• Journal of agricultural medicine and community health
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• v.18 no.1
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• pp.43-54
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• 1993

In order to find the factors associated with the death of hypertensives, 12 year follow-up study for 267 hypertensives whose average blood pressure were 140/90 mmHg or above during their first health screening in 1979-1980 at YongJin Township, Wanju Country, North Cholla Province by the Community Health Team of Chonju Presbyterian Medical Center. The study results are as follows : 1. Initial general characteristics of hypertensives were studied. The age distribution of studied hypertensives showed 27.3% in 40-49 years, 25.8% in 50-59 years, 29.6% in 60-69 years and 17.2% In 70 + years old group. Marital status showed that 82.8% of hypertensives had their wife or husband. 74. 5% were employed on agriculture. 56.5% of hypertensives were illiterate. 2. Among the hypertensives, 91.6% of male and 22.8% of female reported that they were smokers. 82.6% of hypertensives had body mass index lower than 25 Kg/$m^2$. 46.8% of average systolic blood pressure were 160mmHg or above and 54.3% of average diastolic blood pressure were 95mmHg or above. 3. Twenty percent of hypertensives reported that they were treating hypertension at the beginning of follow up, while 68.5% reported that they were not treated. 28.1% reported that they were treating hypertension within 6 months before last follow-up. but 69.3% reported that they were not treated for hypertension within Ii months before last follow up. So 50.6% were classified as never treated group and 41.2% as treated group. 4. Average blood pressure for initial 3 years were calculated. The change of average systolic blood pressure was observed as $161.3{\pm}19.4mmHg$ at the first year, $145.6{\pm}28.0mmHg$ at the second year and $141.4{\pm}37.2mmHg$ at the third year. Average diastolic blood pressure were changed from $96.2{\pm}14.4mmHg$ at the first year to $90.6{\pm}18.6mmHg$ at the second year and $86.4{\pm}22.9mmHg$ at the third year. 5. By the follow-up of hypertensives, 54 hypertensives (46.2%) among 117 male hypertensives and 50 hypertensives (33.3%) among 150 female hypertensives died for 12 years. 42.6% of male death and 52.0% of female death were caused by cerebrovascular diseases. 6. Through univariate statistical test about the association between general characteristics or cardiovascular risk factors of hypertensives and mortality for 12 years, age variable among male and among female age, marital status, occupation. educational level. systolic blood pressure and treatment status were shown as significant variable to influence upon the mortality. 7. By multiple logistic regression analysis, among male age and systolic blood pressure were selected as significant variable to be associated with the total mortality for 12 years. Among female age, systolic blood pressure and treatment status were selected as statistically significant variable to be associated with the total mortality for 12 years.

• Research in Community and Public Health Nursing
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• v.9 no.2
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• pp.350-361
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• 1998

In an attempt to examine the risk factors and analyze an odds ratio for risk factors associated with mild and moderate. severe hypertension, this study was carried out from August, 1987 to September, 1997. From periodic health examinations of insured adults, 747 subjects were assigned to nomotensives, mild hypertensives and moderate' severe hypertensives. Major findings obtained from the study are as follows: 1. The Body mass index(BMI) was revealed a significant difference among the 3 groups. Also, there was a significant positive correlation between the BMI and systolic, dyastolic blood pressure. 2. Cholesterol was revealed to be significantly different among the 3 groups. Also, there was a significant positive correlation between the cholesterol and systolic, dyastolic blood pressure. 3. Urine protein and a cardiovascular family history was revealed to be significantly different among the 3 groups. The presence of urine protein and cardiovascular family history were significantly higher in hypertensives than nomotensives. 4. A preference for salty food, a preference for flesh and the frequency of flesh eating were not significantly different among the 3 groups. 5. Smoking habits, frequency and duration of cigarette smoking were not significantly different among 3 groups. 6. The habit of alcohol consumption and the frequency and duration of alcohol consumption were not significantly different among the 3 groups. 7. The habit of exercise and its frequency and duration were not significantly different among the 3 groups. 8. Statistically significant elevated odds ratios were noted in the following BMI(mild hypertensives; 2.48, moderate. severe hypertensives ; 4.65), urine protein(mild hypertensives ; 2.37, moderate. severe hypertensives; 6.77), cholesterol(moderate. severe hypertensives ;1.64), cardiovascular family histoy(moderate severe hypertensives; 4.77). Based on these results, the significant risk factors of mild, moderate. severe hypertension were BMI, cholesterol, urine protein, and family history, but diet, smoking, alcohol consumption, and exercise had no significant association.

