Immuno-Modulatory Activity of the Crude Polysaccharide from Wild Ginseng Adventitious Root
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Nam, Sohyun
(Korea Food Research Institute)
Rhee, Young Kyoung (Korea Food Research Institute) Hong, Hee-Do (Korea Food Research Institute) Lee, Young-Chul (Korea Food Research Institute) Kim, Young-Chan (Korea Food Research Institute) Shin, Kwang-Soon (Dept. of Food Science and Biotechnology, Kyonggi University) Cho, Chang-Won (Korea Food Research Institute) |
1 | Dubois M, Gilles KA, Hamilton JK, Robers PA, Smith F. 1956. Colorimetric method for determination of sugar and related substances. Anal Chem 28:350-356 DOI |
2 | Hong MH, Lim HK, Park JE, Jun NJ, Lee YJ, Cho MJ, Cho SK. 2008. The antihypertensive and vasodilating effects of adventitious root extracts of wild ginseng. J Korean Soc Appl Chem 51:102-107 과학기술학회마을 DOI ScienceOn |
3 | Jang HI, Shin HM. 2010. Wild Panax ginseng (Panax ginseng C. A. Meyer) protects against methotrexate-induced cell regression by enhancing the immune response in RAW 264.7 macrophages. Am J Chin Med 38:949-960 DOI ScienceOn |
4 | Jeong HS, Kang TS, Woo KS, Paek KY, Yu KW, Yang SJ. 2005. Effects of cultured wild ginseng roots on the alcoholic fermentation. Korean J Food Preserv 12:402-410 과학기술학회마을 |
5 | Jung YJ, Chun H, Kim KI, An JH, Shin DH, Hong BS, Cho HY, Yang HC. 2002. Purified polysaccharide activating the complement system from leaves of Diospyos kaki L. Korean J Food Sci Technol 34:879-884 과학기술학회마을 |
6 | Kabat EA, Mayer MM. 1965. Experimental Immunochemistry. 2nd ed. pp. 133-240. Thormas Publisher. Springfield, IL, USA |
7 | Kim EL, Kim CS, Lee HY, Lee HR, Kim EY, Yoon MC, Shin SS. 2012. Mountain cultivated ginseng water boiled extract decrease blood glucose level and improves lipid metabolism in male db/db mice. Kor J Herbology 27:69-75 DOI ScienceOn |
8 | Kim JW, Lee SH, No HK, Hong JH, Youn KS. 2010. Antioxidant properties of cultured wild ginseng roots extracts. Korean J Food Preserv 17:861-866 과학기술학회마을 |
9 | Kim YS, Park KM, Shin HJ, Song KS, Nam KY, Park JD. 2002. Anticancer activities of red ginseng acidic polysaccharide by activation of macrophages and natural killer cells. Yakhak Hoeji 46:113-119 과학기술학회마을 |
10 | Kim KH, Lee YS, Jung IS, Park SY, Chung HY, Lee IR, Yun YS. 1998. Acidic polysaccharide from Panax ginseng, ginsan, induces Th1 cell and macrophage cytokines and generates LAK cells in synergy with rIL-2. Planta Med 64: 110-115 DOI ScienceOn |
11 | Kwon MH, Sung HJ. 1997. Characteristics of immune response by polysaccharides with complement system activity. Food Sci Ind 30:30-43 |
12 | Park HR, Lee MS, Jo SY, Won HJ, Lee HS, Lee H, Shin KS. 2012. Immuno-stimulating activities of polysaccharide isolated from commercial soy sauce and traditional Korean soy sauce. Korean J Food Sci Technol 44:228-234 DOI ScienceOn |
13 | Kwon SJ, Chung DK. 2004. The immune-enhancing effect of mountain grown ginseng, mountain cultivated ginseng, and Panax ginseng. J Oriental Neuropsychiatry 15:89-102 |
14 | Lee SD, Okuda H. 1990. Effect of acidic polysaccharide of Korean red ginseng on lipolytic action of toxohormone-L from cancerous ascites fluid. Korean J Ginseng Sci 14:67-73 |
