• Title/Summary/Keyword: IL-6 and IL-10

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Analysis of Activation Characteristics of Cyclotron Operating Facility by Concrete Type (사이클로트론 운영 시설의 콘크리트 종류에 따른 방사화 특성 분석)

  • Yong-In Cho;Sang-Il Bae
    • Journal of the Korean Society of Radiology
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    • v.18 no.6
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    • pp.629-637
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    • 2024
  • Medical cyclotrons accelerate protons at high speeds to produce nuclear reactions for the production of radiopharmaceuticals. During this nuclear reaction, high-energy gamma rays and many neutrons are generated. However, it is reported that if exposed to the generated neutrons for a long period of time, the cyclotron accessories and shielding concrete will become radioactive and generate a large amount of radioactive waste when the facility is dismantled. Accordingly, this study aims to evaluate the radioactivity characteristics of different types of concrete used as shielding walls in cyclotron operating facilities. The experiment simulated GE's PETtrace 800 model and five types of concrete shielding walls using the FLUKA code based on Monte Carlo simulation. The simulated cyclotron was evaluated for its source term based on the manufacturer's standards, and the neutron fluence was evaluated according to the type of concrete shielding wall when the cyclotron was in operation. Afterwards, the sum of the radionuclides produced according to the type of concrete and the fraction of radionuclides produced according to the domestic radioactive waste disposal standards were analyzed. As a result, the reliability of the source term evaluation was secured with an error of less than 3%. The distribution of neutron fluence generated depending on the type of concrete when operating the cyclotron showed the highest result at the point of 0.02 eV. As a result of evaluating radionuclides generated depending on the type of concrete, concrete with high iron content tended to generate 54Mn, and concrete with high oxygen content tended to generate 60Co and 152Eu. As a result of analyzing radioactivity characteristics according to the thickness of each type of concrete, concrete with high iron content showed a value below the allowable self-disposal concentration at 50 cm thick, and concrete with high oxygen content showed a value exceeding the allowable self-disposal concentration at 50 cm thick. It is believed that this study can be used as auxiliary data for preliminary radiological evaluation of concrete shielding walls when dismantling a cyclotron.

Hydroponic Culture Possibility and Optimal Solution Strength of 'Pechika' Ever-bearing Strawberry on Highland in Summer (사계성 페치카' 딸기의 고랭지 여름철 양액재배 가능성 및 적정 양액농도 검토)

  • Rhee Han-Cheol;Kang Nam-Jun;Rho Il-Rae;Jung Ho-Jung;Kwon Joon-Kook;Kang Kyung-Hee;Lee Jae-Han;Lee Sung-Chan
    • Journal of Bio-Environment Control
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    • v.15 no.3
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    • pp.250-256
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    • 2006
  • This experiment was conducted to investigate the hydroponic culture possibility and the optimal solution strength of 'Pechika' ever-bearing strawberry in summer highland. Maximum room temperature and minimum root zone temperature of plastic house were $30.8^{\circ}C\;and\;19^{\circ}C$ in highland respectively and $4^{\circ}C\;and\;3^{\circ}C$ lower than in level and. The growth of 'Pechika' was better in highland. There was effective in producing the good yield and fruit quality in highland and the deformed fruits also were decreased. The soluble solid and titratable acidity content increased in highland. Early growth was the most effective in standard solution $(EC\;0.75dS\;m^{-1})$ and had a tendency to be inhibition with increasing nutrient concentration. Standard solution was also the highest to yield about 2,064kg/10a among treatments, and 2/3S, 4/3S, 5/3S by turns. The browning roots and root activity increased when the solution strength was increased, especially in EC $1.25dS{\cdot}m^{-1}$. The soluble solids and acidity content of fruits were increased with higher solution strength. Therefor, the summer hydroponic culture of 'Pechika' ever-bearing strawberry was suitable in highland and effective in standard solution $(EC\;0.75dS{\cdot}m^{-1})$ in solution control.

