• Title/Summary/Keyword: Homology Index

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Truss Ooptimization Using Homology Constraints under Multiple Loadings (호몰로지 제한조건을 이용한 다중하중하의 트러스 최적설계)

  • ;;;Kim, Kyung-Keun;Park, Gyung-Jin
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.20 no.9
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    • pp.2800-2811
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    • 1996
  • The deformation of a structure shall be called homologous, if a given geometrical relation holds, for a given number of structural points, before, during, and after the deformation. Some researchers have utilized the idea on structural design with finite element method. The approaches use the decomposition of the FEM equation or equality of eqality equations to obtain homologous deformation. However, weight reduction and response constraints such as stress, displacement or natural frequency cannot be considered by those theories. An optimization method solving the above problems is suggested to gain homologous deformation. Homology constraints can be considered under multiple loadindg conditions as well as a single loading condition. Homology index is defined for the multiple loading conditions Examples are solved to present the performances of the method.

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THE LEAST NUMBER OF COINCIDENCES WITH A COVERING MAP OF A POLYHEDRON

  • Jezierski, Jerzy
    • Journal of the Korean Mathematical Society
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    • v.36 no.5
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    • pp.911-921
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    • 1999
  • We define the coincidence index of pairs of maps p, f : $\widetilde{X}$ $\rightarrow$ X where p is a covering of a polyhedron X. We use a polyhedral transversality Theorem due to T. Plavchak. When p=identity we get the classical fixed point index of self map of polyhedra without using homology.

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In silico characterisation, homology modelling and structure-based functional annotation of blunt snout bream (Megalobrama amblycephala) Hsp70 and Hsc70 proteins

  • Tran, Ngoc Tuan;Jakovlic, Ivan;Wang, Wei-Min
    • Journal of Animal Science and Technology
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    • v.57 no.12
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    • pp.44.1-44.9
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    • 2015
  • Background: Heat shock proteins play an important role in protection from stress stimuli and metabolic insults in almost all organisms. Methods: In this study, computational tools were used to deeply analyse the physicochemical characteristics and, using homology modelling, reliably predict the tertiary structure of the blunt snout bream (Ma-) Hsp70 and Hsc70 proteins. Derived three-dimensional models were then used to predict the function of the proteins. Results: Previously published predictions regarding the protein length, molecular weight, theoretical isoelectric point and total number of positive and negative residues were corroborated. Among the new findings are: the extinction coefficient (33725/33350 and 35090/34840 - Ma-Hsp70/ Ma-Hsc70, respectively), instability index (33.68/35.56 - both stable), aliphatic index (83.44/80.23 - both very stable), half-life estimates (both relatively stable), grand average of hydropathicity (-0.431/-0.473 - both hydrophilic) and amino acid composition (alanine-lysine-glycine/glycine-lysine-aspartic acid were the most abundant, no disulphide bonds, the N-terminal of both proteins was methionine). Homology modelling was performed by SWISS-MODEL program and the proposed model was evaluated as highly reliable based on PROCHECK's Ramachandran plot, ERRAT, PROVE, Verify 3D, ProQ and ProSA analyses. Conclusions: The research revealed a high structural similarity to Hsp70 and Hsc70 proteins from several taxonomically distant animal species, corroborating a remarkably high level of evolutionary conservation among the members of this protein family. Functional annotation based on structural similarity provides a reliable additional indirect evidence for a high level of functional conservation of these two genes/proteins in blunt snout bream, but it is not sensitive enough to functionally distinguish the two isoforms.

On the Braid Index of Kanenobu Knots

  • Takioka, Hideo
    • Kyungpook Mathematical Journal
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    • v.55 no.1
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    • pp.169-180
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    • 2015
  • We study the braid indices of the Kanenobu knots. It is known that the Kanenobu knots have the same HOMFLYPT polynomial and the same Khovanov-Rozansky homology. The MFW inequality is known for giving a lower bound of the braid index of a link by applying the HOMFLYPT polynomial. Therefore, it is not easy to determine the braid indices of the Kanenobu knots. In our previous paper, we gave upper bounds and sharper lower bounds of the braid indices of the Kanenobu knots by applying the 2-cable version of the zeroth coefficient HOMFLYPT polynomial. In this paper, we give sharper upper bounds of the braid indices of the Kanenobu knots.

