• Nuclear Engineering and Technology
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• 제56권4호
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• pp.1472-1479
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• 2024

Cyber-Physical Energy Systems (CPESs) integrate cyber and hardware components to ensure a reliable and safe physical power production and supply. Renewable Energy Sources (RESs) add uncertainty to energy demand that can be dealt with flexible operation (e.g., load-following) of CPES; at the same time, scenarios that could result in severe consequences due to both component stochastic failures and aging of the cyber system of CPES (commonly overlooked) must be accounted for Operation & Maintenance (O&M) planning. In this paper, we make use of Deep Reinforcement Learning (DRL) to search for the optimal O&M strategy that, not only considers the actual system hardware components health conditions and their Remaining Useful Life (RUL), but also the possible accident scenarios caused by the failures and the aging of the hardware and the cyber components, respectively. The novelty of the work lies in embedding the cyber aging model into the CPES model of production planning and failure process; this model is used to help the RL agent, trained with Proximal Policy Optimization (PPO) and Imitation Learning (IL), finding the proper rejuvenation timing for the cyber system accounting for the uncertainty of the cyber system aging process. An application is provided, with regards to the Advanced Lead-cooled Fast Reactor European Demonstrator (ALFRED).

• 한국가정과교육학회지
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• 제32권1호
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• pp.127-143
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• 2020

본 연구는 건강신념모델에 근거한 가정과 의생활 안전 교수·학습과정안을 개발하고, 이를 활용한 수업이 건강신념에 미치는 효과를 알아보는 데 목적을 두고 있다. ADDIE 모형에 따라 '의복 및 섬유제품의 생산, 착용, 세탁, 보관 과정에서 노출될 수 있는 유해물질', '친환경 섬유', '천연세정제'와 같이 3가지 학습요소에 대하여 건강신념모델을 적용하여 6차시의 교수·학습 과정안을 개발하였다. 개발된 교수·학습 과정안으로 경기도 안양시 소재 남녀공학 중학교 3학년 7개 학급, 총 229명의 학생을 대상으로 2018년 8월 20일부터 9월 7일까지 1주에 2시간씩 3주에 걸쳐 총 6차시로 수업을 실행하였다. 건강신념을 측정한 사전·사후 자료는 통계 프로그램 SPSS/win(version18.0)을 이용하여 대응표본 t-test를 실시하였다. 개발된 교수·학습 과정안을 수업에 적용한 결과 인지된 위협(인지된 민감성과 심각성의 조합), 인지된 이익, 자기효능감 모두 통계적으로 유의미하게 향상되었고, 인지된 장애는 통계적으로 유의미하게 감소되었다. 이상의 결과 건강신념모델을 적용한 가정과 의생활 안전교육 수업은 중학생들이 유해물질로부터의 안전한 의생활을 실천할 수 있도록 하는 안전교육으로서 큰 의미가 있다고 볼 수 있다. 이 연구 결과는 가정과 특색에 맞는 안전교육은 물론 의생활안전교육을 활성화시키는데 도움이 되기를 기대한다.

• Animal Bioscience
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• 제36권1호
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• pp.98-107
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• 2023

Objective: Current quail production is configured as an economic activity in scale. Advancements in quail nutrition have been limited to areas such as breeding and, automation of facilities and ambience. The objective of this study was to evaluate the performance responses, liver and oviduct morphometry, and liver histology of Japanese laying quails subjected to different levels of nitrogen-corrected apparent metabolizable energy (MEn). Methods: A completely random design was used that consisted of nine levels of MEn, six replicates, and five hens per cage with a total of 270 quails. The experimental period lasted for 10 weeks. The variables of performance were subjected to analysis of variance and then regression analysis using the broken-line model. The morphometric and histological variables were subjected to multivariate exploratory techniques. Results: The MEn levels influenced the responses to zootechnical performance. The broken-line model estimated the maximum responses for feed intake, egg production, egg weight, and egg mass as 3,040, 2,820, 1,802, and 2,960 kcal of MEn per kg of diet, respectively. Multivariate analysis revealed that the occurrence of hepatic steatosis and increased levels of Kupffer cells were not related to MEn levels. Conclusion: The level of 2,960 kcal/kg of MEn meets performance variable requirements without compromising hepatic physiology.

