies than the group whose livelihood was maintained by themselves or their children, in the group with a longer period of care, in the drinking group than the non-drinking group, in the group with irregular exercise than the regular exercise, in the group with irregular meals than regular meals, in the group with poor subjective health conditions than good subjective health condition, in the group with a smaller number of daily toothbrushing, in the group with xerostomia than no xerostomia, in the group with a lower OHIP-14, in the group with a lower ADL and IADL, and in the group with a lower CES-D and MMSE-K. In particular, the quality of life was affected more by health-related factors and CES-D and MMSE-K than by other factors. Therefore, it is necessary to make efforts to prevent depression and cognitive impairment, including health-related behavior, with the objective of improving the quality of life for the elderly in long-term care facilities.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.12
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• pp.7229-7235
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• 2013

Background: To determine whether the Health Partner Program is effective in training long-term cancer survivors to be health coaches. Materials and Methods: We randomly assigned cancer survivors who were selected through a rigorous screening process to either the Health Partner Program or the waiting-list control group. The program consisted of 8 weeks of training in health management, leadership, and coaching. At baseline, 8, and 16 weeks, we measured primary outcomes using the Seven Habit Profile (SHP), the Korean Leadership Coaching Competency Inventory (KCCI), Ed Diner's Satisfaction with Life Scale (SWLS), and the Posttraumatic Growth inventory (PTGI) and secondary outcomes using the Hospital Anxiety and Depression Scale (HADS), the Impact of Event Scale-Revised (IES-R), and the Medical Outcomes Study (MOS) short form 36-item questionnaire (SF-36). Results: We recruited 70 subjects and randomly assigned 34 to the intervention group. The Sharpen the Saw habit of the SHP increased significantly more in intervention group than in the control group (p=0.049), as did most PTGI factors. The intervention group also showed a significantly greater enhancement of vitality (p=0.015) and mental health (p=0.049) SF-36 scores but no improvement in KCCI, SWLS, HADS, or IES-R scores. The intervention group also showed a greater clinically meaningful improvement in the "Think Win-Win" of SHP (p=0.043) and in the personal strength score (p=0.025) and total score (p=0.015) of the PTGI. Conclusions: Long-term cancer survivors can benefit from the Health Partner Program to become health coaches.

• Journal of the Korean Wood Science and Technology
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• v.41 no.1
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• pp.42-50
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• 2013

Since 1990's, a plywood for flooring base has gotten customers' demand. Costs of raw material and production increased because of changed environment of industry. Tropical timber such as Red Meranti (Shorea acuminate) used for raw material of the floor has been depleting beside countries in South Eastern Asia changed species of afforestation. As a result, it gets hard to secure good quality of raw material for plywood. Moreover plywood price is increased suddenly after earthquake in Japan. Eucalyptus (Eucalyptus globulus) in china has been using for raw material as a countermeasure of changed environment of industry. In this study, possibility of using flooring consisted of Eucalyptus veneer as crossband layers was checked by deflection experiments. Flooring consisted of Red Meranti was used for comparison. Two factors which impact on deflection are a type of density gradient and density difference between Long-grain veneer and Short-grain veneer. Red Meranti samples are M type of density gradient on the other hand Eucalyptus samples are W type of density gradient. The more samples have high density difference, the more deformation was checked. A sample which has big density difference between core and cross bands layer warp more also deform. Flooring was deformed smaller than plywood and samples which have big density difference was deformed more.

• Journal of dental hygiene science
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• v.14 no.4
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• pp.488-494
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• 2014

The purpose of this study is to analyze the association of oral health of the elderly and oral health quality of life. The subjects of this study were 282 participants who received the fluoride application and the scaling service through program targeting elderly people carried out by a public health center located in Gyeongsangbuk-do Province. Data were collected from January 2011 to December 2011. The result of comparing subscale scores of quality of life related to oral health depending on socioeconomic characteristics showed that functional limitation scores were lower as educational level got higher. The result of comparing subscale scores of quality of life related to oral health depending on status of oral health and frequency of tooth brushing showed that quality in functional limitations, physical pain, psychological discomfort, physical disability, psychological disability, social disability and handicap scores were lower as the number of cavities got more. The result of multiple regression analysis to identify the factors affecting the quality of life related to oral health showed that the number of cavities and installation of denture were significant variables. The results of this study showed that there was significant association of oral health status and oral health related quality of life of the elderly. In order to maintain the oral health related quality of life, it is important to keep many number of residual teeth even if a person gets older and to support the installation of dentures if necessary.

