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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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Integrative understanding of immune-metabolic interaction

  • Im, Seonyoung (Department of Systems Biology, Yonsei University) ;
  • Kim, Hawon (Department of Systems Biology, Yonsei University) ;
  • Jeong, Myunghyun (Department of Systems Biology, Yonsei University) ;
  • Yang, Hyeon (Department of Systems Biology, Yonsei University) ;
  • Hong, Jun Young (Department of Systems Biology, Yonsei University)
  • Received : 2022.03.11
  • Accepted : 2022.05.17
  • Published : 2022.06.30
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Abstract

Recent studies have revealed that the immune system plays a critical role in various physiological processes beyond its classical pathogen control activity. Even under a sterile condition, various cells and tissues can utilize the immune system to meet a specific demand for proper physiological functions. Particularly, a strong link between immunity and metabolism has been identified. Studies have identified the reciprocal regulation between these two systems. For example, immune signals can regulate metabolism, and metabolism (cellular or systemic) can regulate immunity. In this review, we will summarize recent findings on this reciprocal regulation between immunity and metabolism, and discuss potential biological rules behind this interaction with integrative perspectives.

Keywords

Acknowledgement

We apologize that we cannot cite all the seminal papers on this subject. This work was supported by the Yonsei Research Fund (2021-22-0049), Yonsei Signature Research Cluster Program of 2022 (2022-22-0013), and the National Research Foundation of Korea (NRF) Ministry of Science, ICT and Future Planning NRF-2021-22-0049.

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