• Asian Pacific Journal of Cancer Prevention
• /
• v.17 no.2
• /
• pp.799-805
• /
• 2016

Background: There is no standard treatment for patients with platinum-resistant or refractory epithelial ovarian cancer. Single agent chemotherapies have evidence of more efficacy and less toxicity than combination therapy. Most are very expensive, with appreciable toxicity and minimal survival. Since it is difficult to make comparison between outcomes, economic analysis of single-agent chemotherapy regimens and best supportive care may help to make decisions about an appropriate management for the affected patients. Objective: To evaluate the cost effectiveness of second-line chemotherapy compared with best supportive care for patients with platinum-resistant or refractory epithelial ovarian cancer. Materials and Methods: A Markov model was used to estimate the effectiveness and total costs associated with treatments. The hypothetical patient population comprised women aged 55 with platinum-resistant or refractory epithelial ovarian cancer. Four types of alternative treatment options were evaluated: 1) gemcitabine followed by BSC; 2) pegylated liposomal doxorubicin (PLD) followed by BSC; 3) gemcitabine followed by topotecan; and 4) PLD followed by topotecan. Baseline comparator of alternative treatments was BSC. Time horizon of the analysis was 2 years. Health care provider perspective and 3% discount rate were used to determine the costs of medical treatment in this study. Quality-adjusted life-years (QALY) were used to measure the treatment effectiveness. Treatment effectiveness data were derived from the literature. Costs were calculated from unit cost treatment of epithelial ovarian cancer patients at various stages of disease in King Chulalongkorn Memorial Hospital (KCMH) in the year 2011. Parameter uncertainty was tested in probabilistic sensitivity analysis by using Monte Carlo simulation. One-way sensitivity analysis was used to explore each variable's impact on the uncertainty of the results. Results: Approximated life expectancy of best supportive care was 0.182 years and its total cost was 26,862 Baht. All four alternative treatments increased life expectancy. Life expectancy of gemcitabine followed by BSC, PLD followed by BSC, gemcitabine followed by topotecan and PLD followed by topotecan was 0.510, 0.513, 0.566, and 0.570 years, respectively. The total cost of gemcitabine followed by BSC, PLD followed by BSC, gemcitabine followed by topotecan and PLD followed by topotecan was 113,000, 124,302, 139,788 and 151,135 Baht, respectively. PLD followed by topotecan had the highest expected quality-adjusted life-years but was the most expensive of all the above strategies. The incremental cost-effectiveness ratios (ICER) of gemcitabine followed by BSC, PLD followed by BSC, gemcitabine followed by topotecan and PLD followed by topotecan was 344,643, 385,322, 385,856, and 420,299 Baht, respectively. Conclusions: All of the second-line chemotherapy strategies showed certain benefits due to an increased life-year gained compared with best supportive care. Moreover, gemcitabine as second-line chemotherapy followed by best supportive care in progressive disease case was likely to be more effective strategy with less cost from health care provider perspective. Gemcitabine was the most cost-effective treatment among all four alternative treatments. ICER is only an economic factor. Treatment decisions should be based on the patient benefit.

• Proceedings of the Korean Operations and Management Science Society Conference
• /
• 2004.05a
• /
• pp.339-342
• /
• 2004

현재까지 많은 기업들이 정보화를 대세로 인정하고 IT 투자에 막대한 기업 자원을 투입하였다. 특히 닷컴 버블까지 발생했던 지난 몇 년 간 대다수 기업들은 경쟁에서 뒤처지지 않기 위해서 정보화 투자에 대한 효익을 간과한 채 투자에 힘써온 것이 사실이다. 미국의 조사 기관 중 하나인 메타 그룹이 발표한 자료에 따르면 2001년 한 해 동안 전 세계의 대다수 기업들이 IT 투자에 쏟은 투자액만 총 2조 2000억 달러에 달하지만 ROI 등을 고려하여 투자한 기업은 드물었다고 한다. 그러나 세계적인 경기 침체에 따라서 기업 가치에 특별한 효익을 가져다주지 못하다고 판단한 기업들은 IT 투자를 축소하고 있거나 투자 효익에 대한 검증을 원하고 있다. 따라서 본 연구에서는 이러한 평가 방법론 중 대표적인 방법론으로 성과 중심의 BSC(Balanced Scorecard) 방법론, 프로세스 관점에서의 CMM(Capability Maturity Model) 방법론, 운영 관점의 6 시그마 방법론에 대해서 서로 비교 분석해보고 특히 6 시그마 방법론이 두 방법론들 사이에서 제시해 줄 수 있는 공통 관계 및 인과 관계를 분석함으로써 성과 관리 및 프로세스 관리에 대한 관점을 제시하고자 한다.