• The Journal of Internal Korean Medicine
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• v.29 no.4
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• pp.950-961
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• 2008

Objectives : The purpose of this study was to compare cerebral biood flow between hypertensives and normotensives using transcranial doppler ultrasonography (TCD). Methods : I investigated cerebral blood flow of 72 hypertensives and 127 normotensives. To evaluate the cerebral blood flow, I measured the systolic peak velocity(Vs) and mean How velocity (Vm) of the middle cerebral artery(MCA), anterior cerebral artery(ACA), posterior cerebral artery(PCA), basilar artery(BA), and internal carotid artery(ICA) in the two groups using TCD. Result : 1. There was a decrease in the Vs and Vm of all examined vessels of hypertensives in comparison with normotensives. There was a significant difference in the Vs of ACA and Vm of ACA, PCA, ICA. 2. In males, there was a decrease in the Vs of ACA, PCA, ICA and Vm of MCA, ACA, PCA, ICA of hypertensives in comparison with normotensives. However, there was no significant difference in the Vs or Vm of all examined vessels. 3. In females, there was a decrease in the Vs and Vm of all examined vessels of hypertensives in comparison with normotensives. There was a significant difference in the Vs of MCA, ACA and BA and Vm of ACA, PCA and BA. 4. In 30-49 year-olds, there was a decrease in the Vs and Vm of all examined vessels of hypertensives in comparison with normotensives. There was a significant difference in the Vs of ACA and Vm of ACA. 5. In 50-69 year-olds, there was a decrease in the Vs of ACA, PCA, BA, ICA and Vm of all examined vessels of hypertensives in comparison with normotensives. However, there was no significant difference in the Vs or Vm of all examined vessels. 6. In 70-89 vests old. there was a decrease in the Vs. Vm of PCA, BA, ICA of hypertensives in comparison with normotensives. But, there was no significant difference in the Vs, Vm of all examined vessels. Conclusions : There was a significant difference in the cerebral blood now velocity between hypertensives and normotcnsives. These results suggest that blood pressure has influence on cerebral blood flow.

• Korean Journal of Health Education and Promotion
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• v.20 no.3
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• pp.207-219
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• 2003

This study was conducted to identify the effects of the comprehensive nursing aided self-help program for hypertensives. The program educates hypertensives in community areas about blood pressure, self-care, health promoting behaviors, and life satisfaction. For this purpose a one group time series design was used. Sixteen subjects were evaluated from S Community Health center of B city. Self-help programs developed by the author were given to the subjects. The program consisted of group education on hypertension and self-care including blood pressure self-monitoring, recording of self-care activities, and encouraging and reinforcing self-help. The whole program was carried out from October to December in 2002. Data was analyzed by repeated measure ANOVA, and post-hoc Turkey. The results were as follows： There were significant relationships between changes in systolic pressure(F＝10.638. P=.000), diastolic pressure(F＝6.783. p＝.013), self-care(F＝13.506. p＝.000), and health promoting behavior(F＝9.067. p＝.001) at the 6th week and the 9th week. There were no significant relationships between changes in life satisfaction at the 6th week or 9th week. From these results, it can be concluded that the self-help program is an effective nursing strategy to promote self-care of hypertensives in community areas.

