• Biomedical Science Letters
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• v.13 no.1
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• pp.39-45
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• 2007

Numerous psychological stressors playa role in development of the cardiovascular disease. The aim of this study was to determine whether a combined mental activity with experimental subway noise affects hematological physiology. Fifty-four healthy volunteers were divided group I which underwent subway noise (n=24) and group II which underwent a combined mental activity with subway noise (n=30). Venous blood samples were collected for measuring CBC, prothrombine time (PT), activated partial thromboplastine time (APTT), erythrocyte sedimentation rate (ESR), D-dimer and high sensitive C-reactive protein (H-CRP) levels before, 50 min of stress task (S-50m) and 60 min of recovery (R-60m). Changed ratios of granulocyte, lymphocyte, monocyte and platelet counts at S-50m and R-60m were higher in group II compared to group I. RBC count and hematocrit level in group I increased whereas those in group II decreased at S-50m. PT, APTT and ESR in the both groups were shortened at R-60m and the decreased ratios were high in group II compared to group I. H-CRP and D-dimer in the both groups were elevated at S-50m and R-60m while the increased ratios in group II were greater than those in group I. These observations imply that a combined mental activity with experimental subway noise may be a stressor which affects hematological physiology.

• Journal of Embryo Transfer
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• v.24 no.3
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• pp.177-182
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• 2009

This study was conducted to investigate the variation of growth characteristics and reproductive physiology in cloned Hanwoo male calves during growing stage. The hematological parameters, body weight, and plasma hormonal levels, birth to 12 months, were analyzed in the cloned calves (n=3). Differences among treatment means were determined by a student t-test. A probability of P<0.05 was considered statistically significant. The hematological parameters, such as white blood cell, red blood cell, and platelet, were not different in both normal and cloned calves. The difference of body weight, however, was significantly higher in the cloned calves, $5{\sim}6$ months (p<0.05) and $7{\sim}12$ months (p<0.01), than that of the comparators, respectively. The plasma IGF-1 level was statistically significant in the cloned calves, $5{\sim}10$ months, compared to that of the normal calves (p<0.05). However, the plasma testosterone level was not different in both normal and clone calves according to growing stage. Taken together, the cloned Hanwoo male calves are growing faster and maintaining a normal reproductive physiology.

• Nutrition Research and Practice
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• v.12 no.6
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• pp.535-540
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• 2018

BACKGROUND/OBJECTIVES: Propolis has a rich source of bioactive compounds and has renal and hepatic protective properties. The purpose of this study was to investigate the beneficial effect of hydro-ethanolic extract of propolis against paracetamol-induced liver damage and impairment of kidney function, as well as hematological changes in rats. MATERIALS/METHODS: Six groups of rats were used; the first group was served as a control; the second and third groups were treated by propolis extract at a dose of 50 and 100 mg/kg.B.WT. respectively; the fourth group was treated by paracetamol (200 mg/kg.B.WT.); the fifth group was treated by propolis (50 mg/kg.B.WT.) for eight days and then received similar dose of propolis for following seven days with paracetamol at a dose of 200 mg/kg.B.WT. daily for the seven days; and the sixth group was treated with propolis (100 mg/kg.B.WT.) for eight days and then received similar dose of propolis for following seven days with paracetamol at a dose of 200 mg/kg.B.WT. daily for the seven days. All the animals were treated for a period of 15 days. At the end of the experimental period, blood samples were collected for measurement of the liver enzymes, serum albumin, protein and creatinine, blood urea nitrogen, hematological parameters, and urine volume, protein and albumin. RESULTS: Paracetamol over dose significantly lowered hemoglobin, serum total protein, albumin, and uric acid, while it significantly increased blood creatinine, blood urea nitrogen, alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase activities, white blood cells, and platelet count as compared to the control. However, these alterations were significantly attenuated by the use of propolis extract and the effect was dose dependent. Interestingly, propolis prevented paracetamol induced proteinuria, low hemoglobin and body weight loss. CONCLUSIONS: Propolis significantly prevented paracetamol induced renal, hepatic and hematological toxicity and might be useful in the management of liver and renal diseases particularly proteinuria.

