• 생약학회지
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• 제32권2호통권125호
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• pp.145-152
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• 2001

Whangryunhaedok-Tang (WT) is formulated with Coptidis Rhizoma, Phellodendri Cortex, Scutellariae Radix and Gardeniae Fructus, and Daewhang-whangryunhaedok-Tang (DWT) is made by the combination of Rhei Rhizoma, a wellknown anticostipation drug in WT. Therefore, DWT has been evaluated for antihyperlipidemic effects on experimental hyperlipidemic rats and mice induced by corn oil and high cholesterol-diet. Oral administration of DWT significantly inhibited the increase of serum triglyceride and LDL-cholesterol levels, and the decrease of serum HDL-cholesterol levels in hyperlipidemic rats induced by corn oil. Also, oral administration of DWT significantly prevented the increase of serum total cholesterol, triglyceride and LDL-cholesterol, and liver total cholesterol and triglyceride in 1% cholesterol-diet fed mice. These results suggest that DWT is effective for the treatment of hyperlipidemia.

• Preventive Nutrition and Food Science
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• 제13권2호
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• pp.71-76
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• 2008

This study was performed to examine the effects of onion powder supplementation on lipid metabolism in male SD rats fed a high fat and high cholesterol diet. Experimental groups were control (C), high fat fed group (HF), high fat+onion powder intake (OP), high fat+quercetin intake (Q). The HF diet contained 1% cholesterol, 4% lard, 0.3% Na-taurocholate, and quercetin supplementation level was 0.1 g/kg diet. The OP group showed lower body weight gains compared to the control, while there was no significant difference in food efficiency ratio efficiency. When the proportion of fecal bile acids per total lipids was calculated, there was a significant decrease in the HF group compared to the control group, while the levels of the control group was same as that of the OP group. There was no significant difference between the HF and Q groups in bile acid/total lipid in feces. The amount of total cholesterol in liver increased significantly in HF group compared to the control group, while total cholesterol decreased significantly in the OP group compared to the HF group. There was a significant decrease in GOT (glutamic oxaloacetic transaminase) activity in OP and Q groups compared to the HF group. In conclusion, feeding onion powder to hyperlipidemic rates appeared to control weight gain, significantly lower the level of total cholesterol in the liver, and recover GOT activity. We also demonstrated that onion powder intake was more effective than quercetin intake.

• Journal of Community Nutrition
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• 제3권1호
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• pp.21-29
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• 2001

This study was conducted to examine factors with attendance in hyperlipidemia nutrition eduction program among 101 hyperlipidemic outpatients (38 males 63 females) at Samsung Medical Center We employed the Health Belief Model (HBM) as the theoretical framework The individual nutrition education and counseling program was scheduled with 4- half hour session sin 2 to 4 weeks intervals. Upon initiation of the program a trained dietitian surveyed HBM constructs and psychosocial factors. The following were included perceived susceptibility to cardiovascular disease(CVD) perceived severity to CVD percieved benefits to diet modification perceived barriers to persistence in maintaining therapy and self efficicacy and social support from family Sociodemographic data health factors stress level nutrition knowledge, and 24-hour dietary recall behavior were also surveyed All these data was analyzed according to the number of nutrition sessions attended The subjects were 55.9$\pm$9.4 year old and 24.6$\pm$kg/㎡ Sociodemographic factors were not associated with the number of nutrition sessions attended HBM constructs and psychosocial factors were significantly associated with the number of nutrition sessions attended. According to Spearman correlation coefficients. From stepwis regression analyses using HBM constructs as independent variables perceive barriers to persistence in maintaining diet therapy (negative) proved to be the strongest predictors for the number of nutrition sessions attended (partial R$^2$= 72.3%) followed by perceived severity to CVD and self efficacy (model R$^2$=76.6% The findings indicate that HBM constructs and psychosocial factors were closely associated with patient attendance It suggests that information and guidance to minimize patients perceived barriers to diet therapy might help to improve patients to scheduled appointments in nutrition education programs.