• Research in Community and Public Health Nursing
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• v.8 no.1
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• pp.45-60
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• 1997

Essential hypertension is a typical chronic disease requiring adequate and continuous management. Many studies supported that self-care was the essential factor to promote the wellbeing of hypertensives and self-efficacy increased healthy, behavior. The comprehensive self-regulation program was conducted as a nursing intervention on the promotion self-care performance for hypertensives in company. And this self-regulation program was recommended to apply for hypertensives in rural area. The purpose of this study is to identify the general characteristics affecting self-care and interrelationship among the factors including self-care, self-efficacy, HLOC, perceived benefits, barriers and family support. 40 subjects were interviewed from Dec. 1996 to Jan. 1997 and the data was analyzed by the SPSS PC+ program with t-test and multiple correlation to determine the variables affecting the self-care behavior. The results were as follows: 1) Level of self-care was significant difference according to sex(t= -2.27, p=.0l9). religion (t=1.57, p=.055) and smoking habit (t=4.42, P=.000). Perceived self-efficacy was more significantly high among the non-smoking group (t=3.25, P=.000) and female group (t=-2.534, p=.0l3). 2) There were significant positive correlation among the variables: self-care and self-efficacy (r=.5460, p=.000), external-LOC and self-care(r=.2548, p=.056), external-LOC and self-efficacy(r =. 2901, p=.035), self-efficacy and perceived benefits (r=3307, p=.019). And there were significant negative correlation between self-care and barriers (r=-.5438, p=. 000), self-efficacy and barriers (r= - .4153, p=.004). From the above results, it can be concluded that the self-care is more required in male hypertensives and self-efficacy is one of the important factors to increase healthy behavior in cluding self-care. Thus self-regulation program can be recommended in the management of the hypertensives in community settings.

• Korean Journal of Psychosomatic Medicine
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• v.3 no.1
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• pp.19-27
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• 1995

A comparison was made regarding the extent of anger between 50 hypertensives and 50 normotensives, using anger scale. In addition, correlation was investigated between the extent of anger and biological variables such as systolic and diastolic blood pressure, serum total cholesterol, high density lipoprotein(HDL) and triglyceride in each of both the groups. The two groups were matched to each other regarding age, sex, the level of education and body mass index(BMI). The hypertensives scored significantly higher than normotensives in anger suppression, whereas normotensives scored significantly higher than hypertensives in anger expression. In hypertensives, scores of anger suppression and anger expression did not significantly correlate with blood pressure, serum total cholesterol, HDL and triglyceride, respectively. In normotensives, however, scores of anger suppression correlated positively with systolic blood pressure. Male hypertensives scored significantly higher than female hypertensives regarding anger expression, whereas male normotensives scored significantly higher than female normotensives regarding anger expression and anger total subscale, respectively. These results suggest that hypertensives suppressed more anger than normotensives, and that anger suppression in normotensives was more likely to increase blood pressure, supporting the previous reports that suppressed anger may be related to hypertension.

• Research in Community and Public Health Nursing
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• v.12 no.1
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• pp.202-213
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• 2001

This study was conducted to identify the changes of the relationship among general characteristics, self-efficacy. and self-care of the hypertensives in rural area. For this purpose, self-regulation program was carried at two Community Health Practitioner Post located in the suburbs of Daejeon City from September to November. 1999. Data were analyzed with non-parametric statistics, t-test, pearson correlation. The results were as follows; 1. The level of self-care was significantly different according to sex, status of smoking, and the level of self-efficacy of non-smoker was significantly higher than smoker. 2. After self-regulation program, there were significant positive relationship among self-efficacy, self-care, internal locus control, and negative relationship between perceived barrier and self-care. From these results, it can be concluded that the self-regulation program is an effective nursing strategy to promote self-care performance of hypertensives in rural area, and this program can be recommended for the management of hypertensives.

