• The Journal of Korean Academic Society of Nursing Education
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• v.25 no.2
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• pp.206-215
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• 2019

Purpose: This study was conducted to examine the effects of an intervention program for human tissue donation with nurses, modified from the Korea Foundation for Human Tissue Donation, to promote human tissue donation via nurses' knowledge and attitudes toward human tissue donation, and self-efficacy for teaching tissue donation. Methods: A non-equivalent control group quasi-experimental design was adopted, and data were collected from 82 nurses (41 of each group: experimental and comparison) working at a general hospital in Inchon, South Korea. Results: In a multivariate analysis (MANOVA), the integrative effect on outcome variables from the intervention program was statistically significant (p<.001). Accordingly, an ANOVA was performed to determine which individual outcome variable showed a significant effect with intervention, and it was found that the effects of intervention on all the outcome variables (knowledge and attitude, and self-efficacy for teaching human tissue donation) were significant (p<.001). Conclusion: The results of the study showed that the intervention had positive effects on knowledge and attitudes toward tissue donation, and self-efficacy for teaching tissue donation among nurses. These outcome variables derived from the intervention might be essential for eliciting positive behavior toward human tissue donation.

• Food Science and Biotechnology
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• v.18 no.1
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• pp.103-107
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• 2009

Three traditional Chinese medicines, Agrimonia pilosa Ledeb, Grifola umbellata (pers.) Pilat, and Gambogia, are combined to form a compound extract, AGC. In this study, the in vitro and in vivo inhibitory effects of AGC on human gastric carcinoma MGC-803 cells were demonstrated, and the molecular mechanisms underlying these effects are investigated. Our results indicate that AGC inhibited MGC-803 cell growth in a dose-dependent manner as measured by a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay, with an $IC_{50}$ of about $6.045{\pm}0.69{\mu}g/mL$. In vivo, AGC inhibited growth of human gastric carcinoma in xenograft tumors in nude mice, and the inhibitory rate reached 55.2% at 300 mg/kg. The pro-apoptotic activity of AGC was attributed to its ability to decrease the expression of Bcl-2 and Pro-caspase3 and increase the expression of Bax. These results demonstrate that AGC can effectively induce programmed cell death and may be a promising anti-tumor drug in human gastric carcinoma.

• The Journal of Korean Academic Society of Nursing Education
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• v.23 no.3
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• pp.309-318
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• 2017

Purpose: This study aimed to verify the relationship between human rights sensitivity, advocacy attitudes, and advocacy interventions for mentally disabled people in psychiatric nurses and nursing students. Methods: This is a descriptive study. Using questionnaires, data were collected from 206 participants who were recruited from one mental health institute, one general hospital, and one university in S city. Data were analyzed by t-test, ANOVA, Pearson's correlation coefficient using SPSS/WIN 22. Results: The mean age was $33.8{\pm}12.89$. The mean scores of human rights sensitivity, advocacy attitudes, and advocacy intervention was $37.7{\pm}18.09$, $53.7{\pm}5.67$, and $47.4{\pm}7.08$, respectively. Human rights sensitivity correlated significantly with advocacy attitudes (r=.25, p=.020) and advocacy intervention (r=.17, p=.015). Also, there was a significant positive correlation between advocacy attitudes and advocacy intervention (r=.44, p<.001). Conclusion: These findings highlight that advocacy attitudes and advocacy interventions for mentally disabled people could be improved by increasing human rights sensitivity. Tailored education programs will be effective in the field of mental health care services to increase human rights sensitivity.

• Food Science and Industry
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• v.51 no.1
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• pp.8-15
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• 2018

Functional food research has been struggling to demonstrate their beneficial effects in human, however, the physiological changes in humans who are in the target for functional food are very subtle and long term. In addition, it is difficult to obtain significant beneficial effect because of the necessity of using relatively healthy subjects. Relatively healthy subjects are homeostatic, and most of the biomarkers maintain a certain level under the "normal" or "resting" state. Moreover, due to wide inter-individual variation, it is difficult to detect significant changes. To address this problem, research has been actively conducted to identify the efficacy of natural products using 'omics' and 'bioinformatics' technology. In this review, we would like to introduce the human intervention studies applied homeostatic challenge model.

• Korean Journal of Human Ecology
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• v.16 no.1
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• pp.193-204
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• 2007

This research has done for 67 undernutrition people of the aged men and women that are practiced follow-up nutrition intervention programs for 9weeks. The result of health related status, eating habit, food attitude and food intake for 2days is as following. 37.3% of objected old people are drinking, 20.9% of those are smoking and 29.9% of those are exercising. 55.2% of objected old people of the second intervention program about self-rated health say good. Sleeping hours of 25.4% of objected old people is from 6 to 8 hours. Meal amount and appetite above 98% of objected old people, compared to those of before sixty age, are decreasing and similar. 67.8% or 70.1% of the objected old people, compared to those of before sixty age, say same in sweet and salt taste. More significantly increased food group in after intervention than before intervention is vegetables and animal foods. There is no difference between management group and comparison group by ANCOVA analysis. DDS and DVS in management group are no significant differences between before intervention and after intervention.

