• IMMUNE NETWORK
• /
• 제16권5호
• /
• pp.261-270
• /
• 2016

The human immune system has evolved to fight against foreign pathogens. It plays a central role in the body's defense mechanism. However, the immune memory geared to fight off a previously recognized pathogen, tends to remember an original form of the pathogen when a variant form subsequently invades. This has been termed 'original antigenic sin'. This adverse immunological effect can alter vaccine effectiveness and sometimes cause enhanced pathogenicity or additional inflammatory responses, according to the type of pathogen and the circumstances of infection. Here we aim to give a simplified conceptual understanding of virus infection and original antigenic sin by comparing and contrasting the two examples of recurring infections such as influenza and dengue viruses in humans.

• 한국정보디스플레이학회:학술대회논문집
• /
• 한국정보디스플레이학회 2007년도 7th International Meeting on Information Display 제7권1호
• /
• pp.417-420
• /
• 2007

A 12k-bit SRAM has been developed for line memory of system-on-glass (SoG) with lowtemperature poly-silicon (LTPS) thin film transistor (TFT). For accurate sensing even with the large variation and mismatches in the characteristics of LTPS TFT, mismatch immune sense amplifier is developed. The SRAM shows 30ns read access time with 7V supply voltage while dissipating 4.05mW and 1.75mW for write and read operation, respectively

• IMMUNE NETWORK
• /
• 제23권1호
• /
• pp.10.1-10.16
• /
• 2023

Memory T (Tm) cells protect against Ags that they have previously contacted with a fast and robust response. Therefore, developing long-lived Tm cells is a prime goal for many vaccines and therapies to treat human diseases. The remarkable characteristics of Tm cells have led scientists and clinicians to devise methods to make Tm cells more useful. Recently, Tm cells have been highlighted for their role in coronavirus disease 2019 vaccines during the ongoing global pandemic. The importance of Tm cells in cancer has been emerging. However, the precise characteristics and functions of Tm cells in these diseases are not completely understood. In this review, we summarize the known characteristics of Tm cells and their implications in the development of vaccines and immunotherapies for human diseases. In addition, we propose to exploit the beneficial characteristics of Tm cells to develop strategies for effective vaccines and overcome the obstacles of immunotherapy.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• 제9권12호
• /
• pp.4776-4798
• /
• 2015

The location selection of virtual machines in distributed cloud is difficult because of the physical resource distribution, allocation of multi-dimensional resources, and resource unit cost. In this study, we propose a multi-object virtual machine location selection algorithm (MOVMLSA) based on group information, doubly linked list structure and genetic algorithm. On the basis of the collaboration of multi-dimensional resources, a fitness function is designed using fuzzy logic control parameters, which can be used to optimize search space solutions. In the location selection process, an orderly information code based on group and resource information can be generated by adopting the memory mechanism of biological immune systems. This approach, along with the dominant elite strategy, enables the updating of the population. The tournament selection method is used to optimize the operator mechanisms of the single-point crossover and X-point mutation during the population selection. Such a method can be used to obtain an optimal solution for the rapid location selection of virtual machines. Experimental results show that the proposed algorithm is effective in reducing the number of used physical machines and in improving the resource utilization of physical machines. The algorithm improves the utilization degree of multi-dimensional resource synergy and reduces the comprehensive unit cost of resources.

