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http://dx.doi.org/10.4014/jmb.1609.09028

Benzoic Acid Enhances Embryo Implantation through LIF-Dependent Expression of Integrin αVβ3 and αVβ5  

Choi, Hee-Jung (School of Korean Medicine and Healthy Aging Korean Medicine Research Center, Pusan National University)
Chung, Tae-Wook (School of Korean Medicine and Healthy Aging Korean Medicine Research Center, Pusan National University)
Park, Mi-Ju (School of Korean Medicine and Healthy Aging Korean Medicine Research Center, Pusan National University)
Kim, Hyung Sik (Laboratory of Molecular Toxicology, School of Pharmacy, SungKyunKwan University)
You, Sooseong (Korea Institute of Oriental Medicine)
Lee, Myeong Soo (Korea Institute of Oriental Medicine)
Joo, Bo Sun (School of Korean Medicine and Healthy Aging Korean Medicine Research Center, Pusan National University)
Lee, Kyu Sup (Department of Obstetrics and Gynecology, Pusan National University Hospital)
Kim, Keuk-Jun (Department of Clinical Pathology, DaeKyeung University)
Wee, Gabbine (Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation)
Kim, Choong-Yong (Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation)
Kim, Cheorl-Ho (Department of Biological Science, Sungkyunkwan University)
Ha, Ki-Tae (School of Korean Medicine and Healthy Aging Korean Medicine Research Center, Pusan National University)
Publication Information
Journal of Microbiology and Biotechnology / v.27, no.4, 2017 , pp. 668-677 More about this Journal
Abstract
Embryo implantation is the crucial step for a successful pregnancy. Diverse factors, including adhesion molecules, growth factors, and cytokines are important for embryo implantation through improving endometrial receptivity. Benzoic acid (BA), a component of various plants, has been shown to have antifungal and antioxidant effects. However, the effect of BA on embryo implantation remains unknown. Here, we showed the contribution of BA for the enhancement of endometrial receptivity through the leukemia inhibitory factor (LIF)-dependent increase of integrin ${\alpha}V$, ${\beta}3$, and ${\beta}5$ expression. Furthermore, in vivo study using a mifepristone-induced implantation failure model showed that BA definitely improves the numbers of implantation embryos. Taken together, we suggest that BA has a novel function for embryo implantation through the up-regulation of LIF-mediated integrins, and may be a candidate for therapeutic medicine to increase the pregnancy rate.
Keywords
Benzoic acid; leukemia inhibitory factor; integrin; adhesion; endometrial receptivity; implantation;
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