• Title/Summary/Keyword: Immunity Test

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Effects of Probiotic Microbes on Growth Performance, Innate Immunity, and Pathogen Sensitivity in Cultured Olive Flounder (Probiotic 기능을 가진 미생물을 함유한 양어용 생균제가 넙치의 성장, 선천성면역 및 항병능에 미치는 영향)

  • Lee, Ji-Hoon;Chae, Young-Sik;Park, Jung-Jin;Choi, Jun-Ho;Kim, Dong-Gun;Park, Kwan Ha
    • Journal of fish pathology
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    • v.30 no.1
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    • pp.41-49
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    • 2017
  • Probiotic principles can be applied in aquaculture for the purpose of growth and immunity stimulation, disease prevention and eventually better production performance. This study was to assess effects of combinations of microbes containing two Bacillus sp., plus one Lactobacillus sp. as the basal preparation (BSL-LAB), and additional Nitrosomonas sp. (nitrifying bacteria consortium, NBS) in olive flounder (Paralichthys olivaceus). The effects examined were growth parameters, hematologic parameters, innate immunity and pathogen challenge test. Fish were assigned to 4 treatments as Control (no probiotics), Group A (Bacillius and Lactobacillus to culture water), Group B (Bacillius and Lactobacillus both in water and feed), Group C (same as Group B with additional Nitrosomonas in feed). Fish were allocated to the above 4 groups, each group being composed of triplicate 30 fish, for a 7-week feeding in the laboratory. Positive effects were observed both in growth and pathogen sensitivity with all three probiotic combinations. Such effects were attributed to improved innate immune functions. This result indicates that the tested probiotic microbes are beneficial to olive flounder aquaculture.

HALT of High Power Amplifier Module Used in Radar (레이더용 고출력 증폭기 모듈의 HALT)

  • Hwang, Soon-Mi;Kim, Chul-Hee;Lee, Kwan-Hun
    • Journal of Applied Reliability
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    • v.14 no.2
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    • pp.97-102
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    • 2014
  • Radar is an object-detection system that uses radio waves to determine the range, altitude, direction, or speed of objects. High power amplifier Module is the most critical part of the high-power radar transmitter systems. It can be used to detect aircraft, ships, spacecraft, guided missiles, motor vehicles, weather formations, and terrain. Research related to radar has been conducted in various fields according to improvement of the communication technology. But only performance-originated technology development has been dashed; study concerning environment duality and safety concerning reliability are still insufficient. In general, radar module is exposed to the outside, on the means of moving or fixed in a certain place. It should be guaranteed sufficient immunity for a variety of environmental stresses that can occur in the outdoor. HALT is a great process used for quickly finding failure mechanisms in a hardware design and product. By applying various kinds and extreme level of stresses, we can find the operating limits of products. In thesis, we conducted HALT test of the high power amplifier modules which used in military and automotive radar. After the test, we analyzed environmental weaknesses of high power amplifier modules using conventional construction data.

Analysis of Radiation Effects in CMOS 0.18um Process Unit Devices (CMOS 0.18um 공정 단위소자의 방사선 영향 분석)

  • Jeong, Sang-Hun;Lee, Nam-Ho;Lee, Min-Woong;Cho, Seong-Ik
    • The Transactions of The Korean Institute of Electrical Engineers
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    • v.66 no.3
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    • pp.540-544
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    • 2017
  • In this study, we analyzed the effects of TID(Total Ionizing Dese) and TREE(Transient Radiation Effects on Electronics) on nMOSFET and pMOSFET fabricated by 0.18um CMOS process. The size of nMOSFET and pMOSFET is 100um/1um(W/L). The TID test was conducted up to 1 Mrad(Si) with a gamma-ray(Co-60). During the TID test, the nMOSFET generated leakage current proportional to the applied dose, but that of the pMOSFET was remained in a steady state. The TREE test was conducted at TEST LINAC in Pohang Accelerator Laboratory with a maximum dose-rate of $3.16{\times}10^8rad(si)/s$. In that test nMOESFET generated a large amount of photocurrent at a maximum of $3.16{\times}10^8rad(si)/s$. Whereas, pMOSFETs showed high TREE immunity with a little amount of photocurrent at the same dose rate. Based on the results of this experiment, we will progress the research of the radiation hardening for CMOS unit devices.

