• 생약학회지
• /
• 제43권1호
• /
• pp.27-31
• /
• 2012

This study was designed to elucidate the effects of Cirsium japonicum (CJ) extracts on hepatic stellate cells (HSCs, LX-2 cells) proliferation, which is induced by platelet-derived growth factor (PDGF) or transforming growth factor-${\beta}$ (TGF-${\beta}$). The content of total phenol, flavonoid, and silymarin derivatives was more higher in CJ-flower than in CJ-root. Consistent with these results, the LX-2 cells growth inhibition was more effective in CJ-flower extract than in CJ-root extract, the complete growth inhibition concentration was $1{\mu}g/mL$ and $50{\mu}g/mL$, respectively. These results suggest that extracts from CJ-flower can be potentially used as therapeutic substances for the regulatioin of HSCs activation.

• 한국수산과학회지
• /
• 제39권6호
• /
• pp.487-494
• /
• 2006

The effects of water temperature, salinity and irradiance on the growth of harmful algae Chattonella marina isolated from Gamak Bay in South Sea, Korea were investigated. C. marina was able to grow in temperatures of $15-30^{\circ}C$ and salinities of 10-35 psu. Maximum specific growth rate (0.64/day) was observed with combination of $25^{\circ}C$ and 25 psu. Optimal growth (${\ge}70%$ of maximum specific growth rate) was obtained with all salinities of the above $20^{\circ}C$. This result indicated that C. marina is a stenothermal of the high water temperature and euryhaline organism. C. marina was did not grow at irradiance ${\le} 10{\mu}mol$ photons/($m^2\;s$). Photoinhibition did not occur at $300{\mu}mol$ photons/($m^2\;s$), which was the maximum irradiance used in this study. The irradiance-growth curve was described as ${\mu}=0.78(I-11.4)/(I+34.1)$ at $25^{\circ}C$ and 25 psu. The half-saturation photon flux density (PFD) ($K_s$) was $56.9{\mu}mol$ photons/($m^2\;s$) and compensation PFD ($I_c$) was $11.4{\mu}mol$ photons/($m^2\;s$). The result of the present study indicate that C. marina has advantage physiological characteristic to the interspecific competition at the embayment and costal areas of South and West Sea, Korea in summer.

• Biomolecules & Therapeutics
• /
• 제24권6호
• /
• pp.572-580
• /
• 2016

3-Deoxysappanchalcone (3-DSC) has been reported to possess anti-allergic, antiviral, anti-inflammatory and antioxidant activities. In the present study, we investigated the effects of 3-DSC on the proliferation of human hair follicle dermal papilla cells (HDPCs) and mouse hair growth in vivo. A real-time cell analyzer system, luciferase assay, Western blot and real-time polymerase chain reaction (PCR) were employed to measure the biochemical changes occurring in HDPCs in response to 3-DSC treatment. The effect of 3-DSC on hair growth in C57BL/6 mice was also examined. 3-DSC promoted the proliferation of HDPCs, similar to Tofacitinib, an inhibitor of janus-activated kinase (JAK). 3-DSC promoted phosphorylation of ${\beta}$-catenin and transcriptional activation of the T-cell factor. In addition, 3-DSC potentiated interleukin-6 (IL-6)-induced phosphorylation and subsequent transactivation of signal transducer and activator of transcription-3 (STAT3), thereby increasing the expression of cyclin-dependent kinase-4 (Cdk4), fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF). On the contrary, 3-DSC attenuated STAT6 mRNA expression and IL4-induced STAT6 phosphorylation in HDPCs. Finally, we observed that topical application of 3-DSC promoted the anagen phase of hair growth in C57BL/6 mice. 3-DSC stimulates hair growth possibly by inducing proliferation of follicular dermal papilla cells via modulation of $WNT/{\beta}$-catenin and STAT signaling.

• 대한기계학회논문집B
• /
• 제21권11호
• /
• pp.1458-1465
• /
• 1997

This study investigated the effects of pressure on the growth of an impinging spray. We obtained the frozen images which were scattered by Nd ; YAG laser light (pulse width : 7 ns) using synchronization circuit made in the laboratory. For an impinging spray a growth of the penetration length was progressed with increase of the injection pressure but an ambient pressure restrained its growth. The effect of an ambient pressure on penetration was larger than that of an injection pressure. The pressure ratio had an effect on the penetration growth rate. The thickness growth rate depended on both the injection pressure and the ambient pressure compositively. A lower injection pressure or a higher ambient pressure was required for spatial distribution of impinging spray.

