• Clinical and Experimental Reproductive Medicine
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• 제49권3호
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• pp.196-201
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• 2022

Objective: This prospective consecutive study investigated the variation in sperm DNA fragmentation (SDF) in multiple semen samples from patients with cancer. Methods: Eighty-one patients with various cancers underwent multiple semen collections on 3 consecutive days for sperm cryopreservation prior to cancer treatment. A commercial Halosperm kit was used to measure SDF. Within- and between-subject coefficients of variation were estimated via random-effects analysis of variance to assess the consistency of semen parameters and SDF. Intraclass correlation coefficients (ICCs) were calculated to assess the magnitude of the between-subject component of variance relative to the total variance. Results: The volume of semen in the day-2 and day-3 samples was significantly lower compared with the day-1 sample. Most parameters showed high ICC values, suggesting that within-subject fluctuations were small relative to the between-subject variability. The highest ICC values were identified for the SDF (ICC, 0.68; 95% confidence interval [CI], 0.45-0.84) and semen volume (ICC, 0.67; 95% CI, 0.45-0.84). Conclusion: Our findings showed that repeated ejaculates from patients with cancer had stable SDF levels.

• PNF and Movement
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• 제20권3호
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• pp.399-408
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• 2022

Purpose: This study investigated the differences in winged scapula between the symptomatic side and asymptomatic side, the reliability of the winged scapula test, and the correlation between winged scapula and the stability of the scapula in patients with subacromial impingement syndrome. Methods: Twenty-four patients with unilateral subacromial impingement syndrome participated in this study. Winged scapula was compared between the symptomatic and asymptomatic sides using a scapulometer. The reliability of the scapulometer was assessed by calculating the intraclass correlation coefficient (ICC), standard error of measurement (SEM), and minimal clinically important difference (MCID). The correlation between winged scapula and the results of the upper quarter Y-balance test were also obtained. Conclusion: Winged scapula was significantly greater on the symptomatic side compared with the asymptomatic side (p < 0.05). High to excellent ICCs were obtained for the winged scapula test, and SEM and MCID values were obtained for winged scapula (SEM: 0.2-0.3 cm, MCID: 0.6-0.8 cm); however, winged scapula and the results of the upper quarter Y-balance test were not correlated. Conclusion: The scapulometer is useful for measuring winged scapula in patients with subacromial impingement syndrome.

• 보건교육건강증진학회지
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• 제29권2호
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• pp.83-91
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• 2012

Objectives: This study is to examine that drinking problems among university students were accounted for not only by student's individual characteristics but alcohol policy and environmental characteristics of the university in which students were enrolled. Method: Secondary data analysis was employed in which variables under study were derived from a raw data of a nationwide representative sample in 2009. Raw data under analysis included 3,665 students from 63 universities across Korea. Organizational and environmental characteristics of the university were collected from university administrators while individual characteristics and drinking behavior from the students in using self-administrated questionnaire. Multilevel regression analyses were employed to describe alcohol policy effects on students's drinking problems measured by AUDIT by using HLM7.0. Results: ICCs indicate that variation in drinking problem depends on alcohol policy of university. Multilevel regression models identified statistically significant factors in explaining variance of drinking problems. Group means on drinking problem are affected by indicators representing alcohol policy with level of drinking problem of student being decreased in accordance to level of availability of alcohol on campus. Conclusions: It is concluded that drinking problems among university students were associated with both individual characteristics and alcohol policy of the university they enrolled. This study supports policy belief that interventions at environmental as well as individual level are required to prevent drinking problem among university students.

• Radiation Oncology Journal
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• 제32권1호
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• pp.43-47
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• 2014

Purpose: The degree of radiation-induced lung fibrosis (RILF) can be measured quantitatively by fibrosis volume (VF) on chest computed tomography (CT) scan. The purpose of this study was to investigate the interobserver and intraobserver variability in CT-based measurement of VF. Materials and Methods: We selected 10 non-small cell lung cancer patients developed with RILF after postoperative radiation therapy (PORT) and delineated VF on the follow-up chest CT scanned at more than 6 months after radiotherapy. Three radiation oncologists independently delineated VF to investigate the interobserver variability. Three times of delineation of VF was performed by two radiation oncologists for the analysis of intraobserver variability. We analysed the concordance index (CI) and inter/intra-class correlation coefficient (ICC). Results: The median CI was 0.61 (range, 0.44 to 0.68) for interobserver variability and the median CIs for intraobserver variability were 0.69 (range, 0.65 to 0.79) and 0.61(range, 0.55 to 0.65) by two observers. The ICC for interobserver variability was 0.974 (p < 0.001) and ICCs for intraobserver variability were 0.996 (p < 0.001) and 0.991 (p < 0.001), respectively. Conclusion: CT-based measurement of VF with patients who received PORT was a highly consistent and reproducible quantitative method between and within observers.

