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Antibiotics Susceptability of Streptococcus pneumoniae Isolated from Single Tertiary Childrens' Hospital Since 2014 and Choice of Appropriate Empirical Antibiotics (최근 4년간 국내 단일 의료기관을 내원한 소아청소년에서 분리된 폐구균의 항생제 감수성 양상 분석)

  • Jung, Jiwon;Yoo, Ree Nar;Sung, Hungseop;Kim, Mina;Lee, Jina
    • Pediatric Infection and Vaccine
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    • v.26 no.1
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    • pp.1-10
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    • 2019
  • Purpose: We investigated the distribution and antimicrobial resistance of pneumococcal isolates from hospitalized children at Asan Medical Center for recent 4 years, and aimed to recommend proper choice of empirical antibiotics for pneumococcal infection. Methods: From March 2014 to May 2018, children admitted to Asan Medical Center Childrens' Hospital with pneumococcal infection were subjected for evaluation of minimal inhibitory concentration (MIC) for ${\beta}-lactams$ and macrolide antibiotics. Patient's age, underlying disease, gender were retrospectively collected. Using Monte Carlo simulation model and MIC from our study, we predicted the rate of treatment success with amoxicillin treatment. Results: Sixty-three isolates were analyzed including 20.6% (n=13) of invasive isolates, and 79.4% (n=50) of non-invasive isolates; median age were 3.3 years old, and 87.3% of the pneumococcal infections occurred to children with underlying disease. Overall susceptibility rate was 49.2%, 68.2%, and 74.6% for amoxicillin, parenteral penicillin, and cefotaxime respectively. 23.8% and 9.5% of the isolates showed high resistance for amoxicillin, and cefotaxime. Only 4.8% (n=3) were susceptible to erythromycin. Monte Carlo simulation model revealed the likelihood of treatment success was 46.0% at the dosage of 90 mg/kg/day of amoxicillin. Conclusions: Recent pneumococcal isolates from pediatric patients with underlying disease revealed high resistance for amoxicillin and cefotaxime, and high resistance for erythromycin. Prudent choice of antibiotics based on the local data of resistance cannot be emphasized enough, especially in high risk patients with underlying disease, and timely vaccination should be implemented for prevention of the spread of resistant strains.

Fabrication of Strain Sensor Based on Graphene/Polyurethane Nanoweb and Respiration Measurement (그래핀/폴리우레탄 나노웹 기반의 스트레인센서 제작 및 호흡측정)

  • Lee, Hyocheol;Cho, Hyeon-seon;Lee, Eugene;Jang, Eunji;Cho, Gilsoo
    • Science of Emotion and Sensibility
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    • v.22 no.1
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    • pp.15-22
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    • 2019
  • The purpose of this study is to develop a strain sensor based on a nanoweb by applying electrical conductivity to a polyurethane nanoweb through the use of Graphene. For this purpose, 1% Graphene ink was pour-coated on a polyurethane nanoweb and post-treated with PDMS (Polydimethylsiloxane) to complete a wearable strain sensor. The surface characteristics of the specimens were evaluated using a field emission scanning electron microscope (FE-SEM) to check whether the conductive material was well coated on the surface of the specimen. Electrical properties of the specimens were measured by using a multimeter to measure the linear resistance of the specimen and comparing how the line resistance changes when 5% and 10% of the specimens are tensioned, respectively. In order to evaluate the performance of the specimen, the gauge factor was obtained. The evaluation of the clothing was performed by attaching the completed strain sensor to the dummy and measuring the respiration signal according to the tension using MP150 (Biopac system Inc., USA) and Acqknowledge (ver. 4.2, Biopac system Inc., U.S.A.). As a result of the evaluation of the surface characteristics, it was confirmed that all the conductive nanoweb specimen were uniformly coated with the Graphen ink. As a result of measuring the resistance value according to the tensile strength, the specimen G, which was treated with just graphene had the lowest resistance value, the specimen G-H had the highest resistance value, and the change of the line resistance value of the specimen G and the specimen G-H is increased to 5% It is found that it increases steadily. Unlike the resistance value results, specimen G showed a higher gauge rate than specimen G-H. As a result of evaluation of the actual clothes, the strain sensor made using the specimen G-H measured the stable peak value and obtained a signal of good quality. Therefore, we confirmed that the polyurethane nanoweb treated with Graphene ink plays a role as a breathing sensor.

