• Radiation Oncology Journal
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• 제30권4호
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• pp.153-157
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• 2012

Purpose: There has been no definite consensus on standard treatment, either local or systemic, for the Kaposi's sarcoma (KS). Radiotherapy (RT) can be a good local therapeutic choice especially in non-AIDS associated KS (NAKS) for its indolent behavior. Materials and Methods: Medical records of 17 KS patients treated with RT at the Seoul National University Hospital from February 1998 to January 2012 were retrospectively reviewed. One human immunodeficiency virus (HIV)+ patient with 3 lesions was excluded. The total number of the lesion was 23 among the 16 patients. The median follow-up period was 27.9 months. Correlation between response and variables was analyzed using the logistic regression model. Median age of the patients was 75 years. All the 23 lesions were located at the extremities. Fourteen (61%) of those had pain or local swelling as the initial presentation. Ten patients had possible causes of immunodeficiency and were regarded as iatrogenic, and other 6 were classic KS. Median dose of RT was 36 Gy. Results: No KS-related death was observed. Excluding 2 with short-term follow-up only, complete response and partial response were obtained in 2 (9%) and 19 (73%) lesions, respectively. Of those, 3 lesions underwent local progression. Six had out-of-field recurrence after RT. Symptom improvement was achieved in 13 (93%) of 14 patients. Grade 2 skin toxicities were found in 9 lesions but all got improvement after treatment. When divided into responsive and progressive group, free from progression was not related to any of the possible variables. Conclusion: RT is effective in local control of NAKS resulting great response rate.

• IMMUNE NETWORK
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• 제5권3호
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• pp.137-143
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• 2005

Background: Millions of people in the world are suffering from atopic dermatitis (AD), which is a chronic inflammatory skin disease triggered by Th2 immune responses. The NC/Nga mouse is the most extensively studied animal model of AD. Like human AD, NC/Nga mice demonstrate increased levels of IgE, a hallmark of Th2 immune responses. Adaptive immunity cannot be generated without help of innate immunity. Especially natural killer T (NKT) cells and marginal zone B (MZB) cells have been known to play important roles in linking innate immunity to adaptive immunity. Methods: Through flow cytometric analysis and ELISA assay, we investigated whether these lymphocytes might be altered in number in NC/Nga mice. Results: Our data demonstrated that the number of NKT cells was reduced in NC/Nga mice and IFN${\gamma}$ production by NKT cells upon ${\alpha}-GalCer$ stimulation decreased to the levels of CD1d KO mice lacking in NKT cells. However, reduction of NKT cells in NC/Nga mice was not due to CD1d expression, which was normal in the thymus. Interestingly, there was a significant increase of $CD1d^{high}B220^+$ cells in the spleen of NC/Nga mice. Further, we confirmed that $CD1d^{high}B220^+$ cells are B cells, not dendritic cells. These $CD1d^{high}B220^+$ B cells show $IgM^{high}CD21^{high}CD23^{low}$, a characteristic phenotype of MZB cells. Conclusion: We provide the evidence that there are decreased activities of NKT cells and increased number of MZB cells in the NC/Nga mice. Our findings may thus explain why NC/Nga mice are susceptible to AD.

• 정보처리학회논문지B
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• 제14B권4호
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• pp.255-262
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• 2007

본 연구는 칼라 이미지에서 인물의 얼굴 영역을 검출하는 개선된 색상 기반 방식을 제안한다. 제안 방법은 RGB, $YC_bC_r$, YIQ의 세 가지 색상 모델을 조합, 각각 휘도와 색도 성분 조합 히스토그램을 구축하고 구축된 색상 조합 히스토그램을 역전파방식의 신경망에 입력한 후 학습단계의 반본 과정에 Levenberg-Marquadt 알고리즘을 적용한다. 제안 방법은 신경망 학습과정에 Levenberg-Marquadt 알고리즘을 적용하여 얼굴 검출에 가장 많이 사용되는 방법 중 하나인 역전파 신경망이 지역 최소값에 봉착하는 문제점을 해결함으로써 검출 오류율을 낮추는데 기여한다. 또한 색상 조합 히스토그램을 사용한 새로운 색상 조합 기반의 얼굴 영역 검출 방법은 빛의 영향에 강건하도록 휘도 성분을 분리하고 색도 성분을 강조하여 단일 색상 히스토그램보다 신경망에 더 신뢰성 있는 값을 입력함으로써 단일 색상 공간을 사용했을 때보다 높은 얼굴 검출율을 보인다. 실험 결과는 제안 방식이 얼굴 영역 검출 개선에 효과적이며 빛의 변화에 강건함을 보여준다.

