• Title/Summary/Keyword: Immuno-modulatory

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A Pharmacological Review on Portulaca oleracea L.: Focusing on Anti-Inflammatory, Anti- Oxidant, Immuno-Modulatory and Antitumor Activities

  • Rahimi, Vafa Baradaran;Ajam, Farideh;Rakhshandeh, Hasan;Askari, Vahid Reza
    • Journal of Pharmacopuncture
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    • v.22 no.1
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    • pp.7-15
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    • 2019
  • Portulaca oleracea L. (PO) or Purslane is an annual grassy plant that is distributed in many parts of the world, especially the tropical and subtropical areas. PO has some pharmacological properties such as analgesic, antibacterial, skeletal muscle-relaxant, wound-healing, anti- inflammatory and a radical scavenger. This review article is focused on the anti-inflammatory, immuno-modulatory, anti-oxidant and anti-tumor activities of the PO. Anti-inflammatory, immuno-modulatory, anti-oxidant and Anti-tumor effects of PO were searched using various databases until the end of August 2018. The online literature was searched using PubMed, Science Direct, Scopus, Google Scholar and Web of Science. Our review showed that PO exerts its effects through anti-inflammatory properties and balancing the adaptive and innate immune system depending on situations. PO acts as immune-modulator and anti-oxidant agent in both inflammatory states by the dominance of Th2 response such as asthma, cancer and atopic dermatitis and evoked Th1 disorders including hepatitis and multiple sclerosis.

Immuno-Modulatory Activities of Polysaccharides Separated from Jubak in Macrophage Cells (주박(酒粕)에서 분리된 다당류의 대식세포 면역조절 활성)

  • Park, Woo-Young;Sung, Nak-Yun;Byun, Eui-Hong;Oh, Kwang-Hoon;Byun, Myung-Woo;Yoo, Yung Choon
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.44 no.7
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    • pp.1079-1083
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    • 2015
  • Activating macrophage cells play an important role in the host immune defense system. In this paper, immuno-modulatory activities of polysaccharides separated from Jubak (JPS) in macrophage cells were investigated. Immuno-modulatory activities were estimated based on cell proliferation, nitric oxide (NO) and cytokine production, degree of mitogen-activated protein kinases (MAPKs), and nuclear factor (NF)-${\kappa}B$ phosphorylation in RAW264.7 macrophage cells. JPS (62.5 to $250{\mu}g/mL$) did not induce a cytotoxic event. Additionally, NO and proinflammatory cytokines (tumor necrosis factor-${\alpha}$ and interleukin-6) production significantly increased in a dose-dependent manner. Similarly, phosphorylation of MAPKs and NF-${\kappa}B$ increased upon JPS treatment. Therefore, our results suggest that polysaccharides separated from Jubak can induce macrophage activation through MAPK and NF-${\kappa}B$ signaling and induction of Th1 polarization.

The role of immunomodulatory metabolites in shaping the inflammatory response of macrophages

  • Doyoung, Park;Gyumin, Lim;Sung-Jin, Yoon;Hyon-Seung, Yi;Dong Wook, Choi
    • BMB Reports
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    • v.55 no.11
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    • pp.519-527
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    • 2022
  • Macrophage activation has long been implicated in a myriad of human pathophysiology, particularly in the context of the dysregulated capacities of an unleashing intracellular or/and extracellular inflammatory response. A growing number of studies have functionally coupled the macrophages' inflammatory capacities with dynamic metabolic reprogramming which occurs during activation, albeit the results have been mostly interpreted through classic metabolism point of view; macrophages take advantage of the rewired metabolism as a source of energy and for biosynthetic precursors. However, a specific subset of metabolic products, namely immune-modulatory metabolites, has recently emerged as significant regulatory signals which control inflammatory responses in macrophages and the relevant extracellular milieu. In this review, we introduce recently highlighted immuno-modulatory metabolites, with the aim of understanding their physiological and pathological relevance in the macrophage inflammatory response.