Emergence Characteristics of Fire Blight from 2019 to 2023 in Korea (2019-2023년 국내 과수 화상병의 발생 특성)

  • Hyeonheui Ham;Eunjung Roh;Mi-Hyun Lee;Young-Kee Lee;Dong Suk Park;Kyongnim Kim;Bang Wool Lee;Mun Il Ahn;Woohyung Lee;Hyo-Won Choi;Yong Hwan Lee
    • Research in Plant Disease
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    • v.30 no.2
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    • pp.139-147
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    • 2024
  • Erwinia amylovora is a gram-negative plant pathogen that causes fire blight in apple and pear trees, resulting in significant damage worldwide. In this study, we monitored the emergence of fire blight from 2019 to 2023 to determine the emergence patterns and the factors affecting the outbreak of the disease. As a result of the 5-year survey on the emergence of fire blight, a total of 2,029 cases have emerged, mostly in apple trees of 1,378 cases (67.9%) followed by 645 cases (31.8%) in pear trees, and from quince, hawthorn, and mountain ash trees. Fire blight appeared in specific areas of Gyeonggi, Chungnam, Gangwon, and Chungbuk provinces in 2019, but spread to Andong and Yesan in 2021, Muju and Bonghwa in 2023. In 2020 and 2021, there were 744 and 618 cases of fire blight outbreaks, respectively, compared to other years (188-245 cases/year). Notably, 914 of these cases were observed in apple trees from May to July, with 667 cases reported in Chungju and Jecheon. The incidence of fire blight was positively correlated with the daily maximum temperatures and rainy days in January and February, as well as the rainy days in May and June. The average age of the diseased pear trees was 25 years, higher than the 10-year average age of the apple trees. This study provides fundamental information to understand the status and factors affecting the fire blight emergence in Korea. Prevention measures should be established through continuous analysis of the status of fire blight.

Late-onset Hypotension and Late Circulatory Collapse Due to Adrenal Insufficiency in Preterm Infants with Gestational Age Less than 32 Weeks (재태주령 32주 이하 미숙아에서 생후 1주 이후 후기 저혈압 및 부신기능부전과의 관계)

  • Lee, Jin-A;Choi, Chang-Won;Kim, Ee-Kyung;Kim, Han-Suk;Kim, Beyong-Il;Choi, Jung-Hwan
    • Neonatal Medicine
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    • v.18 no.2
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    • pp.211-220
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    • 2011
  • Purpose: Late-onset hypotension in preterm infants is not a rare condition. Late circulatory collapse due to adrenal insufficiency (AI) is one of the major causes of late-onset hypotension. We assessed the incidence and causes of late-onset hypotension. We also compared the clinical findings according to the presence of AI. Methods: In total, 244 preterm infants with a gestational age ${\leq}$32 weeks and who were admitted to the neonatal intensive care unit (NICU) of Seoul National University Boramae Hospital and Seoul National University Hospital from January 2009 to April 2011 were included. Clinical findings were analyzed retrospectively. Results: Forty-four infants (18%) suffered from late-onset hypotension. Hydrocortisone was administered to 30 infants (68.2%) and AI occurred in 16 infants (36.4%). Cesarean section, sepsis before hypotension, and gastrointestinal surgery were independently associated with late-onset hypotension. Intrauterine growth retardation (IUGR) was less frequent in the hydrocortisonetreated group than in infants not treated with hydrocortisone. The AI group had fewer IUGR infants, and the duration of hospitalization was shorter in the AI group than in infants who were not administered hydrocortisone. Blood pressure tended to normalize more quickly in the AI group, however, the difference was not significant. Conclusion: AI was a major cause of late-onset hypotension, and the use of hydrocortisone shortened the length of hospitalization.

