• Journal of Microbiology and Biotechnology
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• v.26 no.2
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• pp.394-401
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• 2016

Recently, the clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein 9 (CRISPR/Cas9) system, a genome editing technology, was shown to be versatile in treating several antibiotic-resistant bacteria. In the present study, we applied the CRISPR/Cas9 technology to kill extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli. ESBL bacteria are mostly multidrug resistant (MDR), and have plasmid-mediated antibiotic resistance genes that can be easily transferred to other members of the bacterial community by horizontal gene transfer. To restore sensitivity to antibiotics in these bacteria, we searched for a CRISPR/Cas9 target sequence that was conserved among >1,000 ESBL mutants. There was only one target sequence for each TEM- and SHV-type ESBL, with each of these sequences found in ~200 ESBL strains of each type. Furthermore, we showed that these target sequences can be exploited to re-sensitize MDR cells in which resistance is mediated by genes that are not the target of the CRISPR/Cas9 system, but by genes that are present on the same plasmid as target genes. We believe our Re-Sensitization to Antibiotics from Resistance (ReSAFR) technology, which enhances the practical value of the CRISPR/Cas9 system, will be an effective method of treatment against plasmid-carrying MDR bacteria.

• 제어로봇시스템학회:학술대회논문집
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• 2001.10a
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• pp.46.2-46
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• 2001

A method of interactive human interface for motion modification of an articulated object model like a human body, a multiple joints robot, etc. has been developed, and implemented to a human body motion model. In the case of computer software models, the initial data setting for overall motion is rather easy. However, modifying or correcting the initially set motion is rather difficult for keeping consistency. In this research, the requirements shown below have mainly been set as the specifications ...

• Journal of the Ergonomics Society of Korea
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• v.6 no.2
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• pp.29-37
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• 1987

This paper discusses the gereral principles to be considered in the design of usef interfaces of graphics packages and presents a top-down design process in systematic way. The effective and convenient user interfaces are analyzed based on human factors criteria and we discuss the properties and application requirements of typical interaction techniques which support primitive tasks. The choice of an interaction technique has a set of input device prerequisites to be met.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.64 no.7
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• pp.1056-1063
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• 2015

In this paper, we develop an interface for aerial photograph platform which consists of a quadrotor and a gimbal using the human body and the head posture. As quadrotors have been widely adopted in many industries such as aerial photography, remote surveillance, and maintenance of infrastructures, the demand of aerial video and photograph has been increasing remarkably. Stick type remote controllers are widely used to control a quadrotor, but this method is not an intuitive way of controlling the aerial vehicle and the camera simultaneously. Therefore, a new interface which controls the serial photograph platform is presented. The presented interface uses the human head movement measured by head-mounted display as a reference for controlling the camera angle, and the human body posture measured from Kinect for controlling the attitude of the quadrotor. As the image captured by the camera is displayed on the head-mounted display simultaneously, the user can feel flying experience and intuitively control the quadrotor and the camera. Finally, the performance of the developed system shown to verify the effectiveness and superiority of the presented interface.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.32 no.2
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• pp.140-146
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• 2009

Since the computer technology has been drastically developed and broadly employed for the design of human machine system, human system interface was somehow digitalized. Actually the operator's working environment employing the digital devices are not be fully digitalized due to its technical constraints so that it has been changed to the hybrid environment which has a combination of digital and analog elements. The hybrid environments need to study its characteristics and the guidelines for the proper design and evaluation purpose. This paper describes the human factor design elements of the console operated under hybrid environment through studying the characteristics of digital and analog environment based on the related human factor guidelines and literatures. The result of this paper implies the contribution to the evaluation of the generic human working environment which digital and analog elements are jointly used.

• 제어로봇시스템학회:학술대회논문집
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• 2001.10a
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• pp.59.4-59
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• 2001

In this paper, wireless interface of the motion between human and robot is implemented. The idea is that if a human who is equiped with device including accelerometer and rate-gyro sensor move his/her arm, then the robot follows human motion. The robot is designed as wheeled type mobile robot with two link arms. The robot´s basic movements such as forward, backward, left, right movement can be controlled from foot sensor which human steps on. Arm movements can be controlled by arm motion of human motion. In order to detect human motion, sensor data analysis from gyro and accelerometer has to be done. Data from sensors are transferred through wireless communication to activate the robot.

• Journal of the Korea Society of Computer and Information
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• v.8 no.4
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• pp.57-62
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• 2003

At the beginning stage of design process, the concept design is required to equip the creative idea thinking and exerts critical effect on the success of production. To support the idea thinking process at the stage of concept design, web-based Creative Group Thinking System(CGTS) was developed. In this vein, the purpose of this study is to investigate the significance of HCI(Human Computer Interface) and UI(User Interface) and to find the way to increase the applicability of the UI of CGTS.

• Journal of Korea Society of Industrial Information Systems
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• v.19 no.5
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• pp.9-14
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• 2014

Recently, various contents using human motion are developed in computer vision and game industries. If we try to apply human motion to application programs and contents, users can experience a sense of immersion getting into it so that the users feel a high level of satisfaction from the contents. In this research, we analyze human head motion using images captured from an webcam and then we apply the result of motion recognition to a game without special devices as an interface. The proposed method, first, segments human head region using an image composed of MHI(Motion History Image) and the result of skin color detection, and then we calculate the direction and distance by the MHI sequence. In experiments, the proposed method for human head motion recognition was tested for controlling a game player. From the experimental results we proved that the proposed method can make a gammer feel more immersed into the game. Furthermore, we expect the proposed method can be an interface of a serious game for medical or rehabilitation purposes.

• Transactions of the Korean Society of Automotive Engineers
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• v.17 no.4
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• pp.16-23
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• 2009

Driving simulators are useful tools not only to test the components of future cars but also to evaluate the telematics service and HMI (Human-Machine Interface). However driving simulators cannot be implemented to test and evaluate the telematics service system because the GPS (Global Positioning System) which contains basic functional support for the telematics module do not work in the VR (virtual reality) environment. This paper presents a method to implement telematics service to a driving simulator by developing the GPS simulator which is able to emulate GPS satellite signals consist of NMEA-0183 protocol and RS232C communication standards. It is expected that the driving simulator with the GPS simulator can be used to study HMI and human-factor evaluations of the commercial telematics system to realize the HiLES (Human-in-the-Loop Evaluation System).

• 한국HCI학회:학술대회논문집
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• 2006.02a
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• pp.88-93
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• 2006

대부분의 입체 영상물은 단지 화면을 입체로 보여주는 것만이 목적이다. 그러나 만약 입체 영상으로 표현된 가상 물체를 손가락을 뻗어 실제로 만져볼 수 있다면 현실감은 더욱 증가할 것이다. 본 연구에서는 입체영상 장치로 만든 가상 비누방울들을 실제 자기 손가락으로 터뜨리는 듯한 느낌을 가질 수 있도록 해주는 가상 현실 게임 시스템을 만들었다. 이 때 두 개의 위치/방향 센서를 이용하여 손가락 끝과 머리의 움직임을 추적하여 가상 공간과 현실 공간의 두 좌표계를 서로 일치시켜 볼 수 있도록 하였으며, 자체 제작한 진동촉각 장치를 이용하여 비누방울을 터뜨릴 때 손가락에 약한 진동 촉감을 제공하여 실제로 자신이 비누방울을 터뜨리는 듯한 느낌을 갖도록 하였다. 이러한 시도를 통해 입체영상 기술을 이용한 가상현실 게임에서의 진동촉각 장치의 활용 가능성을 확인하였다.