• 대한한방부인과학회지
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• 제20권1호
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• pp.161-168
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• 2007

Purpose : The purpose of this study is to identify the difference of clinical effects of gyejibongnyeong-hwan and acupuncture therapy on primary dysmenorrhea. Methods : We studied with ten patients recruited from April, 2003 to Feburary, 2004. Women with organic disease as uterine myoma, ovarian cysts and pelvic inflammatory disease were excluded from this study. We treated them with gyejibongnyeong-hwan or gyejibongnyeong-hwan combined acupuncture therapy for 8weeks. The severity of dysmenorrhea was measured by VAS(Visual Analog Scale). Results : gyejibongnyeong-hwan significantly decreased the severity of dysmenorrhea. And Gyejibongnyeong-hwan combined Acupuncture therapy significantly decreased the severity of dysmenorrhea. The change of VAS of gyejibongnyeong-hwan group is significantly higher than gyejibongnyeong-hwan combined acupuncture. Both of Gyejibongnyeong-hwan and acupuncture did not show hepatic and renal virulence. Conclusion : This study shows that gyejibongnyeong-hwan has remarkable effects on dysmenorrhea patients. Obviously further researches concerning all these area still necessary.

• 대한한방부인과학회지
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• 제34권2호
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• pp.124-141
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• 2021

Objectives: The purpose of this study is to assess the efficacy of Jibaekjihwang-hwan and Daeboeum-hwan combination therapy for the treatment of precocious puberty. Methods: 6 databases were searched from the date of inception until April 2021 for relevant studies. We included randomized controlled trials (RCTs) and non-randomized controlled trials (nRCTs) which focused on effects of Jibaekjihwang-hwan and Daeboeum-hwan on precocious puberty. Results: Total 8 literatures were included in qualitative analysis and meta analysis on results was conducted on 4 synthesizable studies. The response rate was significantly higher in Jibaekjihwang-hwan and Daeboeum-hwan combination group than in conventional therapy group. Also, serum estradiol and follicle stimulating hormone (FSH) level were significantly lower in Jibaekjihwang-hwan and Daeboeum-hwan combination group than in conventional therapy group. Conclusions: It seems that combination therapy of Jibaekjihwang-hwan and Daeboeum-hwan can effectively reduce serum estradiol and FSH level while increasing response rate significantly. Further high quality studies are needed to supplement the efficacy and safety of combination therapy of Jibaekjihwang-hwan and Daeboeum-hwan on precocious puberty.

• 대한한의학방제학회지
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• 제17권1호
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• pp.17-28
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• 2009

Objectives : The result is the followings after investingating composition, dosage and usage of Yukmijihwang-Hwan(六味地黃丸) in literature by country and Era. Methods : Investigated Classics of Oriental Medicine that Yukmijihwang-Hwan is first described. Results : Found 42 literatures searching Yukmijihwang-Hwan in Classics of Oriental Medicine. Literature that Yukmijihwang-Hwan is recorded by first was Yinhaijingwei(銀海精微), but capacity has not recorded. Yukmijihwang-Hwan Medicinal Decoction that eat(Yukmijihwang-Tang: 5 times) as pill than eat(Yukmijihwang-Hwan: 37 times) was more. Literature that composition of Yukmijihwang-Hwan is recorded by Rehmannia glutinosa(熟地黃) is 8 Ryang(兩), Poria cocos(白茯苓) is 3 Ryang, Paeonia suffruticosa(牧丹皮) is 3 Ryang, Alisma Canaliculatum (澤瀉) 3 Ryang, Cornus officinalis(山茱萸) 4 Ryang, Dioscorea batatus(山藥) 4 Ryang was most. Conclusions : Yukmijihwang-Hwan wat difference in composition and capacity that Chinese and Korean Classics of Oriental Medicine. After Dongeuibogam of the Korea is published, composition and capacity are connected until today.

• 대한한방소아과학회지
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• 제23권3호
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• pp.241-262
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• 2009

Objectives This study is designed to investigate the effects of Jujadokseo-hwan on the brain ability and inducing oxidative stresses. Methods We measured the changes of regional cerebral blood flow and mean arterial blood pressure. Then we analyzed histological examination, immunohistochemistric response and anti-oxidant activity of Jujadokseo-hwan. Results 1. Treatment of Jujadokseo-hwan significantly increased regional cerebral blood flow but decreased mean arterial blood pressure. 2. Treatment of Jujadokseo-hwan-induced increase of regional cerebral blood flow was significantly inhibited by pretreatment with indomethacin (1 mg/kg, i.p.), an inhibitor of cyclooxygenase. 3. In histological examination through TTC stain, group I was no change, but group II showed that discolored in the most cortical part. Group III showed that decreased discolor in the cortical part. 4. In immunohistochemistric response of BDNF, group II showed that lower response effect. Group III showed that increase response effect. 5. Treatment of Jujadokseo-hwan increased proliferation rates of Glial cell effectively 6. Treatment of Jujadokseo-hwan accelerated proliferation rates of C6 cells in vitro. In addition, protective effects on cell death induced by paraquat, rotenone and hydrogen peroxide. In addition, activity of SOD were increased by treatment with Jujadokseo-hwan. Conclusions In conclusion, Jujadokseo-hwan can improve of the brain ability, learning ability, memory ability and induce ischemic brain injuries.

