• Asian Pacific Journal of Cancer Prevention
• /
• v.16 no.3
• /
• pp.869-874
• /
• 2015

Background: The prognostic value of microvessel density (MVD), reflecting angiogenesis, detected in ovarian cancer is currently controversial. Here we performed a meta-analysis of all relevant eligible studies. Materials and Methods: A comprehensive search of online PubMed, Medline, EMBASE and Sciencedirect was performed to identify all related articles. The search strategy was designed as 'microvessel density', 'ovarian cancer', 'ovarian neoplasm', 'CD34' and 'angiogenesis'. Results: The studies were categorized by author/year, number of patients, FIGO stage, histology, cutoff value for microvessel density, types of survival analysis, methods of hazard rations (HR) estimation, HR and its 95% confidence interval (CI). Combined hazard ratios suggested that high MVD was associated with poor overall survival (OS) and progression-free survival (PFS), with HR and 95% CIs of 1.84 (1.33-2.35) and 1.36 (1.06-1.66), respectively. Subgroup analysis showed that high MVD detected by CD34 was relevant for OS [HR=1.67 (1.36-2.35)], but not MVD detected with other antibodies [HR=2.11 (0.90-3.31)]. Another subgroup analysis indicated that high MVD in patients without pre-chemotherapy, but not with pre-chemotherapy, was associated with OS [HR=1.88(1.59-2.18 and HR=1.70 (-0.18-3.59)]. Conclusions: The OS and PFS with high MVD were significant poorer than with low MVD in ovarian cancer patients. However, high MVD detected by CD34 seems to be more associated with survival for patients without pre-chemotherapy.

• Elastomers and Composites
• /
• v.54 no.1
• /
• pp.54-60
• /
• 2019

The rapid development of the automobile industry is an important factor that led to the dramatic development of synthetic rubber. The tread part of tire that comes in direct contact with the road surface is related to the service life of the tire. Rubber compounds used in tire treads are often blended with SBR (styrene-butadiene rubber) and BR (butadiene rubber) to satisfy physical property requirements. However, when two or more kinds of rubber are blended, phase separation and silica dispersion problems may occur due to non-uniform mixing of the rubber. Therefore, in this study, we synthesized an SBR copolymer with the same composition as that of a typical SBR/BR blend compound by controlling butadiene content during ESBR (emulsion styrene-butadiene rubber) synthesis. Subsequently, silica filled compounds were manufactured using the synthesized ESBR, and their mechanical properties, dynamic viscoelasticity, and crosslinking density were compared with those of the SBR/BR blended compound. When the content of butadiene was increased in the silica filled compound, the cure rate accelerated due to an increased number of allylic positions, which typically exhibit higher reactivity. However, the T-2 compound with increased butadiene content by synthesis less likely to show an increase in crosslink density due to poor silica dispersion. In addition, the T-3 compound containing high cis BR content showed high crosslink density due to its monosulfide crosslinking structure. Because of the phase separation, SBR/BR blend compounds were easily broken and showed similar $M_{100%}$ and $M_{300%}$ values as those of other compounds despite their high crosslink density. However, the developed blend showed excellent abrasion resistance due to the high cis-1,4 butadiene content and low rolling resistance due to the high crosslink density.

• Journal of Digital Convergence
• /
• v.14 no.4
• /
• pp.221-230
• /
• 2016

This is an experimental study which is designed to identify the joint relationship between communication density and centrality as independent factors to team performance, discovering how they would jointly affect work team performance. Specially different from existing studies, separating team performance into team efficiency and team effectiveness, we identified differential influences to the two independent factors. Findings suggest a competing relationship between communication density and centrality. A framework was proposed to help managers understand the joint effect of density and centrality on performance. Work team has high communication density and low centrality is "Innovating", which is likely to have a great extent of ideas, knowledge and information sharing, and reach high effectiveness. Team with high centrality and low density is characterized as "centralized". Such communication structure may reduce diversity of perspectives and accelerate team decision making. When both density and centrality are low, the team is "Autonomous". To increase external validity, other factors such as leadership, organizational climate influencing on team performance should be reflected in the future research.

• Journal of Surface Science and Engineering
• /
• v.36 no.3
• /
• pp.256-262
• /
• 2003

The current efficiency and the composition of Zn-Cr and Zn-Cr-X (X : Co, Mn) alloy electrodeposits were investigated by using chloride bath with EDTA auditive and flow cell plating system. The current efficiency of Zn-Cr alloy decreased with increasing current density, while it increased with the content of Co and Mn of the Zn-Cr-X alloy bath in high current density region. The Cr content in Zn-Cr alloy increased from 1.4-2.7 to $28wt\%$ with increasing current density and the phase structure of the alloys changed from $\eta-Zn$ through $\eta-Zn+\gamma'-ZnCr\;to\;\gamma'-ZnCr$ with Increasing Cr content of the alloys. The Co content in Zn-Cr-Co alloys increased with Co content of the bath, while Cr content of the alloy increased or decreased in low current density region $(10-75A/dm^2)$ or high current density region $(75-100A/dm^2)$, respectively. $\gamma-ZnCo$ phase was formed in the Zn-Cr-Co alloy with above $9.0wt\%$ Co. The content of Mn and Cr in Zn-Cr-Mn alloys increased or decreased with the increase of current density in high current density region, respectively while Cr content of the alloy decreased noticeably with the increase of Mn content in the bath. Two phases of $\delta_1-ZnMn$ and $\gamma'-ZnCr$ were formed in the Zn-Cr-Mn alloy with above $8.6wt\%$ Mn.