• The Journal of Korean Academy of Sensory Integration
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• v.7 no.2
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• pp.1-12
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• 2009

Objective : The purpose of this study is to find out whether group approach of sensory integration (SI) enhances sensory processing, fine motor function, and social skill for the children with sensory integration disorders. Method : Three children with problems related in sensory integration had got received 21 intervention sessions. We evaluated children with sensory profile(SP), social maturity test, Korean-developmental test of visual perception(K-DTVP), Bruininks-Oseretsky Test of Motor Proficiency(BOTMP) before-and after intervention. The statistical significance of data is tested by the Wilcoxon matched-pair signed rank test. Results : All data of post-intervention did not show any statistically significant differences; SP, social maturity test, K-DTVP, BOTMP. Conclusions : This study is to verify the effect of group SI intervention on sensory processing, fine motor function, and social skill for children with sensory integration disabilities. The results were not statistically significant. However, the average score after SI intervention has been improved in the section of fine motor and social skill comparing to that of pre-intervention period. It would have positive impact for children with sensory integration disabilities. It is needed to study with the larger number of target children and more often treatment session are suggested. The confounding variables also should be controlled in the further study.

• Clinical and Experimental Pediatrics
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• v.51 no.9
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• pp.977-986
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• 2008

Purpose : This study aims to estimate the financial cost of rotavirus infection in Korea in the year of 2005. Methods : The incidence rates used were from the epidemiological profile at Jeoungeub District (5.8 cases/1,000 children <5 years old for inpatients, and 22.65 cases/1,000 children <5 years old for outpatients, per year). The health care cost per capita of rotavirus infection (ICD code: A08.0) was extracted from the Health Insurance Review and Assessment Service database in Korea. The patient survey was conducted to capture information about non-medical costs and associated productivity loss incurred by adult caregivers. Results : The number of annual national cases among children <5 years old with rotavirus infection was estimated to be 69,122 (i.e., 55,030 outpatients and 14,092 inpatients). The total cost of rotavirus infection was estimated at 13.3 billion Korean won, comprising 11 billion Korean won (82.7%) of direct medical costs, 1.6 billion Korean won (12.0%) of direct non-medical costs (e.g., transportation and supplies), and 0.68 billion Korean won (5.1%) of productivity lost by adult caregivers. Conclusion : Rotavirus infection carries not only medical costs but also non-medical and indirect costs; together, these costs incur a significant burden on South Korean society. The impact of rotavirus on quality of life and health among patient caregivers was not considered in this study, but it does merit further research.

• Journal of dental hygiene science
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• v.14 no.1
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• pp.51-58
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• 2014

The purpose of this study was to examine the symptom of dry mouth of workers, their subjective oral symptoms and factors affecting their oral health-related quality of life (Oral Health Impact Profile, OHIP-14) in an effort to provide information on the development of oral health promotion programs geared toward workers. The subjects in this study were the workers in five different companies in North Jeolla Province. After a survey was conducted from August 1 to September 20, 2012, the collected data were analyzed. The findings of the study were as follows: The office workers got 2.59 in oral dryness, and the sales associates got 1.82. The oral dryness of the former was severer than that of the latter (p<0.001). The irregular workers got 2.05 in OHIP-14, and the regular workers got 1.82 (p<0.001). Symptom of dry mouth had a positive correlation to OHIP-14 (r=0.456). OHIP-14 was positively correlated with age (r=0.209) and negatively with academic credential (r=-0.136). OHIP-14 was more significantly affected when their symptom of dry mouth was severer (${\beta}=0.383$, p<0.001), when they were older (${\beta}=0.221$, p<0.001) and when they felt they had oral diseases (${\beta}=0.146$, p<0.01). In conclusion, quality programs should be developed to promote the oral health of industrial workers in consideration of the influential factors for the oral health-related quality of life of the workers, and the government should pay more attention to related policy setting to improve the oral health of industrial workers.