• IMMUNE NETWORK
• /
• 제6권2호
• /
• pp.93-101
• /
• 2006

Background: Memory T lymphocytes of the immune system provide long-term protection in response to bacterial or viral infections/immunization. Ag concentration has also been postulated to be important in determining whether T cell differentiation favors effector versus memory cell development. In the present study we hypothesized that naive Ag-specific $CD4^+$ T cells briefly stimulated with different Ag doses at the primary exposure could affect establishment of memory cell pool after secondary immunization. Methods: To assess this hypothesis, the response kinetics of DO11.10 TCR $CD4^+$ T cells primed with different Ag doses in vitro was measured after adoptive transfer to naive BALB/c mice. Results: Maximum expansion was shown in cells primarily stimulated with high doses of ovalbumin peptide $(OVA_{323-339})$, whereas cells in vitro stimulated with low dose were expanded slightly after in vivo secondary exposure. However, the cells primed with low $OVA_{323-339}$ peptide dose showed least contraction and established higher number of memory cells than other treated groups. When the cell division was analyzed after adoptive transfer, the high dose Ag-stimulated donor cells have undergone seven rounds of cell division at 3 days post-adoptive transfer. However, there was very few division in naive and low dose of peptide-treated group. Conclusion: These results suggest that primary stimulation with a low dose of Ag leads to better memory $CD4^+$ T cell generation after secondary immunization. Therefore, these facts imply that optimally primed $CD4^+$ T cells is necessary to support effective memory pool following administration of booster dose in prime-boost vaccination.

• 한국컴퓨터정보학회논문지
• /
• 제14권7호
• /
• pp.17-24
• /
• 2009

정보시스템에 대한 이용이 늘어남에 따라 소프트웨어 개발 요구와 개발 비용이 증가하게 되었다. 기존에는 통계적 알고리즘 기반의 회귀분석을 이용하여 소프트웨어 개발비용을 산정하였으나 오늘날은 기계학습 방법들이 많이 연구되고 있다. 본 논문에서는 기계학습 기술의 하나인 SVR를 사용하여 소프트웨어 비용을 산정하였고, 이 때 SVR에서 사용하는 파라미터들의 최적 조합을 면역계의 동작원리를 적용한 면역 알고리즘을 적용하여 최적 조합을 찾았다. 소프트웨어 비용산정을 위해 세대수, 기억세포수, 대립유전자수를 변경해 가면서 면역 알고리즘 기반의 SVR을 적용하였고, 그 실험 결과를 기존 연구된 다른 기계학습 방법과 비교 분석하였다.

• 대한미생물학회지
• /
• 제22권2호
• /
• pp.175-184
• /
• 1987

The use of alkylating agent cyclophosphamide(CY), a widely used antitumor drug is well known as a potent immunosuppressant and has been used as a probe for investigating the functional capabilities of lymphocyte subsets of both T and B cells that play an important role in the regulation of the immune response. The present study was undertaken in an effort to assess the effects of CY on immunological memory in murine model. CY, given as a single dose of CY(250mg/kg) before sensitization with sheep red blood cells(SRBC) enhanced the primary response of Arthus and delayed-type hypersensitivity(DTH), as measured by footpad swelling reaction, but suppressed their tertiary DTH response. The similar CY pretreatment enhanced both the primary and tertiary hemagglutinin(HA) responses to SRBC, and the tertiary antibody response against polyvinylpyrroridone(PVP), a thymus-independent antigen but not the primary response against PVP. CY, given as a single dose of 250mg/kg 2 days before the primary immunization and two doses of 100mg/kg 2 days before the secondary and tertiary immunization, markedly suppressed the tertiary DTH and HA responses to SRBC. However, CY, given as small multiple daily doses(10mg/kg) over 4 days before sensitization but not after sensitization, enhanced the secondary HA response to SRBC. Contact sensitivity to dinitrofluorobenzene(DNFB) was suppressed by the drug, given either as a single large dose(300mg/kg) or as multiple dose(10mg/kg) administered 2 days before, together with or after DNFB sensitization. This suppression was more pronounced and more significant when CY was given as multiple dose. However, the enhancement of the secondary contact sensitivity to DNFB by CY was not clear-cut. The splenectomy appears to increase the enhancing effect of CY on contact sensitivity. These results suggest that CY selectively influences the immune response depending on the time of the drug administration relative to immunization and that the secondary or tertiary immune response involve memory cells with different susceptibilities to CY. Moreover, these results suggest that multiple low doses may sesectivley inhibit suppressor T cell proliferation involving DTH, HA or contact sensitivity without effecting helper T cells, but high doses presumably inhibit helper T cells and suppressor T cells with effecting B cells.

