• Journal of Ginseng Research
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• v.44 no.1
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• pp.14-23
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• 2020

Ginseng has been used as a popular herbal medicine in East Asia for at least two millennia. However, 20(R)-ginseng saponins, one class of important rare ginsenosides, are rare in natural products. 20(R)-ginseng saponins are generally prepared by chemical epimerization and microbial transformation from 20(S)-isomers. The C20 configuration of 20(R)-ginseng saponins are usually determined by ¹³C NMR and X-ray single-crystal diffraction. 20(R)-ginseng saponins have antitumor, antioxidative, antifatigue, neuroprotective, and osteoclastogenesis inhibitory effects, among others. Owing to the chemical structure and pharmacological and stereoselective properties, 20(R)-ginseng saponins have attracted a great deal of attention in recent years. In this study, the discovery, identification, chemical epimerization, microbial transformation, pharmacological activities, and metabolism of 20(R)-ginseng saponins are summarized.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.22 no.4
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• pp.330-340
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• 2019

Human breast milk contains numerous biomolecules. Human milk oligosaccharides (HMOs) are the third most abundant component of breast milk, after lactose and lipids. Amongst the synthetized HMOs, 2'-fucosyllactose (2'-FL) and lacto-N-neotetraose (LNnT) are widely studied and are considered safe for infant nutrition. Several studies have reported the health benefits of HMOs, which include modulation of the intestinal microbiota, anti-adhesive effect against pathogens, modulation of the intestinal epithelial cell response, and development of the immune system. The amount and diversity of HMOs are determined by the genetic background of the mothers (HMO secretors or non-secretors). The non-secretor mothers secrete lower HMOs than secretor mothers. The breastfed infants of secretor mothers gain more health benefit than those of non-secretor mothers. In conclusion, supplementation of infant formula with 2'-FL and LNnT is a promising innovation for infant nutrition.

• Journal of Korean Clinical Nursing Research
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• v.23 no.3
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• pp.302-311
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• 2017

Purpose: The purpose of this study was to examine nursing organizational culture and resilience and their effects on quality of nursing service. Methods: A cross-sectional study was conducted. A convenience sampling method was used to collect data from 199 participants who worked in a tertiary hospital in G city. Demographic and work related variables, quality of nursing service, resilience, and nursing organizational culture were measured using validated self-report questionnaires. Results: All of the participants were women and the majority were staff nurses and single. A statistically significant difference in quality of nursing service was found for age, marital status, educational level, clinical career, position and perceived health status. Age, educational level, clinical career, position, resilience, innovation-oriented culture, relation-oriented culture, and hierarchy-oriented culture were significant predictors of quality of nursing service, explaining 47% of total variance. Among the predictors, resilience was the strongest predictor, followed by innovation-oriented culture, and hierarchy-oriented culture. Conclusion: Findings indicate that quality of nursing service can be improved by raising individual nurse's resilience and advancing nursing organizational culture. Considering the identified factors, researchers and administrators need to develop and provide clinical nurses with a variety of programs to improve the quality of their nursing service.

• The Academic Congress of Korean Shoulder and Elbow Society
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• 2003.11a
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• pp.61-63
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• 2003

- Injury to the neurovascular structures can be minimized - Incising the skin only - Using blunt dissection and blunt trocars - Distending the joint - Placing the anterior portals in a more proximal position - With more innovation in instrument and techni

• Korea Journal of Hospital Management
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• v.27 no.4
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• pp.36-55
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• 2022

Purpose: This study explores the diffusion factors of corporate entrepreneurship among members of medical institutions. Methodology/Approach: The study explores the case of Granum Sinapis Center at Seoul St. Mary's Hospital, the first medical institution to establish a support organization for "innovation and start-up" as well as examines the changes in individual perceptions of participants in the institution's in-house contest. Among the 140 participants in the 2nd Contest held in 2022, seven participants were selected for interview in consideration of their job occupation and years of service. In-depth interviews were conducted for each individual. Findings: The participants applied for the contest under the direct and indirect influence of co-workers as well as compensatory factors. An individual's corporate entrepreneurial characteristics can be innate or acquired. The participants of the in-house contest had a positive experience in contrast to the existing organizational culture. The results reveal that emotional support from top and middle managers, along with the role of dedicated departments, can affect innovative behavior. Practical Implications: Contest participants reported personal growth, improved job satisfaction, and a change in perception of the organizational culture; they expressed their willingness to recommend. The results confirm the need to support such systems and shift focus to managerial (emotional) support and dedicated resources for developing individual entrepreneurship.

