• 동의생리병리학회지
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• 제19권1호
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• pp.106-113
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• 2005

Asthma is an inflammatory disease of airways that is induced by Th2 cytokines and inhibited by Th1 cytokines. In this study we wanted to investigate the effect of SCT and BJT on eosinophilla and cytokines of BALF in a mouse model established airway inflammmation. Asthma was induced to male c57/bl6 mice. Allergen-specific antibody responses, cytokine$(IL-4,\;IL-5,\;INF-{\gamma})$, and eosinophil inflammation of the airways were investigated on the BALF and splenocyte. SCT and BJT effectively induced $INF-{\gamma}$ and inhibited IL-4, IL-5 as well as eosinophilic inflammation when SCT and BJT were administered. Total Ig E level in the BALF decreased. SCT was more effectiveness than BJT. It is considered that SCT and BJT have faborable effect on the asthma because the asthma specific series of abnormalities in respiratory system were decreased.

• 대한한방소아과학회지
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• 제7권1호
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• pp.1-16
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• 1993

Experimental studies were done to research the clinical effect of Woohwangporhyonghwan(minus REALGAR and CINNABARIS) and Saengnyosamultang on the Anti-allergie effect in rats and mice. The results obtained as follows: 1. (1) In the effects of Woohwangporhyonghwan(minus REALGAR and CINNABARIS) and Saengnyosamultang on vascular permeability responses to intradermal histamin in rats, Woohwangporhyonghwan(minus REALGAR and CINNABARIS) and Saengnyosamultang revealed significant effect. (2) In the effects of Woohwangporhyonghwan(minus REALGAR and CINNABARIS) and Saengnyosamultang on vascular permeability responses to intradermal serotonin in rats, Woohwangporhyonghwan(minus REALGAR and CINNABARIS) revealed significant effect. 2. In the 48 hour homologous passive cutaneous anaphylaxis in rats provoked by the Ig E-like antibody against egg albumin, Woohwangporhyonghwan(minus REALGAR and CINNABARIS) and Saengnyosamultang revealed significant effect. 3. In the delayed type hypersensitivity responses to picryl chloride in mice, Woohwangporhyonghwan(minus REALGAR and CINNABARIS) revealed significant effect. 4. In the delayed type hypersensitivity responses to SRBC(Sheep Red Blood cell) in mice, Woohwangporhyonghwan(minus REALGAR and CINNABARIS) and Saengnyosamultang revealed significant effect. According to above-stated results, Woohwangporhyonghwan(minus REALGAR and CINNABARIS) and Saengnyosamultang were concluded to be effective as anti-allergic regimen and recommended to be used for treatment of allergic diseases.

• 대한한방소아과학회지
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• 제5권1호
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• pp.15-27
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• 1991

Experimental studies were done to research the clinical effects of Yongdamsagantang and Yongdamsagantang-gamibang (Yongdamsagantang with Lonicerae Flos and Forsythiae Fructusadded) on the Anti-allergic effect in rats and mice. The results obtained as follows; 1. In the effects of Yongdamsagantang and Yongdamsagantang-gamibang on vascular permeability responses to intradermal histamine in rats, Yongdamsagantang group revealed none significant affect, but Yongdamsagantang-gamibang group revealed significant effect. 2. In the effects of Yongdamsagantang and Yongdamsagantang-gamibang on vascular permeability responses to intradermal serotonin in rats, Yongdamsagantang and Yongdamsagantang-gamibang group revealed significant effect. 3. In the 48hrs homologous passive cutaneous anaphylaxis in rats provoked by the IgE-like antibody against egg albumin, Yongdamsagantang group revealed none significant effect, but Yongdamsagantang-gamibang group revealed significant effect. 4. In the delayed type hypersensitivity responses to Picryl Chloride in mice, Yongdamsagantang and Yongdamsagantang-gamibang group revealed none significant effect, in the delayed type hypersensitivity responses to SRBC in mice, Yongdamsagantang group revealed none significant effect, but Yongdamsagantang-gamibang group revealed significant effect. According to above-stated results, Yongdamsagantang is none significant Anti-allergic effect. But Yongdamsagantang-gamibang is concluded to be effective as immediated type hypersensitivity and recommended to be used for the treatment of allergic diseases. (Asthma, Allergic urticaria, Allergic rhinitis, etc.)

