• BMB Reports
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• 제38권2호
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• pp.121-127
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• 2005

Drosophila protects itself from infection by microbial organisms by means of its pivotal defense, the so-called innate immunity system. This is its sole defense as it lacks an adaptive immunity system such as is found in mammals. The strong conservation of innate immunity systems in organisms from Drosophila to mammals, and the ease with which Drosophila can be manipulated genetically, makes this fly a good model system for investigating the mechanisms of virulence of a number of medically important pathogens. Potentially damaging endogenous and/or exogenous challenges sensed by specific receptors initiate signals via the Toll and/or Imd signaling pathways. These in turn activate the transcription factors Dorsal, Dorsal-related immune factor (Dif) and Relish, culminating in transcription of genes involved in the production of antimicrobial peptides, melanization, phagocytosis, and the cytoskeletal rearrangement required for appropriate responses. Clarifying the regulatory interactions between the various pathways involved is very important for understanding the specificity and termination mechanism of the immune response.

• Clinical and Experimental Pediatrics
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• 제52권6호
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• pp.649-654
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• 2009

The immune system is comprised of cells and molecules whose collective and coordinated response to the introduction of foreign substance is referred to as the immune response. Defense against microbes is mediated by the early reaction (innate immunity) and the late response (adaptive immunity). Innate immunity consists of the epithelial barrier, phagocytes, complement and natural killer cells. Adaptive immunity, a more complex defense reaction, consists of activation of later-developed lymphocytes that, when stimulated by exposure to infectious agents, increase in magnitude and defensive capabilities with each successive exposure. In this review we discuss recent advances in important primary immune deficiency disorders of innate immunity (chronic granulomatous disease, leukocyte adhesion deficiency) and adaptive immunity (severe combined immune deficiency, Wiskott- Aldrich syndrome).

• Clinical and Experimental Pediatrics
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• 제48권11호
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• pp.1153-1161
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• 2005

As known by other name(natural immunity), the innate immune system comprises all those mechanisms for dealing with infection that are constitutive or built in, changing little with age or with experience of infection. Though in some ways less sophisticated than adaptive immunity, innate immunity should not belittled, since it has evidently protected thousands of species of invertebrates sufficiently to survive for up to 2 billion years. In the innate immune system, molecules of both cellular and humoral types are involved, corresponding to the need to recognize and dispose of different types of pathogen, to promote inflammatory responses and to interact to the adaptive immune system. A major features of innate immunity are the presence of the normal gut flora, complements, macrophages, dendritic cells, natural killer cells and many cytokines that can block the establishment of infection. Both phagocytic cells and complement system have tremendous potential for damaging host cells, but fortunately they are normally only triggered by foreign materials, and usually most of their destructive effects are focussed on the surface of these or in the safe environment of the phagolysosome. This article addreses the comprehensive mechanisms of the major components of the innate immune system to prevent the infection.

• 한국항해학회지
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• 제20권2호
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• pp.97-107
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• 1996

The method of Electromagnetic Wave Immunity Test is continuously endeavored by IEC and CISPR as international unification, but it has not been established yet. The main reason is why it is difficult to obtain the measurement method and normalization of threshold to find out the complicated parameters for Electromagnetic Wave immunity Test. So far, thus, the Electromagnetic Wave Immunity Test is carried out case by case as the electromagnetic environment, which is set up Electromagnetic Wave Immunity Test. This study has developed an algorithm and measurement software suitable for IEC1000-4 Regulations, where a ready-made Amplifier, and Signal Generator have been used and an interconnecting Interface Board has been constructed for connecting with the other apparatuses, i.e., RF Switch, Power Meter, Field Sensor, Pre-Amp., etc. Therefore, we have achieved the aim to develop an automated software using OOP method and the measurement system.