CLASSIFICATION OF FREE ACTIONS OF FINITE GROUPS ON 3-DIMENSIONAL NILMANIFOLDS

  • Koo, Daehwan;Oh, Myungsung;Shin, Joonkook
    • Journal of the Korean Mathematical Society
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    • v.54 no.5
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    • pp.1411-1440
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    • 2017
  • We study free actions of finite groups on 3-dimensional nil-manifolds with the first homology ${\mathbb{Z}}^2{\oplus}{\mathbb{Z}}_p$. By the works of Bieberbach and Waldhausen, this classification problem is reduced to classifying all normal nilpotent subgroups of almost Bieberbach groups of finite index, up to affine conjugacy.

Clustered Segment Index for Efficient Approximate Searching on the Secondary Structure of Protein Sequences (클러스터 세그먼트 인덱스를 이용한 단백질 이차 구조의 효율적인 유사 검색)

  • Seo Min-Koo;Park Sang-Hyun;Won Jung-Im
    • Journal of KIISE:Databases
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    • v.33 no.3
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    • pp.251-260
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    • 2006
  • Homology searching on the primary structure (i.e., amino acid arrangement) of protein sequences is an essential part in predicting the functions and evolutionary histories of proteins. However, proteins distant in an evolutionary history do not conserve amino acid residue arrangements, while preserving their structures. Therefore, homology searching on proteins' secondary structure is quite important in finding out distant homology. In this manuscript, we propose an indexing scheme for efficient approximate searching on the secondary structure of protein sequences which can be easily implemented in RDBMS. Exploiting the concept of clustering and lookahead, the proposed indexing scheme processes three types of secondary structure queries (i.e., exact match, range match, and wildcard match) very quickly. To evaluate the performance of the proposed method, we conducted extensive experiments using a set of actual protein sequences. CSI was proved to be faster than the existing indexing methods up to 6.3 times in exact match, 3.3 times in range match, and 1.5 times in wildcard match, respectively.

Molecular Cloning of cDNA Encoding a Putative Eugenol Synthase in Tomato (Solanum lycopersicum 'Micro-Tom') and Prediction of 3D Structure and Physiochemical Properties (토마토 'Micro-Tom' 과실의 eugenol synthase 유전자 클로닝, 단백질의 3차 구조 및 생리화학적 특성 예측)

  • Kang, Seung-Won;Seo, Sang-Gyu;Lee, Tai-Ho;Lee, Gung-Pyo
    • Journal of agriculture & life science
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    • v.46 no.4
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    • pp.9-20
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    • 2012
  • Eugenol is a volatile compound synthesized by eugenol synthase in various plants and belongs to phenylpropene compounds. However, characteristics of eugenol synthase in tomato has not been known. Therefore, we cloned a full length cDNA of a putative eugenol synthase from tomato 'Micro-Tom' using rapid amplification of cDNA ends (RACE) technique and named a clone SlEGS. Open reading frame of SlEGS was 921bp long and its deduced amino acid sequence was 307bp. The BLAST analysis indicated that SlEGS shared high similarity with PhEGS1 (67.1%) and CbEGS2 (69.4%). Amino acid composition of SlEGS was determined by CLC genomics workbench tool and 3D structure of SlEGS was constructed by homology modeling using Swiss-PDB viewer and validated using PROCHECK and ProSA-web tool. In addition, the physiochemical properties of SlEGS was evaluated using ExPASy's ProtParam tool. Molecular weight was 33.93kDa and isoelectric point was 5.85 showing acidic nature. Other properties such as extinction coefficient, instability index, aliphatic index, and grand average hydropathy was also analyzed.