• Journal of Periodontal and Implant Science
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• v.53 no.3
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• pp.218-232
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• 2023

Purpose: This study evaluated the efficacy of a tube-shaped poly(ε) caprolactone - β tricalcium phosphate (PCL-TCP) scaffold with the incorporation of human umbilical cord-derived mesenchymal stem cells (hUCMSCs) and platelet-rich plasma (PRP) for bone regeneration in the procedure of single-stage sinus augmentation and dental implantation in minipigs. Methods: Implants were placed in the bilateral sides of the maxillary sinuses of 5 minipigs and allocated to a PCL-TCP+hUCMSCs+PRP group (n=5), a PCL-TCP+PRP group (n=5), and a PCL-TCP-only group (n=6). After 12 weeks, bone regeneration was evaluated with soft X-rays, micro-computed tomography, fluorescence microscopy, and histomorphometric analysis. Results: Four implants failed (2 each in the PCL-TCP+hUCMSCs+PRP and PCLTCP+hUCMSC groups). An analysis of the grayscale levels and bone-implant contact ratio showed significantly higher mean values in the PCL-TCP+hUCMSCs+PRP than in the PCL-TCP group (P=0.045 and P=0.016, respectively). In fluoromicroscopic images, new bone formation around the outer surfaces of the scaffolds was observed in the PCLTCP+hUCMSCs+PRP group, suggesting a tenting effect of the specially designed scaffolds. Bone regeneration at the scaffold-implant interfaces was observed in all 3 groups. Conclusions: Using a tube-shaped, honeycombed PCL-TCP scaffold with hUCMSCs and PRP may serve to enhance bone formation and dental implants' osseointegration in the procedure of simultaneous sinus lifting and dental implantation.

• International Journal of Quality Innovation
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• v.9 no.3
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• pp.1-14
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• 2008

Patient satisfaction with the Emergency Department(ED) in a hospital is related to the length of stay, and especially to the amount of waiting time for medical treatments. ED overcrowding decreases quality and efficiency, therefore affecting hospitals' profitability. This paper presents a forecasting and simulation model for resource management of the ED at Moses H. Cone Memorial Hospital. A linear regression forecasting model is proposed to predict the number of ED patient arrivals, and then a simulation model is provided to estimate the length of stay of ED patients, system throughput, and the utilization of resources such as triage nurses, patient beds, registered nurses, and medical doctors. The near future load level of each resource is presented using the proposed models.

• Journal of the Korea Safety Management & Science
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• v.10 no.3
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• pp.55-62
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• 2008

This is to prevent accidents that can be caused during the process of hospital logistics and accidents in relation to the traceability of medical wastes. And this is also to set up the logistic management system of medical wastes is hospital where the safety of patients shall to regard as the first priority. through these case studies effective operating plans shall be provided.

• Korean Journal of Occupational Health Nursing
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• v.20 no.1
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• pp.1-13
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• 2011

Purpose: This study was conducted to compare the characteristics of organizational structure and occupational satisfaction among nurses in general hospital and small to medium-sized hospital and to investigate the affecting factors on their occupational satisfaction. Methods: The study was based on the cross-sectional descriptive survey. A self-report questionnaire was used to collect data from 343 nurses between June and July, 2010. Data were analyzed by ${\chi}^2$-test, t-test, ANOVA, Scheffe's test, Pearson's correlation coefficient, and multiple regression using the SPSS/WIN 14.0 program. Results: Hierarchical structure was dominant in general hospital whereas relationship was highly valued in small to medium-sized hospital. Occupational satisfaction was positively correlated with work environment built on relationship, innovation and tasks. Factors significantly influencing on occupational satisfaction in general hospital included innovative work environment, nurses' income and their health status ($R^2$=40.3%). For the small to medium-sized hospital, they included innovative work environment, satisfaction in life, tasks and professionalism ($R^2$=40.4%). Conclusion: Organizational structure, especially innovative work environment and relationship-oriented attitude had a significant influence on nurses' occupational satisfaction. Therefore, nursing administrators have to develop and consider organizational structure to improve occupational satisfaction.

• Journal of East-West Nursing Research
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• v.26 no.2
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• pp.185-195
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• 2020

Purpose: This study examines the factors affecting patient-centered nursing among regional public hospital nurses, with a focus on communications, professionalism, organizational culture, and teamwork. Methods: We included 162 nurses working at five regional public hospitals in G province. Data were collected from October 7 through October 19, 2019 using self-report questionnaires. Data were analyzed using descriptive statistics, t-test or ANOVA, Pearson's correlation coefficient, and hierarchical multiple regression analysis using SPSS (Version 24.0). Results: The factors affecting patient-centered nursing included an innovation-oriented culture, working in an intensive care unit, hierarchy-oriented culture, and nursing professionalism. These variables explained 43% of patient-centered nursing. Conclusions: These results suggest that enhancing an innovation-oriented culture is necessary for patient-centered nursing and to improve nurses' awareness about the importance of patient-centered nursing. Moreover, organizational efforts are required to increase nurses' professionalism through suitable educational programs in regional public hospitals.