• Nutrition Research and Practice
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• v.8 no.5
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• pp.571-579
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• 2014

BACKGROUND/OBJECTIVES: The objectives were to investigate the effect of a 12-wk intervention with behavioral modification on clinical characteristics and dietary intakes of young and otherwise healthy obese and to identify factors for successful weight loss. The goal was to lose 0.5 kg per week by reducing 300-500 kcal/day and by increasing physical activities. SUBJECTS AND METHODS: Forty four obese subjects (BMI > 25) and 19 normal weight subjects (BMI 18.5-23) finished the 12-week intervention. Obese subjects participated in 5 group educations and 6 individual counseling sessions. Normal weight subjects attended 6 individual counseling sessions for evaluations of dietary intake and exercise pattern. Anthropometric and clinical characteristics and 3-day dietary records were evaluated at baseline and week12. RESULTS: Weight and serum triglyceride and free fatty acid concentrations in obese group decreased significantly with intervention. Intakes of energy, fat, and cholesterol decreased significantly in the obese. Active participation, realistic weight loss goal setting, and weight gain after high school graduation not during childhood were identified as key factors for successful weight loss. CONCLUSIONS: The 12-week intervention with behavioral modification resulted in reduced energy and fat intakes and led to significant weight loss and improvements of clinical characteristics in the obese. The finding that those who became obese during childhood lost less weight indicates the importance of 'early' intervention.

• Nutrition Research and Practice
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• v.17 no.6
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• pp.1238-1254
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• 2023

BACKGROUND/OBJECTIVES: Weight loss via a mobile application (App) or a paper-based diary (Paper) may confer favorable metabolic and anthropometric changes. SUBJECTS/METHODS: A randomized parallel trial was conducted among 57 adults whose body mass indices (BMIs) were 25 kg/m² or greater. Participants randomly assigned to either the App group (n = 30) or the Paper group (n = 27) were advised to record their foods and supplements through App or Paper during the 12-week intervention period. Relative changes of anthropometries and biomarker levels were compared between the 2 intervention groups. Untargeted metabolic profiling was identified to discriminate metabolic profiles. RESULTS: Out of the 57 participants, 54 participants completed the trial. Changes in body weight and BMI were not significantly different between the 2 groups (P = 0.11). However, body fat and low-density lipoprotein (LDL)-cholesterol levels increased in the App group but decreased in the Paper group, and the difference was statistically significant (P = 0.03 for body fat and 0.02 for LDL-cholesterol). In the metabolomics analysis, decreases in methylglyoxal and (S)-malate in pyruvate metabolism and phosphatidylcholine (lecithin) in linoleic acid metabolism from pre- to post-intervention were observed in the Paper group. CONCLUSIONS: In the 12-week randomized parallel trial of weight loss through a App or a Paper, we found no significant difference in change in BMI or weight between the App and Paper groups, but improvement in body fatness and LDL-cholesterol levels only in the Paper group under the circumstances with minimal contact by dietitians or health care providers.

• Biomolecules & Therapeutics
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• v.25 no.2
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• pp.194-201
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• 2017

Lysophosphatidylethanolamine (LPE), a lyso-type metabolite of phosphatidylethanolamine, has been reported to be an intercellular signaling molecule. LPE mobilizes intracellular $Ca^{2+}$ through G-protein-coupled receptor (GPCR) in some cells types. However, GPCRs for lysophosphatidic acid (LPA) were not implicated in the LPE-mediated activities in LPA GPCR overexpression systems or in SK-OV3 ovarian cancer cells. In the present study, in human SH-SY5Y neuroblastoma cells, experiments with $LPA_1$ antagonists showed LPE induced intracellular $Ca^{2+}$ increases in an $LPA_1$ GPCR-dependent manner. Furthermore, LPE increased intracellular $Ca^{2+}$ through pertussis-sensitive G proteins, edelfosine-sensitive-phospholipase C, 2-APB-sensitive $IP_3$ receptors, $Ca^{2+}$ release from intracellular $Ca^{2+}$ stores, and subsequent $Ca^{2+}$ influx across plasma membranes, and LPA acted on $LPA_1$ and $LPA_2$ receptors to induce $Ca^{2+}$ response in a 2-APB-sensitive and insensitive manner. These findings suggest novel involvements for LPE and LPA in calcium signaling in human SH-SY5Y neuroblastoma cells.

• Korean Journal of Applied Biomechanics
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• v.33 no.2
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• pp.52-61
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• 2023

Objective: This study aimed to investigate the effect of a combined functional intervention program on the pain-related questionnaire, the erector spinae contractile properties, and trunk extensor strength of prime-aged females with non-specific chronic low back pain. Method: 16 (female: 16) prime-aged subjects (age: 60.88 ± 6.09 years, height: 158.16 ± 5.58 cm, weight: 59.05 ± 9.44 kg) participated in this study. Results: Except for Tampa Scale of Kinesiophobia all pain-related questionnaires revealed a significant decrease after the intervention program (p<.001). Tensiomyography of the erector spinae revealed a significant post-intervention program increase in the maximum radial displacement (p<.05) and velocity of contraction (p<.05), however, there wasn't a significant post-intervention program change in the contraction time. Additionally, Trunk extensor strength showed a significant increase post-intervention program (p<.001). Conclusion: Our results indicated that the combined functional intervention program positively changed pain-related questionnaires and reduced erector spinae muscle stiffness, increasing the velocity of erector spinae contraction. Additionally, improved the trunk extensor strength.

• Journal of the Ergonomics Society of Korea
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• v.30 no.4
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• pp.443-450
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• 2011

Objective: The aim of this paper is to introduce ergonomic guidelines and intervention procedures for farm workers. Background: It is necessary to ameliorate the conditions of risky and hazardous work for farm workers. Method: Various references and books have been reviewed to assess ergonomic guidelines and intervention procedures for farm workers. Results: Human centered intervention has become an important approach not only to prevent musculoskeletal disorders but also to enhance the efficiency of work for farm workers. Conclusion: Farm work should be improved by active cooperation with researchers in field of ergonomics. Application: These results can be used to provide baseline information for more effective improvements of farm work.