Immuno-modulatory and Anti-carcinogenic Property of Cordyceps militaris and Paecilomyces japonicus (동충하초의 면역조절 및 항암효과)

  • Jung Han Sol;Kwon Jin;Lee Tae Gyu;Lee Kwang Gyu;Oh Chan Ho
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.16 no.2
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    • pp.327-331
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    • 2002
  • The purpose of this research was to investigate the immuno-modulatory effect and anti-carcinogenic property of Cordyceps militaris(CM) and/or Paecilomyces japonicus (PJ). The proliferation of cultured splenocytes and thymocytes were enhanced by the addition of 10 ㎍/ml of CM and/or PJ. B lymphocytes subpopulation in splenocytes were increased both CM and/or PJ administered(p.o. for 7 days)-mice. Thymic T lymphocytes, especially TH cells were significantly increased in CM-administered mice. CM and/or PJ treatment inhibited the cell viability of L 1210 mouse leukemia and HL60 human leukemia cells and induced the apoptosis of L1210 and HL60 cells. In addition, CM and/or PJ increased the hemaggutination(HA) titer against SRBC. These results suggest that CM and/or PJ have an immuno-modulatory action and anti-carcinogenic property.

Immuno-Modulatory Activity of the Crude Polysaccharide from Wild Ginseng Adventitious Root (산삼 배양근에서 분리한 다당의 면역자극 활성에 미치는 효과)

  • Nam, Sohyun;Rhee, Young Kyoung;Hong, Hee-Do;Lee, Young-Chul;Kim, Young-Chan;Shin, Kwang-Soon;Cho, Chang-Won
    • The Korean Journal of Food And Nutrition
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    • v.25 no.4
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    • pp.755-761
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    • 2012
  • In this study, we examined immuno-modulatory activities of crude polysaccharides from wild ginseng adventitious roots (WGAR). The crude polysaccharide (WGAR-CP) was isolated from WGAR by hot water extraction, ethanol precipitation, and dialysis. The major constituents in WGAR-CP were neutral sugar (64.77%), and uronic acid (34.32%). WGAR-CP demonstrated anti-complementary activity dose-dependently. The immuno-modulatory effects of WGAR-CP were also analyzed by measuring nitric oxide and cytokines in the supernatants of mouse peritoneal macrophages. Mouse peritoneal macrophages stimulated with WGAR-CP produced nitric oxide and various cytokines such as interleukin (IL)-6 and IL-12 in a dose-dependent manner. In conclusion, WGAR-CP may have immuno-modulatory activities by activating a complementary system and macrophages, which produces cytokines.

Comparison Study of Immunomodulatory Activity of Polysaccharide and Ethanol Extracted from Sargassum fulvellum (참모자반 조다당 추출물과 에탄올 추출물의 대식세포 및 비장세포 활성 비교)

  • Byun, Eui-Hong
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.44 no.11
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    • pp.1621-1628
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    • 2015
  • The immune system plays an important role in maintaining and protecting human health. In the present study, comparison of immuno-modulatory activities between polysaccharides (SFP) and ethanol (SFE) extracts separated from Sargassum fulvellum in macrophages and murine splenocytes were investigated. Immuno-modulatory activities of macrophages were estimated based on cell proliferation, nitric oxide (NO), inducible NO synthase (iNOS), and cytokine production in RAW 264.7 macrophage cells, and lipopolysaccharide was used as a positive control. SFP and SFE treatment did not affect cytotoxicity in RAW 264.7 macrophage cells, and SFP treatment significantly increased NO and cytokine production ($TNF-{\alpha}$, IL-6, and $IL-1{\beta}$), whereas SFE did not contribute to the increase in NO and cytokine production. In the case of splenocytes, SFP treatment increased splenocyte proliferation and also highly increased production of Th-1 type cytokines (IL-2 and $IFN-{\gamma}$) than those of SFE. Through this study, we confirmed that immuno-modulatory activities of Sargassum fulvellum may be due to polysaccharide extracts and this can be a potential nutraceutical.

A comparative study of the immuno-modulatory activities of ethanol extracts and crude polysaccharide fractions from Annona muricata L. (가시여지잎(Annona muricata L.) 에탄올 추출물과 조다당 분획분의 면역활성 비교)

