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Radiation Therapy for Primary Eyelid Cancers in Tunisia

  • Belaid, A;Nasr, C;Benna, M;Cherif, A;Jmour, O;Bouguila, H;Benna, F
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.7
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    • pp.3643-3646
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    • 2016
  • Management of eyelid cancers is based on surgery and/or radiotherapy (RT). The treatment objective is to control tumors with acceptable functional and esthetic outcomes. The aim of this study was to evaluate the results of radiation therapy in management of epithelial eyelid cancers, reviewing retrospectively the clinical records of patients treated in our institution from January 1989 to December 2013. We focused on clinical and histological features, treatment characteristics, tolerance and disease control. One hundred and eight patients (62 men and 46 women) were enrolled, with a mean age of 61 years [ranges 15-87]. The most frequent tumor location was the inner canthus (42.6%). Median tumor size was 21 mm [ranges 4-70]. Histological type was basal cell carcinoma in 88 cases (81.5%), squamous cell carcinoma in 16 (14.8%) and sebaceous carcinoma in 4 (3.7%). Radiation therapy was exclusive in 67 cases (62%) and post-operative for positive or close margins in the remaining cases. Kilovoltage external beam radiotherapy (KVRT) was used in 63 patients (58.3%) and low-dose-rate interstitial brachytherapy in 37 (34.3%). Eight (7.4%) were treated with cobalt or with a combination of KVRT-cobalt, KVRT-electron beams, KVRT-brachytherapy or cobalt-electron beams. The total delivered radiation doses were 70 Gy (2 Gy/fraction) in 62 patients (57.4%), 66 Gy (2 Gy/fraction) in 37 (34.3%) and 61.2 Gy (3.4Gy/fraction) in 9 (8.3%). After a median follow-up of 64 months, we noted 10 cases of local recurrences(9.2%): 7 after exclusive and 3 after post-operative RT. No local recurrence occurred in patients treated with brachytherapy. Actuarial 5-year local recurrence-free rate, disease-free survival and overall survival were respectively 90%, 90% and 97%. T-stage was found to be a significant factor for recurrence (p=0.047). All acute radiation-related reactions were scored grade I or II. Delayed effects were eye watering in 24 cases (22.2%), eye dryness in 19 (17.6%), unilateral cataract in 7 (6.4%) and ectropion in 4 (3.7%). Radiation therapy and especially brachytherapy is an efficient treatment of eyelid cancers, allowing eye conservation and functional preservation with good local control rates and acceptable toxicity.

Design of a Dual-band Snowflake-Shaped Microstrip patch Antenna With Short-pin For 5.2/5.8 GHz WLAN System (WLAN System을 위한 Short-Pin을 갖는 Snowflake 모양의 Dual-band(5.2/5.8 GBz) 마이크로스트립 패치 안테나 설계 및 제작)

  • Song, Jun-Sung;Choi, Sun-Ho;Lee, Hwa-Choon;Kwak, Kyung-Sup
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.34 no.4A
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    • pp.324-329
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    • 2009
  • In this paper, a novel Snowflake-shaped microstrip patch antenna for application in the WLAN(5.2/5.8GHz) band is designed and fabricated. The size of antenna is $21.2{\times}16mm^2$ and substrate is used Taconic-RF30. To obtain sufficient bandwidth in Return loss <-10dB and dual resonance characteristic, the Short-pin is inserted on the patch and the coaxial probe source is used. The measured results of fabricated antenna show 220MHz and 135MHz bandwidth in Return loss <-10dB referenced to the WLAN(5.2/5.8GHz) band. The measured antenna gain is $4.7{\sim}6.9dBi$ in the WLAN(5.2/5.8GHz) band. The experimental 3-dB beam width in I-plane and H-plane are $73.2^{\circ}/82.75^{\circ}$ for 5.1500Hz, $74.56^{\circ}/83.63^{\circ}$ for 5.3500Hz, and $86.24^{\circ}/85.15^{\circ}$ for 5.7850Hz, respectively.

