Regulations of Reversal of Senescence by PKC Isozymes in Response to 12-O-Tetradecanoylphorbol-13-Acetate via Nuclear Translocation of pErk1/2 |
Lee, Yun Yeong
(Department of Biochemistry and Molecular Biology, Ajou University School of Medicine)
Ryu, Min Sook (Department of Biochemistry and Molecular Biology, Ajou University School of Medicine) Kim, Hong Seok (Department of Molecular Medicine, Inha University, College of Medicine) Suganuma, Masami (Research Institute for Clinical Oncology, Saitama Cancer Center) Song, Kye Yong (Department of Pathology, Chung-Ang University College of Medicine) Lim, In Kyoung (Department of Biochemistry and Molecular Biology, Ajou University School of Medicine) |
1 | Abel, E.L., Angel, J.M., Kiguchi, K., and DiGiovanni, J. (2009). Multistage chemical carcinogenesis in mouse skin: fundamentals and applications. Nat. Protoc. 4, 1350-1362. DOI |
2 | Alessandrini, A., Crews, C.M., and Erikson, R.L. (1992). Phorbol ester stimulates a protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product. Proc. Natl. Acad. Sci. USA 89, 8200-8204. DOI |
3 | Alexandropoulos, K., Qureshi, S.A., and Foster, D.A. (1993). Ha- Ras functions downstream from protein kinase C in v-Fpsinduced gene expression mediated by TPA response elements. Oncogene 8, 803-807. |
4 | Araujo, H., Danziger, N., Cordier, J., Glowinski, J., and Chneiweiss, H. (1993). Characterization of PEA-15, a major substrate for protein kinase C in astrocytes. J. Biol. Chem. 268, 5911-5920. |
5 | Ashendel, C.L. (1985). The phorbol ester receptor: a phospholipidregulated protein kinase. Biochim. Biophys. Acta 822, 219-242. DOI |
6 | Bardwell, A.J., Flatauer, L.J., Matsukuma, K., Thorner, J., and Bardwell, L. (2001). A conserved docking site in MEKs mediates high-affinity binding to MAP kinases and cooperates with a scaffold protein to enhance signal transmission. J. Biol. Chem. 276, 10374-10386. DOI |
7 | Beausejour, C.M., Krtolica, A., Galimi, F., Narita, M., Lowe, S.W., Yaswen, P., and Campisi, J. (2003). Reversal of human cellular senescence: roles of the p53 and p16 pathways. EMBO J. 22, 4212-4222. DOI |
8 | Buchner, K. (1995). Protein kinase C in the transduction of signals toward and within the cell nucleus. Eur. J. Biochem. 228, 211-221. DOI |
9 | Campisi, J. (2005). Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 120, 513-522. DOI |
10 | Camps, M., Nichols, A., Gillieron, C., Antonsson, B., Muda, M., Chabert, C., Boschert, U., and Arkinstall, S. (1998). Catalytic activation of the phosphatase MKP-3 by ERK2 mitogen-activated protein kinase. Science 280, 1262-1265. DOI |
11 | Candas, D., Fan, M., Nantajit, D., Vaughan, A.T., Murley, J.S., Woloschak, G.E., Grdina, D.J., and Li, J.J. (2013). CyclinB1/Cdk1 phosphorylates mitochondrial antioxidant MnSOD in cell adaptive response to radiation stress. J. Mol. Cell Biol. 5, 166-175. DOI |
12 | Chang, L., and Karin, M. (2001). Mammalian MAP kinase signalling cascades. Nature 410, 37-40. DOI |
13 | Cruzalegui, F.H., Cano, E., and Treisman, R. (1999). ERK activation induces phosphorylation of Elk-1 at multiple S/T-P motifs to high stoichiometry. Oncogene 18, 7948-7957. DOI |
14 | Chen, R.H., Sarnecki, C., and Blenis, J. (1992). Nuclear localization and regulation of erk- and rsk-encoded protein kinases. Mol. Cell Biol. 12, 915-927. DOI |
15 | Clemens, M.J., Trayner, I., and Menaya, J. (1992). The role of protein kinase C isoenzymes in the regulation of cell proliferation and differentiation. J. Cell Sci. 103, 881-887. |
16 | Collado, M., Gil, J., Efeyan, A., Guerra, C., Schuhmacher, A.J., Barradas, M., Benguria, A., Zaballos, A., Flores, J.M., Barbacid, M., et al. (2005). Tumour biology: senescence in premalignant tumours. Nature 436, 642. DOI |
17 | Devanand, P., Kim, S.I., Choi, Y.W., Sheen, S.S., Yim, H., Ryu, M.S., Kim, S.J., Kim, W.J., and Lim, I.K. (2014). Inhibition of bladder cancer invasion by Sp1-mediated BTG2 expression via inhibition of DNA methyltransferase 1. FEBS J. 281, 5581-5601. DOI |
18 | Jaken, S. (1990). Protein kinase C and tumor promoters. Curr. Opin. Cell Biol. 2, 192-197. DOI |
19 | Kazi, J.U., and Soh, J.W. (2008). Induction of the nuclear protooncogene c-fos by the phorbol ester TPA and v-H-Ras. Mol. Cells 26, 462-467. |
20 | Kikkawa, U., Takai, Y., Tanaka, Y., Miyake, R., and Nishizuka, Y. (1983). Protein kinase C as a possible receptor protein of tumorpromoting phorbol esters. J. Biol. Chem. 258, 11442-11445. |
