Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Effect of Daewhang-whangryunhaedok-Tang on Hyperlipidemia

대황황련해독탕의 항고지혈증 작용

  • Kim, Young-Suk (College of Oriental Medicine, Kyung Hee University) ;
  • Jung, Eun-Ah (East-West Medical Research Institute, Kyung Hee University) ;
  • Chang, Jong-Chul (College of Oriental Medicine, Kyung Hee University) ;
  • Yang, Hyung-Kil (College of Oriental Medicine, Kyung Hee University) ;
  • Cho, Gi-Ho (College of Oriental Medicine, Kyung Hee University) ;
  • Bae, Hyung-Sup (College of Oriental Medicine, Kyung Hee University) ;
  • Lee, Kyung-Sup (College of Oriental Medicine, Kyung Hee University) ;
  • Kim, Dong-Hyun (College of Pharmacy, Kyung Hee University) ;
  • Kim, Nam-Jae (East-West Medical Research Institute, Kyung Hee University)
  • Published : 2001.06.30
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Abstract

Whangryunhaedok-Tang (WT) is formulated with Coptidis Rhizoma, Phellodendri Cortex, Scutellariae Radix and Gardeniae Fructus, and Daewhang-whangryunhaedok-Tang (DWT) is made by the combination of Rhei Rhizoma, a wellknown anticostipation drug in WT. Therefore, DWT has been evaluated for antihyperlipidemic effects on experimental hyperlipidemic rats and mice induced by corn oil and high cholesterol-diet. Oral administration of DWT significantly inhibited the increase of serum triglyceride and LDL-cholesterol levels, and the decrease of serum HDL-cholesterol levels in hyperlipidemic rats induced by corn oil. Also, oral administration of DWT significantly prevented the increase of serum total cholesterol, triglyceride and LDL-cholesterol, and liver total cholesterol and triglyceride in 1% cholesterol-diet fed mice. These results suggest that DWT is effective for the treatment of hyperlipidemia.

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