• Journal of Microbiology and Biotechnology
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• 제27권4호
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• pp.668-677
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• 2017

Embryo implantation is the crucial step for a successful pregnancy. Diverse factors, including adhesion molecules, growth factors, and cytokines are important for embryo implantation through improving endometrial receptivity. Benzoic acid (BA), a component of various plants, has been shown to have antifungal and antioxidant effects. However, the effect of BA on embryo implantation remains unknown. Here, we showed the contribution of BA for the enhancement of endometrial receptivity through the leukemia inhibitory factor (LIF)-dependent increase of integrin ${\alpha}V$, ${\beta}3$, and ${\beta}5$ expression. Furthermore, in vivo study using a mifepristone-induced implantation failure model showed that BA definitely improves the numbers of implantation embryos. Taken together, we suggest that BA has a novel function for embryo implantation through the up-regulation of LIF-mediated integrins, and may be a candidate for therapeutic medicine to increase the pregnancy rate.

• 대한지역사회영양학회지
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• 제11권6호
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• pp.740-749
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• 2006

The objective of this study was to develop nutrition education materials for older adults, 'nutritional management for healthy aging'. A booklet and four leaflets were developed based on lesson plans. Topics of the lesson plans included eating habit assessment. Korean food guide pyramid, meal planning, eating sensibly and weight management. The titles of the leaflets were 'Eating right for healthy aging', 'Eat calcium-rich foods', 'Enjoy fruits & vegetables' and 'Weight management'. Illustrations and icons appropriate to the texts were designed using illustrator 9.0 and Photoshop 6.0. Booklet (letter size, 5 chapters, 44 pages) and leaflets (B4 size, 6 sections) focused on modifying undesirable eating habits, providing practical tips for desirable behaviors, and behavioral modification such as recording in a food diary, goal setting and increasing self-efficacy. The drafts were pilot-tested by interviews with older adults(n=10), and minor changes were made. The characteristics of revised materials are as follows; i) materials focused on providing desirable eating behaviors for healthy aging, ii) messages were simple and specific, iii) large fonts(13 pt) were used and materials included interesting pictures and illustrations, iv) materials provided tips for balanced diets and recipes fur older adults, v) materials included sections for participation of learners including assessment of nutritional risk factors and obesity, meal planning and games. The revised materials are self-explanatory and can be used by older adults and in nutrition education for older adults.

• Nutrition Research and Practice
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• 제8권5호
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• pp.550-557
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• 2014

BACKGROUND/OBJECTIVES: Angelica keiskei is a green leafy vegetable rich in plant pigment phytochemicals such as flavonoids and carotenoids. This study examined bioavailability of flavonoids and carotenoids in Angelica keiskei and the alteration of the antioxidant performance in vivo. SUBJECTS AND MATERIALS: Absorption kinetics of phytochemicals in Angelica keiskei were determined in healthy older adults (> 60 y, n = 5) and subjects with metabolic syndrome (n = 5). Subjects consumed 5 g dry Angelica keiskei powder encapsulated in gelatin capsules with a low flavonoid and carotenoid liquid meal. Plasma samples were collected at baseline, 0.5, 1, 2, 3, 4, 5, 6, 7, and 8 h. Samples were analyzed for flavonoids and carotenoids using HPLC systems with electrochemical and UV detection, respectively, and for total antioxidant performance by fluorometry. RESULTS: After ingestion of Angelica keiskei increases in plasma quercetin concentrations were observed at 1-3 and 6-8 hr in the healthy group and at all time points in the metabolic syndrome group compared to baseline (P < 0.05). Plasma lutein concentrations were significantly elevated in both the healthy and metabolic syndrome groups at 8 hr (P < 0.05). Significant increases in total antioxidant performance were also observed in both the healthy and the metabolic syndrome groups compared to baseline (P < 0.05). CONCLUSIONS: Findings of this study clearly demonstrate the bioavailability of phytonutrients of Angelica keiskei and their ability to increase antioxidant status in humans.