• Korean Journal of Medicinal Crop Science
• /
• v.18 no.1
• /
• pp.22-27
• /
• 2010

This study was carried out to investigate the physicochemical characteristics of 3-year-old ginseng (for Samgyetang product) cultured by various seeding density in direct-sowing culture. Ginsengs were cultured by the seeding density, 275, 300, 330 352 and 396 seeds per Kan, $180{\times}90cm$ area. Survived rate (82.1%) were the highest in plot of 352 seeds sowed, length and leaf width were high in plot of 300 and 352 seeds. Root yield grain was increased with increase of the seeding density in direct-sowing culture except 352 seeds sowed. Average root weight and diameter were the highest in plot of 352 seeds sowed, 31.6 g and 18.4 mm, respectively. Crude saponin and each ginsenosides content were the highest in plot of 275 seeds sowed. Rg1 content was decreased, Rc and Rb2 content were increased with increase of the seeding density. Total soluble sugar content was the highest in plot of 330 seeds sowed and the lowest in plot of 396 seeds sowed, and oligo- and disaccaride content were high in plot of 330 and 352 seeds sowed. Reological characteristics of ginsengs cultivated according to various seeding density, hardness and springness were high and maximum fracture force was low with decrease of the seeding quantity.

• ALGAE
• /
• v.29 no.3
• /
• pp.217-225
• /
• 2014

Land-based seaweed (Gracilaria) cultivation systems may provide products with high quality and biosafety for human consumption, as well as for other high value applications. However, a limitation for this land based system is high management costs. The objective of this study was to determine if the management costs for Gracilaria cultivation can be reduced without a decrease in productivity by using $CO_2$ injection along with a high stocking density and high photosynthetically active radiation (PAR), and commercially available fertilizers. When Gracilaria tikvahiae was cultivated at a high stocking density and high PAR, coupled with $CO_2$ enhancement, the productivity was significantly higher than that at a lower stocking density, low light without $CO_2$ injection. We also found that G. tikvahiae grown in a medium of commercially available fertilizer (Jack's Special, JS) showed a similar growth rate and productivity to that grown in von Stosch's enriched (VSE) seawater, while the cost for JS media is only 2% of the cost for VSE. These results suggest that $CO_2$ injection and commercial fertilizer may be a potential way to provide sustainability in land-based Gracilaria cultivation systems.

• The Transactions of the Korean Institute of Power Electronics
• /
• v.23 no.3
• /
• pp.217-224
• /
• 2018

In this study, the optimal design methods of soft-switching cell for high-voltage DC-DC converter (HDC) of fuel cell electric vehicles (FCEVs) is proposed for high efficiency and high power density. The appropriate soft-switching cell for FCEVs is chosen by analyzing the losses of HDC which adopts soft-switching cell. The proposed optimal design methods for the soft-switching cell are divided into two purposes which are improvement of efficiency and power density. Two kinds of design methods enable to improve fuel efficiency and cost, respectively. The proposed design methods are validated with the experimental results based on the specification and hardware used in actual FCEVs.

• Bulletin of the Korean Chemical Society
• /
• v.32 no.12
• /
• pp.4341-4346
• /
• 2011

Impact sensitivity, one of the most important screening factors for novel high energy density materials (HEDMs), was predicted by use of quantitative structure-property relationship (QSPR) based on the electrostatic potential (ESP) values calculated on the van der Waals molecular surface (MSEP). Among various 3D descriptors derived from MSEP, we utilized total and positive variance of MSEP, and devised a new QSPR equation by combining three other parameters. We employed 37 HEDMs bearing a benzene scaffold and nitro substituents, which were also utilized by Rice and Hare. All the molecular structures were optimized at the B3LYP/6-31G(d) level of theory and confirmed as minima by the frequency calculations. Our new QSPR equation provided a good result to predict the impact sensitivities of the molecules in the training set including zwitterionic molecules.

• Laser Solutions
• /
• v.15 no.3
• /
• pp.7-10
• /
• 2012

Dimensions (line/space) of circuits in IC substrates for high-end chips (e.g. CPU, etc.) are anticipated to decrease as small as $10{\mu}m/10{\mu}m$ in 2014. Since current etch-based circuit-patterning processes are not able to address the urgent requirement from industry, laser-based circuit patterning processes are under active research in which UV laser is used to engrave embedded circuits patterns into IC substrates. In this paper, we used a nanosecond UV laser to directly fabricate embedded circuit patterns into IC substrates with/without ceramic powders. In experiments, we engraved embedded circuit patterns with dimensions (width/depth) of abut $10{\mu}m/10{\mu}m$ and $6{\mu}m/6{\mu}m$ into the IC substrates. Due to the recoil pressure occurring during ablation, the circuit patterning of the IC substrates with ceramic powders showed the higher ablation rate.

• The Transactions of the Korean Institute of Electrical Engineers B
• /
• v.50 no.7
• /
• pp.315-322
• /
• 2001

High speed brushless permanent magnet(PM) machines need a key technology to minimize the iron core losses in stator and the eddy current losses in the retained sleeve and magnets caused by slotting harmonics. Thus, slotless or iron-coreless brushless PM machines have been applied for a very high rotational speed and/or the ripple-free torque. Unfortunately, slotless or coreless PM machines have lower open-circuit field than slotted and/or iron-cored types, which cause to reduce power density. Fortunately, Halbach array can generate the strong magnetic field systems without additional magnetic materials. In this paper, the 4-pole Halbach array is applied to the high speed machine and is compared with the radial magnetized PM array in field system. The iron-/air-cored stator of PM machine is constructed with/without winding slots. Open circuit magnetic fields of each type are presented from the analytical method and finite element method. Consequently, it is confirmed that the Halbach array field system with slotless stator is more suitable to the high speed motor because it has high flux density, sinusoidal flux distribution than others.