• 대한본초학회지
• /
• 제20권2호
• /
• pp.83-89
• /
• 2005

Objectives : This study was performed to investigate the effects of Perilla frutescens var. acuta extracts on growth inhibition of Streptococcus pyogenes KCTC 3208. Methods : Measured growth inhibition of Streptococcus pyogenes KCTC 3208 by concentration of the Perilla frutescens var. acuta. extract and collection periods of the Perilla frutescens var. acuta. and picking region of the Perilla frutescens var. acuta. Results : The Perilla frutescens var. acuta. extract is effective on retarding growth of Streptococcus pyogenes KCTC 3208. At 3% the growth of Streptococcus pyogenes KCTC 3208 was suddenly retarded. The stem of Perilla frutescens var. acuta. extract in a sunny place on June is more effective then its leaf. Conclusions : These results suggest that Perilla frutescens var. acuta. extract is effective in growth inhibition of Streptococcus pyogenes KCTC 3208.

• Biotechnology and Bioprocess Engineering:BBE
• /
• 제5권5호
• /
• pp.350-354
• /
• 2000

The growth promotion of a Taxus brevifolia cell suspension culture was investigated using conditioning factors. The conditioning factors produced and secreted from cultured cells usually stimulate cell division and the production of secondary metabolites. Therefore, the effective incubation time for the optimal secretion of conditioning factors was firstly determined for the promotion of cell growth. Conditioned media obtained by cultivating for 2 and 5 days showed the promotion of initial cell growth during the early cell growth period. However, the positive effect of the conditioning factors on the initial cell growth did not continue because of the depletion of the medium nutrients. Accordingly, the addition of a carbon source to the conditioned medium prolonged the positive effect on the cell growth. The addition of sucrose to the conditioned medium resulted in the maximum cell density being reached 4 days earlier compared to the control group and an increased substrate yield.

• Nuclear Engineering and Technology
• /
• 제45권3호
• /
• pp.385-392
• /
• 2013

Zirconium and zirconium alloys are widely used as nuclear reactor core materials such as fuel cladding and guide tubes because they have excellent corrosion- and radiation-resistant properties. In the reactor core, zirconium alloys are subjected to high-energy neutron fluence, causing radiation-induced dislocation and growth. To discern a possible correlation between radiation-induced dislocation and growth, characteristics of dislocation and growth in zirconium and its alloys are examined. The radiation-induced dislocation including and dislocation loops is reviewed in various temperature and fluence ranges, and their growth behavior is examined in the same way. To further a fundamental understanding, radiation-induced growth prediction models are briefly reviewed. This research will assist in the design of zirconium based components as well as the safety analysis of various reactor conditions, in both research and commercial reactors.

• 농업과학연구
• /
• 제36권2호
• /
• pp.179-184
• /
• 2009

본 연구는 젖소 초유를 마우스에 급여후 성장과 사료섭취에 관하여 연구한 것이다. 초유구, 시유구, 대조구로 나누어 각 시험구당 10마리씩 나누어 실험하였다. 마우스의 사료섭취는 시험기간 2주 동안 대조구는 4.73 g, 시유구는 3.95 g, 초유구는 3.4.1g 이었다. 마우스의 시유 및 초유섭취는 시험기간 2주 동안 대조구는 0 g, 시유구는 9.93 g 섭취, 초유구는 10.17 g을 섭취하였다. 물 섭취는 2주간 대조구가 6.28 g, 시유구가 4.74 g, 초유구가 4.67 g을 섭취하였다. 마우스의 증체율은 초유구가 대조구에 비해서 16.73%(P<0.05) 높았다. 마우스 혈액으로부터 조사한 엘러지와 관련된 사이토카인 IL-4는 초유에서 낮게 나타났다. 따라서 젖소 초유가 마우스의 증체율 및 사료 섭취에 큰 영향을 미치는 것으로 사료된다.

• 대한치과의사협회지
• /
• 제13권9호
• /
• pp.820-822
• /
• 1975

• 한국분말야금학회:학술대회논문집
• /
• 한국분말야금학회 2005년도 추계학술강연 및 발표대회강연 및 발표논문 초록집
• /
• pp.27-27
• /
• 2005