• Journal of Korean Medicine Rehabilitation
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• v.19 no.3
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• pp.33-46
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• 2009

Objectives : The objective of the study was to summarize randomized clinical trials(RCTs) that have assessed the effectiveness of herbal medicine on treatment of obesity and to propose better process of study. Methods : NLM Medline(pubmed), EMBASE, the Cochrane library, Science Direct, EBSCO, 4 Korean medical databases were systematically searched and 4 Korean medical journals were manually searched for clinical trials investigating the efficacy of herbal medicines on treatment of overweight or obese people from 1998 to 2008. The methodological quality was assessed using a Jadad score and validity was assessed using Oxford Pain Validity Scale(OPVS). Results : 14 RCTs met all the inclusion criteria. The methodological and ethical quality of the trials was generally low. The mean score by Jadad was 2.6 and the mean score of validity was 11.2. Complex herbal medicine was used in 8 RCTs and single herbal medicine was used in 6 RCTs. Except 1 RCT, the other RCTs reported positive effects of herbal medicine on treatment of obesity. Herbal medicines didn't seem to affect toxicity. In general adverse events relevant with the therapy were minor, but more than half of RCTs did not report about the safety or adverse events of herbal medicine, questioning their reliability. Conclusions : Although most RCTs concluded the efficacy and safety of herbal medicines on treatment of obesity, the quality of trials was low in general. Further rigorous clinical trials using complex herbal medicine should be performed.

• Proceedings of the PSK Conference
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• 2002.04a
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• pp.192.1-192.1
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• 2002

• Korean Journal of Pharmacognosy
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• v.44 no.2
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• pp.161-167
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• 2013

Aldose reductase (AR) has been shown to play an important role in the development of the diabetic complications. To discover novel treatments for diabetic complications from natural sources, 59 Chinese herbal medicines have been investigated for inhibitory activities on AR. Among them, 10 herbal medicines, Catalpa fargesii (stem and leaf), Saussurea Laniceps(whole plant), Alnus nepalensis(stem and leaf), Swertia macrosperma (whole plant), Woodfordia fruticosa (stem and leaf), Elsholtzia bodinieri (whole plant), Elsholtzia fruticosa (whole plant), Rosa multiflora (fruit), Nardostachys chinensis (whole plant), Eurya groffii (stem and leaf) exhibited a significant inhibitory activity compared with 3,3-tetramethyleneglutaric acid (TMG) as positive control. Particularly, 4 herbal medicines, C. fargesii (stem and leaf), S. Laniceps (whole plant), A. nepalensis (stem and leaf), S. macrosperma (whole plant) showed two times more potent inhibitory activity than TMG ($5.37{\mu}g/ml$).

• Korean Journal of Pharmacognosy
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• v.44 no.3
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• pp.298-304
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• 2013

In this study, 64 Korean herbal medicines have been investigated with an in vitro evaluation systems using glycation end products (AGEs) formation inhibitory activity. Of these, 30 herbal medicines ($IC_{50}<50{\mu}g/ml$) were found to have significant AGEs formation inhibitory activity. Of these, four herbal medicines ($IC_{50}<5{\mu}g/ml$) were found to have significant AGEs formation inhibitory activity. Particularly, Cornus controversa (branches and leaves), Acer ginnala (stems and leaves), Platycarya strobilacea (flowers) and Picrasma quassioides (stems), showed more potent inhibitory activity (approximately 17-27 fold) than the positive control aminoguanidine ($IC_{50}=77.04{\mu}g/ml$).

• Korean Journal of Pharmacognosy
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• v.44 no.3
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• pp.305-311
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• 2013

Advanced glycation end products (AGEs) have been postulated to play a central role in the development of diabetic complications. A variety of different agents that inhibit AGEs have been under investigation. In this study, 54 herbal medicines from China have been investigated with an in vitro evaluation system using AGEs formation inhibitory activity. Of these, 6 herbal medicines ($IC_{50}<5{\mu}g/ml$) were found to have significant AGEs formation inhibitory activity. Particularly, herbal medicines Punica granatum (peels), Terminalia chebula (fruits), Rheum palmatum (roots), Oxyria digyna (stems and leaves), Anisodus luridus (roots) and Quercus schottkyana(stems and leaves) showed more potent inhibitory activity (approximately 9-43 fold) than the positive control aminoguanidine ($IC_{50}=77.04{\mu}g/ml$).