• 한국식품영양과학회지
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• 제29권3호
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• pp.453-459
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• 2000

This study was performed to investigate the effect of dietary crab shell powder on lipid metabolism in diet induced hyperlippidemic rats. Sixteen male Sprague-Dawley rats were divided into two groups and fed 20% (w/w) carb shell powder supplemented diet for 4 weeks. Energy intake and weight gain were lower in experimental group than in control group. Concentrations of plasma triglyceride, total cholesterol, LDL-cholesterol, and atherogenic index (AI) were decreased and concentration of HDL-cholesterol was increased by crab shell powder supplementation. Concentrations of liver total cholesterol and triglyceride were significantly lower in experimental group. The crab shell decreased triglyceride and cholesterol concentration in plasma and liver, and increased bile acid excretion in feces. Therefore, the crab shell powder is assumed to exhibit function of chitin or chitosan that effects on lipid metabolism and cholesterol reabsorption.

• Journal of Nutrition and Health
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• 제31권9호
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• pp.1411-1421
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• 1998

본 연구에서는 경희의료원 내과에 내원하고 있는 고지혈증 환자를 대상으로 12주 동안 영양상담을 통하여 식사조절을 실시하였으며. 이들 환자들의 apo E 유전자 다형성의 분포양상을 조사하였다 또한 그들의 식습관 분석과 더불어 영양상담 및 교육에 의한 식사조절이 apo E 유전자 다형성에 따라 혈중 지질 농도에 미치는 효과를 관찰함으로써, apo E 유전자 다형성과 식사 조절 후 혈청 지질 농도와의 상호 연관성을 조사하여 다음과 같은 결과를 얻었다. 1) 고지혈증 환자의 apo E 유전자 다형성의 분포양상을 살펴보면 apo E3/3가 70.6% . apo E3/4가 23.5%. 그리고 apo E2/3가 5.8%의 분포를 나타냈다. 일반적 특성인 연령, 몸무게, BMI, %IBW, WHR. 그리고 혈압에서는 apo E 유전자형에 따른 차이가 나타나지 않았으나 12주의 식사조절 후 모든 환자들에서 몸무게, BMI, %IBW, WHR, 그리고 혈압 감소의 경향을 보였다. 2) 고지혈증 환자가 평소 섭취하고 있는 식사 종류는 밥과 면류, 국류, 나물 및 무침류, 구이 및 조림류, 전류 및 볶음요리, 찌게류로 조사되었다. 3) 고지혈증 환자는 영양상담 후 포화지방과 콜레스테롤이 많은 음식의 섭취빈도가 감소하였고, 짠 음식 중 알, 젓갈류의 섭취가 감소하였다. 단음식과 인스턴트 식품의 섭취빈도도 감소하였다. 튀긴음식 섭취와 간식의 빈도도 감소하여 고지혈증 환자를 대상으로 실시한 12주간의 영양상담은 환자들의 식습관과 식품섭취 개선에 좋은 효과를 보였다. 4) 고지혈증 환자의 영양상담 전 식사는 탄수화물 : 단백질 : 지방의 비율이 64.2 : 15.7 : 20.1이었던 반면, 상담 후에는 그 비율이 66.0 : 15.7 : 18.3으로 지방의 섭취비율이 다소 낮아졌다. 또한 영양상담 이전의 콜레스테를 섭취는 236.0mg/day이었으며, 상담 후에는 109.8mg/day로 섭취량이 감소하였다. 5) 영양상담 전의 혈청 LDL-콜레스테롤은 apo E3/4군에서 164.2m조dl, E3/3군에서 133.4mg/dl 그리고 E2/3군에서 112.2mg/dl로 apo E3/4군에서 가장 높았고, 그 다음이 E3/3, 그리고 E2/3의 순으로 나타났으며 , 상담 후 apo E3/4에서 가장 많이 감소하였다. (13.3%) 영양상담 후. 혈청 총 콜레스테롤은 ape E3/4에서 15.6%, E3/3에서 8.5% 감소하였다(p<0.01). 혈청 중성지방과 VLDL-콜레스테를 수준도 모든 군에서 감소하였으며, 특히 3/3군에서 유의성있게 감소하였다. 그러나 HDL-콜레스테를 농도에는 각 군간에 차이없이 증가하는 양상을 보였다. Apo E3/4환자들에서 총 콜레스테롤과 LDL-콜레스테롤이 가장 크게 감소하여 식사조절의 효과가 가장 높은 것으로 나타났다. 6) Apo E 유전자 다형성에 따른 고지혈증환자에서 BMI의 감소량이 클수록 혈청 총 콜레스테를 수준이 비례적으로 감소하였지만(r=0.373, p<0.05), 혈청 중성지방과의 상관관계는 나타나지 않았다. 또한 포화지방의 섭취량이 감소함에 따라 혈청 콜레스테롤농도가 유의적으로 감소하였다(r=0.900, p<0.01).