• 대한한방소아과학회지
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• 제8권1호
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• pp.27-37
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• 1994

This Experimental study was done to investigate the effect of the Taklisodok-um on the Anti-allergic response. The results were obtained as follows: 1. On vascular permeability response to the intradermal injected Histamine, the Taklisodok-um treated group revealed more significant decrease than control group. 2. On vascular permeability response to the intradermal injected Serotonin, the Taklisodok-um treated group revealed more significant decrease than control group. 3. In the 48hrs homologous passive cutaneous anaphylaxis provoked by the IgE-like antibody against white egg albumin, there was no significant difference between the Taklisodok-um treated group and control group. 4. The Taklisodok-um treated group revealed more significant inhibitory effect than control group in the delayed type hypersensitivity response to Picryl chloride. 5. The Taklisodok-um treated group revealed more significant inhibitory effect than control group in the delayed type hypersensitivity response to SRBC. According to the above-stated results, it is considered that the Taklisodok-um could be applied widely to the type I and IV allergic diseases.

• 대한한방소아과학회지
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• 제8권1호
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• pp.13-26
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• 1994

Experimental studies were done to research the clinical effects of Sipyungtang and Sipyungtang-gamibang (sipyungtang with Anemarrhenae Rhizoma added) on the Anti-allergic effect. The results obtained as follows; 1. In the effects of Sipyungtang and Sipyungtang-gamibang on vascular permeability responses to intradermal Histamine, Sipyungtang group revealed none significant effect, but Sipyungtang-gamibang group revealed significant effect. 2. In the effects of sipyungtang and Sipyungtang-gamibang on vascular permeability responses to intradermal serotonin, Sipyungtang group revealed none significant effect, but Sipyungtang-gamibang group revealed significant effect. 3. In the 48hrs homologous passive cutaneous anaphylaxis provoked by the IgE-like antibody against egg white albumin, Sipyungtang and Sipyungtang-gamibang groups revealed none significant effect. 4. In the delayed type hypersensitivity responses to Picryl Chloride, Sipyungtang and Sipyungtang-gamibang groups revealed none significant effect. 5. In the delayed type hypersensitivity responses to SRBC, Sipyung-tang and Sipyungtang-gamibang groups revealed significant effect.

• 대한한방소아과학회지
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• 제6권1호
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• pp.1-14
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• 1992

Experimental studies were done to research the clinical effects of Juguieum and Juguieum-gamibang(Juguieum with Lonicerae Flos and Forsythiae Fructus added) on the Antiallergic effect. The results obtained as follows; 1. In the effects of Jugieum and Jugieum-gamibang on vascular permeability responses to intradermal histamine, Juguieum group revealed none significant effect, but Jugieum-gamibang group revealed significant effect. 2. In the effects of Juguieum and Juguieum-gamibang on vascular permeability responses to intradermal serotonin, Juguieum and Juguieum-gamibang groups revealed significant effect. 3. In the 48hrs homologous passive cutaneous amaphylaxis provoked by the IgE-like antibody against egg albumin, Juguieum and Juguieum-gamibang groups revealed significant effect. 4. In the delayed type hypersensitivity responses to Picryl Chloride, Juguieum and Juguieum-gamibang groups revealed significant effect. 5. In the delayed type hypersensitivity responses to SRBC, Juguieum group revealed significant effect, but Jugieum-gamibang group revealed none significant effect. According to above-stated results, Juguieum and Juguieum-gamibang are concluded to be effective as anti-allergic regimen and recommended to be used for the treatment of type I and type IV allergic disease.