• The Journal of Korean Medicine
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• v.31 no.3
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• pp.47-54
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• 2010

Objective: To derive information on the efficacy of Sam-chul-kun-bi-tang (SKT), by evaluating its anti-inflammatory effect. SKT is a widely-used herbal formula in traditional Korean medicine. In man y studies, plant-derived anti-inflammatory efficacies have been investigated for their potential inhibitory effects on lipopolysaccharide (LPS)-stimulated macrophages. This study was performed to examine the anti-inflammatory effects of SKT extract on LPS-stimulated RAW 264.7 cells. Methods: The production of nitric oxide (NO), prostaglandin $(PG)E_2$, tumor necrosis factor (TNF)-$\alpha$ and interleukin (IL)-6 were examined in a macrophage cell line, RAW 264.7 cells, in the presence of SKT. RAW 264.7 cells were incubated with LPS 1 ${\mu}g/mL$ and SKT for 18 hrs. The anti-inflammatory activity of SKT was investigated by carrageenan-induced paw edema in rats. The paw volume was measured at 2 and 4 hrs following carrageenan-induced paw edema in rats. Results: SKT showed inhibitory effect on $PGE_2$, TNF-$\alpha$ and IL-6 in LPS-stimulated RAW 264.7 cells. But SKT was not inhibitory effect on NO by LPS-stimulated RAW 264.7 cells. Administration of SKT (1 g/kg) also showed a reduction in carrageenan-induced paw edema on rats. Conclusion: These results suggest that SKT has anti-inflammatory activities in both in vitro and in vivo models.

• Korean Journal of Oriental Medicine
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• v.14 no.1
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• pp.41-48
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• 2008

This article examines the origin and growth of Jecheon Herbal Market(JHM). JHM was established in 1928 at the Jecheon Market Main causes of the growth of JHM is widely considered as the fact that it was located to the sources of herbal product, domestic or wild, and its convenient access in transportation aspect. Since the Independence of Korea, the control of the import of herbal medications from abroad served for the main factor of JHM's growth. Nowadays JHM is estimated as second to Gyungdong Herbal Market in total. However, among production-oriented markets it has been ranked first.

• Journal of Haehwa Medicine
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• v.28 no.1
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• pp.13-25
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• 2019

Objectives : This study analyzed domestic case reports of syndrome differentiation and herbal medicine treatment for tic disorder published from 2000 to 2018 and aimed to seize the latest trend of Korean herbal medicine treatment according to syndrome differentiation. Methods : We searched herbal medicine treatment of tic disorder through five major Korean academic literature databases; NDSL, KTKP, KISS, RISS, DBPIA. Results : 12 articles were included in this study from 49 articles. These studies were analyzed by year, evaluation criteria, Korean treatments, treatment effects, syndrome differentiation, herbal medication, duration of medication, and type of herbal medicine. Treatment results were assessed by YGTSS. Most cases accompanied Korean integrative treatments and only one case report used herbal medicine alone. Most common type of syndrome differentiation for patients was spleen. Duration of medication varied according to each case and decoction was the most used type of herbal medication. Conclusions : It has been reported that herbal medicine treatment according to the syndrome differentiation could be effective in treating tic disorder. This study suggests that additional studies will be required to justify classification of syndrome differentiation and the sole effectiveness of herbal medicine on tic disorder.

• Proceedings of the Zoological Society Korea Conference
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• 2003.08a
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• pp.131.3-131
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• 2003

No Abstract, See Full Text

• Korean Journal of Oriental Medicine
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• v.6 no.1
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• pp.59-68
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• 2000

The purpose of this study is to encourage the circulation of good quality of oriental medicine and to improve national welfare. Investigation for the induction of quality inscription system was conducted by mail and interview. The data were analyzed by SAS. The major results were as follows: The portion of subjects agree to necessity of quality inscription was 78.5%. In the question of side effect against quality inscription, the rate of negative was 67.7%. The responses answered that the necessity of quality inscription was not economical profit but authority of knowledge and improvement on health(37.8%), established market for herbal medicine(34.7%) and effect of clinical care(23.9%), respectively These results might be useful information for establishing of quality inscription system for herbal medicine.