Browse > Article

Screening of Korean Herbal Medicines with Inhibitory Activity on Advanced Glycation End Products Formation (IX)  

Lee, Yun Mi (Korean Medicine-Based Herbal Drug Development Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine)
Kim, Young Sook (Korean Medicine-Based Herbal Drug Development Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine)
Kim, Joo Hwan (Department of Life Science, Gachon University)
Kim, Jin Sook (Korean Medicine-Based Herbal Drug Development Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine)
Publication Information
Korean Journal of Pharmacognosy / v.44, no.3, 2013 , pp. 298-304 More about this Journal
Abstract
In this study, 64 Korean herbal medicines have been investigated with an in vitro evaluation systems using glycation end products (AGEs) formation inhibitory activity. Of these, 30 herbal medicines ($IC_{50}<50{\mu}g/ml$) were found to have significant AGEs formation inhibitory activity. Of these, four herbal medicines ($IC_{50}<5{\mu}g/ml$) were found to have significant AGEs formation inhibitory activity. Particularly, Cornus controversa (branches and leaves), Acer ginnala (stems and leaves), Platycarya strobilacea (flowers) and Picrasma quassioides (stems), showed more potent inhibitory activity (approximately 17-27 fold) than the positive control aminoguanidine ($IC_{50}=77.04{\mu}g/ml$).
Keywords
Advanced glycation end products (AGEs); diabetic complications; Korean herbal medicines;
Citations & Related Records
Times Cited By KSCI : 8  (Citation Analysis)
연도 인용수 순위
1 Yang, S., Litchfield, J. E. and Baynes, J. W. (2003) AGE breakers cleave model compounds, but do not break maillard crosslinks in skin and tail collagen from diabetic rats. Arch. Biochem. Biophys. 412: 42-46.   DOI
2 Huebschmann, A. G., Vlassara, H., Regensteiner, J. G. and Reusch, J. (2006) Diabetes and advanced glycoxidation end products. Diabetes care 29:1420-1432.   DOI
3 Yokozawa, T., Nakagawa, T. and Terasawa, K. (2001) Effects of oriental medicines on the production of advanced glycation endproducts. J. trad. Med. 18:107-112.
4 Rahbar, S. and Figarola, J. L. (2003) Novel inhibitors of advenced glycation endproducts. Arch. Biochem. Biophys. 419: 63-79.   DOI
5 Wilkinson-Berka, J. L., Kelly, D. J., Koerner, S. M., Jaworski, K., Davis B., Thallas, V. and Cooper, M. E. (2002) ALT-946 and aminoguanidine, inhibitors of advanced glycation, improve severe nephropathy in the diabetic transgenic (mREN-2) 27 rat. Diabetes 51: 3283-3289.   DOI
6 Peppa, M., Brem, H., Cai, W., Zhang, J. G., Basgen, J., Li, Z., Vlassara, H. and Uribarri, J. (2006) Prevention and reversal of diabetic nephropathy in db/db mice treated with alagebrium (ALT-711). Am. J. Nephrol. 26: 430-436.   DOI
7 Jang, D. S., Kim, J. M., Lee, Y. M., Kim, Y. S., Kim. J. H. and Kim, J. S. (2006) Puerariafuran, a new inhibitor of advanced glycation end products (AGEs) isolated from the roots of Pueraria lobata. Chem. Pharm. Bull. 54: 1315-1317.   DOI
8 Jang, D. S., Lee, Y. M., Jeong, I. H. and Kim, J. S. (2010) Constituents of the flowers of Platycodon grandiflorum with inhibitory activity on advanced glycation end products and rat lens aldose reductase in vitro. Arch. Pharm. Res. 33: 875-880.   DOI