• International Journal of Advanced Culture Technology
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• 제6권3호
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• pp.59-68
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• 2018

This study was a cross-sectional descriptive study of the effects of emotional happiness on aging preparation for 45-60 year olds. Participants of this study were 312 volunteers and data was collected online, the collection period was from May 15, 2018 to May 31, 2018. The tools used in the research were the emotional happiness developed by Watson et al (1988) et al., the aging preparation developed by JH Lee (2009). Analysis was done using t-test, ANOVA, Pearson correlation, and regression by SPSS 18.0. As a result of the analysis, 84.0% of participants felt physically healthy and 89.8% felt mental health. The spouses of participants were physically 83.4% healthy and mentally 82.7% healthy. The correlation between emotional happiness, health cognition and aging preparation showed that physical health had a correlation with mental health (r = .482, p <0.01) and emotional happiness (r = .369, p <0.01), economic aging preparation (r = .411, p <0.01), social aging preparation (r = .119, p <0.01). Mental health was correlated with emotional happiness (r = .491, p <0.01), economic aging preparation (r = .411, p <0.01) and social aging preparation. Difference between emotional happiness and retirement preparation according to presence or absence of disease, emotional happiness (t = -4.503, p <0.01) and economic aging preparation (t = -4.960, p <0.01) were statistically significant. Emotional happiness affects the preparation of old age, emotional happiness affects to physical aging preparation under statistical significance (F=25.191, p<0.01), economic aging preparation (F=1131.783, p<0.01), and social aging preparation (F=147.672, p<0.01) which were sub components of aging preparation. Emotional happiness showed a 7.5% effect on the preparation of physical aging, 78.4% on economic aging preparation and 32.3% on social aging preparation. Based on the above results, it can be concluded that physical health and mental health are related to emotional happiness, economic aging preparation, and social aging preparation. And also these results can be inferred that the illness causes emotional less feeling of happiness and economic difficulty. Based on the results of this study, emotional well - being influences the retirement preparation significantly at statistical significance. Therefore, if the concept of emotional happiness is introduced to the old-age preparation program, it will be more client centered program.

• 동의생리병리학회지
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• 제28권5호
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• pp.530-536
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• 2014

Root barks of Paeonia suffruticosa Andrews (PS) was reported as contraindicated drugs of pregnancy by many Korean medical classics. Recently, a major ingredient component of PS, paeonol was reported that has contraceptive effect on early pregnancy in rats. However, the accurate molecular mechanism is not clear. In this study, we showed that PS decreased the expression of receptor for leukemia inhibitory factor (LIFR) in human endometrial Ishikawa cells at non-toxic dose, although the expression of leukemia inhibitory factor (LIF) was increased by PS. In addition, PS inhibited the adhesion of human trophoblastic JAR cells onto Ishikawa cells. Given importance of LIF-LIFR signaling pathway in the process of embryo implantation, the decreased LIFR expression by PS will be a good explanation on the PS- or its ingredient compounds-induced contraception.

• 디지털융복합연구
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• 제16권5호
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• pp.361-372
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• 2018

본 연구의 목적은 중년여성의 노화 도구를 개발하는 것으로 연구대상자는 대도시 중년여성 385명을 대상으로 수집하였고, 개발과정은 예비문항 개발, 내용 타당도와 신뢰성 검증, 최종 문항의 요인분석 및 신뢰도와 타탕도를 검증하였다. 요인분석 결과 본 도구는 9개의 요인으로 구성되었고, '자기성취감', '신체변화적응', '심리변화적응', '대인관계', '갱년기증상적응', '경제적 안정', '신체건강유지', '사회적 지지', '사회변화적응'으로 명명되었다. 본 연구에서 개발한 도구는 전체 설명변량이 64.03%로 충분하였으며, 전체 신뢰도도 Cronbach' ${\alpha}$값 .90으로 높았고, 우울과의 상관관계 분석에서는 부적 상관관계(r=-.69, p<.001)가 있는 것으로 나타나 동시타당도가 검증되었다. 본 도구는 높은 타당성과 신뢰도를 가지는 것으로 확인되어 중년여성의 성공적 노화를 측정하기 위한 도구로 유용할 것이다. 본 연구에서 개발한 도구는 반복 연구를 통해 추후 중년여성의 성공적 노화를 지지하기 위한 프로그램 개발의 기초자료를 마련하는데 기여할 것으로 사료된다.