• IMMUNE NETWORK
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• 제15권1호
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• pp.9-15
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• 2015

Streptococcus pneumoniae (the pneumococcus) causes a major upper respiratory tract infection often leading to severe illness and death in the elderly. Thus, it is important to induce safe and effective mucosal immunity against this pathogen in order to prevent pnuemocaccal infection. However, this is a very difficult task to elicit protective mucosal IgA antibody responses in older individuals. A combind nasal adjuvant consisting of a plasmid encoding the Flt3 ligand cDNA (pFL) and CpG oligonucleotide (CpG ODN) successfully enhanced S. pneumoniae-specific mucosal immunity in aged mice. In particular, a pneumococcal surface protein A-based nasal vaccine given with pFL and CpG ODN induced complete protection from S. pneumoniae infection. These results show that nasal delivery of a combined DNA adjuvant offers an attractive potential for protection against the pneumococcus in the elderly.

• Annals of Clinical Neurophysiology
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• 제22권2호
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• pp.112-116
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• 2020

Guillain-Barré syndrome (GBS) and Miller Fisher syndrome (MFS) can present with overlapping features. A 56-year-old female developed ptosis and diplopia after an upper respiratory infection, and presented with facial palsy, dysarthria, brachial weakness, ataxia, and areflexia. Mild weakness of both legs appeared after a few days. Anti-ganglioside complex antibody were positive to IgG GM1/GQ1b and GQ1b/sulfatide antibodies. The present case suggests that the manifestation of overlap between MFS/PCB variants and GBS could be caused by antiganglioside complex antibodies.

• 한방안이비인후피부과학회지
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• 제14권2호
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• pp.231-241
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• 2001

Mahwang-Shin-Gung-San has been found inhibiting the mast cell-mediated anaphylactic reaction. This report describes an inhibitory effect of Mahwang-Shin-Gung-San (MSGS) on the immediate-type cutaneous allergic reactions. MSGS has concentration -dependently inhibited the ear swelling response induced by compound 48/80 in mouse by intradermal injection. The mast cells in mouse ear tissue undergone ear-swelling response by compound 48/80 were stained by alcian blue/nuclear fast red. MSGS significantly inhibited the compound 48/80-induced degranulation from mast cells in ear tissue. MSGS concentration-dependently inhibited the histamine release from the rat peritoneal mast cells (RPMC) by compound 48/80. We also studied the effect of MSGS on mast cell-dependent passive cutaneous anaphylaxis (PCA) activated by dinitrophenyl IgE antibody. MSGS showed potent inhibition of PCA by oral administration. These results indicate that MSGS inhibits immediate-type allergic reactions by inhibition of mast cell degranulation in vivo and in vitro.

• 생약학회지
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• 제50권3호
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• pp.175-184
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• 2019

Mast cells are crucial as effector cells in the immediate-type allergic reaction. Lentinus edodes has been the popular edible mushroom in oriental countries and reported to have immunomodulatory, anti-tumor, anti-atherogenic, anti-viral, and anti-allergic activities. However, the roles of L. edodes in mast cell-mediated anaphylactic reaction have not been fully elucidated. In this research, we have demonstrated the effects of the methanol extract of L. edodes (MELE) on mast cell-mediated anaphylaxis-like and anaphylactic reactions. MELE suppressed systemic anaphylaxis-like reaction, plasma histamine levels, and ear swelling response in mice treated with compound 48/80. MELE also suppressed passive systemic and cutaneous anaphylaxis mediated by anti-dinitrophenyl IgE. In accordance with these findings, MELE dose-dependently decreased histamine release from RPMC evoked by compound 48/80 or the antigen-antibody reaction. To clarify the mechanism of degranulation system, intracellular cAMP levels as well as calcium influx in RPMC was evaluated. In compound 48/80-treated RPMC, MELE blocked calcium uptake into the cells. In addition, MELE elevated the intracellular cAMP content and significantly attenuated compound 48/80-induced cAMP reduction in RPMC. Taken together, we propose the clinical use of MELE in mast cell-mediated immediate-type allergic diseases.