• 한국약용작물학회지
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• 제18권1호
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• pp.1-8
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• 2010

Inonotus obliquus is one of the immune-regulatory substances and is recognized to play the role in the metabolic process of inflammation, allergy and immuntiy. The purpose of this study was to evaluate the effects of water extracts of Inonotus obliquus (IOW) on the liver lymphocyte immune function in the Sprague-Dawley male rats treated with carbon tetrachloride ($CCl_4$) to induce liver damage. Rats were fed with each experimental diet and water for 4 weeks. We found that effects of IOW on interferon-gamma (IFN-$\gamma$), signal transducer and activator of transcription 1 (STAT1), phospho-signal transducer and activator of transcription 1 (pSTAT1) and GATA-binding protein 3 (GATA-3) were decrease in vivo. Interleukin-4 (IL-4), STAT6, pSTAT6 and T-box expressed in T-cells (T-bet) decreased significantly lower in $CCl_4$+IOW group than the $CCl_4$ group. Our data indicated that cytokine protein production were increased in $CCl_4$ group and $CCl_4$+IOW group. As a result of this study, we assume that IOW fed could regulate the immuno-modulating functions through regulate the cytokine production capacity activated by liver damage.

• IMMUNE NETWORK
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• 제16권3호
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• pp.165-175
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• 2016

Ambroxol is used in COPD and asthma to increase mucociliary clearance and regulate surfactant levels, perhaps through anti-oxidant and anti-inflammatory activities. To determine the role and effect of ambroxol in an experimental model of asthma, BALB/c mice were sensitized to ovalbumin (OVA) followed by 3 days of challenge. Airway hyperresponsiveness (AHR), lung cell composition and histology, and cytokine and protein carbonyl levels in bronchoalveolar lavage (BAL) fluid were determined. Ambroxol was administered either before the first OVA challenge or was begun after the last allergen challenge. Cytokine production levels from lung mononuclear cells (Lung MNCs) or alveolar macrophages (AM) were also determined. Administration of ambroxol prior to challenge suppressed AHR, airway eosinophilia, goblet cell metaplasia, and reduced inflammation in subepithelial regions. When given after challenge, AHR was suppressed but without effects on eosinophil numbers. Levels of IL-5 and IL-13 in BAL fluid were decreased when the drug was given prior to challenge; when given after challenge, increased levels of IL-10 and IL-12 were detected. Decreased levels of protein carbonyls were detected in BAL fluid following ambroxol treatment after challenge. In vitro, ambroxol increased levels of IL-10, IFN-γ, and IL-12 from Lung MNCs and AM, whereas IL-4, IL-5, and IL-13 production was not altered. Taken together, ambroxol was effective in preventing AHR and airway inflammation through upregulation of Th1 cytokines and protection from oxidative stress in the airways.

• Animal Bioscience
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• 제37권3호
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• pp.481-491
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• 2024

Objective: This study determined fermentation characteristics of commonly used feedstuffs, especially tropical roughages, for dairy cattle in Southeast Asia. This information is considered relevant in the context of the observed low milk fat content and milk production in Southeast Asia countries. Methods: A total of 29 feedstuffs commonly used for dairy cattle in Vietnam and Thailand were chemically analysed and subjected to an in vitro gas production (GP) test. For 72 h, GP was continuously recorded with fully automated equipment and methane (CH₄) was measured at 0, 3, 6, 9, 12, 24, 30, 36, 48, 60, and 72 h of incubation. A triphasic, nonlinear, regression procedure was applied to analyse GP profiles while a monophasic model was used to obtain kinetics related to CH₄ production. Results: King grass and VA06 showed a high asymptotic GP related to the soluble- and non-soluble fractions (i.e. A1 and A2, respectively) and had the highest acetate to propionate ratio in the incubation fluid. The proportion of CH₄ produced (% of GP at 72 h) was found to be not different (p>0.05) between the various grasses. Among the selected preserved roughages (n = 6) and whole crops (n = 4), sorghum was found to produce the greatest amount of gas in combination with a relatively low CH₄ production. Conclusion: Grasses belonging to the genus Pennisetum, and whole crop sorghum can be considered as suitable ingredients to formulate dairy rations to enhance milk fat content in Vietnam/Thailand.

• 한국식품영양학회지
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• 제20권3호
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• pp.259-264
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• 2007

Ginger(Zingiber officinale Roscoe) has been used as a raw material in many various traditional preparations since the ancient times. As a component of traditional health products, ginger is known to be effective as an appetite enhancer, and has anti-cold and anti-inflammatory activities. This study was performed to investigate the immunomodulative effects of Zingiber officinale Roscoe in mice, using ex vivo experiments. In order to elucidate ginger's immunomodulative effects of Ginger, water extracts were orally administered to mice, and isolated macrophages were used as the experimental model. To identify the ex vivo effects, six to seven week old Balb/c mice were fed a chow diet ad libitum and the ginger water extracts were administered orally every other day for two or four weeks at two different concentrations(50 and 500 mg/kg b.w.). The results show that IL-IO and $IFN-{\gamma}$ were detected in the 500 mg/kg b.w. supplemented group with LPS stimulation in all cases. Also, the $IFN-{\gamma}$ /IL-10 ratio ranged from 3~5 with mitogen stimulation such as Con A and LPS. In conclusion, this study suggests that ginger extracts may enhance the immune function by regulating the cytokine(IL-10 and $IFN-{\gamma}$) production capacity of activated macrophages in mice.

