• 대한의용생체공학회:의공학회지
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• 제29권5호
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• pp.376-383
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• 2008

High-flux dialysis treatment removes various toxins via diffusion as well as convection, which is induced by ultrafiltration and backfiltration. In this study, in vitro (Using the distilled water and the bovine's blood) comparison test was performed to determine whether utilization of a high flux dialyzer paired with different pumps would increase the efficiency of convection. At the same blood flow rates, a pulsatile pump and a roller pump were employed to propel the distilled water and bovine whole blood to a high flux dialyzer. Pressures at the dialyzer inlet and outlet in the blood circuit and in the dialysate circuit were measured, respectively. From these data, we calculated the transmembrane pressure and predicted the ultrafiltration and backfiltration rates developed by both pumps. Using the bovine's blood experiment, ultrafiltration and backfiltration rates were 1.6 times higher with the pulsatile pump than with the roller pump. We conclude that utilization of a pulsatile pump in high flux hemodialysis treatments increases ultrafiltration volume, compared with a roller pump under conditions of the same blood flow rate.

• 한국임상수의학회:학술대회논문집
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• 한국임상수의학회 2007년도 춘계학술대회
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• pp.117-117
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• 2007

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2022년도 추계학술발표대회
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• pp.282-283
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• 2022

본 논문에서 기존의 혈액투석기는 회전하는 모터를 사용하여 구성하였으나 이러한 모터는 정밀도, 반복정밀도가 50um 이하로 가공물 가공시에 치기공사나 치과의사가 사람에 맞추어 다시 작업을 해야하는 불편함과 시간적, 작업자의 피로도를 높일수 있는데 이러한 모터에 스크류나 밸트를 연결하여 선형적으로 움직일 수 있는 리니어모듈과 리니어모터를 적용하게되면 20um수준의 고정밀의 위치 제어가 가능한 혈액투석기를 만들 수 있었다. 또한 MEMS센서를 이용하여 모터의 상태를 모니터링하고 임계값을 지정하여 이상 신호 발생시 모터를 멈추어 위험상황에 대해서 인공지능기법을 이용하여 정지하거나 관리자에게 알림을 주어 효과적으로 혈액투석기를 운영할 수 있도록 하였다.

• 대한임상독성학회지
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• 제7권1호
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• pp.38-40
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• 2009

Formalin is a water-soluble, colorless, pungent, irritating and highly reactive gas. A 40% solution of formaldehyde in water, also known as formalin, is used as a disinfectant, antiseptic, deodorant, tissue fixative and embalming fluid. Ingestion can lead to immediate deleterious effects on almost all systems of the body including gastrointestinal tract, central nervous system, cardiovsacular system and hepato-renal system, causing gastrointestinal hemorrhage, cardiovsacular collapse, unconsciousness or convulsions, severe metabolic acidosis and acute respiratory distress syndrome. We treated a 39-year-old woman who ingested 300 ml formalin in a suicidal attempt. Despite hemodialysis, death occurred after 23 h.

• Tuberculosis and Respiratory Diseases
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• 제59권1호
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• pp.86-92
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• 2005

Goodpasture's syndrome is a disease that is characterized by hemoptysis, anemia, and glomerulonephritis with renal failure. Goodpasture reported a case of a young man who expired as a result of a pulmonary hemorrhage and glomerulonephritis at the recovery phase after an influenza infection in 1919. In 1958, Stanton et al. described a combined case of these two diseases as Goodpasture's syndrome. Since then, antiglomerular basement membrane antibody(anti-GBM Ab) has been confirmed to play an important role in the mechanism of this syndrome, and it was reported that this syndrome was an autoimmune disease. The triad of alveolar hemorrhage, glomerulonephritis and circulating anti-GBM Ab forms the basis of a diagnosis of Goodpasture's syndrome. When patients are affected by disease, the relief of symptoms can be accomplished by eliminating the anti-GBM Ab from the circulatory system through hemodialysis, plasmapheresis and immunoabsorption. However, the patients usually die from a massive pulmonary hemorrhage when the diagnosis or treatment is delayed. The incidence of Goodpasture's syndrome is common in the western world, but it is extremely rare in Korea with only five cases being reported. In three of these cases, pulmonary hemorrhage and renal failure was the initial manifestation. Therefore, hemodialysis or plasmapheresis were absolutely essential treatments. We report a case of Goodpasture's syndrome in Korea with a normal renal function.

• 대한한방내과학회지
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• 제43권2호
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• pp.191-200
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• 2022

Intractable hiccups are those which persist for more than one month and can often occur in patients with disorders of the central nervous system, such as stroke, epilepsy, or brain tumor. An 80-year-old male patient undergoing conservative hemodialysis for diabetic nephropathy, recently developed paralysis and dysphagia due to central nervous system complications including stroke and epilepsy. He was admitted to the ◯◯ Oriental Medicine Hospital, and treated with herbal medicine (Gyulpijugyeo-tang, Jeonssiigong-san, and Ijin-tang) and electrical acupuncture for 30 days. No side effects were observed during hospitalization. The frequency and duration of hiccups were measured daily and found to reduce, and the effect persisted during his admission. The patient took no other nervous system drugs. In conclusion, Korean medicine like gyulpijugyeo-tang and acupuncture can be effective for patients with intractable hiccups who cannot use alternative drugs or treatment, because of other complications.