Using Viable Eggs to Determine Oviposition Models and Life Table Analysis of Riptortus pedestris (Fabricius) (Hemiptera: Alydidae) (톱다리개미허리노린재의 수정란을 이용한 산란모형과 생명표분석)

  • Ahn, Jeong Joon;Choi, Kyoung San;Koh, Sang Wook
    • Korean journal of applied entomology
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    • v.58 no.2
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    • pp.111-120
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    • 2019
  • Riptortus pedestris (Fabricius) (Hemiptera: Alydidae) is an economically important insect pest of soybean and fruit trees. We investigated the temperature effects on the adult fecundity and longevity, and determined the parameters of oviposition models and life table at different constant temperatures 15.8, 19.7, 24.0, 27.8, 32.6, 34.0, and $35.5^{\circ}C$. R. pedestris females reproduced successfully from 19.7 to $35.5^{\circ}C$ except $15.8^{\circ}C$. The longevity of R. pedestris was longest at $15.8^{\circ}C$ and it decreased with increasing temperature (76.6 days at $19.7^{\circ}C$ and 20.6 days at $35.5^{\circ}C$). The number of total eggs and viable eggs was highest at $24.0^{\circ}C$ (193.5 and 151.2). Egg hatchability was highest at $27.8^{\circ}C$ (84.0%). We compared the results of oviposition models and life table parameters using both total eggs and viable eggs. The parameter value (c: the maximum reproductive capacity) (190 eggs) of temperature dependent total fecundity model using total eggs was higher than that of the model using viable eggs. When we analyzed the life table parameter the values of net reproductive rate and mean generation time using viable eggs were lower than those using total eggs. The oviposition models and life table analysis using viable eggs will be helpful to understand the real population transition of R. pedestris in agricultural system.

The properties of optical glass of BaO-GeO2-La2O3 system with ZnO (ZnO가 포함된 BaO-GeO2-La2O3 계 광학 유리 특성)

  • Lee, Ji-Sun;Lim, Tae-Young;Hwang, Jonghee;Lee, Youngjin;Jeon, Dae-Woo;Kim, Sun-Woog;Ra, Yong-Ho;Kim, Jin-Ho
    • Journal of the Korean Crystal Growth and Crystal Technology
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    • v.29 no.5
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    • pp.208-214
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    • 2019
  • The glass of $BaO-GeO_2-La_2O_3-ZnO$ system with a transmittance of more than 75 % at mid-wave infrared (MWIR) region in the range of $3{\mu}m$ to $5{\mu}m$ is manufactured and its property is evaluated. After selecting construction that can melt glass through flow button test, $BaO-GeO_2-La_2O_3$ system where 10 mol%, 20 mol% of ZnO were added respectively were melted at $1350^{\circ}C$ for 1 hour and $BaO-GeO_2-La_2O_3$ system of glass was manufactured. Among them, with 20 mol% of ZnO, 16 mol% BaO-56 mol% $GeO_2-8mol%$ $La_2O_3-16mol%$ ZnO system of glass was found to has less than $660^{\circ}C$ of glass transition temperature, more than 1.70 of refractive index, and more than 530 of knoop hardness. Therefore, it is concluded that glass of $BaO-GeO_2-La_2O_3-ZnO$ system of glass with 20 mol% ZnO has good melting conditions at low temperatures and excellent optical properties, thus, can be utilized for special optical materials field.

Components and Function of Artichoke Tea Prepared by Steaming and Drying Method (증숙 건조 방식으로 제조한 돼지감자차의 성분 및 기능성)

