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Original Antigenic Sin Response to RNA Viruses and Antiviral Immunity

  • Mee Sook Park (Department of Microbiology, The Institute of Viral Diseases, College of Medicine, Korea University) ;
  • Jin Il Kim (Department of Microbiology, The Institute of Viral Diseases, College of Medicine, Korea University) ;
  • Sehee Park (Department of Microbiology, The Institute of Viral Diseases, College of Medicine, Korea University) ;
  • Ilseob Lee (Department of Microbiology, The Institute of Viral Diseases, College of Medicine, Korea University) ;
  • Man-Seong Park (Department of Microbiology, The Institute of Viral Diseases, College of Medicine, Korea University)
  • Received : 2016.07.13
  • Accepted : 2016.08.15
  • Published : 2016.10.31
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Abstract

The human immune system has evolved to fight against foreign pathogens. It plays a central role in the body's defense mechanism. However, the immune memory geared to fight off a previously recognized pathogen, tends to remember an original form of the pathogen when a variant form subsequently invades. This has been termed 'original antigenic sin'. This adverse immunological effect can alter vaccine effectiveness and sometimes cause enhanced pathogenicity or additional inflammatory responses, according to the type of pathogen and the circumstances of infection. Here we aim to give a simplified conceptual understanding of virus infection and original antigenic sin by comparing and contrasting the two examples of recurring infections such as influenza and dengue viruses in humans.

Keywords

Acknowledgement

This study was supported by a grant from the TEPIK (Transgovernmental Enterprise for Pandemic Influenza in Korea), which is part of the Korea Healthcare Technology R&D Project of the Ministry of Health & Welfare, Republic of Korea (Grant No.: A103001).

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