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http://dx.doi.org/10.5223/pghn.2019.22.4.330

The Role of Two Human Milk Oligosaccharides, 2'-Fucosyllactose and Lacto-N-Neotetraose, in Infant Nutrition  

Hegar, Badriul (Cipto Mangunkusumo Hospital, Faculty of Medicine, University of Indonesia)
Wibowo, Yulianti (Nestle Nutrition Institute)
Basrowi, Ray Wagiu (Nestle Nutrition Institute)
Ranuh, Reza Gunadi (Soetomo Hospital, Faculty of Medicine University Airlangga)
Sudarmo, Subianto Marto (Soetomo Hospital, Faculty of Medicine University Airlangga)
Munasir, Zakiudin (Cipto Mangunkusumo Hospital, Faculty of Medicine, University of Indonesia)
Atthiyah, Alpha Fardah (Soetomo Hospital, Faculty of Medicine University Airlangga)
Widodo, Ariani Dewi (Harapan Kita Hospital)
Supriatmo, Supriatmo (Adam Malik Hospital)
Kadim, Muzal (Cipto Mangunkusumo Hospital, Faculty of Medicine, University of Indonesia)
Suryawan, Ahmad (Soetomo Hospital, Faculty of Medicine University Airlangga)
Diana, Ninung Rose (Kariadi Hospital)
Manoppo, Christy (Kandou Hospital)
Vandenplas, Yvan (KidZ Health Castle, UZ Brussel, Vrije Universiteit Brussel)
Publication Information
Pediatric Gastroenterology, Hepatology & Nutrition / v.22, no.4, 2019 , pp. 330-340 More about this Journal
Abstract
Human breast milk contains numerous biomolecules. Human milk oligosaccharides (HMOs) are the third most abundant component of breast milk, after lactose and lipids. Amongst the synthetized HMOs, 2'-fucosyllactose (2'-FL) and lacto-N-neotetraose (LNnT) are widely studied and are considered safe for infant nutrition. Several studies have reported the health benefits of HMOs, which include modulation of the intestinal microbiota, anti-adhesive effect against pathogens, modulation of the intestinal epithelial cell response, and development of the immune system. The amount and diversity of HMOs are determined by the genetic background of the mothers (HMO secretors or non-secretors). The non-secretor mothers secrete lower HMOs than secretor mothers. The breastfed infants of secretor mothers gain more health benefit than those of non-secretor mothers. In conclusion, supplementation of infant formula with 2'-FL and LNnT is a promising innovation for infant nutrition.
Keywords
Human milk; Oligosaccharide; 2'-fucosyllactose; Lacto-N-neotetraose; Infant; Breast feeding;
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