CHARACTERISTICS OF HETEROEPITAXIALLY GROWN $Y_2$O$_3$ FILMS BY r-ICB FOR VLSI

  • Choi, S.C.;Cho, M.H.;Whangbo, S.W.;Kim, M.S.;Whang, C.N.;Kang, S.B.;Lee, S.I.;Lee, M.Y.
    • Journal of the Korean institute of surface engineering
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    • v.29 no.6
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    • pp.809-815
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    • 1996
  • $Y_2O_3$-based metal-insulator-semiconductor (MIS) structure on p-Si(100) has been studied. Films were prepared by UHV reactive ionized cluster beam deposition (r-ICBD) system. The base pressure of the system was about $1 \times 10^{-9}$ -9/ Torr and the process pressure $2 \times 10^{-5}$ Torr in oxygen ambience. Glancing X-ray diffraction(GXRD) and in-situ reflection high energy electron diffracton(RHEED) analyses were performed to investigate the crystallinity of the films. The results show phase change from amorphous state to crystalline one with increasingqr acceleration voltage and substrate temperature. It is also found that the phase transformation from $Y_2O_3$(111)//Si(100) to $Y_2O_3$(110)//Si(100) in growing directions takes place between $500^{\circ}C$ and $700^{\circ}C$. Especially as acceleration voltage is increased, preferentially oriented crystallinity was increased. Finally under the condition of above substrate temperature $700^{\circ}C$ and acceleration voltage 5kV, the $Y_2O_3$films are found to be grown epitaxially in direction of $Y_2O_3$(1l0)//Si(100) by observation of transmission electron microscope(TEM). Capacitance-voltage and current-voltage measurements were conducted to characterize Al/$Y_2O_3$/Si MIS structure with varying acceleration voltage and substrate temperature. Deposited $Y_2O_3$ films of thickness of nearly 300$\AA$ show that the breakdown field increases to 7~8MV /cm at the same conditon of epitaxial growing. These results also coincide with XPS spectra which indicate better stoichiometric characteristic in the condition of better crystalline one. After oxidation the breakdown field increases to 13MV /cm because the MIS structure contains interface silicon oxide of about 30$\AA$. In this case the dielectric constant of only $Y_2O_3$ layer is found to be $\in$15.6. These results have demonstrated the potential of using yttrium oxide for future VLSI/ULSI gate insulator applications.

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Surface Characteristics of Type II Anodized Ti-6Al-4V Alloy for Biomedical Applications

  • Lee, Su-Won;Jeong, Tae-Gon;Yang, Jae-Ung;Jeong, Jae-Yeong;Park, Gwang-Min;Jeong, Yong-Hun
    • Proceedings of the Korean Institute of Surface Engineering Conference
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    • 2017.05a
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    • pp.77-77
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    • 2017
  • Titanium and its alloys offer attractive properties in a variety of applications. These are widely used for the field of biomedical implants because of its good biocompatibility and high corrosion resistance. Titanium anodizing is often used in the metal finishing of products, especially those can be used in the medical devices with dense oxide surface. Based on SAE/AMS (Society of Automotive Engineers/Aerospace Material Specification) 2488D, it has the specification for industrial titanium anodizing that have three different types of titanium anodization as following: Type I is used as a coating for elevated temperature forming; Type II is used as an anti-galling coating without additional lubrication or as a pre-treatment for improving adherence of film lubricants; Type III is used as a treatment to produce a spectrum of surface colours on titanium. In this study, we have focused on Type II anodization for the medical (dental and orthopedic) application, the anodized surface was modified with gray color under alkaline electrolyte. The surface characteristics were analyzed with Focused Ion Beam (FIB), Scanning Electron Microscopy (SEM), surface roughness, Vickers hardness, three point bending test, biocompatibility, and corrosion (potentiodynamic) test. The Ti-6Al-4V alloy was used for specimen, the anodizing procedure was conducted in alkaline solution (NaOH based, pH>13). Applied voltage was range between 20 V to 40 V until the ampere to be zero. As results, the surface characteristics of anodic oxide layer were analyzed with SEM, the dissecting layer was fabricated with FIB method prior to analyze surface. The surface roughness was measured by arithmetic mean deviation of the roughness profile (Ra). The Vickers hardness was obtained with Vickers hardness tester, indentation was repeated for 5 times on each sample, and the three point bending property was verified by yield load values. In order to determine the corrosion resistance for the corrosion rate, the potentiodynamic test was performed for each specimen. The biological safety assessment was analyzed by cytotoxic and pyrogen test. Through FIB feature of anodic surfaces, the thickness of oxide layer was 1.1 um. The surface roughness, Vickers hardness, bending yield, and corrosion resistance of the anodized specimen were shown higher value than those of non-treated specimen. Also we could verify that there was no significant issues from cytotoxicity and pyrogen test.