• Research in Community and Public Health Nursing
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• v.6 no.2
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• pp.234-249
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• 1995

Essential hypertension, one of the leading primary cause of death in Korea, is a typical chronic disease requiring adequate and continuous management. Though these hypertensives need to maintain desirable health practice by themselves for their life time, many previous studies indicated that most of the essential hypertensives have no specific symptoms and thus, reluctant to follow appropriate medical regimens causing the condition further aggravated and complicated. Thus the comprehensive self-regulation program was conducted as a nursing intervention on the promotion self-care 'performance and improvement in physical parameters of hypertensives. For this purpose, a one group quasi -experimental research with pre and post test design was used. And the whole program was carried out from October, 1993 to February, 1994. Self-regulation program was consisted with group education on hypertension and self-care, self-regulation including the blood pressure self-monitoring and recording, recording of daily self-care activities, and encouraging and reinforcing self-efficacy through verbal persuation and enactive attainment. The subjects were asked to measure their own blood pressure by themselves twice per day and to record blood pressure and the daily self-care performance according to the instructions provided during the whole period of 9 weeks. The data was analyzed by experimental stages: the first week, the fifth week, and the ninth week since the experimental imput began. Data were analyzed by the SPSS PC+ program with paired t -test and F-test, and multiple correlation to determine the variables affecting the effect of program. The results were as follows : 1) Subjects in J company were significantly lower diastolic blood pressure than K company after the program (t=2.39, p=.024). Level of cholesterol was significant difference according to position(t=2.23, p=.034), family history (t=-2.66, p=.013), diagnosis duration, and career(t=2.88, p=.055). Perceived self-efficacy was more significantly increased among the group with family history(t=-3.00, p=.013). 2) Before the program, there were significant positive correlation among the variables: internal-LOC and self-efficacy(r=.3952, p=.015), external-LOC and barriers (r=.6515, p=.000), chance-LOC and Barriers(r=.4133, p=.012). However there were significant negative correlation between internal-LOC and barriers (r=-.3236, p=.041, external-LOC and self -efficacy(r=-.3517, p=.028), self-efficacy and barriers(r=-.6654, p=.000). 3) There were significant relationships between changes in self - care performance and self-efficacy at 5th week (r=.5313, p=.001) and changes in self-efficacy at 9th week(r=.4586, p=.005). 4) After the program, internal health locus of control and perceived benefits showed significant correlation(r=.5673, p=.001, but perceived barriers was negative correlation with perceived self-efficacy (t=-4242, p=.01). From the above results, it can be concluded that the self-regulation program is an effective nursing strategy through the change of variables to promote self-care performance of hypertensives and to increase the self-efficacy. Thus this program can be recommended in the management of the hypertensives in workplaces and community settings.

• Animal cells and systems
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• v.8 no.1
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• pp.41-47
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• 2004

The kallikrein-kinin system affects regulation of blood pressure, and genes encoding for the components of this system have been considered as good candidates for hypertension. To evaluate the relationship between genetic polymorphisms of candidate genes involved in this system and hypertension, we performed case-control studies using genetic markers in Korean normotensives and hypertensives, respectively. By association study, there was a marginal association with hypertension in AA genotype distribution of A1789G polymorphism in the hKLK1 gene (P=0.0754). Thus, this genetic polymorphism may weakly contribute to the susceptibility to hypertension in Koreans. We also observed that significant linkage disequilibrium exists among three polymorphic sites in the hKLK1 gene studied, suggesting that the three genetic polymorph isms can be useful as genetic markers in clinical association studies. Further studies using larger sample sizes and more genetic markers will be needed to clarify genetic influence of kallikrein-kinin system for hypertension.

• Environmental Analysis Health and Toxicology
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• v.20 no.3 s.50
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• pp.249-258
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• 2005

Blood pressure, obesity and bone mineral density are multifactorial traits influenced by genetic factor. The purpose of this study was to clarify the association between three genetic polymorphisms in the estrogen receptor-$\alpha$ (ER -$\alpha$) gene and essential hypertension in korean population. One hundred and seventy-one people including 90 normotensives and 81 essential hypertentives were recruited. Among genetic polymorphisms studied, the Xba I RFLP in the intron 1 of this gene polymorphism was significantly associated with essential hypertension in women, suggesting the sexual dimorphism in genetic effect (P (<) 0.05). Further studied suggest that a larger sample size of this study are needed.