• Molecules and Cells
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• 제39권3호
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• pp.266-279
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• 2016

The mechanism by which 12-O-tetradecanoylphorbol-13-acetate (TPA) bypasses cellular senescence was investigated using human diploid fibroblast (HDF) cell replicative senescence as a model. Upon TPA treatment, protein kinase C (PKC) ${\alpha}$ and $PKC{\beta}1$ exerted differential effects on the nuclear translocation of cytoplasmic pErk1/2, a protein which maintains senescence. $PKC{\alpha}$ accompanied pErk1/2 to the nucleus after freeing it from $PEA-15pS^{104}$ via $PKC{\beta}1$ and then was rapidly ubiquitinated and degraded within the nucleus. Mitogen-activated protein kinase docking motif and kinase activity of $PKC{\alpha}$ were both required for pErk1/2 transport to the nucleus. Repetitive exposure of mouse skin to TPA downregulated $PKC{\alpha}$ expression and increased epidermal and hair follicle cell proliferation. Thus, $PKC{\alpha}$ downregulation is accompanied by in vivo cell proliferation, as evidenced in 7, 12-dimethylbenz(a)anthracene (DMBA)-TPA-mediated carcinogenesis. The ability of TPA to reverse senescence was further demonstrated in old HDF cells using RNA-sequencing analyses in which TPA-induced nuclear $PKC{\alpha}$ degradation freed nuclear pErk1/2 to induce cell proliferation and facilitated the recovery of mitochondrial energy metabolism. Our data indicate that TPA-induced senescence reversal and carcinogenesis promotion share the same molecular pathway. Loss of $PKC{\alpha}$ expression following TPA treatment reduces pErk1/2-activated SP1 biding to the $p21^{WAF1}$ gene promoter, thus preventing senescence onset and overcoming G1/S cell cycle arrest in senescent cells.

• 복식문화연구
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• 제7권4호
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• pp.52-68
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• 1999

The purpose of this study was to be inquired inner contemplation of the tattoo expressed in the modern costumes. For this study, related documentaries and pictures or photos were analyzed in terms of the theretical background for the history of tattoo, the relation between tattoo and the modern western costumes. The primary source of pictures or photos are Vogue, Collections, Collezioni, Harper\`s Bazaar, Modain, Model et Mode etc. The human\`s needs of body decoration had constantly pursued on the body and costumes from the first until lately. Especially in the recents, as the tattoo is implicated a dynamic and charming method of all kinds of body decoration, it\`s used a motive of modern western costumes. The original tattoo means a picture, word etc. that was put permanently onto their skin using a needle and coloring matter. But, these days tattoo is an expression of street style for something new in the subculture. The results were as a follows : The inner meaning of tattoo represented in the modern costumes was classified into two categories. First, the tattooing was a very important factor to complete fashion design through the history of modern costumes, and also the elaborate tattoo of the body was displayed unrestricted formativeness as the skinhead\`s tattoo, raceless\`s ambiguity of street style and artistic decoration, because that can be faded easily. Second, Tattoo Look was expressed as tattoo prints of the see-through, elastic textiles in the modern costumes. That is, the tattoo enhanced the effect of dramatic atmosphere other formative arts as well as the modern costumes by Tattoo Look. Similarity, Tattoo Look could be interpreted as the change of the aesthetic consciousness by the influence of the subculture. Accordingly, in the end of a this century, many experimental designers had applied tattoo to modern costumes. So this study will stand as an important clue to foresee the future costume\`s style and change.

• 한국산업정보학회논문지
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• 제12권3호
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• pp.60-68
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• 2007

본 논문에서는 자동으로 사용자의 얼굴 표정을 인식할 수 있는 시스템을 제안한다. 제안된 시스템은 휴리스틱 정보를 기반으로 설계된 트리 구조를 이용하여 행복, 역겨움, 놀람의 감정과 무표정을 인식한다. 카메라로부터 영상이 들어오면 먼저 얼굴 특징 검출기에서 피부색 모델과 연결성분 분석을 이용하여 얼굴 영역을 획득한다. 그 후에 신경망 기반의 텍스처 분류기를 사용하여 눈 영역과 비 눈 영역으로 구분한 뒤 눈의 중심 영역과 에지 정보를 기반으로 하여 눈, 눈썹, 입 등의 얼굴 특징을 찾는다. 검출된 얼굴 특징들은 얼굴 표정 인식기에 사용되며 얼굴 인식기는 이를 기반으로 한 decision tree를 이용하여 얼굴 감정을 인식한다. 제안된 방법의 성능을 평가하기 위해 MMI JAFFE, VAK DB에서 총 180장의 이미지를 사용하여 테스트하였고 약 93%의 정확도를 보였다.

• 패션비즈니스
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• 제21권6호
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• pp.47-65
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• 2017

This study is intended to compare an actual wedding dress being made completely through 3D software, and compare it with an actual dress of a real model by using collective tools for comparative analysis. The method of the study was conducted via a literature review along with the production of the dresses. In the production, two wedding dresses for the small wedding ceremony were designed. Each of the design was made into both 3D and an actual garment. The results are as follows. First, the 3D whole body scanner reflects the measure of the exact human body size, however there were some difficulties in matching what the customer wanted, because the difference of the skin color and the hair style. Second, the pattern of the dress is much more easily altered than it was in the real production. Third, the silhouette of the virtual and the actual person with the dress was nearly the same. Fourth, textile tool was much more convenient because of the use of real-time rendering on the virtual dresses. Lastly, the lace and biz decoration were flat, and the luster was duller than in reality. Prospectively, the consumer will decide their own design of variety through the use of the avatar without wearing the actual dresses, and they would demand what the another one desired, different from the presented ones by making the corrections by themselves. Through this process, the consumer would be actively participating in the design, a step which would finally lead to the two way designing rather than the one way design of present times.

