• 한국생명과학회:학술대회논문집
• /
• 한국생명과학회 2007년도 제48회 학술심포지움 및 추계국제학술대회
• /
• pp.106.1-106.1
• /
• 2007

See Full Text

• Journal of Mechanical Science and Technology
• /
• 제17권7호
• /
• pp.1016-1025
• /
• 2003

The rupture of blood vessels in the human brain results in serious pathological and medical problems. In particular, brain hemorrhage and hematomas resulting from impact to the head are a major cause of death. As such, investigating the tensile behavior and rupture of blood vessels in the brain is very important from a medical point of view. In the present study, the tensile characteristics of the blood vessels in the human brain were analyzed using a quasi-static uniaxial tensile test, and the properties of the arteries and veins compared. In addition, to compare the tensile behavior and demonstrate the validity of the experimental results, blood vessels from the legs of pigs were also tested and analyzed. The overall results were in accordance with the histological structures and previous medical reports.

• International Journal of Stem Cells
• /
• 제17권2호
• /
• pp.158-181
• /
• 2024

This study offers a comprehensive overview of brain organoids for researchers. It combines expert opinions with technical summaries on organoid definitions, characteristics, culture methods, and quality control. This approach aims to enhance the utilization of brain organoids in research. Brain organoids, as three-dimensional human cell models mimicking the nervous system, hold immense promise for studying the human brain. They offer advantages over traditional methods, replicating anatomical structures, physiological features, and complex neuronal networks. Additionally, brain organoids can model nervous system development and interactions between cell types and the microenvironment. By providing a foundation for utilizing the most human-relevant tissue models, this work empowers researchers to overcome limitations of two-dimensional cultures and conduct advanced disease modeling research.

• 생약학회지
• /
• 제27권4호
• /
• pp.350-353
• /
• 1996

The effects of acid hydrolysis product of Panax ginseng and MeOH extract of Euphorbia humifusa on the growth of human brain tumor cells were evaluated using U-373 MG human astrocytoma and SK-N-MC human neuroblastoma cells as model cellular systems. These plant extracts induced cytotoxicity in both cells in a dose-dependent manner. These cytotoxic effects were significantly inhibited by GSH, an antioxidant, in both cells. BAPTA/AM, an intracellular $Ca^{2+}$ chelator, significantly blocked the cytotoxic effects of these extracts in U-373 cells, but enhanced these effects in SK-N-MC cells. These results suggest that the plant extracts may be a valuable choice for the studies on the treatment of human brain tumors.

• Archives of Pharmacal Research
• /
• 제18권3호
• /
• pp.159-163
• /
• 1995

Previously, we have reported that methylene blue (MB) induces cytotoxicity in human brain tumor cells through the generation of free radicals. In this study the effect of deferoxamine (DFO), an iron chelator, on MB-induced cytotoxicity was investigated using SK-N-MC human neuroblastoma and U-373 MG human astrocytoma cells as model cellular systems. The cytotoxic effect of MB was potentiated by DFO. The potentiation effect of DFO was significantly blocked by either stoichiometric amounts of ferric ion, various antioxidants, hydroxyl radical scavengers or intracellular $Ca^{2+}$ release blockers. These results suggest that hydroxyl radical and intracellular $Ca^{2+}$ may act as important mediators of the enhanced cytotoxicity by MB and DFO. These results further suggest that the combined treatment with MB and DFO may be useful for the therapeutical applications of human brain tumors.

• 대한의생명과학회지
• /
• 제7권2호
• /
• pp.65-70
• /
• 2001

We have carried out PCR reactions to investigate if cytochrome P450 (P450) enzymes (1A1, 1A2, 2C8, 2E1 and 3A4), which are well hewn to be the key enzymes in detoxification process and/or synthesis of steroids in the liver, are expressed in the human brain, too. P450 1A1, 2C8 and 2E1 were expressed clearly. However, P450 1A2 and 3A4 were not detectable. Their expression levels in the human brain could be extremely low or they were not expressed at all. One base substitution at nucleotide 290 (A->G) was identified in P450 1A1. It is suspected to be an individual polymorphism. Our results should contribute to the better understanding of the role of cytochrome P450 enzymes in the human brain.

• 한국의학물리학회:학술대회논문집
• /
• 한국의학물리학회 2002년도 Proceedings
• /
• pp.359-359
• /
• 2002

Brain Stimulator processes both visual and audible stimulus and send them human sensory organ. The stimulus was accepted by our sensory organ effect upon human mental function. In this study, we examine the actual effect of commercial brain stimulator using tMRI system.

• 대한예방한의학회지
• /
• 제4권2호
• /
• pp.214-234
• /
• 2000

This study was carried to identify whether acupuncture of several acupuncture points can affect the brain and to observe which aspects appear in EEG mapping, using electroencephalography. Those results are as follows ; 1. The pattern of resting computerized EEG map in intact human is appered normal 2. Each Acupuncture in Kwan Weon or Jog Sam Ri meridian points bring about the increase in $\theta,\;\alpha-wave$ activity and at various area of the cerebrium and the decrease in $\delta,\;\beta-wave$ activity. It strands to reason that brain function is elevated On the other hand , synchronous acupuncture bring about the decrease of brain function in view of the decrease of $\delta,\;\theta-wave$ activity at frontal area, and the unstable brain state in view of the increase of $\beta-wave$ activity. 3. Acupuncture in Hyeon Jong meridian point bring about the increase of $\delta,\;\theta-wave$ activity at frontal area and $\beta-wave$ activity at temporal area. From these we deduce that brain function is declined and brain is unstable. Synchronous acupuncture with other meridian points reversly showed that brain function is elevated. 4. Synchronous acupuncture in Kwan Weon , Jog Sam Ri, Hyeon Jong bring about the decrease of the brain function and the unstable brain state, showing the pattern of increased $\delta,\;\theta-wave$ activity at frontal, parietal area, and increased $\beta-wave$ activity at temporal area.

• 한국산학기술학회논문지
• /
• 제16권11호
• /
• pp.7508-7512
• /
• 2015

뇌파로 의도를 접속하여 기계를 작동하는 뇌-기기 접속(Brain-Computer Interface, BCI) 기반의 인간-로봇상호작용(Human-Robot Interaction, HRI) 플랫폼을 제안한다. 사람의 뇌파로 의도를 포착하고 포착된 뇌파 신호에서 의도를 추출하거나 연관시키고 추출된 의도로 기기를 작동하게 하는 포착, 처리, 실행을 수행하는 플랫폼의 설계, 운용 및 구현 과정을 소개한다. 제안된 플랫폼의 구현 사례로 처리기에 구현된 상호작용 게임과 처리기를 통한 외부 장치 제어가 기술되었다. BCI 기반 플랫폼의 의도와 감지 사이의 신뢰성을 확보하기 위한 다양한 시도들을 소개한다. 제안된 플랫폼과 구현 사례는 BCI 기반의 새로운 기기 제어 작동 방식의 실현으로 확장될 것으로 기대된다.

• 한국HCI학회:학술대회논문집
• /
• 한국HCI학회 2009년도 학술대회
• /
• pp.642-645
• /
• 2009

Brain Computer Interface (BCI) is a communication pathway between devices (computers) and human brain. It treats brain signals in real-time basis and discriminates some information of what human brain is doing. In this work, we develop a EEG BCI system using a feature extraction such as common spatial pattern (CSP) and a classifier using Fisher linear discriminant analysis (FLDA). Two-class EEG motor imagery movement datasets with both cued and uncued are tested to verify its feasibility.