  • Hwang, Eun Gyeong;Lee, Seon Hyeon;Kim, Byung Ki;Kim, Soo Jung;Ann, Yong Geun;Doryoon, Monk;Oh, Sung-Cheon
    • Journal of the Korean Applied Science and Technology
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    • v.36 no.1
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    • pp.1-12
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    • 2019
  • After making tea by steaming the Artichoke(Hellanthus tuberosus) nine times and drying them nine times, the ingredients and functions of the Artichoke tea were compared to those of M. It had 342.27kcal/100g in its own deloped Artichoke tea, 73.87g/100g of carbohydrates, 6.80g/100g of crude ash and 8.21g/100g of crude protein. The total of free sugars were 32.66mg/100, among them, fructose 17.40, sucrose 9.03 and glucose 6.05 mg/100g. The total mineral contents of the developed tea was 2,785.67mg/100g. It was 2,563.93mg/100g of potassium, 97.52mg/100g of calcium and 88.78mg/100g of magnesium. The saturated fat of Artichoke tea was 30.34mg/100g and unsaturated fat was 69.66mg/100g, among which the linoleic acid was 47.0mg/100%, palmitic acid was 25.31mg/100% and linolenic acid was 8.61mg/100g. DPPH radical scavenging was 34.2% of teas that were developed, 5.2% of M's for comparison, and 44.0% of index materials. ABTS radical scavenging was 93.0% of teas developed, 61.9% of M's tea and 47.6% of index materials, and SOD like activity was 2.7% of teas developed and 1.6% of M's tea. The flavonoid content was 2.8 fold of the tea developed, 2.0 fold of M's tea and 1.7 fold of index material. The polyphenol content was 38.2 fold, 8.92 fold of M's tea and 14.0 fold of index material. The inhibition rate for ${\alpha}$-glucosidase was 9.83% teas developed and 8.92% of M's. The sensory evaluation compares to the one time extract and the five time extract. Based on the one-time extract, color of tea developed was 83.7%, the M's tea was 50.0%, the flavor was 78%, M's tea was 42.5%, the delicate taste was 66.7% of teas developed and M's tea was 37.5% and the overall acceptability was 73.3% of teas developed, M's tea was 47.5%. The comparison of M's tea showed that the extract decreased as we made it, and the overall symbol level decreased to 46.3% after five time-extyracts, while that of the developed tea decreased to 73.3%. The Artichoke tea developed this way is believed to have greater antioxidant function, higher effective substance content, and a higher affinity than M's tea an index material for comparison purposes.

Nutritional status and related parental factors according to the breakfast frequency of elementary school students: based on the 2013~2015 Korea National Health and Nutrition Examination Survey (초등학생의 아침식사 빈도에 따른 영양상태와 부모 관련요인 분석 : 2013 ~ 2015년 국민건강영양조사 자료를 활용하여)

  • Yu, So Young;Yang, Yoon Jung
    • Journal of Nutrition and Health
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    • v.52 no.1
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    • pp.73-89
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    • 2019
  • Purpose: This study was conducted to identify the dietary life and nutritional status of Korean elementary school students according to breakfast frequency and to clarify the relationship between breakfast frequency of elementary school students and parental dietary and social environmental factors. Methods: This study used data from the 2013 ~ 2015 Korea National Health and Nutrition Examination Survey (KNHANES VI). The subjects were 1,325 elementary school students aged 6 to 11 years old. Subjects were categorized into two groups: a skipping breakfast group (ate breakfast 0 ~ 4 times per week), eating breakfast group (ate breakfast 5 ~ 7 times per week) by sex and grade (lower grade: 1st ~ 3rd/upper grade: 4 th ~ 6 th). Results: Among upper grade boys and girls, the skipping breakfast group had a higher rate of childhood obesity than the eating breakfast group. In lower grade boys, the mothers of the skipping breakfast group had higher rates of economic activity and eating breakfast alone without family members than the mothers of the eating breakfast group. For lower grade boys and girls and upper grade boys, the skipping breakfast group had a higher rate of parents who did not eat breakfast than the eating breakfast group. The energy intake of the breakfast consumed by all subjects was less than 25% of the Estimated Energy Requirements (EER). Moreover, for upper grade boys and girls, the skipping breakfast group had a higher rate of subjects whose daily intake was below the Estimated Average Requirement (EAR) for iron than the eating breakfast group. Conclusion: Breakfast frequency of elementary school students was related to childhood obesity. The frequency of eating breakfast among elementary school students was related to the dietary life factors of parents such as breakfast frequency and dietary condition. Intake for breakfast was less than 25% of the EER, while the skipping breakfast group had a higher rate of subjects whose daily intake was below the EAR for iron than the eating breakfast group. Therefore, it is necessary to consider diverse forms of policy support such as opening nutrition education programs for parents and practicing morning meals at school for elementary school students to provide regular and balanced breakfasts.