• 생약학회지
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• 제37권1호통권144호
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• pp.11-15
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• 2006

Hwan Myeong Hwan (環明丸) is Chinese patent medicine which is used for presbyopia and eye disease. It consists of 23 kind of powdered crude drugs. In powered crude drugs, it is hard to identify each component by chemical analysis or morphological examination. However, the method of identification of powdered crude drugs has not been clearly established. For the identification of individual crude drugs in such powdery mixtures, microscopic method may advantageously be used as it requires only a small amount of specimens. In this study, it is demonstrated that the microscopic method is very effective for the identification of 23 crude drug ingredients in Hwan Myeong Hwan.

• 대한한의학회지
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• 제28권3호통권71호
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• pp.57-69
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• 2007

Objectives : Diabetes is a disease in which the body does not produce or properly use insulin. Etiological studies of diabetes and its complications have shown that oxidative stress might play a major role. Therefore, many methods have been tried to regulate free oxygen radicals for treating diabetes and its complications. Ojung-hwan, composed of five crude herbs, has been considered effective for treating symptoms of aging. In male ob/ob mouse of severe obesity, hyperinsulinemia and hyperlipidemia, which are features of NIDDM, the hyperglycemic activities and mechanisms of Ojung-hwan were examined. Methods : Mice were grouped and treated for 5 weeks as follows. Both the lean (C57/BL6J black mice) and diabetic (ob/ob mice) control groups received standard chow. The experimental groups were fed a diet of chow supplemented with 30 and 90 mg Ojung-hwan per 1 kg of body weight for 14 days. The effects of Ojung-hwan extract on the ob/ob mice were observed by measuring the serum levels of glucose, insulin, lipid components, and the kidney levels of superoxide anion radical (${\cdot}\;O{_2}{^-}$), MDA+HAE, GSH/GSSG ratio, and also the enzyme activities involved in polyol pathway. Results : Ojung-hwan lowered the levels of serum glucose and insulin in a dose-dependent manner. Total cholesterol, triglyceride and free fatty acid levels decreased, while the HDL-cholesterol level increased, in Ojung-hwan treated groups. Renal aldose reductase and sorbitol dehydrogenase activities increased in the ob/ob mice, whereas they were inhibited in the Ojung-hwan treated groups. Ojung-hwan inhibited the generation of ${\cdot}\;O{_2}{^-}$ in the kidney. Finally, MDA+HAE levels increased and GSH/GSSG ratio decreased in the ob/ob mice, whereas they improved in the Ojung-hwan treated groups. Conclusions : Ojung-hwan showed antidiabetic and antihyperlipidemic activities by regulating theactivities of polyol pathway enzymes, scavenging reactive oxygen species and reducing the MDA+HAE levels in the ob/ob mice.

• 대한한의학회지
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• 제21권2호
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• pp.25-36
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• 2000

Objectives : This study demonstrates the effects of Daejo-hwan on learning and memory impairment induced by L-NAME (75 mg/kg) treatment and on cerebral ischemic damage induced by middle cerebral artery (MCA) occlusion in rats. Methods : Daejo-hwan emulsion (73.3 mg/100 g/l ml) was administered to rats along a timed study schedule. The Moms water maze was used for learning and memory test of the rats. The MCA was occluded by using the intraluminal thread method. The brain slices were stained by 2 % triphenyl tetrazolium chloride (TTC) and 1 % cresyl violet solution. Infarct size, neuron cell number and size in penumbra was measured by using computer image analysis system. Results : 1. The escape latency of the Daejo-hwan treated group decreased significantly with respect to the control group. 2.The memory score of the Daejo-hwan treated group showed increase tendency, And the swimming distance was not different between the normal, the control, and the Daejo-hwan treated group. 3. The infarct size of the Daejo-hwan treated group decreased significantly with respect to the control group. 4. The total infarct volume of the Daejo-hwan treated group showed decrease tendency. And the brain edema index of the Daejo-hwan treated group decreased significantly with respect to the control group. 5. The neuron cell number and cell size in penumbra of the Daejo-hwan treated group increased significantly with respect to the control group. Conclusions : According to the above results, it is supposed that Daejo-hwan is clinically applicable to the vascular dementia.

