• IMMUNE NETWORK
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• v.12 no.6
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• pp.223-229
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• 2012

Clinical and preclinical in vivo immune cell imaging approaches have been used to study immune cell proliferation, apoptosis and interaction at the microscopic (intra-vital imaging) and macroscopic (whole-body imaging) level by use of ex vivo or in vivo labeling method. A series of imaging techniques ranging from non-radiation based techniques such as optical imaging, MRI, and ultrasound to radiation based CT/nuclear imaging can be used for in vivo immune cell tracking. These imaging modalities highlight the intrinsic behavior of different immune cell populations in physiological context. Fluorescent, radioactive or paramagnetic probes can be used in direct labeling protocols to monitor the specific cell population. Reporter genes can also be used for genetic, indirect labeling protocols to track the fate of a given cell subpopulation in vivo. In this review, we summarized several methods dealing with dendritic cell, macrophage, and T lymphocyte specifically labeled for different macroscopic whole-body imaging techniques both for the study of their physiological function and in the context of immunotherapy to exploit imaging-derived information and immune-based treatments.

• Journal of the Korean Society for Nondestructive Testing
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• v.33 no.2
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• pp.232-240
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• 2013

This paper presents recent advances in damage visualization algorithms of laser generated ultrasonic propagation imaging(UPI) system. An effective damage evaluation method is required to extract correct information from raw data to properly characterize anomalies present in structure. A temporal-reference free imaging system provides easy and rapid defect inspection capability with less computational complexity. In this paper a number of methods such as ultrasonic wave propagation imaging(UWPI), anomalous wave propagation imaging(AWPI), ultrasonic spectral imaging(USI), wavelet ultrasonic propagation imaging(WUPI), variable time window amplitude mapping(VTWAM), time point adjustment(TPA), time of flight and amplitude mapping(ToF&Amp) and ultrasonic wavenumber imaging(UWI) are discussed with instances of successful implementation on various structures.

• The Journal of the Acoustical Society of Korea
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• v.29 no.1E
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• pp.1-10
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• 2010

The difference in echogenicity between cancerous and normal tissues is not quite distinguishable in ultrasound B-mode imaging. However, tumor or cancer in breast or prostate tends to be stiffer than the surrounding normal tissue. Thus, imaging the stiffness contrast between the two different tissue types is helpful for quantitative diagnosis, and such a method of imaging the elasticity of human tissue is collectively referred to as ultrasound elasticity imaging. Recently, elasticity imaging has established itself as an effective diagnostic modality in addition to ultrasound B-mode imaging. The purpose of this paper is to present various elasticity imaging methods that have been reported up to now and to describe their principles of operation and characteristics.

• Journal of the Optical Society of Korea
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• v.16 no.1
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• pp.29-35
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• 2012

We propose a subpixel scale elemental image generation method to correct the errors created by finite display pixel size in integral imaging. In this paper, two errors are mainly discussed: pickup-and-display mismatch error and mismatch error between pixel pitch and lens pitch. The proposed method considers the relative positions between lenses and pixels in subpixel scale. Our proposed pickup method calculates the position parameters, generates an elemental image with pixels completely inside the lens, and generates an elemental image with border pixels using a weighted sum method. Appropriate experiments are presented to verify the validity of the proposed method.

• Nuclear Medicine and Molecular Imaging
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• v.43 no.5
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• pp.451-458
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• 2009

Purpose: Optical molecular luminescence imaging is widely used for detection and imaging of bio-photons emitted by luminescent luciferase activation. The measured photons in this method provide the degree of molecular alteration or cell numbers with the advantage of high signal-to-noise ratio. To extract useful information from the measured results, the analysis based on a proper quantification method is necessary. In this research, we propose a quantification method presenting linear response of measured light signal to measurement time. Materials and Methods: We detected the luminescence signal by using lab-made optical imaging equipment of animal light imaging system (ALIS) and different two kinds of light sources. One is three bacterial light-emitting sources containing different number of bacteria. The other is three different non-bacterial light sources emitting very weak light. By using the concept of the candela and the flux, we could derive simplified linear quantification formula. After experimentally measuring light intensity, the data was processed with the proposed quantification function. Results: We could obtain linear response of photon counts to measurement time by applying the pre-determined quantification function. The ratio of the re-calculated photon counts and measurement time present a constant value although different light source was applied. Conclusion: The quantification function for linear response could be applicable to the standard quantification process. The proposed method could be used for the exact quantitative analysis in various light imaging equipments with presenting linear response behavior of constant light emitting sources to measurement time.

