• Journal of Life Science
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• v.27 no.4
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• pp.398-407
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• 2017

BTG 1 (B-cell translocation gene 1) gene was first identified as a translocation gene in a case of B-cell chronic lympocytic leukemia. BTG1 is a member of the BTG/TOB family with sharing a conserved N-terminal region, which shows anti-proliferation properties and is able to stimulate cell differentiation. In this study, we identified and characterized the pacific oyster Crassostrea gigas BTG1 (cg-BTG1) gene from the gill cDNA library by an Expressed Sequence Tag (EST) analysis and its nucleotide sequence was determined. The cg-BTG1 gene encodes a predicted protein of 182 amino acids with 57% 56% identities to its zebrafish and human counterparts, and is an intron-less gene, which was confirmed by PCR analysis of genomic DNA. Maximal homologies were shown in conserved Box A and B. The deduced amino acid sequence shares high identity with other BTG1 genes of human, rat, mouse and zebrafish. The phylogenic analysis and sequence comparison of cg-BTG1 with other BTG1 were found to be closely related to the BTG1 gene structure. In addition, the predicted promoter region and the different transcription-factor binding site like an activator protein-1 (AP-1) response element involved in negative regulation and serum response element (SRE) were able to be identified by the genomic DNA walking experiment. The quantitative real-time PCR analysis showed that the mRNA of cg-BTG1 gene was expressed in gill, heart, digestive gland, intestine, stomach and mantle. The cg-BTG1 gene was expressed mainly in heart and mantle.

• Advances in biomechanics and applications
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• v.1 no.3
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• pp.187-210
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• 2014

With the goal of increasing the survivorship of the prosthesis and anticipating primary stability problems of new prosthetic implants, finite element evaluation of the micromotion, at an early stage of the development, is mandatory. This allows assessing and optimizing different designs without manufacturing prostheses. This study aimed at investigating, using finite element analysis (FEA), the difference in the prediction of the primary stability of cementless hip prostheses implanted into a $Sawbones^{(R)}$ 4th generation, using the manufacturer's mechanical properties and using mechanical properties close to that of human bone provided by the literature (39 papers). FEA was carried out on the composite $Sawbones^{(R)}$ implanted with a straight taper femoral stem subjected to a loading condition simulating normal walking. Our results show that micromotion increases with a reduction of the bone material properties and decreases with the augmentation of the bone material properties at the stem-bone interface. Indeed, a decrease of the cancellous Young modulus from 155MPa to 50MPa increased the average micromotion from $29{\mu}m$ up to $41{\mu}m$ (+42%), whereas an increase of the cancellous Young modulus from 155MPa to 1000MPa decreased the average micromotion from $29{\mu}m$ to $5{\mu}m$ (-83%). A decrease of cortical Young modulus from 16.7GPa to 9GPa increase the average global micromotion from $29{\mu}m$ to $35{\mu}m$ (+33%), whereas an increase of the cortical Young modulus from 16.7GPa to 21GPa decreased the average global micromotion from $29{\mu}m$ to $27{\mu}m$ (-7%). It can also be seen that the material properties of the cancellous structure had a greater influence on the micromotion than the material properties of the cortical structure. The present study shows that micromotion predicted at the stem-bone interface with material properties of the $Sawbones^{(R)}$ 4th generation is close to that predicted with mechanical properties of human femur.

• Korean Journal of Human Ecology
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• v.18 no.6
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• pp.1303-1314
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• 2009