• Preventive Nutrition and Food Science
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• 제17권1호
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• pp.14-21
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• 2012

The purpose of this study was to investigate the anti-allergy activities of persimmon leaf extract (PLE) on a phthalic anhydride (PA)-induced allergic mouse model. A human leukemic mast cell line (HMC-1) was used to examine the inhibitory activity of PLE on the histamine release by human leukemic mast cells. PLE inhibited histamine release from HMC-1 cells in response to cross-linkage of high-affinity IgE receptor-${\alpha}$ ($Fc{\varepsilon}RI{\alpha}$). Additionally, a PA-induced allergic mouse model was used to investigate the effects of PLE in vivo. Mice were orally administrated with or without PLE of single dose (250 mg/kg/day) for 31 days. Oral intake of PLE significantly inhibited passive cutaneous reactions. Oral administration of PLE to PA-induced allergic mice also led to a striking suppression of the development of contact dermatitis, ear swelling and lymph node weight. In addition, PA-specific IL-4 production of draining lymph node cells was markedly diminished by PLE oral administration, but not IFN-${\gamma}$. Furthermore, PLE treatment suppressed PA-induced thymus and activation-regulated chemokine (CCL17) and cutaneous T cell-attracting chemokine (CCL27) expressions in ear tissues. Based on these results, we suggest that PLE may have therapeutic potential as an effective material for management of irritant contact dermatitis or related inflammatory diseases.

• Asian-Australasian Journal of Animal Sciences
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• 제29권7호
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• pp.909-924
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• 2016

The gut is the largest organ that helps with the immune function. Gut health, especially in young pigs has a significant benefit to health and performance. In an attempt to maintain and enhance intestinal health in pigs and improve productivity in the absence of in-feed antibiotics, researchers have evaluated a wide range of feed additives. Some of these additives such as zinc oxide, copper sulphate, egg yolk antibodies, mannan-oligosaccharides and spray dried porcine plasma and their effectiveness are discussed in this review. One approach to evaluate the effectiveness of these additives in vivo is to use an appropriate disease challenge model. Over the years, researchers have used a number of challenge models which include the use of specific strains of enterotoxigenic Escherichia coli, bacteria lipopolysaccharide challenge, oral challenge with Salmonella enteric serotype Typhimurium, sanitation challenge, and Lawsonia intercellularis challenge. These challenge models together with the criteria used to evaluate the responses of the animals to them are also discussed in this review.

• 노동경제논집
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• 제24권1호
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• pp.97-124
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• 2001

자녀양육에 수반되는 시간적 금전적 비용부담이 기혼여성의 노동시장 진입과 경력단절에 가장 큰 영향을 미치는 요인으로 지적한 선행 연구들은 이에 대한 정책적 지원을 강조하였다. 사회복지정책이 발달한 국가에서 세대간 동거(co-residence)는 고령층의 의료 및 부양과 관련된 공적 비용을 사적 비용으로 전환하고, 공식적인 부양을 비공식적인 것으로 대체하는 동시에 기혼여성의 노동공급을 증가시킨다는 관점에서 정책 설정에서 주요한 개선방안으로 인식되고 있다. 본 연구는 "한국노동패널" 2차년도(1999) 자료를 이용하여 부모세대와의 동거상태, 부모 및 기혼여성 본인의 건강상태가 기혼여성의 노동공급에 미치는 영향을 살펴본다. Tobit모형의 추정 결과, 동거 여부, 여성노인과의 동거, 노동시장 근로를 하지 않는 여성노인과의 동거는 동거하는 노인의 건강상태에 관계 없이 기혼여성의 노동공급량에 정(+)의 효과를 미치는 것으로 나타났다. 세대간 동거는 세대간 사적 자원이전 (intergenerational private transfer of resources)을 통하여 기혼여성의 노동공급에 긍정적인 영향올 미치며, 이는 세대간 사적 자원이전이 여성노인을 중심으로 시간자원의 이전이라는 형태를 취하고 있음을 의미한다.