21 | Kim, H.S., and Lim, I.K. (2009). Phosphorylated extracellular signalregulated protein kinases 1 and 2 phosphorylate Sp1 on serine 59 and regulate cellular senescence via transcription of p21Sdi1/Cip1/Waf1. J. Biol. Chem. 284, 15475-15486. |
22 | Lee, Y.Y., Kim, H.S., and Lim, I.K. (2015). Downregulation of PEA-15 reverses G1 arrest, and nuclear and chromatin changes of senescence phenotype via pErk1/2 translocation to nuclei. Cell. Signal. 27, 1102-1109. DOI |
23 | Kim, H.S., Song, M.C., Kwak, I.H., Park, T.J., and Lim, I.K. (2003). Constitutive induction of p-Erk1/2 accompanied by reduced activities of protein phosphatases 1 and 2A and MKP3 due to reactive oxygen species during cellular senescence. J. Biol. Chem. 278, 37497-37510. DOI |
24 | Krueger, J., Chou, F.L., Glading, A., Schaefer, E., and Ginsberg, M.H. (2005). Phosphorylation of phosphoprotein enriched in astrocytes (PEA-15) regulates extracellular signal-regulated kinase-dependent transcription and cell proliferation. Mol. Biol. Cell 16, 3552-3561. DOI |
25 | Kwak, I.H., Kim, H.S., Choi, O.R., Ryu, M.S., and Lim, I.K. (2004). Nuclear accumulation of globular actin as a cellular senescence marker. Cancer Res. 64, 572-580. DOI |
26 | Lim, I.K., Won Hong, K., Kwak, I.H., Yoon, G., and Park, S.C. (2000). Cytoplasmic retention of p-Erk1/2 and nuclear accumulation of actin proteins during cellular senescence in human diploid fibroblasts. Mech. Ageing Dev. 119, 113-130. DOI |
27 | Lu, Z., Liu, D., Hornia, A., Devonish, W., Pagano, M., and Foster, D.A. (1998). Activation of protein kinase C triggers its ubiquitination and degradation. Mol. Cell Biol. 18, 839-845. DOI |
28 | Menice, C.B., Hulvershorn, J., Adam, L.P., Wang, C.A., and Morgan, K.G. (1997). Calponin and mitogen-activated protein kinase signaling in differentiated vascular smooth muscle. J. Biol. Chem. 272, 25157-25161. DOI |
29 | Nishikawa, K., Toker, A., Johannes, F.J., Songyang, Z., and Cantley, L.C. (1997). Determination of the specific substrate sequence motifs of protein kinase C isozymes. J. Biol. Chem. 272, 952-960. DOI |
30 | Nishizuka, Y. (1992). Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 258, 607-614. DOI |
31 | Nishizuka, Y. (1995). Protein kinase C and lipid signaling for sustained cellular responses. FASEB J. 9, 484-496. DOI |
32 | Oliva, J.L., Caino, M.C., Senderowicz, A.M., and Kazanietz, M.G. (2008). S-Phase-specific activation of PKC alpha induces senescence in non-small cell lung cancer cells. J. Biol. Chem. 283, 5466-5476. DOI |
33 | Pearson, G., Robinson, F., Beers Gibson, T., Xu, B.E., Karandikar, M., Berman, K., and Cobb, M.H. (2001). Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr. Rev. 22, 153-183. |
34 | Renganathan, H., Vaidyanathan, H., Knapinska, A., and Ramos, J.W. (2005). Phosphorylation of PEA-15 switches its binding specificity from ERK/MAPK to FADD. Biochem. J. 390, 729-735. DOI |
35 | Rodier, F., Munoz, D.P., Teachenor, R., Chu, V., Le, O., Bhaumik, D., Coppe, J.P., Campeau, E., Beausejour, C.M., Kim, S.H., et al. (2011). DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion. J. Cell Sci. 124, 68-81. DOI |
36 | Rodriguez, P., Mitton, B., and Kranias, E.G. (2005). Phosphorylation of glutathione-S-transferase by protein kinase C-alpha implications for affinity-tag purification. Biotechnol Lett. 27, 1869-1873. DOI |
37 | Thomas, S.M., DeMarco, M., D'Arcangelo, G., Halegoua, S., and Brugge, J.S. (1992). Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases. Cell 68, 1031-1040. DOI |
38 | Wen-Sheng, W., and Jun-Ming, H. (2005). Activation of protein kinase C alpha is required for TPA-triggered ERK (MAPK) signaling and growth inhibition of human hepatoma cell HepG2. J. Biomed. Sci. 12, 289-296. DOI |
39 | Vaidyanathan, H., Opoku-Ansah, J., Pastorino, S., Renganathan, H., Matter, M.L., and Ramos, J.W. (2007). ERK MAP kinase is targeted to RSK2 by the phosphoprotein PEA-15. Proc. Natl. Acad. Sci. USA 104, 19837-19842. DOI |
40 | Vernier, M., Bourdeau, V., Gaumont-Leclerc, M.F., Moiseeva, O., Begin, V., Saad, F., Mes-Masson, A.M., and Ferbeyre, G. (2011). Regulation of E2Fs and senescence by PML nuclear bodies. Genes Dev. 25, 41-50. DOI |
41 | Wright, W.E., and Shay, J.W. (2001). Cellular senescence as a tumor-protection mechanism: the essential role of counting. Curr. Opin. Genet. Dev. 11, 98-103. DOI |
42 | Yang, S.H., Yates, P.R., Whitmarsh, A.J., Davis, R.J., and Sharrocks, A.D. (1998). The Elk-1 ETS-domain transcription factor contains a mitogen-activated protein kinase targeting motif. Mol. Cell Biol. 18, 710-720. DOI |
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