• Archives of Pharmacal Research
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• 제29권3호
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• pp.256-264
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• 2006

Salicornia herbacea L. (Chenopodiaceae) has been used as a seasoned vegetable by living in coastal areas. S. herbacea (SH) has been demonstrated to stimulate cytokine production, nitric oxide release, and to show anti-oxidative effect. In a series of investigations to develop potential anti-diabetic and/or anti-hyperlipidemic agents from Korean indigenous plants, 50% ethanol extract of Salicornia herbacea was found to prevent the onset of the hyperglycemia and hyperlipidemia induced by high fat diet in ICR mice. At 6 week old, the ICR mice were randomly divided into five groups; two control and three treatment groups. The control mice were to receive either a regular diet (RD) or high-fat diet (HFD), and the treatment groups were fed a high fat diet with either 350 mg/kg, 700 mg/kg of SH (SH350 and SH700) or 250 mg/kg of met-formin (MT250) for a 10-week period. SH not only reduced body weight but also corrected associated hyperglycemia and hyperlipidemia in a dose dependent manner. SH exerted beneficial effects on the plasma glucose and lipid homeostasis possibly ascribed to its specific effects on lipogenesis related genes (SREBP1a, FAS, GAPT), and PEPCK, glucose 6-phosphatase gene expressions in liver. Ethanol extract of S. herbacea has potential as a preventive agent for type 2 diabetes (and possibly hyperlipidemia) and deserves future clinical trial.

• Nutrition Research and Practice
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• 제8권2호
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• pp.165-171
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• 2014

BACKGROUND: Groundwater is believed to possess many beneficial effects due to its natural source of various minerals. In this study, we examined the effects of natural Jeju groundwater S1 (Samdasoo$^{TM}$), S2 and S3 pumped up from different locations of Jeju Island, Korea, along with local tap water, on body weight gain, serum lipids and lipoproteins, and liver histopathology in high-fat diet-induced hyperlipidemic rats. MATERIALS/METHODS: Rats were randomly and equally divided into 6 groups. Different water samples were supplied to the hyperlipidemic rats as their daily drinking water and the widely-used anti-hyperlipidemic drug simvastatin was used as a positive control. Body weight, serum lipids and lipoproteins were measured weekly. Liver weight, liver index and liver histopathology were examined after the execution of the rats. RESULTS: After drinking Jeju groundwaters for two months, S2 but not S3 significantly reduced weight growth and serum triglycerides levels and increased high density lipoprotein-C (HDL-C) without affecting total cholesterol or LDL-C. S1 and particularly S2 significantly reduced the severity of liver hypertrophy and steatosis. All Groundwaters had much higher contents of vanadium (S3>S2>S1>>tap water) whereas S1 and S2 but not S3 markedly blocked autoxidation of ferrous ions. CONCLUSION: Jeju Groundwater S1 and particularly S2 exhibit protective effects against hyperlipidemia and fatty liver and hypothesize that the beneficial effect of Jeju Groundwaters may be contributed from blockade of autoxidation of ferrous ions rather than their high contents of vanadium.