Comparative Analysis of Heavy Metal Contamination, Mineral Composition and Spectral Characteristics of White, Reddish Brown and Mixed Precipitates Occurring at Osip Stream Drainage, Gangwondo, South Korea (강원도 오십천 수계에 분포하는 백색침전물, 적갈색침전물 및 혼합침전물의 중금속 오염, 광물조성 및 분광학적 특성의 비교분석)

  • Lim, Jeong Hwa;Yu, Jaehyung;Shin, Ji Hye;Koh, Sang-Mo
    • Economic and Environmental Geology
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    • v.52 no.1
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    • pp.13-28
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    • 2019
  • This study analyzed precipitation environment, heavy metal contamination, and mineral composition of white, reddish brown and mixed precipitates occurring at the Osip stream drainage, Gangwondo. Furthermore, spectral characteristics of the precipitates associated with heavy metal contamination and mineral composition was investigated based on spectroscopic analysis. The pH range of the precipitates was 4.43-6.91 for white precipitates, 7.74-7.94 for reddish brown precipitates, and 7.59-7.9 for the mixed precipitates, respectively. XRF analysis revealed that these precipitates were contaminated with Ni, Cu, Zn, and As. The white precipitates showed high Al concentration compared to reddish brown precipitates as much as 3.3 times, and the reddish brown precipitates showed high Fe concentration compared to white precipitates as much as 15 times. XRD analysis identified that the mineral composition of the white participates was aluminocoquimbite, gibbsite, quartz, saponite, and illite, and that of reddish brown precipitates was aluminum isopropoxide, kaolinite, goethite, dolomite, pyrophyllite, magnetite, quartz, calcite, pyrope. The mineral composition of the mixed precipitates was quartz, albite, and calcite. The spectral characteristics of the precipitates was manifested by gibbsite, saponite, illite for white precipitates, goethite, kaolinite, pyrophyllite for reddish brown precipitates, and albite for the mixed precipitates, respectively. The spectral reflectance of the precipitates decreased with increase in heavy metal contamination, and absorption depth of the precipitates indicated that the heavy metal ions were adsorbed to saponite and illite for white precipitates, and goethite and magnetite for reddish brown precipitates.

Soil Washing Coupled with the Magnetic Separation to Remediate the Soil Contaminated with Metal Wastes and TPH (자력선별과 토양세척법을 연계하여 금속폐기물과 TPH로 복합 오염된 토양 동시 정화)

  • Han, Yikyeong;Lee, Minhee;Wang, Sookyun;Choi, Wonwoo
    • Economic and Environmental Geology
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    • v.52 no.1
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    • pp.1-12
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    • 2019
  • Batch experiments for the soil washing coupled with the magnetic separation process were performed to remediate the soil contaminated with metal and oil wastes. The soil was seriously contaminated by Zn and TPH (total petroleum hydrocarbon), of which concentrations were 1743.3 mg/kg and 3558.9 mg/kg, respectively, and initial concentrations of Zn, Pb, Cu, and TPH were higher than the 2nd SPWL (soil pollution warning limit: remediation goal). The soil washing with acidic solution was performed to remove heavy metals from the soil, but Pb and Zn concentration of the soil maintained higher than the 2nd SWPL even after the soil washing with acidic solution. The 2nd soil washing was repeated to increase the Pb and Zn removal efficiency and the Zn and Pb removal efficiencies additionally increased by only 8 % and 5 %, respectively, by the 2nd soil washing (> 2nd SPWL). The small particle separation from the soil was conducted to decrease the initial concentration of heavy metals and to increase the washing effectiveness before the soil washing and 4.1 % of the soil were separated as small particles (< 0.075 mm in diameter). The small particle separation lowered down Zn and Pb concentrations of soil to 1256.3 mg/kg (27.9 % decrease) and 325.8 mg/kg (56.3 % decrease). However, the Zn concentration of soil without small particles still was higher than the 2nd SPWL even after the soil washing, suggesting that the additional process is necessary to lower Zn concentration to below the 2nd SPWL after the treatment process. As an alternative process, the magnetic separation process was performed for the soil and 16.4 % of soil mass were removed, because the soil contamination was originated from unreasonable dumping of metal wastes. The Zn and Pb concentrations of soil were lowered down to 637.2 mg/kg (63.4 % decrease) and 139.6 mg/kg (81.5 % decrease) by the magnetic separation, which were much higher than the removal efficiency of the soil washing and the particle separation. The 1st soil washing after the magnetic separation lowered concentration of both TPH and heavy metals to below 2nd SPWL, suggesting that the soil washing conjugated with the magnetic separation can be applied for the heavy metal and TPH contaminated soil including high content of metal wastes.