• 대한약침학회지
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• 제10권3호
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• pp.63-69
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• 2007

Objectives We performed this study in order to investigate the effects of Sedang-Hwan(世糖丸) and modified Sedang-Hwan(世糖丸變方)on the diabetes mellitus. Methods We injected a vein with 65mg/kg of streptozotocin(STZ) on the rats. And then administered Sedang-Hwan(Sample 1 group); 18.7mg/kg/day, modified Sedang-Hwan; 16.5mg/kg/day(Sample 2 group) to Sample groups and observed the body weight, glucose and insulin levels. Results 1. The Sample 1, 2 groups showed a high suppressive effect of body weight loss compared to Control group. 2. The Sample 1, 2 groups’ glucose level showed a effective in lowering level compared to Control group. 3. The sample 1, 2 groups showed a higher insulin level than Control group. Conclusions Conclusively, modified Sedang-hwan was recognized to have decrease effect of serum glucose of the diabetic rats induced by streptozotocin. It is also required to study on the further detailed mechanism of decrease effect of serum glucose by modified Sedang-hwan.

• 대한한방내과학회지
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• 제31권3호
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• pp.401-414
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• 2010

Objectives : This study was carried out to investigate the effects of Soche-hwan extract on indomethacin-induced gastric mucosal lesions of mice. Methods : Experimental mice were divided randomly into four groups. The normal group, the gastropathy group of gastro-inflammation elicited mice, the misoprostol group of mice administered misoprostol after gastro-inflammation elicitation and the Soche-hwan group of mice administered Soche-hwan after gastro-inflammation elicitation. Results : The hemorrhagic erosion of gastric mucosa, the damage of arrangement of mucous secreted cells and HSP70 increased in the gastro-inflammation elicited group, but decreased significantly in the misoprostol and Soche-hwan extract administered groups. Cell proliferation of gastric mucosa decreased in the gastro-inflammation elicited group, but increased significantly in the misoprostol and Soche-hwan extract administered groups. The distribution of mucosal neck cells and mucosal surface cells and PNA positive reactions of surface mucus cells decreased in the gastro-inflammation elicited group, but increased significantly in the misoprostol and Soche-hwan extract administered groups. COX-1 positive cells decreased in the gastro-inflammation elicited group, but increased significantly in the misoprostol and Soche-hwan extract administered groups. iNOS mRNA and COX-2 mRNA increased in the gastro-inflammation elicited group, but decreased significantly in the Soche-hwan extract administered group. NF-kB p65, iNOS and COX-2 increased in the gastro-inflammation elicited group, but decreased significantly in the misoprostol and Soche-hwan extract administered groups. Conclusion : Soche-hwan extract had excellent effects on indomethacin-induced gastric mucosal lesions in mice.

• 대한한의학방제학회지
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• 제19권1호
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• pp.79-90
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• 2011

Objectives : This study was performed to analysis the composition of herbal formulations about a series of Wolgug-Hwan(WGH, formed by Gukchur-won and Sagung-san) in Dongeuibogam written by Heo Jun. Methods : The series of WGH in Dongeuibogam were selected by 'Prescription Lineage Graph' (http://164.125.206.43/PrescriptionLineageGraph.aspx) established by prof. Lee at Pusan National University. In the analysis of a series of WGH, we used some formulation books including classics. Results : Gaeuldogi-tang(GDT) is formed by WGH, Yeonggangchulgam-tang(YGT), Yugil-san (YIS) and Gungchul-san. Cheongul-san(CUS) is formed by WGH, Ijin-tang(IJT), YGT and Haegeum -hwan(HGH). Sosikcheongul-san(SCS) is formed by CUS and IJT. Jeungmiijin-tang(JIT) is formed by WGH, IJT, Sambaek-tang and Gyullyeonjichul-hwan. Sihoeokgan-tang(SET) is formed by WGH, Sihosogan-san(SSS) and Jigolpi-eum. Wolgukbohwa-hwan(WBH) is formed by WGH, Bohwa-hwan, Mokyangjichul-hwan and Hwangnyeon-tang(HNT). Chimsa-hwan(CSH) is formed by WGH, Injinho-tang(IHT), Yungmisamneung-hwan, Jeungmisamul-tang and Sinseongugi-tang. Conclusions : SCS, CUS, or JIT has been used frequently in case of phlegm-fire. These are formulated by the combination of WGH and IJT with Samseon-san or HGH or Jichul-hwan according to the special symptoms, respectively. SET which is formulated by WGH and SSS has been used in case of stagnation of liver-qi. GDT, WBH or CSH has been used in damp-heat. These are formulated by the combination of WGH with YIS, HNT, or IHT, respectively.