• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.3 no.1
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• pp.13-18
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• 2010

In this study, heart rate through ECG R-R intervals using the methods about how to automatically extract studied. Heart rate as measured by the naked eye, using the 2-order differential equations to extract heart rate, using self-correlation function to extract the heart rate was compared contemplate. To verify its efficacy and validity in practical applications, these method has been applied to MIT/BIH database. Based on this, making a ECG meter automatic heart rate measurements, and our ECG meter was compared with the existing ICU.

• 제어로봇시스템학회:학술대회논문집
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• 1997.10a
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• pp.1639-1642
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• 1997

In this paper, the autonomic function analysis system was designed to noninvasively assess the autonomic function of cardiovascular system. Orthostatic stress protocol was designed to stimulate the autonomic nervous system. designed protocol and analysis algorithm were evaluated by experiments for 25 normal subjects and 22 hemiplegia patients. Data were processed by usign the power spectral analysis. Nwe indexes of autonomic function, LF$_{N}$ and HF$_{N}$, were proposed and were compared with LF/HF ratio. New indexes of the sympathetic and parasympathetic activity, respectively. The IST and the DPT are balanced and have positive value for normal subjects during orthostatic stress but not for hempilegia patients. This result suggest that the IST and the DPT are used as new criteria of normal autonomic function during orthostatic stress.ess.

• Molecules and Cells
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• v.38 no.6
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• pp.580-586
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• 2015

While increasing evidence indicates the important function of histone methylation during development, how this process influences cardiac development in vertebrates has not been explored. Here, we elucidate the functions of two histone H3 lysine 4 (H3K4) methylation enzymes, SMYD3 and SETD7, during zebrafish heart morphogenesis using gene expression profiling by whole mount in situ hybridization and antisense morpholino oligonucleotide (MO)-based gene knockdown. We find both smyd3 and setd7 are highly expressed within developing zebrafish heart and knock-down of these genes led to severe defects in cardiac morphogenesis without altering the expressions pattern of heart markers, including cmlc2, vmhc, and amhc. Furthermore, double knock-down by coinjection of smyd3 and setd7 MOs caused the synergistic defects in heart development. As similar to knock-down effect, overexpression of these genes also caused the heart morphogenesis defect in zebrafish. These results indicate that histone modifying enzymes, SMYD3 and SETD7, appear to function synergistically during heart development and their proper functioning is essential for normal heart morphogenesis during development.

• Journal of Chest Surgery
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• v.18 no.4
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• pp.718-731
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• 1985

Renal dysfunction is a common complication of open-heart surgery: a form of controlled hemorrhagic shock, and successful perioperative management of renal dysfunction depends on recognition of the risk factors and optimal management of factors influencing renal function, including cardiopulmonary bypass, and early detection of renal failure. Changes in renal functional parameters including Ccr, Cosm, CH2O, FENa, and RFI were observed prospectively in forty five patients operated on at Dept. of Thoracic and Cardiovascular Surgery, S.N.U.H., from April to June, 1985. They were 23 males and 22 females with 35 acquired and 10 congenital heart diseases and the mean age and body surface area of them were 38.010.3 years [22-63] and 1.5518 M2[1.151.92] respectively. Followings are the conclusion. 1. The Ccr, representative of renal function, is significantly improved from 90.231.3 ml/min/M2 preoperatively to 101.536.4 ml/min/M2 postoperative and day [P<0.05], and all patients were classified as postoperative renal functional class I of Abel, which representing adequate renal protection during our cardiopulmonary bypass. 2. The Cosm is significantly elevated at immediate postperfusion time and remained high at postoperative one day representing osmotic diuresis at that time, but CH2O shows no significant changes at immediate postperfusion period and is decreased significantly at postoperative one day, representing recovery of renal concentrating ability at that time with decreasing urine flow. 3. The absolute value and changing tendency in FENa and RFI during perioperative period shows no diagnostic reliability on these parameters, but those of CH2O appear to reveal future renal function more accurately than Ccr 4. The depth of hypothermia may be protective upon renal function against the ill effects of prolonged nonpulsatile cardiopulmonary bypass. 5. The depth of the hypothermia, pump time of more than 150 minutes, poor cardiac function, and intraoperative events such as embolism appear to be related with immediate postperfusion renal function. 6. Hemoglobinuria and hemolysis, poor preoperative renal function, history of cardiac surgery, and massive transfusion associated with bleeding appear not to be related with renal dysfunction.

• Journal of Korean Medical classics
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• v.30 no.3
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• pp.55-76
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• 2017

Objectives : The transition of the 29 diagrams of Heart originated from MingTangZangFuTu will be used to understand the shape of heart and the changes of people's understanding of heart. Methods : The 29 diagrams of Heart originated from MingTangZangFuTu are divided according to their shape elements (Heart itself, internal curvatures, structures above heart, wuzangxi, and excursus). Then its transitions are analyzed, and each shape element is compared to modern anatomy and its textual basis is searched. Results : The lengthy cylinderical organ situated above the heart is composed of upper part consisting with joints and the lower part void of joints. The upper part is Pyewan (such as the lungs) and fall into trachea. The lower part is Xinxi or Feixi which are either relative vein (or aorta) or left bronchus that passes behind the heart. This depiction of the structures around the heart can be considered to have composed by actual observance of a physical heart, a method that is similar to anatomy. However, the shape of the heart itself is described as a lotus flower that has not been bloomed, a depiction which finds its origin from Zhongguangbuzhu huangdineijing suwen (762). The three short curvatures inside the heart is described as Pericardium, influenced by Shisijingfahui (1341) in its depiction, or as sammo, influenced by Nanjing. Structures that are connected directly from the heart to spleen, kidney, and uterus are not found in modern anatomy. The saying in Excursus "All cords of five internal organs belong to heart" is based on Huatuoxuanmenneizhaotu, and this is changed to the saying cords of four internal organs belong to heart in Leijingtuyi for the first time. Conclusions : The authors of medical scriptures at the time did not have a method of direct observance when they were copying heart diagrams. Therefore, they made changes to the source material's diagram and excursus while being influenced by Nanjing, Huatuoxuanmenneizhaotu, and Shisijingfahui. Then the doctors' understandings with regards to the shape and function of heart were reflected during that process.