  • Kim, Yi-Eun;Lee, Joeng-Hee;Sung, Nak-Yun;Ahn, Dong-Hyun;Byun, Eui-Hong
    • Korean Journal of Food Science and Technology
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    • v.49 no.4
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    • pp.453-458
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    • 2017
  • This study compared the immuno-modulatory effects of ethanol extracts (A. muricata L. ethanol extracts, ALE) and crude polysaccharide fraction (A. muricata L. crude polysaccharide fraction, ALP) from Annona muricata L. in macrophages. Immuno-modulatory activity was determined by assessing cell viability, nitric oxide (NO) production, inducible NO synthase (iNOS) expression and cytokine production in RAW 264.7 a macrophage cell line. Both ALE and ALP treatment did not affect cytotoxicity, and ALP treatment significantly increased NO production. Additionally, cytokine production [tumor necrosis factor ($TNF-{\alpha}$; $2909.04{\pm}4.1pg/mL$), interleukin (IL)-6; $662.84{\pm}5.3pg/mL$, and $IL-1{\beta}$; $852.37{\pm}2.2pg/mL$), was highly increased in the ALP ($250{\mu}g/mL$) treated group compared to the ALE ($250{\mu}g/mL$) treated group ($TNF-{\alpha}$; $1564.50{\pm}6.1pg/mL$, IL-6; $517.24{\pm}4.1pg/mL$ and $IL-1{\beta}$; $237.23{\pm}1.8pg/mL$). Moreover, ALP treatment considerably increased the expression of mitogen-activated protein kinase (MAPKs) and nuclear $factor-{\kappa}B$ ($NF-{\kappa}B$) in the macrophages. Therefore, ALP can induce macrophage activation through MAPK and $NF-{\kappa}B$ signaling and this can be a potential candidate for development of nutraceuticals.

Glycine max Fermented by a Novel Probiotic, Bifidobacterium animalis subsp. lactis LDTM 8102, Increases Immuno-Modulatory Function

  • Kim, Jae Hwan;Jeong, Minju;Doo, Eun-Hee;Koo, Young Tae;Lee, Seon Joo;Jang, Ji Won;Park, Jung Han Yoon;Huh, Chul Sung;Byun, Sanguine;Lee, Ki Won
    • Journal of Microbiology and Biotechnology
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    • v.32 no.9
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    • pp.1146-1153
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    • 2022
  • Many probiotic species have been used as a fermentation starter for manufacturing functional food materials. We have isolated Bifidobacterium animalis subsp. lactis LDTM 8102 from the feces of infants as a novel strain for fermentation. While Glycine max has been known to display various bioactivities including anti-oxidant, anti-skin aging, and anti-cancer effects, the immune-modulatory effect of Glycine max has not been reported. In the current study, we have discovered that the extract of Glycine max fermented with B. animalis subsp. lactis LDTM 8102 (GFB 8102), could exert immuno-modulatory properties. GFB 8102 treatment increased the production of immune-stimulatory cytokines in RAW264.7 macrophages without any noticeable cytotoxicity. Analysis of the molecular mechanism revealed that GFB 8102 could upregulate MAPK2K and MAPK signaling pathways including ERK, p38, and JNK. GFB 8102 also increased the proliferation rate of splenocytes isolated from mice. In an animal study, administration of GFB 8102 partially recovered cyclophosphamide-mediated reduction in thymus and spleen weight. Moreover, splenocytes from the GFB 8102-treated group exhibited increased TNF-α, IL-6, and IL-1β production. Based on these findings, GFB 8102 could be a promising functional food material for enhancing immune function.

The Immuno-modulatory Effect of Root of Asarum sieboldii Miq. Water Extract on OVA-induced Asthma (세신 전탕액 경구투여가 천식 억제 및 면역조절에 미치는 영향)

  • Jo, Seoung Eun;Kang, Jae Hui;Lee, Hyun
    • Journal of Acupuncture Research
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    • v.33 no.1
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    • pp.23-36
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    • 2016
  • Objectives : The aim of this study was to investigate the asthma-suppressive and immuno-regulatory effect of AHCR-HA (Root of Asarum sieboldii Miq. water extract) on OVA (ovalbumin)-induced asthma in mice. Methods : All C57BL/6 mice experimental groups, except the Normal and N-AHCR groups, were sensitized with OVA. The mice in the N-AHCR group and the OVA-AHCR group were treated with water extract of AHCR (1 %) by an oral administration, and the OVA-Saline group were treated with saline solution. Oral dosesof AHCR water extract and saline were administered for 8 weeks, three times a week. Results & Conclusion : The lung weight and total cells in the lungs of the OVA-AHCR group decreased significantly compared with those of the OVA-Saline group. Total leukocytes and eosinophils in BALF and photomicrographs of the OVA-AHCR group decreased significantly compared with those of the OVA-Saline group. The collagen accumulation in the lung sections of the OVA-AHCR group decreased significantly compared with those of the OVA-Saline group. The concentrations of IL-4, IL-5, IL-13 and IgE in BALF and the serum of the OVA-AHCR group decreased significantly compared with those of the OVA-Saline group. The mRNA expressions of $TNF-{\alpha}$, $IL-1{\beta}$, IL-4, IL-5 and IL-13 in the lungs of the OVA-AHCR group decreased significantly compared with those of the OVA-Saline group.