The purpose of this study lies in examining the characteristics of differentiated body types for plus-size women and obtaining basic data for the wide-ranging choices of ready-made clothing in a consumer's place. The results of this study displayed no significant differences for subjects in their 30s and 40s in comparison to standards by ages but showed a significant difference with subjects in their 50s when compared with the data from Size Korea (2004). Research data in the height and length categories were lower, and the majority of data from the other categories were higher. In order to analyze the characteristics of a plus-size woman's body, 4 factors were differentiated into 3 types with 17 categories: Factor 1 was the element of the thickness of the trunk, factor 2 was the element of the thickness of the lower body and legs, factor 3 was the element of shoulder size and factor 4 was the element of the upper body length. The accumulation rate was shown to be 74.47%. The characteristics for each type were as follows: Type 1 is a body type with a relatively thin waist, small width and girth of upper body and curvy lower body, type 2 is the average body type, and type 3 is a body type with big breasts and abdominal obesity. The standard body type belonged to type 2. According to the correspondency test between age and type, the characteristics of type 1 corresponded relatively close to the measures of subjects in their 40s and relatively far from subjects in their 30s to 50s while type 2 and type 3 appeared to be similar to subjects in their 50s.

• International Journal of Automotive Technology
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• v.5 no.1
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• pp.33-46
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• 2004

A finite element model development of a 50th percentile male cervical spine is presented in this paper. The model consists of rigid, geometrically accurate vertebrae held together with deformable intervertibral disks, facet joints, and ligaments modeled as a series of nonlinear springs. These deformable structures were rigorously tuned, through failure, to mimic existing experimental data; first as functional unit characterizations at three cervical levels and then as a fully assembled c-spine using the experimental data from Duke University and other data in the NHTSA database. After obtaining satisfactory validation of the performance of the assembled ligamentous cervical spine against available experimental data, 22 cervical muscle pairs, representing the majority of the neck's musculature, were added to the model. Hill's muscle model was utilized to generate muscle forces within the assembled cervical model. The muscle activation level was assumed to be the same for all modeled muscles and the degree of activation was set to correctly predict available human volunteer experimental data from NBDL. The validated model is intended for use as a post processor of dummy measurement within the simulated injury monitor (SIMon) concept being developed by NHTSA where measured kinematics and kinetic data obtained from a dummy during a crash test will serve as the boundary conditions to "drive" the finite element model of the neck. The post-processor will then interrogate the model to determine whether any ligament have exceeded its known failure limit. The model will allow a direct assessment of potential injury, its degree and location thus eliminating the need for global correlates such as Nij.

• Korean Institute of Interior Design Journal
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• no.27
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• pp.20-27
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• 2001

The tendency of formalization in Contemporary Architecture deeply relies on the thought of Western Philosophy, which emphasizes the art of image perceived visually but ignores the body and perception of a human beig who uses the architecture and lives in it. On the contrary, Merleau-Ponty asserted long time ago that the world and the body are inseparably related to each other. The phenomenology is important in Architecture, since the center of thought should be taken back to the human body if a artistic meaning can be obtained by Architecture. From this point of view, the meaning of Contemporary Architecture can be renewed by the phenomenological idea of Merleau-Ponty as a means of expanding thought that overcomes the limit of formalization in Contemporary Architecture. This research aims to ream from Steven Holl's work, and show the Architectural elements that are used for preceptual experience of phenomenon and the function of those element sin Architectural space of his works. The result of study on about the phenomenal light and water in Architectural space of Steven Holl is as follows; First, in perceptional experience of phenomenon, time is an important element, which is successive and make a field that cause perceptional experience. Second, light, as a phenomenological element, acted as a means of expressing the comparison and change of light and shadow in Architectural space and showing the change of color by the diversity of time in inner space. Third, water, as a phenomenal lens, not only acted functional but also functioned as an element of sensual experience in Architectural space. It acted as an image containing time, space, just like a mirror that reflect the environment.

• Journal of Biomedical Engineering Research
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• v.21 no.3 s.61
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• pp.285-293
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• 2000

Age-related changes in the geometry of human lumbar spine would lead to changes of its mechanical behaviors. To investigate the effects of the geometric changes, no age-related changes in the material/mechanical properties were considered. Using the finite element method. two age-related models of lumbar spine segments (L3-L4) were constructed. The annulus of the models was modeled as laminate composite elements with 16 layers and 6 materials. The spinal stiffness and facet reaction of the lumbar spine increased with the age-related geometric changes in various combined loadings. Fiber and transverse tensile strains of the inner annulus. cancellous bone stress and end-plate stress decreased with the age-related geometric changes whereas fiber/layer compressive strains of the annulus. facet reaction. ligament reaction and end-plate rigidity increased. Consequently, it appears that in the normal age-related deterioration of discs, the age-related geometric change contributes to the increase of spinal stiffness (the decrease in range of the motion segment), preventing an excessive deformation of the disc.