• Journal of the Korea Society of Computer and Information
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• v.15 no.11
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• pp.1-9
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• 2010

As the process technology scales down, an interconnection has became a major performance constraint for multi-core processors. Recently, in order to mitigate the performance bottleneck of the interconnection for multi-core processors, a 3D integration technique has drawn quite attention. The 3D integrated multi-core processor has advantage for reducing global wire length, resulting in a performance improvement. However, it causes serious thermal problems due to increased power density. For this reason, to design efficient 3D multi-core processors, thermal-aware design techniques should be considered. In this paper, we analyze the temperature on the 3D multi-core processors in function unit level through various experiments. We also present temperature characteristics by varying application features, cooling characteristics, and frequency levels on 3D multi-core processors. According to our experimental results, following two rules should be obeyed for thermal-aware 3D processor design. First, to optimize the thermal profile of cores, the core with higher cooling efficiency should be clocked at a higher frequency. Second, to lower the temperature of cores, a workload with higher thermal impact should be assigned to the core with higher cooling efficiency.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 1992.10a
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• pp.59-64
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• 1992

터빈 블레이드와 같이 회전하는 구조물의 파단은 공진 근처에서 진동이 발 생할 때에 이에 기인하는 피로에 의하여 발생한다. 그러므로 이와 같은 파단 을 피하기 위해서는 설계 단계에서 이론적인 계산에 의하여 구조물의 고유 진동수를 결정하는 것이 상당히 중요하다. 판이 회전을 받게 되면 원심력에 의하여 판의 강성이 증가하므로 고유진동수가 회전하지 않는 판의 고유진동 수보다는 상당히 증가하게 된다. 이에 대한 연구가 국내외에서 상당수 행하 여졌지만, 연구의 대부분이 회전의 영향을 고려하지 않은 정지판(stationary plate)에 대한 것이며 뢰전을 고려한 연구는 극히 제한되어 있다. 또한 회전 의 영향을 고려한 연구의 대부분이 해석 대상을 보로서 단순화 시켰고 해법 으로는 유한요소법과 Ritz법 등을 사용하였다. 이는 블레이드가 지니고 있는 기하학적인 형상과 진동 특성이 해석적인 방법으로 해결하는 데에는 상당한 어려움이 있기 때문이다. 실제적으로는 터빈 블레이드와 같은 회전체의 진동 특성이 설치각이나 비틀림각, 판의 형상비, 회전속도 등의 변화에 의하여 영 향을 받기 때문에 보와 같은 진동 거동을 보이기보다는 판이나 셀과 같은 진동 거동을 보이므로 보다 정확한 해석을 수행하기 위해서는 해석 대상을 판이나 셀로서 취급하는 것이 타당하다. 따라서 본 연구에서는 위와 같은 이 유 때문에 해석 대상을 등방성 사각판과 직교이방성 복합재료 사각판으로 선택하였으며, 구조물의 고유진동수에 영향을 미치는 다음과 같은 인자들을 해석에 고려하였다. 1. 회전속도 (rotational speed) 2. 설치각 (setting angle) 3. 허브의 반경 (hub radius) 4. 판의 형상비 (aspect ratio) 5. 적층순서 (stacking sequence)구조물에 대한 동적실험(dynamic test)을 통하여 단기간에 동적특성을 결정하고 SDM(structure dynamic modification)이나 FRS(force response simulation)를 수행하여 임의의 좌표 공간에 대한 진동수준을 해석적으로 예측할 뿐만 아니라 구조물의 진동제어 를 위한 동적인자를 변경시킬 수 있는 정보를 제공하며 장비를 방진할 경우 신뢰성 있는 전달률을 결정할 수 있다. 실험적으로 철교, 교량이나 건물의 철골구조 및 2층 바닥 등 대,중형의 복잡한 구조물에 대항 동특성을 나타내 는 모빌리티를 결정할 경우 충격 가진 실험이 사용되는 실험장비 측면에서 나 실험을 수행하는 과정이 대체적으로 간편하다. 그러나 이 경우 대상 구조 물을 충분히 가진시킬수 있는 용량의 대형 충격기(large impact hammer)가 필요하게 된다. 이러한 동적실험은 약 길이 61m, 폭 16m의 4경간 교량에 대 하여 동적실험을 수행하여 가능성을 확인하였다. 여기서는 실험실 수준의 평 판모델을 제작하고 실제 현장에서 이루어질 수 있는 진동제어 구조물에 대 한 동적실험 및 FRS를 수행하는 과정과 동일하게 따름으로써 실제 발생할 수 있는 오차나 error를 실험실내의 차원에서 파악하여 진동원을 있는 구조 물에 대한 진동제어기술을 보유하고자 한다. 이용한 해마의 부피측정은 해마경화증 환자의 진단에 있어 육안적인 MR 진단이 어려운 제한된 경우에만 실제적 도움을 줄 수 있는 보조적인 방법으로 생각된다.ofile whereas relaxivity at high field is not affected by τS. On the other hand, the change in τV does not affect low field profile but stron