생약학회지 (Korean Journal of Pharmacognosy)
- 제32권2호통권125호
- /
- Pages.145-152
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- 2001
- /
- 0253-3073(pISSN)
- /
- 2288-9299(eISSN)
대황황련해독탕의 항고지혈증 작용
Effect of Daewhang-whangryunhaedok-Tang on Hyperlipidemia
-
김영석
(경희대학교 한의과대학)
;
- 정은아 (경희대학교 동서의학연구소) ;
- 장종철 (경희대학교 한의과대학) ;
- 양형길 (경희대학교 한의과대학) ;
-
조기호
(경희대학교 한의과대학)
;
- 배형섭 (경희대학교 한의과대학) ;
-
이경섭
(경희대학교 한의과대학)
;
-
김동현
(경희대학교 약학대학)
;
-
김남재
(경희대학교 동서의학연구소)
-
Kim, Young-Suk
(College of Oriental Medicine, Kyung Hee University)
;
- Jung, Eun-Ah (East-West Medical Research Institute, Kyung Hee University) ;
- Chang, Jong-Chul (College of Oriental Medicine, Kyung Hee University) ;
- Yang, Hyung-Kil (College of Oriental Medicine, Kyung Hee University) ;
-
Cho, Gi-Ho
(College of Oriental Medicine, Kyung Hee University)
;
- Bae, Hyung-Sup (College of Oriental Medicine, Kyung Hee University) ;
-
Lee, Kyung-Sup
(College of Oriental Medicine, Kyung Hee University)
;
-
Kim, Dong-Hyun
(College of Pharmacy, Kyung Hee University)
;
-
Kim, Nam-Jae
(East-West Medical Research Institute, Kyung Hee University)
- 발행 : 2001.06.30
초록
Whangryunhaedok-Tang (WT) is formulated with Coptidis Rhizoma, Phellodendri Cortex, Scutellariae Radix and Gardeniae Fructus, and Daewhang-whangryunhaedok-Tang (DWT) is made by the combination of Rhei Rhizoma, a wellknown anticostipation drug in WT. Therefore, DWT has been evaluated for antihyperlipidemic effects on experimental hyperlipidemic rats and mice induced by corn oil and high cholesterol-diet. Oral administration of DWT significantly inhibited the increase of serum triglyceride and LDL-cholesterol levels, and the decrease of serum HDL-cholesterol levels in hyperlipidemic rats induced by corn oil. Also, oral administration of DWT significantly prevented the increase of serum total cholesterol, triglyceride and LDL-cholesterol, and liver total cholesterol and triglyceride in 1% cholesterol-diet fed mice. These results suggest that DWT is effective for the treatment of hyperlipidemia.
키워드