Net Shapes of the Model Set Net in the Flow (흐름에 대한 모형 정치망의 형상 변화)

  • Kim, Boo-Young;Yun, Il-Bu;Kwon, Byeong-Guk;Lee, Ju-Hee
    • Journal of the Korean Society of Fisheries and Ocean Technology
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    • v.40 no.2
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    • pp.104-114
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    • 2004
  • A study was carried out to estimate the deformation of the set net according to the current by the model test in the circulation water channel. The tension of the frame line and the variation of net shapes were measured to investigate the deforming of the model set net in the flow. The results are obtained as follows; 1. The tensions (y) of the frame line according to the flow speed(x) from 0.0m/s to 0.6m/s were expressed by the experimental equation as follow : y= 1814.1x+115.12 2. In case of the upperward flow with fish court net, deformed angle in the upperward net was changed from 0$^{\circ}$ to 79$^{\circ}$, the inclined passage net was from 0$^{\circ}$ to 56$^{\circ}$. Besides, the depth ratio of the first bag net changed from 1.0 to 0.42 and the second bag net was from 1.0 to 0.41, and deformed angle in the downward of the bag net was from 0$^{\circ}$ to 87$^{\circ}$. 3. In case of the upperward flow with bag net, deformed angle in the upperward net was changed from 0$^{\circ}$ to 60$^{\circ}$, the inclined passage net was from 0$^{\circ}$ to 13$^{\circ}$. Besides, the depth ratio of the first bag net changed from 1.0 to 0.27 and the second bag net was from 1.0 to 0.15. In the flow speed 0.3m/s, the inclined passage net rised up to the entry of the bag net and then prevented it more over 90% in 0.5m/s. A deformed angle in the downward of the fish court net was from 0$^{\circ}$ to 58$^{\circ}$. 4. To minimize the deformation of each part in model set net, it needs to attach the moving weight out of the fish court net, inclined passage net and bag net. Besides, it needs to adjust the tension of the net twine for the maintenance of the shape.

Effect of Juvenile Hormone Analog Manina on Silkworm, Bombyx Mori L. II. Varietal Differences in Cocoon Productivity of the Leading Silkworm Varieties by Topical Application of Juvenile Hormone Analog "Manina". (유약 홀몬에 관한 연구 II. 장려 잠품종에 대한 합성유약홀몬 "마니나"의 증견효과)

  • Ma, Yeong-Il;Gwon, Yeong-Ha;Lee, Sang-Pung
    • Journal of Sericultural and Entomological Science
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    • v.26 no.1
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    • pp.25-29
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    • 1984
  • Since 1966, practical use of active heavy analogs of the hormones has been also worked out as an insecticide and brought the features of it to the light as cocoon producer. On the other hand, it is expected to afford the increase of silk productivity resulted from control of the fifth larval period by delaying normal development. With these regards, some of analogs have been tried to apply practically to the silkworm for an increase of cocoon productivity. One of the synthesized juvenile hormone available is "Manina". And it is presently used for the increase of silk productivity in Korea. For the practical use, it is very essential the varietal differences in the increase of silk productivity by topical application was tested and the obtained results are summarized as follows. 1. It was evident that the fifty larval period was extended by topical application after 48 hrs. of the last ecdysis, ranging from 8 hrs. to one day, as compared to the control. 2. In pupal rates, there is no significance between control and treatments. It proved that there was no toxicity to silkworm by topical application in general, except jam 120. With regards to an increase of cocoon yield in Japanese, it was resulted from 17∼24% of cocoon yield from 10,000 larvae, as compared to that of control. In case of Chinese, the incrasing rates were varied from 15∼26% of cocoon yield, 17.8kg of it with 26% increase for Jam 122 and 16.7kg of it with 25% increase for Jam 118. In case of all hybrids, an increase of the cocoon yield took places from 20% to 31% and the weight of cocoon layer for the Japanese increased by 6 to 14%, those for the Chinese by 4 to 7% and those for the hybrids ranged from 21 to 29% increase. 3. It was recognized that the hybrid vigor rate took places with the hybrids between high responsing parents to juvenile hormones.

