• Journal of the Korea Convergence Society
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• v.10 no.9
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• pp.257-264
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• 2019

This study was to investigate the relationship between the smoking status and the number of tooth loss according to the daily average smoking amount of the elderly in Korea using the raw data of the 6th National Health and Nutrition Survey. The study subjects were 4,037 elderly people aged 65 or older. As a result, it was found that 2.35 times more severe heavy smoking in the past, 3.01 times in the current light smoker, 3.27 times in the current heavy smoker, Respectively. This study confirmed that there is a difference in the risk of tooth loss according to the average daily smoking amount. Therefore, in order to increase and maintain the residual teeth as much as possible, it can be suggested as an objective data of smoking cessation treatment at the dental clinic and contribute to motivation.

• Journal of Korean society of Dental Hygiene
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• v.19 no.6
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• pp.951-961
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• 2019

Objectives: This study aims to evaluate how the amount and duration of smoking effects the bleeding and pain of gingival among adolescents in Korea while also taking into consideration the impact of drinking. Methods: Data were utilized from a web-based survey of youth health behaviors conducted by the Korean Center for Disease Control and Prevention in 2016. The subjects of the study included 65,528 adolescents from middle and high schools. As dependent variables, bleeding and pain of gingival were used. Data were analyzed using the SPSS Version 20.0 program. Results: After adjusting for the general characteristics and oral health behaviors of the subjects, in the long-term, the ≥0.52 PY group (heavy smoker) experienced 1.28 times higher bleeding and pain of gingival than the <0.52 PY group (light smoker) among adolescents who smoke and drink at the same time. Adolescents who smoked without drinking did not show any difference on bleeding and pain of gingival according to the amount of smoking in the short- and long-term. However, the findings reveal that there was a difference on bleeding and pain of gingival according to tooth brushing frequency. Conclusions: In order to promote the periodontal health of adolescents, it is argued that programs and projects should be implemented to prevent, educate, and control simultaneous behaviors of smoking and drinking.

• The Korean Journal of Food And Nutrition
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• v.12 no.3
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• pp.290-299
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• 1999

This study was conducted to investigate drinking smoking exercise and environmental characteristics and it's risk factors for hypercholesterolemia (HC) in Korean. 344 adult men who took the annual health check-ups at D or J hospitals were participated in this corss-sectional study. The subjects were grouped by plasma total cholesterol level into three groups: normal cholesterolemic(n=139) borderline hyper-cholesterolemic (n=93) and hypercholesterolemic (n-112) groups. The data of plasma cholesterol level in the subjects were collected from medical records. Drinking smoking and exercise habits family and disease history personality type and stress level of subjects were investigated by using questionaries. The subjects with HC had longer drinking duration and drunk more frequently. The proportion of smok-er heavy smoker($\geq$2pack/day) and longer smoker ($\geq$30yrs) showed high in the HC but there were no significancy. The subjects with HC had preference for light exercise and exercised more frequently but there were no significant difference. The family history of cardiovascular diseases was higher in the were not different among the three groups. The relative risks on HC were 1.33 for family history, 1.22 for severe stress 1.06 for smoking and 1.04 for exercise.

• Journal of Periodontal and Implant Science
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• v.31 no.4
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• pp.803-810
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• 2001

The purposes of this study were to investigate the relationship between cigarette smoking levels and periodontal status. 199 subjects, consisting of male 127 and female 72, classified by smoking levels and duration were selected: Patients who had smoked for more than 20 cigarettes/day were considered heavy smokers, 10 to 19, moderate smokers; 1-9, light smokers:0, non-smoker. And smokers were divided into ones who had smoked for more than 20 years, 10-19 years, less than 10 years and non-smokers. Heavy smokers and moderate smokers showed significantly greater pocket depths, less clinical attachment levels, more molar furcation involvements, greater alveolar bone loss and higher scores of plaque index than light smokers and non-smokers,(p < 0.05). When the duration of smoking was considered as a factor, scores of clinical parameters were worse and alveolar bone loss were significantly greater in long-term smokers, who had smoked for more than 20 years. In conclusion, cigarette smoking is associated with periodontal status.