• Childhood Kidney Diseases
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• 제28권1호
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• pp.44-50
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• 2024

Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease that affects multiple organs. More than half of the patients with SLE have kidney involvement, and up to 10% of patients with lupus nephritis develop end-stage renal disease (ESRD). Central nervous system (CNS) involvement in SLE occurs in 21% to 95% of patients. Severe neurological manifestations such as seizures, cerebrovascular disease, meningitis, and cerebrovascular accidents can develop in childhood-onset SLE, but cerebral infections, such as brain abscess and hemorrhage, are seldom reported in lupus nephritis, even in adults. Here, we report a rare case of childhood-onset SLE with ESRD, cerebral abscess, and hemorrhage. A 9-year-old girl diagnosed with lupus nephritis was administered high-dose steroids and immunosuppressant therapy to treat acute kidney injury (AKI) and massive proteinuria. The AKI deteriorated, and after 3 months, she developed ESRD. She received hemodialysis three times a week along with daily peritoneal dialysis to control edema. She developed seizures, and imaging showed a brain abscess. This was complicated by spontaneous cerebral hemorrhage, and she became unstable. She died shortly after the hemorrhage was discovered. In conclusion, CNS complications should always be considered in clinical practice because they increase mortality, especially in those with risk factors for infection.

• 정보처리학회논문지B
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• 제17B권6호
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• pp.437-444
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• 2010

본 논문에서는 한의학의 진단법인 사진법 중 망진(望診)이론을 기반으로 인체 오장 중 가장 중요한 장기의 하나인 신장의 질환 진단을 위해 영상처리기법을 적용하여 색과 신장 질환과의 상관성을 분석하는 방법을 제안하고자 한다. 이를 위해 안면 영상을 처리하고 분석하여 신장 질환에 따른 얼굴색의 색차를 시각화, 객관화하기 위한 방법을 제시하고자 한다. 특히 본 논문은 신장질환자 중 만성신부전으로 인해 혈액 투석 치료 중인 신장 기능 이상자 들을 대상으로 피 실험자 집단군을 구성하고 안면 영상 및 임상 자료를 수집하여 한의학적 망진 이론에서 신장과 관련된 얼굴 부위가 지각 이며 신장에 이상이 생길 경우 이 부위를 통해 흑색이 발현한다는 이론을 가설로 제시하고 안면 영상 중 지각 부위를 추출하는 알고리즘과 이 부위의 흑색의 변화를 측정 하는 방법에 대해 제안하고자 한다. 끝으로 임상 실험 및 자료 분석을 통해 제안한 방법의 유용성을 입증하고자 한다.

• 대한기계학회논문집B
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• 제39권12호
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• pp.921-925
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• 2015

매년마다 신장질환으로 고통 받는 사람들이 증가하는 추세이다. 가장 흔한 치료법 중 하나는 혈액 투석인데, 이 방법은 많은 시간이 걸리고, 비용이 많이 드는 방법이다. 이러한 이유 때문에, 인공신장 연구의 중요성이 대두되고 있다. 혈액에서 크레아티닌을 여과하는 것은 신장의 주요 기능 중 하나이다. 우리는 이 기능에 초점을 맞춘 새로운 2 채널 마이크로 플루이딕 칩을 고안하였다. 두 개의 PDMS 층을 결합하기 위하여, 아크릴을 가공한 하우징 시스템이 개발하였으며, 이 방법은 여과막을 쉽게 바꿀 수 있다는 이점이 있다. 우리는 알루미늄 양극 산화물(AAO)을 여과막으로 사용하였다. 여과된 용액은 자페반응(Jaffe reation)을 이용하여, 크레아티닌 농도별 흡광도 차이를 분석하였다. 크레아티닌의 양에 대한 표준식을 만들어, 측정한 데이터를 보간하여 여과된 용액의 농도를 확인하였다. 실험을 통하여 유량 및 크레아티닌 농도에 따른 여과율을 얻을 수 있었다.

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
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• 제24권3호
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• pp.49-57
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• 2018

Purpose: The increase in patients requiring hemodialysis has resulted in an increase dialysis-associated infections risk. but there are no Renal Dialysis unit design standard meet specified safety and quality standards. Therefore, appropriate Establish standards and legal regulation is important for the provision of initial certification and maintenance of facility, equipment, and human resource quality. Methods: Literature survey on the design guideline and standards of Renal Dialysis unit design in Korea, U.S, Germany, Singapore, Hongkong, Dubai. Results: There are no established standards for facilities in dialysis units in Korea. To prevent infections in dialysis patients, necessary establish standards. Considering the domestic and overseas Health-care facilities standards, the major factors to be considered in the medical environment for Renal Dialysis Unit are as follows. First, planning to separate Clean areas(treatment area) from contaminated areas(medical waste storage area). Second, ensure sufficient space and minimum separation distance. Although there may be differences depending on the circumstances of individual institutions, renal dialysis unit consider the space to prevent droplet transmission. Third, secure infrastructure of infection prevention such as sufficient amount of hand hygiene sinks. Hand washing facilities for staff within the Unit should be readily available. Hand hygiene sinks should be located to prevent water from splashing into the treatment area. Fourth, Heating, ventilation and air conditioning (HVAC) system for Renal Dialysis Unit is all about providing a safer environment for patients and staff. Implications: The results of this paper can be the basic data for the design of the Renal Dialysis Units and relevant regulations.