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Occurrence of Weed Flora and Changes in Weed Vegetation in Orchard Fields of Korea (우리나라 과수원에 발생하는 잡초 현황과 군락 변화)

  • Lee, In-Yong;Oh, Young-Ju;Hong, Sun-Hee;Heo, Su-Jeoung;Lee, Chae-Young;Park, Kee Woong;Cho, Seng-Hyun;Kwon, Oh-Do;Im, Il-Bin;Kim, Sang-Kuk;Seong, Deok-Gyeong;Chung, Young-Jae;Kim, Chang-Seog;Lee, Jeongran;Seo, Hyun-A
    • Weed & Turfgrass Science
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    • v.6 no.1
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    • pp.21-27
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    • 2017
  • This study was investigated in order to occurrence of weed flora in orchard (apple, grape, peach, pear etc.) fields and to the establishment of weed control basic data in these weeds. And this study was survey on 2015. As a result of the study on orchard weeds, there were total of 492 weeds including 63 families. Among all the weeds, 159 species were annual, 97 species were winter annual and 236 were perennial. Each fruit tree patterns of occurrence weeds, 306 species 50 families in apple orchard, 304 species 50 families in pear orchard, 286 species 50 families in grape orchard, and 288 species 48 families in peach orchard. Dominance was the highest with Digitaria ciliaris followed by Artemisia princeps, Stellaria aquatica, Commelina communis, Acalypha australis etc. in order. And exotics weeds occurred 127 species. Trifolium repens was the highest in importance analysis and the followings were in order of Conyza canadensis, Chenopodium album, Taraxacum offcinale, Rumex crispus etc. Changes in weed vegetation in orchard during 30 years, did not very many changed. In 1990, D. ciliaris, Persicaria hydropiper, Portulaca loeracea were dominant. In 2003, D. ciliaris was the most abundant species, followed by A. australis, A. princeps species. And in 2015, also D. ciliaris was the most dominant, followed by A. princeps, S. aquatica.

Discrimination of Sediment Provenance Using $^{87}Sr/^{86}Sr$ Ratios in the East China Sea ($^{87}Sr/^{86}Sr$비를 이용한 동중국해 대륙붕 퇴적물의 기원 연구)

  • Youn, Jeung-Su;Lim, Chong-Il;Byun, Jong-Cheol;Jung, Hoi-Soo
    • The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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    • v.10 no.1
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    • pp.92-99
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    • 2005
  • To discriminate the provenance of shelf sediments in the East China Sea, textural and elemental compositions along with strontium isotopic ratio ($^{87}Sr/^{86}Sr$) were analyzed and compared with the sediments originated from Chinese rivers. The sediments in the study area are composed of fine-grained mud with a mean grain size of $47\;{\phi}$ and their $CaCO_3$, contents range from 3.9 to 11.5% (average 7.6%). In the study area, the content of most metallic elements are strongly constrained by sediment grain size (quartz dilution effect) and that of biogenic material and, thereby, their spatial distribution seems not enough for understanding sediment provenance in the study area. The muddy sediments of the Yangtze river have much lower $^{87}Sr/^{86}Sr$ ratio ($0.71197{\sim}0.71720$) than the Yellow Sea shelf muddy sediments which are supposed to be originated from the Huanghe river ($0.72126{\sim}0.72498$), suggesting the distribution pattern of $^{87}Sr/^{86}Sr$ ratios as a new tracer to discriminate the provenance of shelf sediments in the study area. Different source rock compositions and weathering processes between both drainage basins may account for the differences in $^{87}Sr/^{86}Sr$ ratio. Although the ratios show wide range, from 0.71445 to 0.72184 with an average 0.71747 in the study area, they are close to the values of the Yangtze river sediments, suggesting that the sediments were mainly originated from the Yangtze river. The previous studies on the dispersal pattern of modern sediments and the physico-chemical properties of seawater in the Yellow and East China seas support the possibility that the fine-grained Yangtze river sediments can reach to the East China Sea shelf as well as to the southeastern Yellow Sea.