• Journal of the Korea Convergence Society
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• v.11 no.2
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• pp.315-321
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• 2020

This research explores the change of smoking cessation motivation, maintenance(6months) from the heavy smokers who have experienced residential treatment. Data was collected by the questionnaires about participates motivation from 1st August 2015 to 31st December 2018. Total participates were 1317 that 1248 males (94.8%) and 69 females (31.3%). The most of participants answered their period of smoking was 31-40years as 31.3% (413p) of total participants. Motivation improved after residential treatment, and the 6-month success group had overall cessation of smoking cessation (F=6.52, p=.011), In the subcategories, pre-contemplation(F=5.12, p=.024), contemplation(F=.90, p= .341), preparation-level1(F=5.79, p=.016) and preparation-level2(F=1.33, p=.249) were statistically significant. Thus, this research investigates that the residential program for smoking cessation actually works to the heavy smokers to increased their motivation and that the 6-month success group had stronger.

• Journal of Preventive Medicine and Public Health
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• v.35 no.2
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• pp.123-128
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• 2002

Objective : To examine the relationship between cigarette smoking, alcohol and cancer mortality in men in the Kangwha cohort after 12 years and 10 months of follow up. Methods : The subjects consisted of 2,681 men in the Kangwha cohort aged over 55 in 1985. Number of deaths and the time to death front all cancers and other cause were measured and the data for the smoking and drinking habits were obtained from the baseline survey data in 1985. All subjects were categorized into four groups according to their smoking habits: non-smokers, ex-smokers, mode(ate-smokers (1-19 cigarettes per day), heavy-smokers ($\geq$20 cigarettes per day). In addition, they were also categorized according to their drinking habits: non-drinkers, light-drinkers ($\leq$1 drink per week), moderate-drinkers (<3 drinks per day), heavy-drinkers ($\geq$3 drinks per day). The cancer specific death rates were calculated according to their smoking and drinking status. The adjusted risk ratio for all cancer deaths according to their smoking and drinking status were estimated using the Cox's proportional hazard regression model. Results : Using nonsmokers as the reference category, the adjusted risk ratio for all cancer deaths were 1.573(95% CI=1.003-2.468) for heavy-smokers. For lung cancer deaths, the adjusted risk ratios were 3.540(95% CI=1.251-10.018) for moderate-smoker and 4.114(95% CI=1.275-13.271) for heavy-smokers. Compared to non-drinkers, the adjusted risk ratio for stomach cancer was 2.204(95% CI=1.114-4.361) for light-drinkers. Conclusion : Smoking is the most significant risk factor for cancer deaths particularly lung cancer.

• Journal of Chest Surgery
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• v.35 no.12
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• pp.909-913
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• 2002

The large cell neuroendocrine carcinoma is uncommon and its diagnostic criteria was recently established as pulmonary neuroendocrine carcinoma. A 74-year-old man who was a heavy smoker without symptoms was presented with a lung mass in right lower lobe. He was diagnosed as having large cell neuroendocrine carcinoma by needle biopsy. He was treated with right lower lobe lobectomy and mediastinal lymph node dissection. We experienced one case of large cell neuroendocrine carcinoma of lung and report it with reference.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.9
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• pp.5495-5501
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• 2013