The usefulness of skin test in evaluation of immunity to varicella (수두에 대한 면역력 평가에 있어서 피부 시험의 유용성)

  • Kim, Ji-Young;Lee, Hye Jeen;Kim, Me Jin;Kim, Young Ho;Jung, Ji A;Yang, Seung;Hwang, Il Tae;Lee, Hae Ran
    • Clinical and Experimental Pediatrics
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    • v.51 no.4
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    • pp.377-382
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    • 2008
  • Purpose : The aim of this study is to assess the usefulness of skin test by an inactivated, 1/50 diluted solution of attenuated varicella vaccine in evaluating the immune status to varicella. Methods : Total 41 subjects (22 males, 19 females, aged 1-32 years) were enrolled from July to August, 2005. Past medical history including varicella infection, varicella vaccination were investigated through questionnaires. The skin test solution was prepared from solution of attenuated varicella vaccine(Oka strain) which was inactivated by exposure to room temperature for 10 days and diluted at 1/50 with normal saline. Skin test was done by injecting 0.1 mL of the solution intradermally into the volar surface of the right forearm and sterile normal saline was used as a control on the left forearm. Positive reaction was defined when the transverse diameter of the induration was 5 mm or more. Serum varicella zoster virus specific IgG antibody test by ELISA (enzyme-linked immunosorbent assay) was done. Results : In adults, the sensitivity of the varicella zoster virus skin test compared to ELISA was 94.7% and the positive predictive value was 100%. In children, both the positive predictive value and specificity were 100% but the sensitivity and the negative predictive value were 50% and 30.7% respectively. Children showed smaller skin test reactivity compared to adults. Conclusion : The varicella zoster virus skin test using inactivated, 1/50 diluted solution of attenuated varicella vaccine was proved as one of the useful tools for evaluating the immunity and susceptibility of the varicella zoster virus.

SRAM소자의 SER 및 Latchup 신뢰성 연구

  • Lee Jun-Ha;Lee Heung-Ju;Jo Hyeon-Chan;Lee Gang-Hwan;Gwon O-Geun
    • Proceedings of the Korean Society Of Semiconductor Equipment Technology
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    • 2005.05a
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    • pp.63-66
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    • 2005
  • A soft error rate neutrons is a growing problem for integrated circuits with technology scaling. In the acceleration test with high-density neutron beam, a latch-up prohibits accurate estimations of the soft error rate (SER). This paper presents results of analysis for the latch-up characteristics in the circumstance corresponding to the acceleration SER test for SRAM. Simulation results, using a two-dimensional device simulator, show that the deep p-well structure has better latch-up Immunity compared to normal twin and triple well structures. In addition, it is more effective to minimize the distance to ground power compared with controlling a path to the $V_{DD}$ power.

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Analysis of Cell Latch-up Effect in SRAM Device (SRAM 소자의 Cell Latch-up 현상 분석)

  • Lee Jun-Ha;Lee Hoong-Joo
    • Proceedings of the KAIS Fall Conference
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    • 2004.11a
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    • pp.203-205
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    • 2004
  • A soft error rate neutrons is a growing problem for terrestrial integrated circuits with technology scaling. In the acceleration test with high-density neutron beam, a latch-up prohibits accurate estimations of the soft error rate (SER). This paper presents results of analysis for the latch-up characteristics in the circumstance corresponding to the acceleration SER test for SRAM. Simulation results, using a two-dimensional device simulator, show that the deep p-well structure has better latch-up immunity compared to normal twin and triple well structures. In addition, it is more effective to minimize the distance to ground power compared with controlling a path to the $V_{DD}$ power.

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A Study on the Measurement Method of Test Waveform for System-level HEMP Immunity Test (체계 수준 HEMP 내성 시험을 위한 시험파형 계측 기법 연구)

  • Yeo, Saedong
    • Journal of the Korea Institute of Military Science and Technology
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    • v.22 no.2
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    • pp.233-240
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    • 2019
  • High-altitude ElectroMagnetic Pulse(HEMP) is a high-power electromagnetic pulse caused by nuclear explosions at altitudes above 30 km. This pulse can cause serious damage to the electrical/electronic device. Therefore, there are a lot of studies on the effects of HEMP in the literature. When conducting studies on the effects of HEMP, it is essential to measure the simulated HEMP. Depending on the need for measurement, this paper focuses on the HEMP measurement method. This paper proposes a measurement method using frequency domain compensation to extract the correct waveform and solves the offset problem more efficiently than the conventional methods. The proposed method is verified by experiment using HEMP simulator and measurement system in ADD.