9 Jang, D. S., Lee, G. Y., Lee, Y. M., Kim, Y. S., Sun, H., Kim, D. H. and Kim, J. S. (2009) Flavan-3-ols having a gammalactam from the roots of Actinidia arguta inhibit the formation of advanced glycation end products in vitro. Chem. Pharm. Bull. 57: 397-400.   DOI
10 Jang, D. S., Yoo, N. H., Kim, N. H., Lee, Y. M., Kim, C. S., Kim, J. Kim, J. H. and Kim, J. S. (2010) 3,5-Di-O-caffeoylepi- quinic acid from the leaves and stems of Erigeron annuus inhibits protein glycation, aldose reductase and cataractogenesis. Biol. Pharm. Bull. 33: 329-333.   DOI
11 Lee, J., Jang, D. S., Kim, N. H., Lee, Y. M., Kim, J. and Kim, J. S. (2011) Galloyl glucoses from the seeds of Cornus officinalis with inhibitory activity against protein glycation, aldose reductase, and cataractogenesis ex vivo. Biol. Pharm. Bull. 34: 443-446.   DOI
12 Kim, J. M., Jang, D. S., Lee, Y. M., Yoo, J. L., Kim. Y. S., Kim, J. H. and Kim, J. S. (2008) Aldose reductase and protein glycation inhibitory principles from the whole plant of Duchesnea chrysantha. Chem. Biodivers. 5: 352-356.   DOI
13 Yoo, N. H., Jang, D. S., Lee, Y. M., Jeong, I. H., Cho, J. H., Kim, J. H. and Kim, J. S. (2010) Anthraquinones from the roots of Knoxia valerianoides inhibit the formation of advanced glycation end products and rat lens aldose reductase in vitro. Arch. Pharm. Res. 33: 209-214.   DOI
14 Lee, G. Y., Jang, D. S., Lee, Y. M., Kim, J. M. and Kim, J. S. (2006) Naphthopyrone glucosides from the seeds of Cassia tora with inhibitory activity on advanced glycation end products (AGEs) formation. Arch. Pharm. Res. 29: 587-590.   DOI
15 Sohn, E. J., Kim, Y. S., Kim, C. S., Lee, Y. M. and Kim, J. S. (2009) KIOM-79 prevents apoptotic cell death and AGEs accumulation in retinas of diabetic db/db mice. J. Ethnopharmacol. 121: 171-174.   DOI
16 Sohn, E., Kim, J., Jeong, I. H., Kim, C. S., Kim, Y. S. and Kim, J. S. (2011) Combination of medicinal herbs KIOM-79 reduces advanced glycation end product accumulation and the expression of inflammatory factors in the aorta of Zucker diabetic fatty rats. Evid. Based Complement. Alternat. Med. 2011:784136. Epub 2011 Feb 15.
17 Kim, Y. S., Lee, Y. M., Kim, C. S., Sohn, E. J., Jang, D. S. and Kim, J. S. (2006) Inhibitory effect of KIOM, a new herbal prescription, on AGEs formation and expression of type IV collagen and TGF-$\beta$1 in STZ-induced diabetic rats. Kor. J. Pharmacogn. 37: 103-109.
18 Kim, Y. S., Kim, J., Kim, C. S., Sohn, E. J., Lee, Y.M., Jeong, I. H., Kim, H., Jang, D. S. and Kim, J. S. (2009) KIOM-79, an inhibitor of AGEs-protein cross-linking, prevents progression of nephropathy in Zucker diabetic fatty rats. Evid. Based Complement. Alternat. Med. 2009 Jul 15. [Epub ahead of print]
19 Jeong, I. H., Kim, J. M., Jang, D. S., Kim, J. H., Cho, J. H. and Kim, J. S. (2009) Screening of Korean herbal medicines with inhibitory activity on advanced glycation end products (AGEs) formation (III). Kor. J. Pharmacogn. 40: 382-387.
20 Jang, D. S., Lee, Y. M., Kim, Y. S. and Kim, J. S. (2006) Screening of Korean traditional herbal medicines with inhibitory activity on advanced glycation end products (AGEs) formation. Kor. J. Pharmacogn. 37: 48-52.
21 Lee, Y. M., Kim, Y. S., Kim, J. M., Jang, D. S., Kim, J. H., Yoo, J. L. and Kim, J. S. (2008) Screening of Korean herbal medicines with inhibitory activity on advanced glycation end products (AGEs) formation (II). Kor. J. Pharmacogn. 39: 223-227.