• 한국식품영양과학회지
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• 제31권4호
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• pp.679-684
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• 2002

고지혈증 유발 식이와 양하, 양하근경 및 생강분말의 혼합급이가 흰쥐의 혈청 및 간장의 지질대사에 미치는 영향을 검토하고자 식이에 각각 3%씩 첨가하여 4주간 실험사육하였다. 혈청 총콜레스테롤 농도는 대조군에 비하여 전 실험군이 유의적으로 낮았으며, HDL-콜레스테롤 농도는 양하와 양하근경 급여군이 대조군에 비하여 높게 나타났다. 유리콜레스테롤 및 콜레스테릴 에스테르의 농도는 전 실험군이 대조군에 비하여 유의적으로 낮았고, 콜레스테릴 에스테르 농도비는 대조군이 72.36%, 실험군에서 62.14~65.33%였다. Chylomicron, LDL 및 VLDL 농도는 대조군에 비하여 전 실험군에서 유의적으로 낮았다. 중성지질 및 인지질은 대조군에 비하여 전 실험군이 유의적으로 낮았다. 간장 중의 총콜레스테롤, 중성지질, 유리콜레스테롤 및 콜레스테릴 에스테르의 농도는 대조군에 비하여 각 실험군에서 유의적인 감소를 나타내었으나 인지질의 농도는 유의적인 차이가 없었다.

• 한국식품영양과학회지
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• 제37권3호
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• pp.302-308
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• 2008

비배당체 이소플라본 고함유 대두분말이 고지방식이를 섭취한 흰쥐의 지질대사와 항산화 효과에 미치는 영향을 조사하고자 식이성 고지혈 흰쥐를 정상군(NO), 고지방식이군(CO), 고지방식이에 비배당체 이소플라본 고함유 대두분말 10%, 20%(w/w) 첨가군(BFF10, BFF20)으로 나누어 7주간 사육한 결과는 다음과 같다. 비배당체 이소플라본 고함유 대두분말 섭취는 체중과 간 무게를 유의적으로 감소시켰으며, CO군에 비해 혈청의 총 콜레스테롤, LDL-콜레스테롤, 중성지질 농도가 유의적으로 감소하였다. 간조직 손상시 활성증가가 우려되는 alanine amino transferase와 aspartate amino transferase 수준도 유의적으로 감소하였다. Thiobarbituric acid reactive substance의 생성량은 비배당체 이소플라본 고함유 대두분말의 첨가량이 높을수록 현저하게 감소되었으며 superoxide dismutase 활성은 농도 의존적으로 증가시키는 것으로 나타났다.

• 한방비만학회지
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• 제18권1호
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• pp.27-35
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• 2018

Objectives: The aim of this study is to investigate the effects of Daecheongryoung-tang (DCR) therapy on body weight, serum total cholesterol, high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol, triglyceride, free fatty acid, total lipid, phospholipid level and complete blood cell count of obese rats. Methods: 34 rats are divided into 4 groups, the rats in the normal group are 7 and the rats in the other group are 9 per group; Normal group (general fat diet and no medication), Control group (high-fat diet and no medication), DCR_L group (high-fat diet and DCR 250 mg medication) and DCR_H group (high-fat diet and DCR 500 mg medication). DCR is administrated for 6 weeks. Results: There is significant statistical difference between Control group and DCR-H group for the body weight, the total cholesterol, LDL cholesterol, triglyceride, free fatty acid level. Also, there is significant statistical difference among Control group, DCR_L group and DCR_H group for body weight, triglyceride, free fatty acid and phospholipid level. Conclusions: These results suggest that medication of DCR_L and DCR_H is effective for the treatment of obesity.