Evaluation of stream flow and water quality behavior by weir operation in Nakdong river basin using SWAT (SWAT을 이용한 낙동강유역의 보 개방에 따른 하천유량 및 수질 거동 분석)

  • Lee, Ji Wan;Jung, Chung Gil;Woo, So Young;Kim, Seong Joon
    • Journal of Korea Water Resources Association
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    • v.52 no.5
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    • pp.349-360
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    • 2019
  • The purpose of this study is to evaluate the stream flow and water quality (SS, T-N, and T-P) behavior of Nakdong river basin ($23,609.3km^2$) by simulating the dam and weir operation scenarios using SWAT (Soil and Water Assessment Tool). The operation senarios are the simultaneous release for all dam and weirs (scenario 1), simultaneous release for all weirs (scenario 2), and sequential release for the weirs with one month interval from upstream weirs (scenario 3). Before evaluation, the SWAT was calibrated and validated using 11 years (2005-2015) daily multi-purpose dam inflow at 5 locations (ADD, IHD, HCD, MKD, and MYD), multi-function weir inflow at 7 locations (SHW, GMW, CGW, GJW, DSW, HCW, and HAW), and monthly water quality monitoring data at 6 locations (AD-4, SJ-2, EG, HC, MK-4, and MG). For the two dam inflow and dam storage, the Nash-Sutcliffe efficiency (NSE) was 0.56~0.79, and the coefficient of determination ($R^2$) was 0.68~0.90. For water quality, the $R^2$ of SS, T-N, and T-P was 0.64~0.79, 0.51~0.74, and 0.53~0.72 respectively. For the three scenarios of dam and weir release combination suggested by the ministry of environment, the scenario 1 and 3 operations were improved the stream water quality (for T-N and T-P) within the 3 months since the time of release, but it showed the negative effect for 3 months after compared to scenario 2.

The Causal Relation between Win-Win Growth Strategies of Small and Medium-Sized Businesses and Corporate Performance (중소기업의 동반성장 전략과 기업성과의 인과 관계)

  • Ban, Won Ho
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.19 no.12
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    • pp.552-560
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    • 2018
  • Since 1960's, the large conglomerates of South Korea have grown due to the corporate-centered, fast-paced growth drive, while the small and medium-sized businesses supported the country's economy as the subordinate structure of these conglomerates. Due to the globalization of the business environments, the focus of competition shifted from competitions between individual companies to one between networks of companies. Therefore, more emphasis is now put on the capabilities of the cooperation networks between companies rather than the capabilities of individual companies. Therefore, in this study, the author examined the influence of the win-win growth strategy elements through cooperation with small and medium-sized businesses upon corporate performance. This study was conducted with the workers of small and medium-sized businesses that have previous cooperation experiences with South Korean conglomerates over the period from March 2 to May 17, 2018. For this, a total of 515 questionnaires were retrieves to obtain the data for analysis. The analysis was conducted using SPSS 22.0 and AMOS 18.0. The analytical processes that were taken included exploratory factor analysis, confirmatory factor analysis, confidence analysis, correlation analysis, and structural equation analysis model. The results of the analysis showed that, first of all, the win-win growth strategy factors that affected the strategic performance, which is a part of cooperate performance were, respectively, harmonization with the goals, production technical support, and quality system. Second, the win-win growth strategy factors that affected the financial performance, which is a part of corporate performance, turned out to be harmonization with the goals, quality system, and incentive. With the results of this study, it was shown that the elements such as harmonization with the goals, production technical support, quality systems, and incentives were key infrastructural factors that affected the corporate performance directly. On the other hand, its implication is that informative or knowledge-related factors, such as joint knowledge creation, do not have their own added values, while they are not too much likely to affect corporate performances for the moment.