• Journal of Acupuncture Research
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• 제38권3호
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• pp.200-204
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• 2021

Background: Standardized procedures for the clinical application of fire cupping methods have not been established. In particular, the pressure parameters have not been fully characterized and described. Therefore, using various materials, this study investigated the pressure range exerted during fire cupping therapy. Methods: In this study, 3 differently sized (small, medium, large) glass and bamboo cups were used in the cotton ball fire cupping procedure to measure the pressure inside the cup applied to a human skin model. The pressure in each cup was measured 15 times for a total of 90 measurements. Results: A small bamboo cup had the minimum overall pressure (-305.4 mmHg), whereas the large glass cup exerted the maximum pressure (-401.3 mmHg), followed by the medium glass cup, large bamboo cup, small glass cup, and medium bamboo cup. The average pressure exerted by the cotton ball method for all cups ranged from -348.715 mmHg to -358.694 mmHg (95% confidence interval). Overall, the glass cups had a greater pressure than the bamboo cups in all groups (p < 0.001). Among the glass cups used, the larger the size of the cup, the higher the average pressure detected (-381.947 mmHg to -391.973 mmHg; p < 0.05). Conclusion: Large glass cups which are widely used in clinical practice, when used in the fire cupping method exerted pressure ranging from -381.947 mmHg to -391.973 mmHg (95% CI).

• 한국정보기술학회 영문논문지
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• 제10권1호
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• pp.71-83
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• 2020

In this paper, we propose a system that can detect the shape of a hand at high speed using an FPGA. The hand-shape detection system is designed using Verilog HDL, a hardware language that can process in parallel instead of sequentially running C++ because real-time processing is important. There are several methods for hand gesture recognition, but the image processing method is used. Since the human eye is sensitive to brightness, the YCbCr color model was selected among various color expression methods to obtain a result that is less affected by lighting. For the CbCr elements, only the components corresponding to the skin color are filtered out from the input image by utilizing the restriction conditions. In order to increase the speed of object recognition, a median filter that removes noise present in the input image is used, and this filter is designed to allow comparison of values and extraction of intermediate values at the same time to reduce the amount of computation. For parallel processing, it is designed to locate the centerline of the hand during scanning and sorting the stored data. The line with the highest count is selected as the center line of the hand, and the size of the hand is determined based on the count, and the hand and arm parts are separated. The designed hardware circuit satisfied the target operating frequency and the number of gates.

• 환경생물
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• 제38권2호
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• pp.271-277
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• 2020

가습기 살균제 성분(PHMG, PGH, CMIT/MIT)의 노출에 의한 다양한 장기에 대한 독성들에 대해서 피해사례는 계속 증가하고 있으나, 세포모델과 동물모델에서의 연구와 보고는 아직 부족한 실정이다. 심혈관 독성, 간 독성, 배아 독성에 대해서는 최근 알려져 있으나 뇌신경 독성과 피부 독성에 대해서는 상대적으로 적게 알려져 있다. 본 연구에서는 이들 세 가지 성분들의 피부 독성과 뇌신경 독성을 사람 피부섬유세포와 제브라피쉬 동물모델을 대상으로 각각 평가하였다. 사람피부섬유세포에 세 가지의 성분들을 0, 2, 4, 6, 8, 16 mg L^-1 (최종농도)로 처리하였을 때, 세포 생존율은 PHMG가 33%로 가장 낮았고, PGH가 49%, CMIT/MIT가 40%의 생존율을 보였다. 세포배양액 내의 산화물을 정량해본 결과, PHMG 처리된 세포가 28 nmol MDA로 가장 높았고, PGH가 13 nmol MDA, CMIT가 21 nmol MDA를 보였다. 제브라피쉬 사육수조에 PHMG, PGH, CMIT를 40 mg L^-1의 최종농도가 되도록 희석한 후, 제브라피쉬를 30분간 노출시킨 후 중뇌의 광시개영역(optic tectum)을 횡면 미세절단하여 산화물의 생성정도를 비교해본 결과, CMIT/MIT를 처리한 그룹에서 대조군 대비 17배 많은 산화물의 생성이 있었고, PGH를 처리한 그룹에서는 15배, PHMG를 처리한 그룹에서는 11배 많은 산화물이 관찰되어 심각한 뇌신경계 독성을 보여주었다. 결론적으로 세 가지 종류의 가습기 살균제 성분들에서 모두 심각한 피부세포 독성과 뇌신경계 독성이 나타났는데, 피부 독성은 특히 PHMG가, 뇌신경계 독성은 특히 CMIT/MIT가 가장 심각하였다. 이들 결과들은 가습기 살균제에 노출된 어린이들이 뇌신경계 독성을 통하여 언어장애, 운동장애, 발달장애 등을 겪게 될 수도 있음을 실험적으로 제시한다.