Reliability Verification of FLUKA Transport Code for Double Layered X-ray Protective Sheet Design (이중 구조의 X선 차폐시트 설계를 위한 FLUKA 수송코드의 신뢰성 검증)

  • Kang, Sang Sik;Heo, Seung Wook;Choi, Il Hong;Jun, Jae Hoon;Yang, Sung Woo;Kim, Kyo Tae;Heo, Ye Ji;Park, Ji Koon
    • Journal of the Korean Society of Radiology
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    • v.11 no.7
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    • pp.547-553
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    • 2017
  • In the current medical field, lead is widely used as a radiation shield. However, the lead weight is very heavy, so wearing protective clothing such as apron is difficult to wear for long periods of time and there is a problem with the danger of lethal toxicity in humans. Recently, many studies have been conducted to develop substitute materials of lead to resolve these problems. As a substitute materials for lead, barium(Ba) and iodine(I) have excellent shielding ability. But, It has characteristics emitting characteristic X-rays from the energy area near 30 keV. For patients or radiation workers, shielding materials is often made into contact with the human body. Therefore, the characteristic X-rays generated by the shielding material are directly exposured in the human body, which increases the risk of increasing radiation absorbed dose. In this study, we have developed the FLUKA transport code, one of the most suitable elements of radiation transport codes, to remove the characteristic X-rays generated by barium or iodine. We have verified the reliability of the shielding fraction of the structure of the structure shielding by comparing with the MCPDX simulations conducted as a prior study. Using the MCNPX and FLUKA, the double layer shielding structures with the various thickness combination consisting of barium sulphate ($BaSO_4$) and bismuth oxide($Bi_2O_3$) are designed. The accuracy of the type shown in IEC 61331-1 was geometrically identical to the simulation. In addition, the transmission spectrum and absorbed dose of the shielding material for the successive x-rays of 120 kVp spectra were compared with lead. In results, $0.3mm-BaSO_4/0.3mm-Bi_2O_3$ and $0.1mm-BaSO_4/0.5mm-Bi_2O_3$ structures have been absorbed in both 33 keV and 37 keV characteristic X-rays. In addition, for high-energy X-rays greater than 90 keV, the shielding efficiency was shown close to lead. Also, the transport code of the FLUKA's photon transport code was showed cut-off on low-energy X-rays(below 33keV) and is limited to computerized X-rays of the low-energy X-rays. But, In high-energy areas above 40 keV, the relative error with MCNPX was found to be highly reliable within 6 %.

Ferritin, an Iron Storage Protein, Associates with Kinesin 1 through the Cargo-binding Region of Kinesin Heavy Chains (KHCs) (철 저장 단백질 ferritin과 kinesin 1 결합 규명)

  • Jang, Won Hee;Jeong, Young Joo;Lee, Won Hee;Kim, Mooseong;Kim, Sang-Jin;Urm, Sang-Hwa;Moon, Il Soo;Seog, Dae-Hyun
    • Journal of Life Science
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    • v.26 no.6
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    • pp.698-704
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    • 2016
  • The intracellular transport of organelles and protein complexes is mediated by kinesin superfamily proteins (KIFs). The first kinesin, kinesin 1, was identified as a molecular motor protein that moves various organelles and protein complexes along the microtubule rails in cells. Kinesin 1 is a tetramer of two heavy chains (KHCs, also called KIF5s) and two kinesin light chains (KLCs). KIF5s interact with many different proteins through their tail region, but their binding proteins have not yet been fully identified. To identify the interaction proteins for KIF5A, we performed yeast two-hybrid screening and found a specific interaction with ferritin heavy chain (Frt-h), which has a role in iron storage and detoxification. Frt-h bound to the amino acid residues between 800 and 940 of KIF5A and to other KIF5s in the yeast two-hybrid assay. The coiled-coil domain of Frt-h is essential for interaction with KIF5A. In addition, ferritin light chain (Frt-l) interacted with KIF5s in the yeast two-hybrid assay. In addition, these proteins showed specific interactions in the glutathione S-transferase (GST) pull-down assay. An antibody to KHC specifically co-immunoprecipitated Frt-h and Frt-l from mouse brain extracts. These results suggest the kinesin 1 motor protein may transport the ferritin complex in cells.