• Korean Business Review
• /
• v.21 no.2
• /
• pp.111-136
• /
• 2008

The central purpose of this study is to examine the relationships among learning and growth perspective, internal business process perspective, custom perspective, financial perspective, and general performance. To achieve this purpose, this study uses Kaplan and Norton's(1996) Balanced Scorecard Model theory. A field survey was undertaken through questionnaire sampling a population of construction companies. The data was collected from 185 firms in Korea for the analysis. The major findings of this study can be summarized as follows; Theoretical consideration and empirical study indicate statistically significant relationship(F=7.68, p=0.000). Especially, Financial perspective appeared to mediate the relationship between non-financial perspectives and general performance. It concludes that Non-financial perspectives significant affect the financial perspective and general performance. But, there are several limitations and directions for future research that should be noted. The potential limitation of this study concerns sampling and for selection process. Future research needs to reduce potential bias by collecting data which allows multiple industries for a subset of the sample.

• IE interfaces
• /
• v.16 no.3
• /
• pp.382-391
• /
• 2003

Supply chain performance management is the essential part of various business activities in supply chain management area, and integrating it with general business management improves the supply chain performance. Although supply chain performance management is important and expected of market growth, there are few researches on this area and lack of practical applications. To resolve these problems, this paper presents a new performance management methodology for a supply chain integrating SCOR (Supply Chain Operational Reference) model and Balanced Scorecard (BSC). And we develop a framework of the Supply Chain Performance Management System (SCPMS) based on this methodology, and implement a prototype system.

• Information Systems Review
• /
• v.9 no.3
• /
• pp.157-181
• /
• 2007

Main concerns of IT project managements are concentrated on the output control and process management. IT project, however, is difficult to measure the quality of achievement, because it produces invisible and intangible outputs. Many studies have been carried on to quantify the intangible aspects of process management. However, most of them have been focused on the technological aspects. This study measures the priority of factors to manage IT project by applying the IT-BSC and PMBOK method. Established indexes include the factors of managerial, social and future-oriented perspectives to check the different aspects of project management over the technical factors. This study uses AHP method for quantitative measurement. This study can be meaningful because of following reasons. First, this study re-arranges IT project management evaluation indexes by balanced scorecard. Second, this model includes human factors of developers and users who are directly related to the project development and operation. Third, important items of each stakeholder have been separated, and the weights of each item have been quantified to have fixed values.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
• /
• v.8 no.2
• /
• pp.129-139
• /
• 2013

This paper is targeted on proposing ameliorating alternative to performance assessment method of GSEM through evaluating the current one, which is initiated by SMBA to induce fair competition among 5 GSEM across the country and accommodate the quality improvement of entrepreneurship education since 2005 after beginning the SMBA support, from the perspective of BSC(Balanced Scorecard) tool. Ultimately, it complements the policy defects of SMBA over GSEM, in particular, in the process of performance assessment and management. This paper carries out two studies as follow. First, throughout reviewing the previous studies relating to BSC applications to non-profit organization, it set out the direction of introducing BSC in assessing performance of GSEM in order to enhance its effectiveness. Second, it evaluate the rationality of performance assessing tools apllied to GSEM by SMBA on the basis of BSC application over non-profit organization, especially in education institution. Research results shows the following implications. First, the current evaluation system over GSEM is just merely assessment itself and not much contributions for the post performance management. Second, The annual evaluation just remains to check up whether the policy goals are met or not. Third, the current evaluation puts much emphasis just on financial inputs and hardware infra, not considering human resources and utilization of government policy and institution. Fourth, the policy goals are unilaterally focused on entrepreneurs. Fifth, the current evaluation systems do not contain any indexes relating to learning and growth perspectives for concerning sustainable and independent growing up. However, lack of empirical testing require this paper to need the further study in the future.