• IMMUNE NETWORK
• /
• 제16권2호
• /
• pp.126-133
• /
• 2016

Unlike conventional T cells, innate CD8 T cells develop a memory-like phenotype in the thymus and immediately respond upon antigen stimulation, similar to memory T cells. The development of innate CD8 T cells in the thymus is known to require IL-4, which upregulates Eomesodermin (Eomes). These features are similar to that of virtual memory CD8 T cells and IL-4-induced memory-like CD8 T cells generated in the peripheral tissues. However, the relationship between these cell types has not been clearly documented. In the present study, IL-4-induced memory-like CD8 T cells generated in the peripheral tissues were compared with innate CD8 T cells in terms of phenotype and function. When an IL-4/anti-IL-4 antibody complex (IL-4C) was injected into C57BL/6 mice daily for 7 days, the Eomes^hiCXCR3⁺ CD8 T cell population was markedly increased in the peripheral lymphoid organs and blood. These cells were generated from naïve CD8 T cells or accumulated via the expansion of pre-existing CD44^hiCXCR3⁺ CD8 T cells. Initially, the majority of these CXCR3⁺ CD8 T cells expressed low levels of CD44, which was followed by the conversion to the CD44^hi phenotype. This conversion was associated with the acquisition of enhanced effector function. After discontinuation of IL-4C treatment, Eomes expression levels gradually decreased in CXCR3⁺ CD8 T cells. Taken together, the results of this study demonstrate that IL-4-induced memory-like CD8 T cells generated in the peripheral lymphoid tissues are phenotypically and functionally similar to the innate CD8 T cells generated in the thymus.

• 정보보호학회논문지
• /
• 제14권6호
• /
• pp.125-134
• /
• 2004

스마트카드와 같이 계산능력이나 메모리가 제한된 암호학적인 장치를 구현할 때 부채널 공격을 고려해야 할 뿐만 아니라 장치내에 내장되어 있는 암호학적인 알고리즘은 적은 메모리를 이용하여 효율적인 연산을 수행해야 한다. 이러한 목적으로 부채널 공격에 대한 윈도우 기반의 대응방법으로 Moller 방법, Okeya-Takagi 방법, Overlapping window 방법 등이 제안되었다. 하지만 Moller 방법과 Okeya-Takagi 방법은 SPA에 안전한 대응방법이기 때문에 다른 공격들(DPA, Second-Order DPA, Address-DPA)을 방어하기 위하여 추가적인 연산이 요구되며 Overlapping window 방법은 많은 저장 공간을 요구하는 단점이 있다. 본 논문에서는 기존의 대응방법들에 대하여 장단점을 분석하고 각각의 대응방법들의 장점을 이용하여 기존의 모든 부채널 공격에 안전하면서 효율적인 대응방법을 제안한다. 더욱이 제안하는 대응방법은 혼합 좌표계를 이용하여 효율성을 더욱더 높일 수 있다.

• 대한한방소아과학회지
• /
• 제25권1호
• /
• pp.40-48
• /
• 2011

Objectives: The purpose of this study is to evaluate the effect of Gonjadaesungchimjoongbang on spatial learning abilities and memories in ischemic brain injury. Methods: Rats were separated into three groups; (1) Normal, (2) Saline medication after ischemic brain injuries (control), (3) Gonjadaesungchimjoongbang medication after ischemic brain injuries (experiment). Ischemic brain injuries was induced by MCA occlusion and reperfusion. Morris water maze test was conducted for spatial learning and memory tests. Then, the change of BDNF in the hippocampus($7^{th}$, $14^{th}$ day) was examined by immunohistoche- mistry. Results: In Morris water maze test, spatial learning abilities and memory functioning were considerably increased in the experiment group as oppose to control group on $7^{th}$ and $14^{th}$ day(p<0.01). Moreover, immunohistochemistric response of BDNF in the hippocampus indicated that the more increased immune reaction was found in the experiment group as oppose to the control group on $7^{th}$ and $14^{th}$ day. Conclusions: Gonjadaesungchimjoongbang can improve the learning abilities and memories in ischemic brain injury.