• Proceedings of the KOSOMBE Conference
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• v.1997 no.05
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• pp.402-405
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• 1997

The analysis of heart sounds is a noninvasive diagnostic method useful to diagnose heart valve function. In this paper we compared the ability of spectral analysis method for prosthetic heart valve sounds. Phonocardiograms of prosthetic heart valve were analyzed in order to derive frequency domain feature suitable for the classification of the valve state. The FFT-based methods did not provide sufficient frequency resolution to completely characterize the spectrum of prosthetic heart valve sounds. A high resolution parametric methods were shown to give superior frequency resolution. In parametric methods, all methods provide a 1st & 2nd & 3rd frequency component. But Shank method provided a most dominant frequency peak.

• Journal of Chest Surgery
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• v.24 no.10
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• pp.967-972
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• 1991

Between Feb. 1982 and July 1990, 173 patients [male: 89, female: 84] Who underwent heart valve replacement for acquired valvular heart disease on the Department of Thoracic and Cardiovascular Surgery, School of Medicine, Pusan National University, were reviewed for return to work after heart valve replacement. The replaced valve were mitral [128, 74.0%], aortic[10, 5.8%], mitral & aortic[35, 20.2%]. Two tricuspid valve replacement were excluded. Several important factors influencing the return to work were age, the employment status before surgery, the number of replaced valve, the pre - op NYHA functional class and cardiac function [ejection fraction]. These factors were closely related to the optimal time of heart valve replacement. It can be concluded that the rate of return to work and the quality of life would be improved if valve replacement were performed at an earlier stage of valvular heart disease.

• Journal of Chest Surgery
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• v.44 no.6
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• pp.413-417
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• 2011

Background: Sleeve lobectomy for lung cancer in close proximity to or involving the carina is widely accepted. Operative morbidity and mortality rates, recurrence, and survival rates have varied considerably across studies. Materials and Methods: From March of 2005 to July of 2010, sleeve lobectomy was performed in 19 patients and pneumonectomy was performed in 20 patients. In this paper, the results of sleeve lobectomy and pneumonectomy for patients with lung cancer will be compared and evaluated. Results: There were no postoperative complications in either group, but there was one mortality in the pneumonectomy group. There was better preservation of pulmonary function in the sleeve lobectomy group than the pneumonectomy group (p=0.066 in FVC, p=0.019 in FEV1). The 3-year survival rates were 46.7% in the sleeve lobectomy group and 54.5% in the pneumonectomy group (p=0.505). The 3-year disease-free survival rates were 38% in the sleeve lobectomy group and 45.8% in the pneumonectomy group (p=0.200). Conclusion: Sleeve lobectomy for lung cancer showed low mortality, low bronchial anastomotic complication rates, and good preservation of pulmonary function.

• BMB Reports
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• v.49 no.8
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• pp.414-423
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• 2016

MG53 is a member of the TRIM-family protein that acts as a key component of the cell membrane repair machinery. MG53 is also an E3-ligase that ubiquinates insulin receptor substrate-1 and controls insulin signaling in skeletal muscle cells. Since its discovery in 2009, research efforts have been devoted to translate this basic discovery into clinical applications in human degenerative and metabolic diseases. This review article highlights the dual function of MG53 in cell membrane repair and insulin signaling, the mechanism that underlies the control of MG53 function, and the therapeutic value of targeting MG53 function in regenerative medicine.

• The Journal of Korean Obstetrics and Gynecology
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• v.20 no.4
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• pp.101-110
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• 2007

Purpose: Oligomenorrhea is clinically important because it can be progressed to amenorrhea. The purpose of this study is to analyse Autonomic Nerve Function of some oligomenorrheic patients by using HRV(Heart Rate Variability). Methods: We studied 35 patients visiting OO Oriental Hospital from 1st November 2006 to 31th May 2007. One woman who takes antidepressant is excluded. 17 oligomenorrheic group and 17 normal menstrual cycle group were compared with HRV. The SPSS 12.0 for windows was used to analyze the data and Mann Whitney U-test were used to verify the results. Results: Mean PR, LF norm, LF/HF ratio of oligimenorrheic group are higher than normal menstrual cycle group. But there is no statistically significance. SDNN, RMS-SD, ln TP, ln VLF, ln LF, ln HF, HF norm of oligimenorrheic group are lower than normal menstrual cycle group. But there is no statistically significance. Conclusion: It can be suggested that oligomenorrhea can be related to increased activities of sympathetic nerve and decreased activities of general autonomic nerve function. But, we need study with more subjects for settling this.