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http://dx.doi.org/10.13045/acupunct.2016003

The Immuno-modulatory Effect of Root of Asarum sieboldii Miq. Water Extract on OVA-induced Asthma  

Jo, Seoung Eun (Department of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Daejeon University)
Kang, Jae Hui (Department of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Daejeon University)
Lee, Hyun (Department of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Daejeon University)
Publication Information
Journal of Acupuncture Research / v.33, no.1, 2016 , pp. 23-36 More about this Journal
Abstract
Objectives : The aim of this study was to investigate the asthma-suppressive and immuno-regulatory effect of AHCR-HA (Root of Asarum sieboldii Miq. water extract) on OVA (ovalbumin)-induced asthma in mice. Methods : All C57BL/6 mice experimental groups, except the Normal and N-AHCR groups, were sensitized with OVA. The mice in the N-AHCR group and the OVA-AHCR group were treated with water extract of AHCR (1 %) by an oral administration, and the OVA-Saline group were treated with saline solution. Oral dosesof AHCR water extract and saline were administered for 8 weeks, three times a week. Results & Conclusion : The lung weight and total cells in the lungs of the OVA-AHCR group decreased significantly compared with those of the OVA-Saline group. Total leukocytes and eosinophils in BALF and photomicrographs of the OVA-AHCR group decreased significantly compared with those of the OVA-Saline group. The collagen accumulation in the lung sections of the OVA-AHCR group decreased significantly compared with those of the OVA-Saline group. The concentrations of IL-4, IL-5, IL-13 and IgE in BALF and the serum of the OVA-AHCR group decreased significantly compared with those of the OVA-Saline group. The mRNA expressions of $TNF-{\alpha}$, $IL-1{\beta}$, IL-4, IL-5 and IL-13 in the lungs of the OVA-AHCR group decreased significantly compared with those of the OVA-Saline group.
Keywords
Asthma; AHCR-HA; Immuno-modulatory effect;
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Times Cited By KSCI : 4  (Citation Analysis)
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