Studies on Genetic Stability of Micropropagated Plants and, Reintroduction in an Endemic and Endangered Taxon: Syzygium travancoricum Gamble (Myrtacae)

  • Ajith Anand
    • Journal of Plant Biotechnology
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    • v.5 no.4
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    • pp.201-207
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    • 2003
  • Tissue culture techniques arguably are an important approach for ex situ conservation of rare and endangered plant species. However, there is utmost importance on maintaining the genetic integrity of the introduced plants especially in tree species. To examine the genetic integrity of the micropropagated plants, we randomly screened few hardened plants of Syzygium travancoricum, a critically endangered tree taxon, using Randomly Amplified Polymorphic DNA (RAPD) markers. Twenty-three random. primers were tried and twenty-five polymorphic loci were identified. The dendrogram based on the Unweighted Pair-Group Method Arithmetic Average and Nei's similarity index depicted about 97% homology between the mother plants and micropropagated plants. Further, an attempt was made to reintroduce the micropropagated plants in the wild. Over three hundred small trees could be successfully established.

Effects of coconut oil pulling and professional toothbrushing on gingivitis (치은염 환자에게 적용한 오일풀링과 전문가 칫솔질법의 효과)

  • Lee, Mi-Ra;Moon, Sang-Eun;Kim, Yun-Jeong;Kim, Seon-Yeong;Cho, Hye-Eun;Kang, Hyun-Joo
    • Journal of Korean society of Dental Hygiene
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    • v.19 no.3
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    • pp.375-385
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    • 2019
  • Objectives: The purpose of this study was to provide basic data for gingivitis management programs by dental hygienists by evaluating the effect of oral health education, oil pulling, and professional toothbrushing on gingivitis. Methods: A total of 38 subjects were divided into three groups: control group (12 subjects), experimental group 1 (13 subjects), and experimental group 2 (13 subjects). The control and experimental groups were instructed to brush using the rotating method. Distilled water was provided to the control group after training. Coconut oil was provided every morning for about 10 minutes. In the experimental group 2, a professional brushing method was used at each visit. Results: There were no significant differences in oral health among the three groups, and there was homology between patient hygiene performance (PHP) index (p=0.144) and bleeding rate (p=0.213). The PHP index showed a significant interaction between the group and measurement time. The control and experimental groups showed changes in the PHP index with time (F=3.711; p=0.013). The bleeding rate showed a significant interaction between the group and measurement period. The control and experimental groups showed changes in the bleeding rate with time (F=6.707; p<0.001). Conclusions: Oral health education, professional toothbrushing, and oil pulling specialists in oral care of gingivitis were effective in managing gingivitis. It is necessary to educate people on self-management methods for oral health promotion using gingivitis management programs by dental hygienists.

Backbone 1H, 15N, and 13C Resonance Assignments and Secondary Structure of a Novel Protein OGL-20PT-358 from Hyperthermophile Thermococcus thioreducens sp. nov.

  • Wilson, Randall C.;Hughes, Ronny C.;Curto, Ernest V.;Ng, Joseph D.;Twigg, Pamela D.
    • Molecules and Cells
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    • v.24 no.3
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    • pp.437-440
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    • 2007
  • $OGL-20P^T$-358 is a novel 66 amino acid residue protein from the hyperthermophile Thermococcus thioreducens sp. nov., strain $OGL-20P^T$, which was collected from the wall of the hydrothermal black smoker in the Rainbow Vent along the mid-Atlantic ridge. This protein, which has no detectable sequence homology with proteins or domains of known function, has a calculated pI of 4.76 and a molecular mass of 8.2 kDa. We report here the backbone $^1H$, $^{15}N$, and $^{13}C$ resonance assignments of $OGL-20P^T$-358. Assignments are 97.5% (316/324) complete. Chemical shift index was used to determine the secondary structure of the protein, which appears to consist of primarily ${\alpha}$-helical regions. This work is the foundation for future studies to determine the three-dimensional solution structure of the protein.