Background: Alu elements are one of the most common repetitive sequences that now constitute more than 10% of the human genome and potential targets for epigenetic alterations. Correspondingly, methylation of these elements can result in a genome-wide event that may have an impact in cancer. However, studies investigating the genome-wide status of Alu methylation in cancer remain limited. Objectives: Oral squamous cell carcinoma (OSCC) presents with high incidence in South-East Asia and thus the aim of this study was to evaluate the Alu methylation status in OSCCs and explore with the possibility of using this information for diagnostic screening. We evaluated Alu methylation status in a) normal oral mucosa compared to OSCC; b) peripheral blood mononuclear cells (PBMCs) of normal controls comparing to oral cancer patients; c) among oral epithelium of normal controls, smokers and oral cancer patients. Materials and Methods: Alu methylation was detected by combined bisulfite restriction analysis (COBRA) at 2 CpG sites. The amplified products were classified into three patterns; hypermethylation ($^mC^mC$), partial methylation ($^uC^mC+^mC^uC$), and hypomethylation ($^uC^uC$). Results: The results demonstrate that the $%^mC^mC$ value is suitable for differentiating normal and cancer in oral tissues (p=0.0002), but is not significantly observe in PBMCs. In addition, a stepwise decrease in this value was observed in the oral epithelium from normal, light smoker, heavy smoker, low stage and high stage OSCC (p=0.0003). Furthermore, receiver operating characteristic (ROC) curve analyses demonstrated the potential of combined $%^mC$ or $%^mC^mC$ values as markers for oral cancer detection with sensitivity and specificity of 86.7% and 56.7%, respectively. Conclusions: Alu hypomethylation is likely to be associated with multistep oral carcinogenesis, and might be developed as a screening tool for oral cancer detection.

• Tuberculosis and Respiratory Diseases
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• v.69 no.3
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• pp.177-183
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• 2010

Background: Smoking reduces pulmonary function and induces various lung diseases. Recently, the rate of emphysema detection has increased due to lung cancer screening with low-dose chest computed tomography (CT). The purpose of this study was to evaluate changes in lung function associated with emphysema in healthy smokers. Methods: One hundred and ninety one healthy smokers, who had undergone a low-dose chest CT (LDCT) scan as part of lung cancer screening and had revisited the health center after a median 23.9 months' time, were recruited into this study. The severity of emphysema was calculated by the direct observation of a radiologist and a pulmonologist indipendently. Longitudinal changes in lung function according to emphysema based on LDCT and type of smoker was analyzed. Results: Of the participants in this study, 25% of healthy smokers had emphysema, which was mild in severity, in older patients (p=0.003) and in heavy smokers (p<0.001). $FEV_1/FVC$ and FEF25-75% were decreased in current smokers with emphysema (p=0.001 and p=0.009, respectively) and without emphysema (p=0.001 and p=0.042). Although lung function was not decreased in ex-smokers without emphysema, $FEV_1/FVC$ and FEF25-75% were decreased in ex-smoker with emphysema (p=0.020 and p=0.010). Conclusion: Upon examination with LDCT, the prevalence of emphysema was higher in healthy smokers was than in non-smokers. Lung function was diminished in smokers with emphysema, in spite of former smoker.

• Journal of Environmental Health Sciences
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• v.45 no.2
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• pp.142-153
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• 2019

Objectives: The aim of this study was to determine environmental chemical exposure related to residential and personal lifestyle characteristics in the adult Korean population. The observations of this study can provide information useful for developing reduction approaches for exposure to chemicals among the general adult population. Methods: The second stage of the Korean National Environmental Health Survey (KoNHES) was conducted from 2012 to 2014, with 6,478 persons participating. Using the results of the survey, the relationship between exposure levels of heavy metals and organic chemicals and exposure factors, e.g. residential and personal lifestyle characteristics, were analyzed. Results: The exposure levels of VOCs and PAHs were significantly lower in participants living at a distance of more than 100 m from roads versus living closer to roads. Home ventilation lowered VOC and PAH exposure but did not lower chemical exposure from household products. Use of public transportation showed lower exposure to heavy metals, VOCs, and PAHs. Current smoker was significantly higher for levels of heavy metals, VOCs, and PAHs, and the exposure trend was similar for current drinkers. Physical activity was related with higher exposure to phthalates and environmental phenols. Conclusion: Our observations based on a nationally representative population for Korea show that exposure to chemicals varies by residential and personal lifestyle, and this should be considered for developing appropriate mitigation measures and policies. Given the health concerns surrounding environmental chemicals, it is necessary to develop comprehensive measures to reduce chemical exposure.