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Mechanism Study on Inhibition of Pregnancy by Root Barks of Paeonia suffruticosa  

Choi, Hee Jung (Department of Korean Medical Science, Division of Applied Medicine, and Korean Medical Research Center for Healthy Aging, School of Korean Medicine, Pusan National University)
Kim, Eun Young (Department of Korean Medical Science, Division of Applied Medicine, and Korean Medical Research Center for Healthy Aging, School of Korean Medicine, Pusan National University)
Choi, Hee Jin (Department of Korean Medical Science, Division of Applied Medicine, and Korean Medical Research Center for Healthy Aging, School of Korean Medicine, Pusan National University)
Park, Mi Ju (Department of Korean Medical Science, Division of Applied Medicine, and Korean Medical Research Center for Healthy Aging, School of Korean Medicine, Pusan National University)
Chung, Tae Wook (Department of Korean Medical Science, Division of Applied Medicine, and Korean Medical Research Center for Healthy Aging, School of Korean Medicine, Pusan National University)
Park, Seong Ha (1st Division of Clinical Medicine, School of Korean Medicine, Pusan National University and Department of Internal Medicine, Pusan National University Korean Medical Hospital)
Kim, So Yeon (1st Division of Clinical Medicine, School of Korean Medicine, Pusan National University and Department of Internal Medicine, Pusan National University Korean Medical Hospital)
Ha, Ki Tae (Department of Korean Medical Science, Division of Applied Medicine, and Korean Medical Research Center for Healthy Aging, School of Korean Medicine, Pusan National University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.28, no.5, 2014 , pp. 530-536 More about this Journal
Abstract
Root barks of Paeonia suffruticosa Andrews (PS) was reported as contraindicated drugs of pregnancy by many Korean medical classics. Recently, a major ingredient component of PS, paeonol was reported that has contraceptive effect on early pregnancy in rats. However, the accurate molecular mechanism is not clear. In this study, we showed that PS decreased the expression of receptor for leukemia inhibitory factor (LIFR) in human endometrial Ishikawa cells at non-toxic dose, although the expression of leukemia inhibitory factor (LIF) was increased by PS. In addition, PS inhibited the adhesion of human trophoblastic JAR cells onto Ishikawa cells. Given importance of LIF-LIFR signaling pathway in the process of embryo implantation, the decreased LIFR expression by PS will be a good explanation on the PS- or its ingredient compounds-induced contraception.
Keywords
Root barks of Paeonia suffruticosa(牧丹皮); Contraception; Contraindicated drugs of pregnancy; LIF; LIFR;
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