Analysis of Impulse Withstand Voltage Performance of Lighting Equipment (조명기기의 임펄스내전압 성능의 분석)

  • Lee, Bok-Hee;Pang, Pyung-Ho
    • Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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    • v.28 no.3
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    • pp.91-96
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    • 2014
  • Modern electronic circuits are becoming more vulnerable to damage by surges, and it is required to improve the impulse withstand voltage performance of electrical and electronic equipment. This paper presents the impulse withstand voltage performance of lighting equipment connected to power lines, and the impulse withstand voltage tests for fluorescent lamp, LED lamp and halogen lamp were carried out according to the reference standards under normal service conditions. To conduct performance tests against lightning surge, a combination wave ($1.2/50{\mu}s$ voltage - $8/20{\mu}s$ current) was employed. The test surge was applied between lines or between line and ground of the specimen to be measured. The test surge was applied synchronized at the peak value of the positive and negative AC voltage waves. As a consequence, some specimens satisfied the impulse withstand voltage test criteria, but lighting equipment such as 36W fluorescent lamps, 5W and 5.5W LED lamps and 50W halogen lamp were damaged at the test voltage levels between power lines. It is needed to improve the qualities of lighting equipment to satisfy EMC immunity requirements of equipment for general lighting purposes.

Immunity of Electronic Equipments Against Potable High Voltage Generator (휴대형 고전압 발생기에 대한 전자기기의 내성)

  • Lee, Jong-Ig;Yeo, Junho
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2017.10a
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    • pp.61-62
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    • 2017
  • In this study, we introduce some main functions and specifications of a recently commercialized potable compact high voltage generator. USB killer has been designed to test surge protection circuitry of electronic equipments using USB ports. USB killer transforms 5V DC power supplied by USB port into a sufficiently high voltage over 200V DC through oscillator, transformer, voltage multiplier, and rectifier. The power charged in a high-capacity condenser can be applied back into the electronic equipments as an electric shock to destroy them or test protection circuits. USB killer is a readily available item, and one can test a variety of electronic equipments. We introduce some test results known over the internet and those obtained from our tests.

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The Effect of Gyogam-dan on Depression and Immunity on Repeated Stress in Ovariectomized Rats (교감단이 우울행동과 면역기능에 미치는 효과)

  • Cheong, Hyun-Cheol;Kim, Song-Baek;Seo, Yun-Jung;Cho, Han-Baek;Choi, Chang-Min
    • The Journal of Korean Obstetrics and Gynecology
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    • v.26 no.3
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    • pp.18-32
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    • 2013
  • Objectives: In this research, the effect of Gyogam-dan (GGD) on depression and immunity were assessed in ovariectomized rats subjected to repetitive stress. GGD is the prescription consisting of Poria cocos and Cyperi Rhizoma. Methods: Ovariectomized rats were repeatedly stressed over a 2-week period. After GGD (100 or 400 mg/kg) were orally administered, Elevated Plus Maze (EPM) and forced swimming test (FST) were performed to evaluate depressive and anxiety response. As well, the change of corticosterone (CORT) and the change of interleukin-$1{\beta}$ (IL-$1{\beta}$) and interleukin-4 (IL-4) in blood serum and in brain were mesured. Results: 1. In the EPM, there were no statistically significant differences among the groups. 2. In the FST, immobility time significantly decreased in rats of each experiment group compared with the control group (p<0.01). 3. Serum CORT level were decreased in 400 mg GGD group (p<0.05). 4. On IL-$1{\beta}$ and IL-4 measurement in the serum and brain, there were not significant increase or decrease compared with the control group. Conclusions: These results suggest that GGD is effective to reduce depression-behavior in ovariectomized rats. However, GGD do not has significant efficacy to reduce anxiety-behavior in EPM test. Measurement of serum CORT level reveals significant decrease and it shows anti-depressant like effect. Results on immunity are not significant.