• Journal of Fashion Business
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• v.13 no.1
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• pp.34-50
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• 2009

The purpose of this study was to compare the curricula majored in fashion retail related area at 4-year colleges in Korea and the USA. Courses were divided into 15 elements including basics, design, production, textile, marketing, industry, merchandise planning, promotion, consumer behaviour, management, business, organization, internship and etc.. The research findings were as follows: 1. Most of 'industry' related majors in Korea consisted of fashion manufacture-oriented curricula elements including design, pattern making, tailoring, draping and textile sciences. 2. Fashion Marketing major stressed on a merchandising element and a marketing one, and the Fashion major focused on the promotion element and the merchandising element as well. However, the retail element was less focused than other elements in the Korean colleges. 3. Fashion Retail related majors in the USA College were likely to focus on the practical fashion retail management elements including retail, marketing, management, business, organization behavior and internship specialized by the major. The different curricula between two countries were clearly existed in terms of the major name and the construction of the course element. The results made in the research would be applied with some modification or adjustments in the fashion retail oriented curricula in order to produce the competitive retail human resource in Korea.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.21 no.48
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• pp.101-111
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• 1998

CNS (Car Navigation System) is the most compatible candidate among various in-vehicle information systems as a provider of ITS (Intelligence Transport Systems) information. It generally consists of remote controller, display, CD-changer, GPS receiver and so on. Among them, display is the most important and critical element of the HMI (Human-Machine Interface) suggesting the digital map to the driver. Therefore, it is certain that the display gives cognitive, physical, mental and visual workloads to the driver which are directly related with the driver's and road safety with the success of ITS. Until now, various human factors techniques have been developed and applied to estimate the driver's workload and to collect the driver's requirements of the CNS digital map, for example, mental workload assessment, visual activity analysis, cognitive analysis and so on. In addition to these kinds of techniques, this research performed the human sensibility ergonomics approach to directly investigate and evaluate the driver's requirements and sensibilities of the real products.

• Journal of the Korean Institute of Landscape Architecture
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• v.27 no.3
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• pp.39-49
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• 1999

The objective of this study is to characterize the landscape retaining dynamic character through the distinction between the spatial structure and the landscape. In this study, the landscape was characterized by the image of environment viewed by human being. Firstly, the landscape was disscussed in terms of such three element as the environment viewed by human being, the psychological detachment from the environment and the meaning of image. Secondly, the dynamic character of the landscape was determined by the comparision between the spatial structure of the static elements and the landscape experience through the case study Soshe garden. In the study found that landscape experience depend on the dynamic viewpoint and human views while the spatial structure is stable and static. This study also found that landscape is an open system which can be diachronically transformed by human value, while spatial structure is a synchronic closed system.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1995.10a
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• pp.9-15
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• 1995

When quiescent cells ate stimulated to enter the cell cycle, the thymidine kinase(TK) gene is transcriptionally activated at the border of Gl and 5. In this report we show that the human TK promoter contains multiple protein-binding sites. By site-directed mutagenesis, we identified a protein-binding site on the human TK promoter requited for conferring Gl-S-regulated transcription to a heterologous promoter and dissociated it functionally from an adjacent protein-binding domain containing an inverted CCAAT motif requited for high basal level expression. Substitution-mutation of this site results in constitutive expression of the neo reporter gene in serum-stimulated fibroblasts, as well as in cells arrested in mid-Gl by a temperature-sensitive mutation. The regulatory domains for the human TK promoter exhibit interesting symmetrical features, including a set of CCAAT motifs and sites similar to the novel Yi protein-binding site recently discovered in the mouse TK promoter. Thus, components of the hTK complex is important for hTK gene regulation.