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Estimation Method of Creep Coefficient in Concrete Structures (콘크리트 구조물에서 크리프 계수 추정 방법)

  • Park, Jong-Bum;Park, Jung-Il;Chang, Sung-Pil;Cho, Jae-Yeol
    • Journal of the Korea Concrete Institute
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    • v.21 no.5
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    • pp.619-628
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    • 2009
  • To predict the time-dependent behavior of concrete structures, the models which describe the time-dependent characteristics of concrete, i.e. creep and shrinkage are required. However, there must be significant differences between the displacements that are obtained using the given creep and shrinkage models and the measured displacements, because of the uncertainties of creep and shrinkage model itself and those of environmental condition. There are some efforts to reduce these error or uncertainties by using the model which are obtained from creep test for the concrete in construction site. Nevertheless, the predicted values from this model may be still different from the actual values due to the same reason. This study aimed to propose a method of estimating the creep coefficient from the measured displacements of concrete structure, where creep model uncertainty factor was considered as an error factor of creep model. Numerical validation for double composite steel box and concrete beam showed desirable feasibility of the presented method. Consideration of the time-dependent characteristics of creep as one of the error factors make it possible to predict long-term behaviors of concrete structures more realistically, especially long-span PSC girder bridges and concrete cable-stayed bridges of which major problem is the geometry control under construction and maintenance.

Surficial Sediment Classification using Backscattered Amplitude Imagery of Multibeam Echo Sounder(300 kHz) (다중빔 음향 탐사시스템(300 kHz)의 후방산란 자료를 이용한 해저면 퇴적상 분류에 관한 연구)

  • Park, Yo-Sup;Lee, Sin-Je;Seo, Won-Jin;Gong, Gee-Soo;Han, Hyuk-Soo;Park, Soo-Chul
    • Economic and Environmental Geology
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    • v.41 no.6
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    • pp.747-761
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    • 2008
  • In order to experiment the acoustic remote classification of seabed sediment, we achieved ground-truth data(i.e. video and grab samples, etc.) and developed post-processing for automatic classification procedure on the basis of 300 kHz MultiBeam Echo Sounder(MBES) backscattering data, which was acquired using KONGBERG Simrad EM3000 at Sock-Cho Port, East Sea of South Korea. Sonar signal and its classification performance were identified with geo-referenced video imagery with the aid of GIS (Geographic Information System). The depth range of research site was from 5 m to 22.7 m, and the backscattering amplitude showed from -36dB to -15dB. The mean grain sizes of sediment from equi-distanced sampling site(50 m interval) varied from 2.86$(\phi)$ to 0.88(\phi). To acquire the main feature for the seabed classification from backscattering amplitude of MBES, we evaluated the correlation factors between the backscattering amplitude and properties of sediment samples. The performance of seabed remote classification proposed was evaluated with comparing the correlation of human expert segmentation to automatic algorithm results. The cross-model perception error ratio on automatic classification algorithm shows 8.95% at rocky bottoms, and 2.06% at the area representing low mean grain size.

The consideration about the shielding effect of LEDITE (LEDITE를 이용한 방사선 차폐시설에 관한 고찰)

  • Min Je-soon;Lee Je-hee;Park heung-deuk
    • The Journal of Korean Society for Radiation Therapy
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    • v.15 no.1
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    • pp.11-18
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    • 2003
  • The concrete is usually used to build a radiation therapy facility and the enough concrete thickness for high energy x-ray beam is about 1 meter. But if the space is not enough to build a radiation therapy facility with concrete, the substitute for concrete is needed, and the Ledite can be a good substitute for concrete. In this study, we compared the Ledite with the concrete. The comparing list are the needed shielding thickness, the period of construction and the cost.

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On the Development of the Generalized Slope Deflection Method for the Analysis and Design of Ship Structures (선체(船體) 구조(構造) 해석(解析) 및 설계(設計)를 위한 일반화(一般化) 경사(傾斜) 처짐법(法) 개발(開發)에 관한 연구(硏究))

  • Chang-Doo Jang;Seung-Soo Na
    • Journal of the Society of Naval Architects of Korea
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    • v.29 no.4
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    • pp.202-213
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    • 1992
  • For the analysis and design of ship structures the generalized slope deflection method(GSDM) taking account of axial elongation effect as well as the bending and shearing deformation is developed. Using the span point concept, the existing slope deflection method is easy to transform the variable section to the equivalent uniform one under the bending moment and the shear force, but it is difficult to analyze the web frame with inclined members because the axial deformation effect is not considered. In the present method, the equilibrium conditions including all force components(i.e. axial force, shear force, bending moment) are formulated at the both ends of the variable section beam, such that the usual space frame stiffness equation which can be solved easily by the matrix method is derived. The accuracy and applicability of the present method is demonstrated by analyzing the ship web frame structures.