• 자동차안전학회지
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• 제14권1호
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• pp.14-19
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• 2022

Recently, automobile industries have developed ADAS, smart cars, connected cars, automated driving systems, which communicate with outsides of a vehicle not only in uni-directional way but also in bi-directional way. It is necessary to examine the electromagnetic immunity of vehicles equipped with those communication systems. The electromagnetic immunity tests are carried out in an electromagnetic semi anechoic chamber, which is cut off from the outside electromagnetically. In this study, additional test environments were designed and tested and as a result they are shown to be effective to create test environments in an experimental chamber for electromagnetic immunity tests of vehicles equipped with communication systems.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2013년도 제45회 하계 정기학술대회 초록집
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• pp.92.2-92.2
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• 2013

The design and chemical synthesis of multifunctional nanomaterials have been providing potential applications in biomedical fields such as molecular imaging and drug delivery. Recently, bio-derived and/or synthetic nanostructured materials capable of modulating the immune system have been also issues of interest in immunology-related nanomedicine fields. In this talk, the recent research results on the development of nanostructured materials for enhanced immunity would be presented. I will introduce the chemical strategy for the combination of nanostructured materials and bioactive compounds to improve both anti-cancer immunity and vaccine delivery efficiency.

• 자동차안전학회지
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• 제11권4호
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• pp.50-56
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• 2019

Recently, automobile industries have developed ADAS, smart cars, connected cars, automated driving systems, which use a variety of sensor systems - ultrasonics, cameras, lidars and radars - and communication systems. It is necessary to examine the electromagnetic immunity of vehicles equipped with those systems. The electromagnetic immunity tests are carried out in an electromagnetic semi anechoic chamber, which is cut off from the outside. It is difficult to create test environments in which the radar sensor systems of vehicles work properly in the test chamber. In this study, test jigs were designed and tested and as a result they are shown to be effective to create test environments for electromagnetic immunity tests of vehicles equipped with radar sensors. We also proposed additional safety standards for immunity tests of vehicles with radar systems that currently do not exist.

• 자동차안전학회지
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• 제12권4호
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• pp.7-12
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• 2020

Recently, automobile industries have developed ADAS, smart cars, connected cars, automated driving systems, which use a variety of sensor systems - ultrasonics, cameras, lidars and radars - and communication systems. It is necessary to examine the electromagnetic immunity of vehicles equipped with the sensor systems due to the fact that the normal operation of those systems is very important to the safety of the vehicles. The electromagnetic immunity tests are carried out in an electromagnetic semi anechoic chamber, which is cut off from the outside. It is difficult to create test environments in which the camera sensor systems of vehicles work properly in the test chamber. In this study, test jigs were designed and tested and as a result they are shown to be effective to create test environments for electromagnetic immunity tests of vehicles equipped with camera sensors. We also proposed additional safety standards for immunity tests of vehicles with camera systems that currently do not exist.

• 한국항해학회지
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• 제19권3호
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• pp.29-34
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• 1995

IEC and CISPR have continuously endeavored the measurement method of Immunity Test as international unification, but not established yet. The main reason is that the measurement method and the normalization of threshold to obtain the complicated parameters for Immunity Test are difficult. Thus, the Immunity Test Setups are used differently according to the measured electromagnetic environments. This study developed an Immunity Test System and Algorithm for measurement software suitable for IEC801-3 Regulatons using ready-made amplifier, signal generator, and developes interconnecting interface board interacting with other appratus i.e., RF Switch, Power Meter, Field Sensor and Pre-amp. We are to develope an automated software using Top/Down and OOP(Object Oriented Programming) method.

• BMB Reports
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• 제55권6호
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• pp.259-266
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• 2022

Recent studies have revealed that the immune system plays a critical role in various physiological processes beyond its classical pathogen control activity. Even under a sterile condition, various cells and tissues can utilize the immune system to meet a specific demand for proper physiological functions. Particularly, a strong link between immunity and metabolism has been identified. Studies have identified the reciprocal regulation between these two systems. For example, immune signals can regulate metabolism, and metabolism (cellular or systemic) can regulate immunity. In this review, we will summarize recent findings on this reciprocal regulation between immunity and metabolism, and discuss potential biological rules behind this interaction with integrative perspectives.