• Proceedings of the Korean Geotechical Society Conference
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• 2008.03a
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• pp.7-13
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• 2008

To obtain a shear-wave velocity profile in geotechnical practice, various seismic investigation methods which have their own strength and weakness are being frequently used. Generally, geotechnical site have lateral variation of the properties, so it is needed to determine 2-dimensional shear wave velocity imaging of the site. In this study, harmonic wavelet analysis of wave (HWAW) method is applied to determination of 2-D $V_s$ imaging. HWAW method which is based on time-frequency analysis using harmonic wavelet transform have been developed to determine phase and group velocities of waves. HWAW method uses the signal portion of the maximum local signal/noise ratio to evaluate the phase velocity to minimize the effects of noise. HWAW method determine detailed local $V_s$ profile because one experimental setup which consists of one pair of receivers with spacing of 1~3m is used to determine the dispersion curve of the whole depth. So, 2-D Vs imaging with relatively high resolution can be determined through a series of HWAW test. In order to estimate the applicability of HWAW method, field tests were performed in 4 sites. Through field applications and comparison with other test results, the good accuracy and applicability of the proposed method were verified.

• Journal of Biomedical Engineering Research
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• v.25 no.3
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• pp.183-188
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• 2004

Magnetic resonance current density imaging (MRCDI) is a useful method for measuring electrical current density distribution inside an object. To avoid object rotations during the conventional MRCDI scans, we have reconstructed current density component images by applying a spatial filter to the magnetic field data measured both inside and outside the object. To measure the magnetic field outside the object with MRI, we immersed the object in a water tank. To evaluate accuracy of the current density imaging, we have made a conductivity phantom with a corresponding finite element method model. We have compared the experimentally obtained current density images with the ones calculated by the finite element method. The average errors of the reconstructed current density images were 6.6 ∼ 45.4 ％ when the injected currents were 1 ∼ 24 mA. We expect that the current density component imaging technique can be used in diverse biomedical applications such as electrical therapy system developments and biological electrical safety analysis.

• Journal of Ocean Engineering and Technology
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• v.30 no.3
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• pp.227-233
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• 2016

This paper presents an underwater structure 3D reconstruction method using a 2D multibeam imaging sonar. Compared with other underwater environmental recognition sensors, the 2D multibeam imaging sonar offers high resolution images in water with a high turbidity level by showing the reflection intensity data in real-time. With such advantages, almost all underwater applications, including ROVs, have applied this 2D multibeam imaging sonar. However, the elevation data are missing in sonar images, which causes difficulties with correctly understanding the underwater topography. To solve this problem, this paper concentrates on the physical relationship between the sonar image and the scene topography to find the elevation information. First, the modeling of the sonar reflection intensity data is studied using the distances and angles of the sonar beams and underwater objects. Second, the elevation data are determined based on parameters like the reflection intensity and shadow length. Then, the elevation information is applied to the 3D underwater reconstruction. This paper evaluates the presented real-time 3D reconstruction method using real underwater environments. Experimental results are shown to appraise the performance of the method. Additionally, with the utilization of ROVs, the contour and texture image mapping results from the obtained 3D reconstruction results are presented as applications.

• Journal of the Korean Magnetics Society
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• v.27 no.4
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• pp.145-152
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• 2017

The arterial spin labeling (ASL) is a magnetic resonance imaging (MRI) method that can evaluate tissue perfusion using blood in the body. The characteristic of non-invasive examinations without contrast agents and the quantitative measurement of perfusion volume is possible, which are increasingly being used for clinical and research purposes. Up to the present, The ASL method has lower SNR than the perfusion imaging method using contrast agent and because optimization of various parameter in the imaging process is difficult, Which may result in measurement errors. To improve this, ASL methods using various technologies are introduced. This paper briefly introduces the outline of ASL, its features in imaging process, various techniques, and clinical application.

• Journal of information and communication convergence engineering
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• v.14 no.1
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• pp.57-63
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• 2016

In generally, the resolution of reconstructed three-dimensional images can be seriously degraded by undesired occlusions in the integral imaging system, because the undesired information of the occlusion overlap the three-dimensional images to be reconstructed. To solve the problem of the undesired occlusion, we present an exemplar-based image restoration method in integral imaging system. In the proposed method, a minimum spanning tree-based stereo matching method is used to remove the region of undesired occlusions in each elemental image. After that, the removed occlusion region of each elemental images are re-established by using the exemplar-based image restoration method. For further improve the performance of the image restoration, the structure tensor is used to solve the filling error cause by discontinuous structures. Finally, the resolution enhanced three-dimensional images are reconstructed by using the restored elemental images. The preliminary experiments are presented to demonstrate the feasibility of the proposed method.