Journal of Acupuncture Research

Korean Acupuncture & Moxibustion Medicine Society (대한침구의학회)
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The Immuno-modulatory Effect of Root of Asarum sieboldii Miq. Water Extract on OVA-induced Asthma

세신 전탕액 경구투여가 천식 억제 및 면역조절에 미치는 영향

  • Jo, Seoung Eun (Department of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Daejeon University) ;
  • Kang, Jae Hui (Department of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Daejeon University) ;
  • Lee, Hyun (Department of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Daejeon University)
  • 조성은 (대전대학교 한의과대학 침구의학교실) ;
  • 강재희 (대전대학교 한의과대학 침구의학교실) ;
  • 이현 (대전대학교 한의과대학 침구의학교실)
  • Received : 2016.02.12
  • Accepted : 2016.03.02
  • Published : 2016.03.18
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Abstract

Objectives : The aim of this study was to investigate the asthma-suppressive and immuno-regulatory effect of AHCR-HA (Root of Asarum sieboldii Miq. water extract) on OVA (ovalbumin)-induced asthma in mice. Methods : All C57BL/6 mice experimental groups, except the Normal and N-AHCR groups, were sensitized with OVA. The mice in the N-AHCR group and the OVA-AHCR group were treated with water extract of AHCR (1 %) by an oral administration, and the OVA-Saline group were treated with saline solution. Oral dosesof AHCR water extract and saline were administered for 8 weeks, three times a week. Results & Conclusion : The lung weight and total cells in the lungs of the OVA-AHCR group decreased significantly compared with those of the OVA-Saline group. Total leukocytes and eosinophils in BALF and photomicrographs of the OVA-AHCR group decreased significantly compared with those of the OVA-Saline group. The collagen accumulation in the lung sections of the OVA-AHCR group decreased significantly compared with those of the OVA-Saline group. The concentrations of IL-4, IL-5, IL-13 and IgE in BALF and the serum of the OVA-AHCR group decreased significantly compared with those of the OVA-Saline group. The mRNA expressions of $TNF-{\alpha}$, $IL-1{\beta}$, IL-4, IL-5 and IL-13 in the lungs of the OVA-AHCR group decreased significantly compared with those of the OVA-Saline group.

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