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Design and Growth of InAs Multi-Quantum Dots and InGaAs Multi-Quantum Wells for Tandem Solar Cell (텐덤형 태양전지를 위한 InAs 다중 양자점과 InGaAs 다중 양자우물에 관한 연구)

  • Cho, Joong-Seok;Kim, Sang-Hyo;HwangBoe, Sue-Jeong;Janng, Jae-Ho;Choi, Hyon-Kwang;Jeon, Min-Hyon
    • Journal of the Korean Vacuum Society
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    • v.18 no.5
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    • pp.352-357
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    • 2009
  • The InAs multi-quantum dots (MQDs) solar cell and InGaAs multi-quantum wells (MQWs) solar cell to cover 1.1 eV and 1.3 eV were designed by 1D poisson, respectively. The MQDs and MQWs of 5, 10, 15 layers were grown by molecular beam epitaxy. The photo luminescence results showed that the 5 period stacked MQDs have the highest intensity at around 1.1 eV with 57.6 meV full width at half maximum (FWHM). Also we can observe 10 period stacked MQWs peak position which has highest intensity at 1.31 eV with 12.37 meV FWHM. The density and size of QDs were observed by reflection high energy electron diffraction pattern and atomic force microscope. Futhermore, AlGaAs/GaAs sandwiched tunnel junctions were modified according to the width of GaAs layer on p-type GaAs substrates. The structures with GaAs width of 30 nm and 50 nm have backward diode characteristics. In contrast, tunnel diode characteristics were observed in the 20 nm of that of sample.

Effects of Annealing on Ni/Au Ohmic Contact to Nonpolar p-type GaN

  • Lee, Dong-Min;Kim, Jae-Gwan;Yang, Su-Hwan;Kim, Jun-Yeong;Lee, Seong-Nam;Lee, Ji-Myeon
    • Proceedings of the Korean Vacuum Society Conference
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    • 2012.02a
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    • pp.358-359
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    • 2012
  • 최근 분극 특성이 상이한 무분극 GaN 에피성장에 관한 심도 있는 연구와 함께 전자-전공 캐리어의 주입 및 캐리어의 거동, 방출되는 편광 특성 및 다양한 물리적 특성들에 대해 보고되고 있으며, 광학적 특성 및 물리적 특성의 확보를 위한 많은 연구가 활발히 진행 중이다 [1]. GaN의 ohmic 접촉(ohmic contact)의 형성은 발광 다이오드(light emitting diode), 레이저 다이오드(Laser), 태양전지(solar cell)와 같은 고신뢰도, 고효율 광전자 소자를 제조하기 위해서는 매우 중요하다 [2]. 그러나 이와 함께 병행 되어야 할 무분극 p-GaN 의 ohmic contact에 관한 연구는 많이 이루어지고 있지 않는 실정이다. 따라서 본 논문에서는 r-plane 사파이어 기판 상에 성장된 p-GaN에서의 ohmic 접촉 형성 연구를 위하여 Ni/Au ohmic 전극의 접촉저항 특성을 연구하였다. 본 실험에서는 성장된 a-plane GaN의 Hole농도가 $3.09{\times}1017cm3$ 인 시편을 사용하였다. E-beam evaporation 장비를 이용하여 Ni/Au를 각각 20 nm 그리고80 nm 증착 하였으며 비접촉저항을 측정하기 위해 Circle-Transfer Length Method (C-TLM) 패턴을 사용하였다. 샘플은 RTA (Rapid Thermal Annealing)를 사용하여 $300^{\circ}C$에서 $700^{\circ}C$까지 온도를 변화시키며 전기적 특성을 비교하여 그림 1(a) 나타내었다. 그림에서 알 수 있듯이 $400^{\circ}C$에서 가장 낮은 비접촉저항 값인 $6.95{\times}10-3{\Omega}cm2$를 얻을 수 있음을 발견하였다. 이 때의 I-V curve 도 그림1(b)에 나타낸 바와 같이 열처리에 의해 크게 향상됨을 알 수 있다. 그러나, $500^{\circ}C$ 이상 온도를 증가시키면 다시 비접촉 저항이 증가하는 것을 관찰하였다. XRD (x-Ray Diffraction) 분석을 통하여 $400^{\circ}C$ 이상열처리 온도가 증가하면 금속 표면에 $NiO_2$가 형성되며, 이에 따라 오믹특성이 저하 된다고 사료된다. 또한 $Ni_3N$의 존재를 확인 하였으며 이는 nonpolar surface의 특성으로 인해 nitrogen out diffusion 현상이 동시에 발생하여 계면에는 dopant로 작용하는 질소 공공을 남기고 표면에 $Ni_3N$을 형성하여 ohmic contact의 특성이 저하되기 때문인 것으로 사료된다.

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