Browse > Article

The Distributions of Three Genetic Polymorphisms in the Estrogen $Receptor-\alpha$ Gene in Korean Essential Hypertensives  

Kim Ji Young (Dept. of Life Science, Sahmyook University)
Kang Byung Yong (Research Institute for Life Science, Sahmyook University)
Lee Kang Oh (Dept. of Life Science, Sahmyook University)
Publication Information
Environmental Analysis Health and Toxicology / v.20, no.3, 2005 , pp. 249-258 More about this Journal
Abstract
Blood pressure, obesity and bone mineral density are multifactorial traits influenced by genetic factor. The purpose of this study was to clarify the association between three genetic polymorphisms in the estrogen receptor-$\alpha$ (ER -$\alpha$) gene and essential hypertension in korean population. One hundred and seventy-one people including 90 normotensives and 81 essential hypertentives were recruited. Among genetic polymorphisms studied, the Xba I RFLP in the intron 1 of this gene polymorphism was significantly associated with essential hypertension in women, suggesting the sexual dimorphism in genetic effect (P (<) 0.05). Further studied suggest that a larger sample size of this study are needed.
Keywords
Estrogen Receptor-alpha; Cene Polymorphism and Essential Hypertensives;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Henderson BE, Ross RK, Paganini-Hill A and Mark TM. Estrogen use and cardiovascular disease, Am. J. Obstet. Gynecol. 1986; 154: 1181-1186   DOI
2 Lehrer S, Rabin J, Kalir T and Schachter BS. Estrogen receptor variant and hypertension in women, Hypertension 1993; 21: 439-441   DOI
3 Lehrer S, Sanchez M, Song HK, Dalton J, Levine E, Savorettii P, Thung SN and Schachter B. Estogen receptor B-region polymorphism and spontaneous abortion in women with breast cancer, Lancet 1990; 335: 622-624   DOI   ScienceOn
4 Matsubara Y, Murata M, Kawano K, Zama T, Aoki N, Yoshino H, Watanabe G, Ishikawa K and Ikeba Y. Genotype distribution of estrogen receptor polymorphisms in men and postmenopausal women from healthy and coronary populations and its relation the serum lipid levels, Arterioscler. Thromb. Vasc. Biol. 1997; 17: 3006-3012   DOI
5 Ponglikitmongkol M, Green S and Cambon P. Genomic organization of the human estrogen receptor gene, EMBO J. 1988; 7: 3385-3388
6 Sambrook J, Fritsch EF and Maniatis T. Molecular cloning - a Laboratory Manual, 2nd edition. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press. pp. 9. 16-9. 17., 1989
7 Stampfer MJ, Colditz GA and Willet WC. Postmenopausal estrogen therapy and cardiovascular disease: ten-year follow-up from the nurses; Health Study, N. Engl. J. Med. 1991; 325: 756-762   DOI   ScienceOn
8 Orimo JC, Morrison NA, Nguyen TV, White CP, Kelly PJ, Sambrook PN and Eisman JA. Estrogen receptor genotype and bone mineral density in women and men, J. Bone. Miner. Res. (Suppl) 1995; 10: S170
9 Veldhuis JD and Gwynne JT. Estrogen regulates low density lipoprotein metabolism by cultured swine granulose cells, Endocrinology 1985; 117: 1985
10 박소라, 박재은, 황정규, 정필호, 임창훈, 정호연, 한기옥, 윤현구, 장학철, 한인권, 폐경 후 여성에서 에스트로젠 치료에 대한 혈중 지질의 반응과 에스트로겐 수용체 다형성과의 관계, 대한내분비학회지 1999; 14: 553-561
11 Kobayashi S, Inoue S, Hosoi T, Ouchi Y, Shiraki M and Orimo H. association of bone mineral density with polymorphism of the estrogen receptor gene, J. Bone Miner. Res. 1996; 11: 306-311   DOI   ScienceOn
