Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Cytotoxic Activities of Panax ginseng and Euphorbia humifusa in Human Brain Tumor Cells

인삼 비당부와 땅빈대의 뇌암세포 독성작용

  • Cha, Bae-Cheon (Department of Animal Nutrition & Resources, Sangji University) ;
  • Kim, Jung-Ae (Department of Molecular Biology, Pusan National University) ;
  • Lee, Yong-Soo (Department of Physiology, College of Medicine, Kwandong University)
  • 차배천 (상지대학교 생명자원과학대학 동물영양자원학과) ;
  • 김정애 (부산대학교 분자생물학과) ;
  • 이용수 (관동대학교 의과대학 생리학교실)
  • Published : 1996.12.30
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Abstract

The effects of acid hydrolysis product of Panax ginseng and MeOH extract of Euphorbia humifusa on the growth of human brain tumor cells were evaluated using U-373 MG human astrocytoma and SK-N-MC human neuroblastoma cells as model cellular systems. These plant extracts induced cytotoxicity in both cells in a dose-dependent manner. These cytotoxic effects were significantly inhibited by GSH, an antioxidant, in both cells. BAPTA/AM, an intracellular $Ca^{2+}$ chelator, significantly blocked the cytotoxic effects of these extracts in U-373 cells, but enhanced these effects in SK-N-MC cells. These results suggest that the plant extracts may be a valuable choice for the studies on the treatment of human brain tumors.

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