• Proceedings of the Ginseng society Conference
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• 1993.09a
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• pp.171-178
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• 1993

The effects of Korean Red Ginseng (KRG) in rats submitted to exhaustion exercise have been studied, by measuring different enzymatic and hematological parameters in plasma and muscle. KRG powder was daily administered to 15 male Wistar rats for a period of two weeks. Another group of 15 rats with the same characteristics were administered physiological saline. Both groups were divided as follows: 5 control. 5 exercised till exhaustion and 5 recovered for 48 h after exhaustion. The following results were obtained for the groups treated with KRG in rapport to those treated with saline: - Higher endurance to running, - Increase of the osmotic resistence of red blood cells and higher presence of reticulocytes. - Lower triglyceride levels in plasma. - Increase non statistically significant of urea levels in plasma, - Lower non statistically significant hypoglycemia after exhaustion exercise. - Decrease of liver glycogen after exercise and faster recovery of the resting - level. - Protective effect on tissular damage produced by exhaustion exercise - Lower LDH activity in all studied muscles. only statistically significant in the WG.

• Journal of fish pathology
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• v.36 no.2
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• pp.349-360
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• 2023

Common carp (Cyprinus carpio) (Weight 23.05 ± 6.98 g, Length 12.65 ± 1.38 cm) were exposed to waterborne nitrite at 0, 50, 100, 200, 400 and 800 mg NO₂ ^-/L for 96 hours. The lethal concentration 50 (LC₅₀) of C. carpio exposed to waterborne nitrite was 398.6 mg NO₂ ^-/L. Hemoglobin, hematocrit and RBC count were significantly decreased by waterborne nitrite exposure. The MCV (mean mean corpuscular volume) (µl), MCH (mean corpuscular hemoglobin) (pg) and MCHC (mean corpuscular hemoglobin concentration) (%) were significantly increased. The inorganic component, plasma calcium, was significantly increased, and the organic components such as plasma cholesterol and total protein were significantly increased showing a similar tendency with calcium. In enzymatic components, the AST and ALT were also significantly increased by nitrite exposure. The results of this study indicate that exposure to nitrite can affect the survival and hematological physiology of C. carpio.

• Asian-Australasian Journal of Animal Sciences
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• v.24 no.7
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• pp.912-918
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• 2011

Newly born lambs have to face challenges in a new environment totally different from that of the uterus. Adaptation to extra-uterine life involves functional changes with almost each organ and system in the body undergoing a series of metabolic and anatomical modifications. Failure to adapt the extra-uterine environment can not only lead to homeostatic disturbances but also lead to the death of the affected lambs. Hematological parameters of newly born lambs show variability that differs between breeds of lambs. The purpose of present study was to determine homeostatic responses and physiological reference values in Kajli breed lambs occurring in the neonatal period through changes in blood profile, respiratory rate, heart rate, live weight and rectal, scrotal and skin temperatures. For this purpose, sixteen clinically fit lambs (males = 10 and females = 6) with a mean body weight $6.92{\pm}0.46$ kg were selected. Physiological data of selected parameters of each Kajli lamb was recorded at three day intervals and hematological parameters at five days for a period of 30 days. In general, statistical analysis showed a significant effect of time (p<0.001) on all the studied physiological and hematological parameters except platelets counts, white blood cells and hemoglobin concentration. The results documented in the current study are an addition to existing knowledge of the physiology of Kajli sheep breed should be helpful in developing feeding, disease diagnoses and treatment protocols for newborn Kajli stock.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.48 no.5
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• pp.712-718
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• 2015