• Asian Pacific Journal of Cancer Prevention
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• 제14권1호
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• pp.557-563
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• 2013

Intrahepatic cholangiocarcinoma (ICC) is ranked as one of the top five causes of cancer-related deaths. ICC in Thai patients is associated with infection with the liver fluke, Opisthorchis viverrini, but the molecular basis for development remains unclear. The present study employed a microarray approach to compare gene expression profiles of ICCs and normal liver tissues from the same patients residing in Northeast Thailand, a region with a high prevalence of liver fluke infection. In ICC samples, 2,821 and 1,361 genes were found to be significantly up- and down-regulated respectively (unpaired t-test, p<0.05; fold-change ${\gep}2.0$). For validation of the microarray results, 7 up-regulated genes (FXYD3, GPRC5A, CEACAM5, MUC13, EPCAM, TMC5, and EHF) and 3 down-regulated genes (CPS1, TAT, and ITIH1) were selected for confirmation using quantitative RT-PCR, resulting in 100% agreement. The metallothionine heavy metal pathway contains the highest percentage of genes with statistically significant changes in expression. This study provides exon-level expression profiles in ICC that should be fruitful in identifying novel genetic markers for classifying and possibly early diagnosis of this highly fatal type of cholangiocarcinoma.

• 디지털융복합연구
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• 제16권3호
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• pp.527-532
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• 2018

본 연구는 청소년의 여가활용이 학습 적응성에 미치는 영향력을 분석하고, 여가활용과 학습 적응성 간 관계에서 대인관계의 매개효과를 검증하고자 하였다. 이를 위하여 한국청소년정책연구원이 실시한 '청소년 역량지수 측정 및 국제비교 연구I'에서 수집한 6,637명의 자료를 구조방정식으로 분석하였다. 그에 따르는 결과는 다음과 같다. 첫째, 청소년의 여가활용은 학습 적응성에 직접적인 영향을 미치는 것으로 나타났다. 둘째, 청소년의 여가활용은 대인관계에 직접적인 영향을 미치는 것으로 나타났다. 셋째, 청소년의 대인관계는 학습 적응성에 직접적인 영향을 미치고, 청소년의 여가활용과 학습 적응성 간 관계에서 부분 매개효과를 보였다. 이러한 결과는 청소년의 여가활용은 학습 적응성에 직접적인 영향을 미칠 뿐만아니라, 대인관계에 영향을 미치고 대인관계가 학습 적응성에 영향을 미치는 간접적인 경로를 의미한다. 연구결과를 토대로 청소년의 여가활용과 대인관계 측면에서 학습 적응성을 제고하기 위한 실천적 방안을 제시하였다.

• The Journal of Advanced Prosthodontics
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• 제10권3호
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• pp.252-258
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• 2018

PURPOSE. The purpose of this study was to evaluate the repeatability and matching accuracy between two identical intraoral spectrophotometers. MATERIALS AND METHODS. The maxillary right central incisor, canine, and mandibular left central incisor of each of 30 patients were measured using 2 identical intraoral spectrophotometers with different serial numbers (EasyShade V). The color of each shade tab from 3 shade guides (VITA 3D-Master) was also determined with both devices. All measurements were performed by a single operator. Statistical analyses were performed to verify the repeatability, accuracy, and the differences between the devices with paired t-tests, one-way ANOVA, and intra-class correlation coefficients (ICCs) (${\alpha}=.05$). RESULTS. A high level of measurement repeatability (ICC>0.90) among $L^*$, $a^*$, and $b^*$ color components was observed within and between devices (P<.001). Intra-device matching agreement rates were 80.00% and 81.11%, respectively, while inter-device matching agreement rate was 51.85%. ANOVA revealed no significant different color values within each device, while paired t-test provided significant different color values between both devices. The CIEDE2000 color differences between both devices were $2.28{\pm}1.61$ ${\Delta}E_{00}$ for in-vivo readings. Regarding the clinical matching accuracy of both devices, ${\Delta}E_{00}$ values between teeth and matching shade tabs were $3.05{\pm}1.19$ and $2.86{\pm}1.02$, respectively. CONCLUSION. Although two EasyShade V devices with different serial numbers show high repeatability of CIE $L^*$, $a^*$, and $b^*$ measurements, they could provide different color values and shade for the same tooth.