15 | Lee YS, Chung IS, Lee IR, Kim KH, Hong WS, Yun YS. 1997. Activation of multiple effector pathways of immune system by the antineoplastic immunostimulator acidic polysaccharide ginsan isolated from Panax ginseng. Anticancer Res 17:323-331 |
16 | Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. 1951. Protein measurement with folin phenol regent. J Biochem 193:265 |
17 | Min KC, Jo JS, Kim ES. 1984. Studies on the nonstarchy polysaccharides of Korean ginseng, Panax ginseng C. A. Meyer: II. Physico-chemical properties of petic substances. Korean J Ginseng Sci 8:105-113 |
18 | Oh BM, Kweon MH, Ra KS. 1994. Isolation and characterization of acidic polysaccharides activating complement system from the hot water extracts of Pteridium aquilinum var. latisculum. Korean J Food & Nutrition 7:159-168 |
19 | Okuda H. 1992. Inhibitory substances in Korean red ginseng toward toxohormone-L-a toxic substance secreted from tumor cell. The ginseng review 15:34-37 |
20 | Ryu HS. 2011. Effects of a corn extract on mouse splenocyte and cytokine production by peritoneal macrophages. Korean J Food & Nutr 24:65-70 과학기술학회마을 DOI ScienceOn |
21 | Shin KS. 2012. Immunostimulating plant polysaccharides: Macrophage immunomodulation and its possible mechanism. Food Sci Ind 45:12-22 과학기술학회마을 |
22 | Satio H, Tomioka H, Sato K. 1998. PSK, a polysaccharide from Coriolus versicolor, enhances oxygen metabolism of murine peritoneal macrophages and the host resistance to listerial infection. J Gen Microbiol 134:1029-1035 |
23 | Seo YS, Shin KS. 2012. Immune system-stimulating activities of mucilage polysaccharides isolated from Opuntia humifusa. J Korean Soc Food Sci Nutr 41:95-102 과학기술학회마을 DOI ScienceOn |
24 | Shin JY, Song JY, Yun YS, Yang HO, Rhee DK, Pyo S. 2002. Immunostimulating effects of acidic polysaccharides extract of Panax ginseng on macrophage function. Immunopharmacol Immunotoxicol 24:469-482 DOI ScienceOn |
25 | Wang H, Actor JK, Indrigo J, Olsen M, Dasgupta A. 2003. Asian and Siberian ginseng as a potential modulator of immune function: An in vitro cytokine study using mouse macrophage. Clin Chim Acta 327:123-128 DOI ScienceOn |
26 | Son SH, Choi SM, Hyung SJ, Yun S, Choi MS, Shin EM, Hong YP. 1999. Induction and culture of mountain ginseng adventitious roots and AFLP analysis for identifying mountain ginseng. Biotechnol Bioprocess Eng 4:119-123 DOI |
27 | Song JY, Han SK, Son EH, Pyo SN, Yun YS, Yi SY. 2002. Induction of secretory and tumoricidal activities in peritoneal macrophages by ginsan. Int Immunophrmacol 2:857-865 DOI ScienceOn |
28 |
Sorimachi K, Akimoto K, Ikehara Y, Inafuku K, Okudo A, Yamazaki S. 2001. Secretion of TNF- |
29 | Sundquist M, Johansson C, Wick MJ. 2003. Dendritic cells as inducers of antimicrobial immunity in vivo. Apmis 111:715-724 DOI ScienceOn |
30 | Thomas MJ, Albersheim P. 1972. A gas chromatographic method for the determination of aldose and uronic acid constituents of plant cell wall polysaccharides. Plant Physol 49:926-936 DOI ScienceOn |
31 | Bitter T, Muir HM. 1962. A modified uronic acid carbazole reaction. Anal Biochem 4:330-334 DOI ScienceOn |
32 | Yoon TJ, Yu KW, Shin KS, Suh HJ. 2008. Innate immune stimulation of exo-polymers prepared from Cordyceps sinensis by submerged culture. Appl Microbiol Biotechnol 80:1087-1093 DOI |
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