22 Kim, J. M., Kim, Y. S., Kim, J. H., Yoo, J. L. and Kim, J. S. (2009) Screening of herbal medicines from China and Vietnam with inhibitory activity on advanced glycation end products (AGEs) formation (IV). Kor. J. Pharmacogn. 40: 388-393.
23 Kim, Y. S., Choi, S. H., Kim, J. H. and Kim, J. S. (2011) Screening of herbal medicines from China with inhibitory activity on advanced glycation end products (AGEs) formation (V) Kor. J. Pharmacogn. 42: 46-53.
24 Lee, Y. M., Kim, Y. S., Kim, J. H. and Kim, J. S. (2011) Screening of herbal medicines from China with inhibitory activity on advanced glycation end products (AGEs) formation (VI) Kor. J. Pharmacogn. 42: 161-168.
25 Vinson, J.A. and Howard, III T.B. (1996) Inhibition of protein glycation and advanced glycation endproducts by ascorbic acid and other vitamins and nutrients. J. Nutr. Biochem. 7: 659-663.   DOI
26 Jang, H. M., Hwang, B. Y., Kim, M. S, Lee, D. H. Kang, S. J., Ro, J. S. and Lee, K. S. (1998) Chemical components from the stems bark of Cornus controversa HEMSL. Kor. J. Pharmacogn. 29: 225-230.
27 Choi, S. J., Kim, Y. S., Song, Y. J., Lee, Y. M., Kim, J. H. and Kim, J. S. (2012) Screening of Korean herbal medicines with inhibitory activity on advanced glycation end products formation (VII). Kor. J. Pharmacogn. 43: 345-351
28 Choi, S. J., Song, Y. J., Kim, Y. S., Kim, J. H., Hang, S., Bach, T. T and Kim., J. S. (2012) Screening of herbal medicines from China and Vietnam with inhibitory activity on advanced glycation end products (AGEs) formation (VIII). Kor. J. Pharmacogn. 43: 338-344
29 Seeram, N. P., Schutzki, R., Chandra, A. and Nair, M. G. (2002) Characterization, quantification, and bioactivities of anthocyanins in Cornus species. J. Agric. Food Chem. 50: 2519-2523.   DOI
30 Lee, D., Kang, S. J., Lee, S. H., Ro, J., Lee, K. and Kinghorn, A. D. (2000) Phenolic compounds from the leaves of Cornus controversa. Phytochemistry 53: 405-407.   DOI
31 Lu, R. L., Hu, F. L. and Xia, T. (2010) Activity-guided isolation and identification of radical scavenging components in Gao-Cha tea. J. Food Sci. 75: 239-243.
32 Kim, H. Y. and Oh, J. H. (1999) Screening of Korean forest plants for rat lens aldose reductase inhibition. Biosci .Biotechnol. Biochem. 63: 184-188.   DOI
33 Zhao, F., Gao, Z., Jiao, W., Chen, L. and Yao, X. (2012) In vitro anti-inflammatory effects of beta-carboline alkaloids, isolated from Picrasma quassioides, through inhibition of the iNOS pathway. Planta Med. 78: 1906-1911.   DOI
34 Babu, D., Lee, J. S., Park, S. Y., Thapa, D., Choi, M. K., Kim, A. R., Park, Y. J. and Kim, J. A. (2008) Involvement of NFkappaB in the inhibitory actions of Platycarya strobilacea on the TNF-alpha-induced monocyte adhesion to colon epithelial cells and chemokine expression. Arch. Pharm. Res. 31: 727-735.   DOI
35 Ohmoto, T., Sung, Y., Koike, K. and Nikaido, T. (1985) Effect of alkaloids of simaroubaceous plants on the local blood flow rate. Shoyakugaku Zasshi 39: 28-34.
36 Sung, Y., Koike, K., Nikaido, T., Ohmoto, T. and Sankawa, U. (1984) Inhibitors of cyclic AMP phosphodiesterase in Picrasma quassioides Bennet, and inhibitory activities of related beta-carboline alkaloids. Chem. Pharm. Bull. 32: 1872-1877.   DOI