• 한국전문물리치료학회지
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• 제19권4호
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• pp.55-60
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• 2012

The trochanteric prominence angle test (TPAT) has been used to measure the femoral anteversion angle between the tibial crest and the vertical line. However, the exact anatomical reference of the tibial crest has not yet been identified in the literature. Thus, the purposes of this research were twofold: first, to compare the femoral anteversion angle measured at three different anatomical references of the tibial crest (the proximal tibial crest, the proximal third of tibial crest, and the proximal half of tibial crest) and, second, to determine inter-and intra-rater reliabilities of the femoral anteversion angle measured at these three different anatomical references of the tibial crest during the TPAT. We recruited 14 healthy subjects, and a total of 28 legs were examined. The TPAT was measured using a digital inclinometer. A 1-way repeated-measure analysis of variance was used to compare the femoral anteversion angle measured at three different anatomical references of the tibial crest, and intraclass correlation coefficients (ICCs) were calculated to determine reliability. The femoral anteversion angle measured at the proximal tibial crest was significantly higher than that at the proximal third of the tibial crest and the proximal half of the tibial crest. The inter-and intra-rater reliabilities of femoral anteversion angle were measured at three anatomic references of the tibial crest were all found to be high during the TPAT (ICC=.9 0~.98). In conclusion, clinicians should recognize that the different degrees of the femoral anteversion angle could be measured when different anatomical references of the tibial crest were used, and that reliabilities were high when an exact anatomical reference of the tibial crest was used during the TPAT.

• Imaging Science in Dentistry
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• 제44권2호
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• pp.95-102
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• 2014

Purpose: This study was performed to evaluate the reproducibility of panoramic radiographs of dentulous and edentulous patients. Materials and Methods: The reproducibility of panoramic radiographs was evaluated using the panoramic radiographs acquired from 30 anterior dentulous patients by using a common biting positioning device (dentulous group) and 30 anterior edentulous patients by using chin-support devices to take a panoramic radiograph (edentulous group), respectively; these patients had undergone 3 or more panoramic radiographs. The widths and angles between the designated landmarks were measured on the panoramic radiographs, and the reproducibility was evaluated using the intraclass correlation coefficient (ICC) and the coefficient of variation. Results: In the dentulous and edentulous groups, the ICCs of the mandibular ramus and mandibular angle areas were higher than the condylar head and zygomatic areas. The mandibular ramus and angle areas showed statistically lower mean coefficients of variation than the condylar head and zygomatic areas in the dentulous group. The mandibular angle area showed a significantly lower mean coefficient of variation than the zygomatic area in the edentulous group. By comparing the two groups, each ICC of the edentulous group was lower than that of the dentulous group, and the mean coefficients of variation of the mandibular ramus area, zygomatic area, left condylar inclination, and ramus ratio between the right and the left in the edentulous group were significantly higher than those in the dentulous group. Conclusion: Biting positioning for dentulous patients provided better positioning reproducibility than chin-support positioning when performing panoramic radiography for edentulous patients.

• Physical Therapy Rehabilitation Science
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• 제8권4호
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• pp.218-224
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• 2019

Objective: This reliability study examined the effects of applying varying induced inward pressures using a transducer placed at 0° neutral ankle position (NEU) and 15° ankle dorsiflexion (DF) on tibialis anterior (TA) muscle thickness using a custom-made device with a force indicator during rehabilitative ultrasound imaging. Design: Cross-sectional study. Methods: Twenty-four healthy subjects were recruited in this study. Two examiners measured the muscle thickness of the TA at 0° NEU and 15° DF in 3 conditions of inward pressures (1.0 N, 2.0 N, and 4.0 N) using a custom-made holder. The muscle thickness was measured three times for each of the conditions arranged in random order. For intra- and inter-rater reliability, the intraclass correlation coefficients (ICCs) with 95% confidence intervals, standard error of measurement, minimal detectable change, and coefficient of variation were analyzed. One-way repeated measures analysis of variance was conducted for investigating changes of TA muscle thickness according to the inward pressures of the transducers. Results: The intra-rater reliability of TA muscle thickness measurement was excellent (ICC_3,1: 0.92-0.96) for all conditions (at both ankle joint angles per varying inward pressure). Likewise, the inter-rater reliability of TA muscle thickness measurement was excellent (ICC_2,1: 0.89-0.97) under same conditions. The mean of TA thickness showed the trend of decreasing significantly with increased inward pressures at all ankle joint angles (p<0.05). Conclusions: Use of this custom-made device with a force indicator is useful to accomplish the high intra- and inter-rater reliability of TA muscle thickness measurement at both ankle joint angles in reducing the measurement error.