12 이지현, 임승길, 원영준, 권석호, 차봉수, 송영득, 이현철, 허갑범, 정봉철, 한국인 폐경 후 여성에서 에스트로젠 수용체 유전자 다형성 및 뇨중 에스트로젠 대사물과 골밀도와의 상관성, 대한내분비학회지 1996; 11: 468-478
13 Willing M, Sowers M, Aron D, Clark MK, Burns T, Bunten C, Cutchfield M, D' Agostino D and Jannausch M. Bone mineral density and its change in white women: estrogen and vitamin D receptor genotypes and their interaction, J. Bone Miner. Res. 1998; 13: 695-705   DOI   ScienceOn
14 Mizunuma H, Hosoi T, Okano H, Soda M, Tokizawa T, Kagami I, Miyamoto S, Ibuki Y, Inoue S, Shiraki M and Ouchi Y. Estrogen receptor gene polymorphism and bone mineral density ate the lumbar spine of pre- and postmenopausal women, Bone 1997; 21: 379-383   DOI   ScienceOn
15 Sacks FM and Walsh BW. The effects of reproductive hormones on serum lipoproteins: unresolved issues in biology and clinical practice, Ann. N. Y. Acad. Sci. 1990; 592: 272-285   DOI   PUBMED   ScienceOn
16 Saiki RK, Gelfand DH, Stoffel S, Scharf SJ, Higuchi R, Horn GT, Mullis, KB and Erlich HA. Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase, Science 1988; 239: 487-491   DOI   PUBMED
17 Walsh BW, Schiff I, Rosner B, Greenberg L, Ravnikar V and Sacks FM. Effects of postmenopausal estrogen replacement on the concentrations of plasma lipoproteins, N. Engl. J. Med. 1991; 325: 1196-1204   DOI   ScienceOn
18 Yaich L, Dupont WD, Cavener DR and Parl FF. Analysis of the Pvu II restriction fragment length polymorphism and exon structure of the estrogen receptor gene in breast cancer and peripheral blood, Cancer Res. 1992; 52: 77-83
19 Fridewald WT, Levy RI and Friedrickson, DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma without the use of the preparative ultracentrifuge, Clin. Chem. 1972; 18: 499-502
20 Garcia T, Sanchez M, Cox JL, Shaw PA, Ross JBIA, Lehrer S and Schachter B. Identification of a variant from of the human estrogen receptor with an amino acid replacement, Nucleic Acids Res. 1989; 17: 8364   DOI   ScienceOn
21 Bostein D, White RL, Skolnick M and Davis RW. Construction of a genetic linkage map in man using restriction fragment length polymorphisms, Am. J. Hum. Genet. 1980; 32: 314-331
22 Zuppan PJ, Hall JM, Ponlukitmongkol M, Spelman R and King MC. Polymorphisms at the estrogen receptor locus and linkage relationships on chromosome 6q, Cytogenet. Cell genet. 1989; 51: 1116
23 Patrick TS, Yamamoto T, Goldstein JL and Brouwn MS. Increased mRNA for low density lipoprotein receptor in liver of rabbits trated with 17-ethinyl estradiol, Proc. Natl. Acad. Sci. USA 1986; 83: 792-796   DOI
24 Windler EE, Kovanen PT, Caho YS, Brown MS, Havel RJ and Goldstein JL. The estradiol-stimulated lipoprotein receptor of rat liver, J. Biol. Chem. 1980; 255: 10464-10471
25 Riis BJ, Rodbro P and Christiansen C. The role of serum concentrations of sex steroids and bone turnover in the development and occurrence of postmenopausal osteoporosis, Clacif. Tissue Int. 1986; 38: 318-322   DOI   ScienceOn
26 Stampfer MJ and Colditz GA. Estrogen replacement and coronary heart disease: A quantitative assessment of the epidemiologic evidence, Prev. Med. 1991; 20: 47-63   DOI   ScienceOn
27 김홍규, 김상옥, 김은숙, 김기수, 한국인 여성에서 비타민 D수용체 유전자, 에스트로젠 수용체 유전자 및 제l형 콜라겐 $\alpha$1 유전자의 다형성과 최대골량의 연관성에 관한 연구, 대한내분비학회지 2001; 16: 97-114
28 Albagha OM, McGuigan FE, Reid DM and Ralston SH. Estrogen receptor alpha gene polymorphisms and bone mineral density: haplotype analysis in women from the United Kingdom, J. Bone Miner. Res. 2001; 16: 128-134   DOI   ScienceOn