• 한국노년학
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• 제29권1호
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• pp.117-134
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• 2009

본 연구의 목적은 노인들에게 맞는 건강한 노후에 관한 안정적인 신뢰도와 적절한 타당도를 갖춘 척도를 개발하는 것이다. 서울에 거주하고 노인복지관을 다니며, 정기적으로 운동을 하고 있는 노인 전체 335명(예비 척도 개발에 65세 이상의 노인 127명, 1차 본 조사 척도 개발에 62명, 2차 본 조사 척도 개발에 146명을 대상)을 대상으로 하였고, 건강한 노후에 관한 개방형 질문지와 개발된 건강한 노후 척도를 통해 설문지의 타당도와 신뢰도를 검증하였다. 조사기간은 2006년 6월 12일부터 2006년 10월 27일까지 실시되었고, 자료처리는 Window용 SPSS 통계 Package 12.0 Version을 이용하여 평균, 표준편차, 첨도, 왜도, 신뢰도 분석, 탐색적 요인 분석, 확인적 요인분석을 실시하였다. 연구의 결과는 다음과 같이 나타났다. 첫째, 구성 개념 틀에 근거하여 만들어진 25개의 문항들에 대해서는 노인관련 전공교수 1명, 노인 여가학 박사 2명 등의 자문집단을 통해 내용타당도를 높였다. 둘째, 탐색적 요인분석 결과 건강한 노후 척도는 신체적 건강(6문항), 인지·정신적 건강(6문항), 사회·지지적 건강(8문항)의 3개의 하위요인으로 추출되었다. 셋째, 신뢰도 검사 결과 전체 문항에 대한 Cronbach's α는 .891로 높은 신뢰도를 보였고, 요인별 설문지의 내적 일관성 검정 결과는 각각 .642에서 .885의 범위를 나타냈다. 넷째, 확인적 요인분석 결과 본 연구에서 적합지수로 판단한 NFI, RFI, CFI, Delta 2 IFI값들 은 1에 가깝게 나타났다. 따라서 본 연구에서 결과로 도출된 타당도와 신뢰도의 결과들을 살펴봤을 때, 개발된 건강한 노후에 대한 설문지는 예비조사, 본 조사의 과정을 거쳐 확인된 신뢰도와 타당도가 이론적 기준에 벗어나지 않은 적절한 도구이며, 특히 노인들의 건강한 노후 생활에 대한 기준과 틀을 제시한다는 점에서 그 의의가 있다고 하겠다.

• 한국컴퓨터정보학회논문지
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• 제20권7호
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• pp.115-120
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• 2015

The old people's feelings, emotions, and self-evaluative judgements fluctuate overtime. The purpose of this paper is to proof relations among well-being factors in social activity. Major results of this paper was as follows. First, the social activity participated elderly had higher health status, self-esteem, mental-health, and successful aging than the non-participated elderly. Second, self-esteem and mental health were exposed as important variable for all of the two groups to improve the successful aging. Thus, self-esteem and mental health can become significant indicator of self-empowering and psychological resilience. Third, the strongest total causal effect of successful aging was health status in social activity participated elderly, while self-esteem was the greatest total causal effect of it in the non-participated elderly. Health status had higher indirect effect of successful aging than direct effect of it in both of them.

• 한국영양학회:학술대회논문집
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• 한국영양학회 2002년도 추계학술대회 및 총회
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• pp.128-128
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• 2002

• 국제물리치료학회지
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• 제9권4호
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• pp.1591-1595
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• 2018

The number of healthy older adults is rapidly increasing recently owing to the increase of the elderly population. Therefore, programs for improving the cognitive functions of these healthy seniors are actively being expanded. This study aimed to prevent the decline of cognitive function due to aging by applying a program enhancing cognitive functions to healthy older adults. The objective of this study was to evaluate the effects of Korean computer-based cognitive rehabilitation program (CoTras), which is commonly used in cognitive therapy for the aging, on the memory of the elderly. The subjects had scored at least 24 points in MMSE-K. CoTras was applied once a week (30 minutes) for one month. Electronic pegboard programs were used as an evaluation tool: order memory (difficulty=low) and location memory (difficulty=medium). The order and location memories were compared before and after the intervention. The Wilcoxon signed rank-sum test was used for the study at the significance level of ${\alpha}=.05$. The results showed that CoTras significantly improved order memory and location memory. Therefore, CoTras can be applied to the healthy elderly for improving that memory improvement training has a positive impact on healthy older adults result in the development of memory enhancement programs can be expanded in the future.