• The Journal of Information Systems
• /
• v.17 no.3
• /
• pp.205-233
• /
• 2008

This study suggests the dynamic value chain model, that will be able to not only show changing processes to organization's significant capital by integrating an individual, implicit, and explicit knowledge which affect organizational decision making, but also distinguish the key driver for raising organizational competitive power because it makes possible to analyze sensitivity of performance along with decision making alternatives and policy changes from dynamic view by connecting knowledge management capability, knowledge management activity, and relations with organizational performance with specific strategic map. Recently, a lot of organizations show interest in measuring and evaluating their performance synthetically. In organizations taking knowledge management, they introduce effective value chain model like a dynamic balanced scorecard (DBSC), and therefore they can reflect their knowledge management condition as well as show their changes by checking performance of established vision and strategy periodically. Furthermore, they can ask for their inner members' understanding and participation by communicating with and inspiring their members with awareness that members are one of their group, present a base of benchmarking, and offer significant information for later decision making. The BSC has been a successful framework for measuring an organization's performance in various perspectives through translating an organization's vision and strategy into an interrelated set of key performance indicators and specific actions. The BSC, while having significant strengths over traditional performance measurement methods, however, has its own limitations, due to its static nature, such as overlooking two-way causation between performance indicators and neglecting the impact of delayed feedback flowing from the adoption of new strategies or policy changes. To overcome these limitations, this study employs SD, a methodology for understanding complex systems where dynamic feedback among the interrelated system components significantly impact on the system outcomes. The SD simulation model in the form of DBSC would serve as a useful strategic teaming tool for facilitating an organization's communication process through various scenario analyses as well as predicting the dynamic behavior pattern of their key performance measures over a future time frame. For the demonstration purpose, this study applied the DBSC model to Prototype of Korea manufacturing and service firm.

• IE interfaces
• /
• v.13 no.2
• /
• pp.178-187
• /
• 2000

In this paper, we investigate the system performance when the voice traffic is constructed as the ATM Adaptation Layer type 2(AAL-2) and then it is transmitted to the Base Station Controller(BSC) from the Base Station Transceiver Subsystem(BTS) through El link in International Mobile Telecommunication-2000 (IMT-2000) network. For this purpose, we first briefly describe the architecture of the BTS and the BSC, and then model it as a queueing network. By simulation study, we present the required processing time at traffic control blocks and the timeout time which should be set for multiplexing the user packets in the LIU(Line Interface Unit). Further, we evaluate the performance of physical links and the timeout probability that user packets can not be multiplexed within the established timeout time, and the multiplexing gain. Finally, we present the number of voice users who can be simultaneously admitted on one El link and 99.9% value of the transmission delay from the Radio Channel Element(RCE) to the Selector & Transcoder Subsystem(STS).

• KSCE Journal of Civil and Environmental Engineering Research
• /
• v.33 no.5
• /
• pp.2069-2079
• /
• 2013

Recently, BIM(Building Information Modeling) is on the rise as a customized solution for construction environment, but construction companies rarely introduce and apply BIM in the construction site. Due to such issues, the fact that empirical data for evaluating the quantitative effect of BIM application is insufficient might be an another main reason. In the end, construction companies cannot assure investment effect of BIM and therefore don't make an investment actively. To activate BIM application, the evaluation system that quantitatively assess usability of BIM needs to be developed. This study aims to suggest a methodology that evaluates the usability quantitatively according to introduction and operation of BIM by construction companies. Accordingly, this study analyzes applicability of 4D CAD by developing an evaluation index and its model with BSC(Balanced Score Card) for 4D CAD, which have high practical use among BIM techniques, and verifies the usability as the entire evaluation index of BIM. Therefore, it is expected that the developed assessment model will be utilized as the critical decision-making information in order to introduce related techniques by identifying the usability and operational issues of 4D CAD.

• Journal of Navigation and Port Research
• /
• v.28 no.3
• /
• pp.169-175
• /
• 2004

The purpose of this study is to present the detailed national strategy, from the financial point of view, for global logistics center in the Northeast Asia using the Balance Scorecard Model(BSC) as well as SWOT analysis. It is a core national challenge for Korea to emerge as a logistics hub of the Northeast Asian region, which is directly related to its very existence in the 21st century. In the process of formulating such a vital strategy, various aspects must be considered In conclusion, this study has successfully deduced the preemptive strategy for exceeding other competitors from the financial (budgetary) perspective and the logistics strategy from inner process standpoint of maximizing logistics outcome by carrying out efficient logistics policy.