The effects of salinity on survival, oxygen consumption, and hematological response of greenling Hexagrammos otakii, mean body weight 147.1±3.8 g, were investigated under salinity conditions of 33.4 (control), 33.1, 32.8, 32.2, 31.0, 28.7, 23.9, 14.5, and 3.8 psu, to evaluate physiological effects in relation to changes in salinity. The survival and hematological responses of fish were measured at each salinity after 96- and 24-h exposures. The oxygen consumption rate (OCR) of fish was measured in triplicate under conditions of stepwise salinity exposure (33.4→33.1→32.8→32.2→31.0→28.7→23.9→14.5→3.8 psu) with an interval of 24 h at each salinity, using a continuous flow-through respirometer. No fish mortality was observed in the range of 33.4 to 14.5 psu, but the survival rate was reduced to 53.3% at 3.8 psu after 96 h of exposure. The OCRs did not significantly differ in the range between 33.4 to 28.7 psu (P>0.05), but significantly increased at 23.9 and 14.5 psu, and then dramatically decreased at 3.8 psu compared to the control (P<0.05). Hematological variables, such as glucose, glutamic pyruvic transaminase (GPT), hematocrit, and Na⁺, were affected by reduced salinity. This result may be applicable for habitat and culture management of greenlings.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.21 no.2
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• pp.73-93
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• 1995

The effect of natural products(drug 1, drug 2) on hair growth of frontal scalp of ten stumptailed macaques was investigated in period of 12 months. Drug 1 conteins extracts of Angelica gigantis Radix ok. and drug 2 conteins extracts of Corm Fructus, etc. Photographs of close view of the frontal scalp were taken once every month and folliclogram analysis has been done at pretretment and on 5th, 10th and 12th month after treatment. Drug 1 showed only slight effect or no effect on hair growth and drug 2 exhibited a significant degree of hair regrowth, but the control group exhibited a definite degree of regrowth and increasing density of vellum hair. Also, the physiological parameters, such as body weight, blood pressure, heart rate, serum levels of androgens, hematological measures during the treatment of drug 1, drug 2, and vehicle, were within normal limits. It indicates the drug 2 is the possible appearance of new summit of hair growth.

• Asian-Australasian Journal of Animal Sciences
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• v.24 no.2
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• pp.230-238
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• 2011

Effects of cooling and supplemental recombinant bovine somatotropin (rbST) on hemato-biochemical characteristics were studied at different stages of lactation of crossbred Holstein Friesian cows in a tropical environment. Ten primiparous cows were divided into two groups of five animals each. The first group was housed as the non-cooled animals in an open-sided barn with a tiled roof in a normal shaded house (NS), while the second group was housed as cooled cows in an open-sided barn with a tiled roof under misty fan cooling (MFC). Three injections with rbST (500 mg per dose) at each stage of lactation (early, mid and late lactation) significantly increased total milk yield as compared with pretreatment in both cooled and non-cooled cows. Milk fat was significantly increased, while total solids, solid not fat, milk protein and lactose were not affected by the rbST treatment. Hematological parameters, plasma proteins, albumin, glucose, triglyceride, cholesterol, creatinine, alkaline phosphatase (ALP), plasma inorganic phosphate and the activities of plasma aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were not affected by supplemental rbST in cooled and non-cooled cows. Supplementation of rbST caused a significant decrease in plasma urea concentration, while plasma FFA concentrations significantly increased in both cooled and non-cooled cows. The results of the present study suggest that exogenous rbST is efficacious in increasing milk yield without adverse effects on lactating crossbred Holstein cows in a tropical environment.

• Journal of Physiology & Pathology in Korean Medicine
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• v.16 no.5
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• pp.948-954
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• 2002

This study was carried out to evaluate Effects of Cheongyoung-tang on CHT-Induced Brain Edema and Neurological Disturbance Symptom in Rats. we make a comparative study of the such parameters as neurological severity score(NSS) and changes in water content, lactate, glucose and hematological substance. 1. ΔNSS increased in CYT1 and CYT2 as compared with the control group, which showed no efficacy. 2. In water content of both hemispheres, CYT1 and CYT2 as compared with the control group have no difference. 3. Water content of the left hemisphere decreased in CYT1 and CYT2 as compared with the control group. 4. The lactate level in serum decreased in CYT1 and CYT2 as compared with the control group. 5. In hematological changes, RBC, PLT and MCHC increased in CYT1 and CYT2 as compared with the control group, but MCV decreased. According to these results, CYT has an effect on CHT-induced brain edema and neurological symptom.